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Protein

Single-minded homolog 2

Gene

Sim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Single-minded homolog 2
Alternative name(s):
SIM transcription factor
Short name:
mSIM
Gene namesi
Name:Sim2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98307 Sim2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274421 – 657Single-minded homolog 2Add BLAST657

Proteomic databases

PaxDbiQ61079
PRIDEiQ61079

PTM databases

iPTMnetiQ61079
PhosphoSitePlusiQ61079

Expressioni

Tissue specificityi

Transcripts were detected in high levels in kidney followed by skeletal muscle and lung. Low levels were found in testis, brain and heart. In early fetal development it is found in CNS, developing kidney, tongue epithelium and cartilage primordia.

Gene expression databases

BgeeiENSMUSG00000062713 Expressed in 102 organ(s), highest expression level in esophagus
CleanExiMM_SIM2
GenevisibleiQ61079 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM2 and ARNT.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203255, 1 interactor
CORUMiQ61079
IntActiQ61079, 2 interactors
STRINGi10090.ENSMUSP00000072043

Structurei

3D structure databases

ProteinModelPortaliQ61079
SMRiQ61079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 53bHLHPROSITE-ProRule annotationAdd BLAST53
Domaini77 – 147PAS 1PROSITE-ProRule annotationAdd BLAST71
Domaini218 – 288PACAdd BLAST71
Domaini218 – 288PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini336 – 657Single-minded C-terminalPROSITE-ProRule annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi367 – 386Nuclear localization signalBy similarityAdd BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3559 Eukaryota
ENOG410XY57 LUCA
GeneTreeiENSGT00760000118788
HOGENOMiHOG000236298
HOVERGENiHBG003936
InParanoidiQ61079
KOiK09100
OMAiSDLLYAP
OrthoDBiEOG091G06FQ
PhylomeDBiQ61079
TreeFamiTF317772

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
IPR010578 SIM_C
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PF06621 SIM_C, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
PS51302 SIM_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL
60 70 80 90 100
KMRAVFPEGL GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK
110 120 130 140 150
IMYISETASV HLGLSQVELT GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL
160 170 180 190 200
LQEYEIERSF FLRMKCVLAK RNAGLTCSGY KVIHCSGYLK IRQYMLDMSL
210 220 230 240 250
YDSCYQIVGL VAVGQSLPPS AITEIKLHSN MFMFRASLDL KLIFLDSRVT
260 270 280 290 300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK
310 320 330 340 350
LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTDVEYKEL QLSLDQVSTS
360 370 380 390 400
KSQESWRTTL STSQETRKSA KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE
410 420 430 440 450
CSQVGNWRTS PPTNAVAPPE QQLHSEASDL LYGPPYSLPF SYHYGHFPLD
460 470 480 490 500
SHVFSSKKPG LPAKFGQPQG SPCEVARFFL STLPASSECQ WHCANSLVPS
510 520 530 540 550
SSSPAKNLSE PSPVNAARHG LVPNYEAPSA AARRFCEDPA PPSFPSCGHY
560 570 580 590 600
REEPALGPAK APRQASRDAA RLALARAPPE CCAPPAPEPQ APAQLPFVLL
610 620 630 640 650
NYHRVLARRG PLGSAAPGAP EAAGSLRPRH PGPVAASAPG APRPHYLGAS

VIITNGR
Length:657
Mass (Da):72,513
Last modified:November 1, 1997 - v1
Checksum:iC7904CD24C0ABBAF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P771A0A338P771_MOUSE
Single-minded homolog 2
Sim2
406Annotation score:

Sequence cautioni

The sequence AAA91202 differs from that shown. Reason: Frameshift at positions 382, 390, 430 and 641.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263K → R in BAA09700 (PubMed:8561800).Curated1
Sequence conflicti263K → R in AAB84099 (PubMed:8812055).Curated1
Sequence conflicti336E → G in AAA91202 (PubMed:8812055).Curated1
Sequence conflicti501S → T in AAA91202 (PubMed:8812055).Curated1
Sequence conflicti512S → P in AAB84099 (PubMed:8812055).Curated1
Sequence conflicti541P → R in AAA91202 (PubMed:8812055).Curated1
Sequence conflicti561 – 585APRQA…CCAPP → VLARRPGRARCMWES in AAA91202 (PubMed:8812055).CuratedAdd BLAST25
Sequence conflicti590 – 591QA → HG in AAA91202 (PubMed:8812055).Curated2
Sequence conflicti638A → R in BAA09700 (PubMed:8561800).Curated1
Sequence conflicti638A → R in AAB84099 (PubMed:8812055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42554 mRNA Translation: AAB19098.1
D63383 mRNA Translation: BAA09700.1
U40576 mRNA Translation: AAA91202.1 Frameshift.
AF023873
, AF023864, AF023865, AF023869, AF023871, AF023870, AF023868, AF023867, AF023866, AF023872 Genomic DNA Translation: AAB84099.1
D64135 mRNA Translation: BAA11013.1
CCDSiCCDS37406.1
RefSeqiNP_035507.2, NM_011377.2
UniGeneiMm.4775

Genome annotation databases

EnsembliENSMUST00000072182; ENSMUSP00000072043; ENSMUSG00000062713
GeneIDi20465
KEGGimmu:20465
UCSCiuc008aae.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42554 mRNA Translation: AAB19098.1
D63383 mRNA Translation: BAA09700.1
U40576 mRNA Translation: AAA91202.1 Frameshift.
AF023873
, AF023864, AF023865, AF023869, AF023871, AF023870, AF023868, AF023867, AF023866, AF023872 Genomic DNA Translation: AAB84099.1
D64135 mRNA Translation: BAA11013.1
CCDSiCCDS37406.1
RefSeqiNP_035507.2, NM_011377.2
UniGeneiMm.4775

3D structure databases

ProteinModelPortaliQ61079
SMRiQ61079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203255, 1 interactor
CORUMiQ61079
IntActiQ61079, 2 interactors
STRINGi10090.ENSMUSP00000072043

PTM databases

iPTMnetiQ61079
PhosphoSitePlusiQ61079

Proteomic databases

PaxDbiQ61079
PRIDEiQ61079

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072182; ENSMUSP00000072043; ENSMUSG00000062713
GeneIDi20465
KEGGimmu:20465
UCSCiuc008aae.1 mouse

Organism-specific databases

CTDi6493
MGIiMGI:98307 Sim2

Phylogenomic databases

eggNOGiKOG3559 Eukaryota
ENOG410XY57 LUCA
GeneTreeiENSGT00760000118788
HOGENOMiHOG000236298
HOVERGENiHBG003936
InParanoidiQ61079
KOiK09100
OMAiSDLLYAP
OrthoDBiEOG091G06FQ
PhylomeDBiQ61079
TreeFamiTF317772

Miscellaneous databases

PROiPR:Q61079
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062713 Expressed in 102 organ(s), highest expression level in esophagus
CleanExiMM_SIM2
GenevisibleiQ61079 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
IPR010578 SIM_C
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PF06621 SIM_C, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
PS51302 SIM_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIM2_MOUSE
AccessioniPrimary (citable) accession number: Q61079
Secondary accession number(s): O35391, Q61046, Q61904
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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