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Protein

Upstream stimulatory factor 1

Gene

Usf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream stimulatory factor 1
Alternative name(s):
Major late transcription factor 1
Gene namesi
Name:Usf1
Synonyms:Usf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99542 Usf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274971 – 310Upstream stimulatory factor 1Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ61069
MaxQBiQ61069
PaxDbiQ61069
PRIDEiQ61069

PTM databases

iPTMnetiQ61069
PhosphoSitePlusiQ61069

Expressioni

Gene expression databases

BgeeiENSMUSG00000026641 Expressed in 102 organ(s), highest expression level in spleen
CleanExiMM_USF1
ExpressionAtlasiQ61069 baseline and differential
GenevisibleiQ61069 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).

Binary interactionsi

WithEntry#Exp.IntActNotes
Stat1P422252EBI-2325635,EBI-647118

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204464, 5 interactors
ComplexPortaliCPX-3085 USF1 upstream stimulatory factor complex
CPX-3086 USF1-USF2 upstream stimulatory factor complex
IntActiQ61069, 1 interactor
STRINGi10090.ENSMUSP00000125729

Structurei

3D structure databases

ProteinModelPortaliQ61069
SMRiQ61069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 254bHLHPROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 292Leucine-zipperAdd BLAST22

Phylogenomic databases

eggNOGiENOG410INSE Eukaryota
ENOG4110B3H LUCA
GeneTreeiENSGT00390000004498
HOVERGENiHBG004346
InParanoidiQ61069
KOiK09106
OMAiNQRTIAP
OrthoDBiEOG091G0RH5
PhylomeDBiQ61069
TreeFamiTF323338

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR12565 PTHR12565, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV
60 70 80 90 100
FRTENGGQVM YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT
110 120 130 140 150
SDDAVDTEGA AAETHYTYFP STAVGDGSGG TTSGSTTAVV TTQGSEALLG
160 170 180 190 200
QATPPSTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR
210 220 230 240 250
RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY
260 270 280 290 300
IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG
310
LEVVIKNDSN
Length:310
Mass (Da):33,570
Last modified:November 1, 1996 - v1
Checksum:i7D0AF808A2FDFA1C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q722E9Q722_MOUSE
Upstream stimulatory factor 1
Usf1
296Annotation score:
E0CYP7E0CYP7_MOUSE
Upstream stimulatory factor 1
Usf1
148Annotation score:
F8WGH6F8WGH6_MOUSE
Upstream stimulatory factor 1
Usf1
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41741 Genomic DNA Translation: AAC52921.1
CCDSiCCDS15495.1
RefSeqiNP_001292605.1, NM_001305676.1
NP_001292606.1, NM_001305677.1
NP_033506.1, NM_009480.3
UniGeneiMm.8

Genome annotation databases

EnsembliENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641
ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641
GeneIDi22278
KEGGimmu:22278
UCSCiuc007doj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41741 Genomic DNA Translation: AAC52921.1
CCDSiCCDS15495.1
RefSeqiNP_001292605.1, NM_001305676.1
NP_001292606.1, NM_001305677.1
NP_033506.1, NM_009480.3
UniGeneiMm.8

3D structure databases

ProteinModelPortaliQ61069
SMRiQ61069
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204464, 5 interactors
ComplexPortaliCPX-3085 USF1 upstream stimulatory factor complex
CPX-3086 USF1-USF2 upstream stimulatory factor complex
IntActiQ61069, 1 interactor
STRINGi10090.ENSMUSP00000125729

PTM databases

iPTMnetiQ61069
PhosphoSitePlusiQ61069

Proteomic databases

EPDiQ61069
MaxQBiQ61069
PaxDbiQ61069
PRIDEiQ61069

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641
ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641
GeneIDi22278
KEGGimmu:22278
UCSCiuc007doj.2 mouse

Organism-specific databases

CTDi7391
MGIiMGI:99542 Usf1

Phylogenomic databases

eggNOGiENOG410INSE Eukaryota
ENOG4110B3H LUCA
GeneTreeiENSGT00390000004498
HOVERGENiHBG004346
InParanoidiQ61069
KOiK09106
OMAiNQRTIAP
OrthoDBiEOG091G0RH5
PhylomeDBiQ61069
TreeFamiTF323338

Enzyme and pathway databases

ReactomeiR-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

PROiPR:Q61069
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026641 Expressed in 102 organ(s), highest expression level in spleen
CleanExiMM_USF1
ExpressionAtlasiQ61069 baseline and differential
GenevisibleiQ61069 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR12565 PTHR12565, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSF1_MOUSE
AccessioniPrimary (citable) accession number: Q61069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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