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Protein

Nuclear receptor subfamily 0 group B member 1

Gene

Nr0b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).By similarity1 Publication

GO - Molecular functioni

  • AF-2 domain binding Source: MGI
  • DNA binding Source: MGI
  • DNA hairpin binding Source: MGI
  • double-stranded DNA binding Source: MGI
  • nuclear receptor activity Source: MGI
  • protein domain specific binding Source: MGI
  • protein homodimerization activity Source: MGI
  • RNA binding Source: HGNC
  • sequence-specific DNA binding Source: GO_Central
  • steroid hormone receptor activity Source: InterPro
  • steroid hormone receptor binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 1
Alternative name(s):
Nuclear receptor DAX-1
Gene namesi
Name:Nr0b1
Synonyms:Ahch, Dax1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1352460 Nr0b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537491 – 472Nuclear receptor subfamily 0 group B member 1Add BLAST472

Proteomic databases

PaxDbiQ61066
PRIDEiQ61066

PTM databases

iPTMnetiQ61066
PhosphoSitePlusiQ61066

Expressioni

Tissue specificityi

Expressed in adult cerebral cortex, spinal cord, thymus, heart, lung, ovary, testis, adrenal gland, hypothalamus, spleen and kidney.1 Publication

Developmental stagei

Expressed in E5.5 throughout the embryo except in the proximal visceral endoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000025056 Expressed in 50 organ(s), highest expression level in head
CleanExiMM_NR0B1
ExpressionAtlasiQ61066 baseline and differential
GenevisibleiQ61066 MM

Interactioni

Subunit structurei

Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (PubMed:27601327).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198035, 17 interactors
DIPiDIP-29929N
IntActiQ61066, 13 interactors
MINTiQ61066
STRINGi10090.ENSMUSP00000026036

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61066
SMRiQ61066
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61066

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 671Add BLAST67
Repeati68 – 1352Add BLAST68
Repeati136 – 2023Add BLAST67
Domaini190 – 471NR LBDPROSITE-ProRule annotationAdd BLAST282
Repeati203 – 2554; truncatedAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 2554 X 67 AA tandem repeatsAdd BLAST255

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 17LXXLL motif 15
Motifi80 – 84LXXLL motif 25
Motifi148 – 152LXXLL motif 35
Motifi463 – 468AF-2 motif6

Domaini

Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG005453
InParanoidiQ61066
KOiK08562
OMAiWGCSCGA
OrthoDBiEOG091G0FGK
PhylomeDBiQ61066
TreeFamiTF332386

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR033544 NR0B1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR025900 Nuclear_receptor_repeat
PANTHERiPTHR24081:SF1 PTHR24081:SF1, 2 hits
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF14046 NR_Repeat, 4 hits
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q61066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEDHPWQG SILYNLLMSA KQKHASQEER EVRLGAQCWG CACGAQPVLG
60 70 80 90 100
GERLSGGQAR SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SVATQAPRAR
110 120 130 140 150
FGAPCWGCAC GSAEPLVGRE GLPAGQAPSL LYRCCFCGEE HPRQGSILYS
160 170 180 190 200
LLTSAQQTHV SREAPEAHRR GEWWQLSYCT QSVGGPEGLQ STQAMAFLYR
210 220 230 240 250
SYVCGEEQPQ QISVASGTPV SADQTPATPQ EQPRAPWWDA SPGVQRLITL
260 270 280 290 300
KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE
310 320 330 340 350
LAQDHLHFEM MEIPETNTTQ EMLTTRRQET EGPEPAEPQA TEQPQMVSAE
360 370 380 390 400
AGHLLPAAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK
410 420 430 440 450
YIEGLQWRTQ QILTEHIRMM QREYQIRSAE LNSALFLLRF INSDVVTELF
460 470
FRPIIGAVSM DDMMLEMLCA KL
Length:472
Mass (Da):52,576
Last modified:November 1, 1996 - v1
Checksum:iDE1FB01C30F883CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83180, S83178 Genomic DNA Translation: AAB46875.1
U41568 mRNA Translation: AAC52920.1
CCDSiCCDS30260.1
PIRiJC5199
RefSeqiNP_031456.1, NM_007430.5
UniGeneiMm.5180

Genome annotation databases

EnsembliENSMUST00000026036; ENSMUSP00000026036; ENSMUSG00000025056
GeneIDi11614
KEGGimmu:11614
UCSCiuc009tsd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83180, S83178 Genomic DNA Translation: AAB46875.1
U41568 mRNA Translation: AAC52920.1
CCDSiCCDS30260.1
PIRiJC5199
RefSeqiNP_031456.1, NM_007430.5
UniGeneiMm.5180

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F5CX-ray3.00B/C205-472[»]
ProteinModelPortaliQ61066
SMRiQ61066
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198035, 17 interactors
DIPiDIP-29929N
IntActiQ61066, 13 interactors
MINTiQ61066
STRINGi10090.ENSMUSP00000026036

PTM databases

iPTMnetiQ61066
PhosphoSitePlusiQ61066

Proteomic databases

PaxDbiQ61066
PRIDEiQ61066

Protocols and materials databases

DNASUi11614
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026036; ENSMUSP00000026036; ENSMUSG00000025056
GeneIDi11614
KEGGimmu:11614
UCSCiuc009tsd.1 mouse

Organism-specific databases

CTDi190
MGIiMGI:1352460 Nr0b1

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG005453
InParanoidiQ61066
KOiK08562
OMAiWGCSCGA
OrthoDBiEOG091G0FGK
PhylomeDBiQ61066
TreeFamiTF332386

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

EvolutionaryTraceiQ61066
PROiPR:Q61066
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025056 Expressed in 50 organ(s), highest expression level in head
CleanExiMM_NR0B1
ExpressionAtlasiQ61066 baseline and differential
GenevisibleiQ61066 MM

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR033544 NR0B1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR025900 Nuclear_receptor_repeat
PANTHERiPTHR24081:SF1 PTHR24081:SF1, 2 hits
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF14046 NR_Repeat, 4 hits
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B1_MOUSE
AccessioniPrimary (citable) accession number: Q61066
Secondary accession number(s): O09068, O09147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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