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Protein

Frizzled-7

Gene

Fzd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei567Essential for SDCBP-mediated plasma membrane phosphatidylinositol-4,5-bisphosphate recognitionBy similarity1

GO - Molecular functioni

  • frizzled binding Source: MGI
  • G-protein coupled receptor activity Source: GO_Central
  • PDZ domain binding Source: MGI
  • phosphatidylinositol-4,5-bisphosphate binding Source: MGI
  • Wnt-activated receptor activity Source: MGI
  • Wnt-protein binding Source: MGI

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • mesenchymal to epithelial transition Source: MGI
  • negative regulation of cardiac muscle cell differentiation Source: MGI
  • negative regulation of cell-substrate adhesion Source: BHF-UCL
  • negative regulation of ectodermal cell fate specification Source: MGI
  • non-canonical Wnt signaling pathway Source: MGI
  • non-canonical Wnt signaling pathway via JNK cascade Source: MGI
  • positive regulation of epithelial cell proliferation involved in wound healing Source: MGI
  • positive regulation of phosphorylation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of canonical Wnt signaling pathway Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
  • somatic stem cell division Source: MGI
  • stem cell population maintenance Source: MGI
  • substrate adhesion-dependent cell spreading Source: MGI
  • T cell differentiation in thymus Source: MGI

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-4086400 PCP/CE pathway
R-MMU-4608870 Asymmetric localization of PCP proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7
Short name:
Fz-7
Short name:
mFz7
Gene namesi
Name:Fzd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108570 Fzd7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 254ExtracellularSequence analysisAdd BLAST222
Transmembranei255 – 275Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini276 – 286CytoplasmicSequence analysisAdd BLAST11
Transmembranei287 – 307Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini308 – 334ExtracellularSequence analysisAdd BLAST27
Transmembranei335 – 355Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini356 – 377CytoplasmicSequence analysisAdd BLAST22
Transmembranei378 – 398Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini399 – 421ExtracellularSequence analysisAdd BLAST23
Transmembranei422 – 442Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini443 – 468CytoplasmicSequence analysisAdd BLAST26
Transmembranei469 – 489Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini490 – 526ExtracellularSequence analysisAdd BLAST37
Transmembranei527 – 547Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini548 – 572CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001299733 – 572Frizzled-7Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 110PROSITE-ProRule annotation
Disulfide bondi57 ↔ 103PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 131PROSITE-ProRule annotation
Disulfide bondi120 ↔ 160PROSITE-ProRule annotation
Disulfide bondi124 ↔ 148PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61090
PaxDbiQ61090
PeptideAtlasiQ61090
PRIDEiQ61090

PTM databases

iPTMnetiQ61090
PhosphoSitePlusiQ61090

Expressioni

Gene expression databases

BgeeiENSMUSG00000041075
CleanExiMM_FZD7
GenevisibleiQ61090 MM

Interactioni

Subunit structurei

Interacts with MAGI3 and DVL1. Interacts with MYOC (By similarity). Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621084EBI-8473104,EBI-300895

GO - Molecular functioni

  • frizzled binding Source: MGI
  • PDZ domain binding Source: MGI
  • Wnt-protein binding Source: MGI

Protein-protein interaction databases

BioGridi199780, 2 interactors
IntActiQ61090, 4 interactors
MINTiQ61090
STRINGi10090.ENSMUSP00000041825

Structurei

3D structure databases

ProteinModelPortaliQ61090
SMRiQ61090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 163FZPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi550 – 555Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi570 – 572PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOVERGENiHBG006977
InParanoidiQ61090
KOiK02432
OMAiCVERFSE
OrthoDBiEOG091G0N5M
TreeFamiTF317907

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026552 FZD7
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF31 PTHR11309:SF31, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGPGTAASH SPLGLCALVL ALLGALPTDT RAQPYHGEKG ISVPDHGFCQ
60 70 80 90 100
PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF
110 120 130 140 150
FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN
160 170 180 190 200
FPVHGAGEIC VGQNTSDGSG GAGGSPTAYP TAPYLPDPPF TAMSPSDGRG
210 220 230 240 250
RLSFPFSCPR QLKVPPYLGY RFLGERDCGA PCEPGRANGL MYFKEEERRF
260 270 280 290 300
ARLWVGVWSV LCCASTLFTV LTYLVDMRRF SYPERPIIFL SGCYFMVAVA
310 320 330 340 350
HVAGFLLEDR AVCVERFSDD GYRTVAQGTK KEGCTILFMV LYFFGMASSI
360 370 380 390 400
WWVILSLTWF LAAGMKWGHE AIEANSQYFH LAAWAVPAVK TITILAMGQV
410 420 430 440 450
DGDLLSGVCY VGLSSVDALR GFVLAPLFVY LFIGTSFLLA GFVSLFRIRT
460 470 480 490 500
IMKHDGTKTE KLEKLMVRIG VFSVLYTVPA TIVLACYFYE QAFREHWERT
510 520 530 540 550
WLLQTCKSYA VPCPPGHFSP MSPDFTVFMI KYLMTMIVGI TTGFWIWSGK
560 570
TLQSWRRFYH RLSHSSKGET AV
Length:572
Mass (Da):63,733
Last modified:October 3, 2012 - v2
Checksum:iD0B7DF37B9736183
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262C → S in AAC52432 (PubMed:8626800).Curated1
Sequence conflicti516G → R in AAC52432 (PubMed:8626800).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43320 mRNA Translation: AAC52432.1
AC132574 Genomic DNA No translation available.
CH466548 Genomic DNA Translation: EDL00127.1
CCDSiCCDS14985.1
RefSeqiNP_032083.3, NM_008057.3
UniGeneiMm.297906

Genome annotation databases

EnsembliENSMUST00000114246; ENSMUSP00000109884; ENSMUSG00000041075
GeneIDi14369
KEGGimmu:14369
UCSCiuc011wlq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFZD7_MOUSE
AccessioniPrimary (citable) accession number: Q61090
Secondary accession number(s): G3X953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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