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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

Dvl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the signal transduction pathway mediated by multiple Wnt genes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-201688 WNT mediated activation of DVL
R-MMU-4086400 PCP/CE pathway
R-MMU-4641258 Degradation of DVL
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5663220 RHO GTPases Activate Formins

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name:
Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene namesi
Name:Dvl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:108100 Dvl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457501 – 716Segment polarity protein dishevelled homolog DVL-3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Modified residuei212Omega-N-methylarginineBy similarity1
Modified residuei271Asymmetric dimethylarginine; by PRMT1; alternateBy similarity1
Modified residuei271Symmetric dimethylarginine; by PRMT7; alternateBy similarity1
Modified residuei342Omega-N-methylarginine; alternateBy similarity1
Modified residuei342Symmetric dimethylarginine; by PRMT7; alternateBy similarity1
Modified residuei346PhosphothreonineBy similarity1
Modified residuei614Symmetric dimethylarginine; by PRMT7By similarity1
Modified residuei697PhosphoserineBy similarity1
Modified residuei698Dimethylated arginine; alternateBy similarity1
Modified residuei698Omega-N-methylarginine; alternateBy similarity1
Modified residuei700PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).By similarity
Phosphorylated by CSNK1D.By similarity
Arginine methylation may function as a switch in regulation of function in Wnt signaling.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61062
MaxQBiQ61062
PaxDbiQ61062
PRIDEiQ61062

PTM databases

iPTMnetiQ61062
PhosphoSitePlusiQ61062

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000003233 Expressed in 78 organ(s), highest expression level in brain
CleanExiMM_DVL3
ExpressionAtlasiQ61062 baseline and differential
GenevisibleiQ61062 MM

Interactioni

Subunit structurei

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2 (By similarity). Interacts with DAAM2 (PubMed:22227309).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199344, 9 interactors
CORUMiQ61062
IntActiQ61062, 15 interactors
MINTiQ61062
STRINGi10090.ENSMUSP00000003318

Structurei

3D structure databases

ProteinModelPortaliQ61062
SMRiQ61062
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82DIXPROSITE-ProRule annotationAdd BLAST82
Domaini249 – 321PDZPROSITE-ProRule annotationAdd BLAST73
Domaini422 – 496DEPPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00390000013552
HOGENOMiHOG000017084
HOVERGENiHBG005542
InParanoidiQ61062
KOiK02353
OMAiTNQSDNC
TreeFamiTF318198

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01763 DISHEVELLED3
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61062-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP
110 120 130 140 150
PSMERTGGIG DSRPPSFHPH ASGGSQENLD NDTETDSLVS AQRERPRRRD
160 170 180 190 200
GPEHAARLNG TTKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR
210 220 230 240 250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV
260 270 280 290 300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL
310 320 330 340 350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS
360 370 380 390 400
EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER
410 420 430 440 450
LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW
460 470 480 490 500
LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN
510 520 530 540 550
MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH
560 570 580 590 600
PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG
610 620 630 640 650
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH
660 670 680 690 700
PSYGPPGVPP LYGPPMLMMT PPPAAMGPPG APPGRDLASV PPELTASRQS
710
FRMAMGNPSE FFVDVM
Length:716
Mass (Da):78,123
Last modified:October 3, 2012 - v2
Checksum:i552A5BE4BEA801F0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q967E9Q967_MOUSE
Segment polarity protein dishevelle...
Dvl3
718Annotation score:
E9Q150E9Q150_MOUSE
Segment polarity protein dishevelle...
Dvl3
699Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti460D → E in AAB01761 (PubMed:8922524).Curated1
Sequence conflicti674A → G in AAB01761 (PubMed:8922524).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41285 mRNA Translation: AAB01761.1
AC087898 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97570.1
CCDSiCCDS37287.1
RefSeqiNP_031915.2, NM_007889.2
UniGeneiMm.247259
Mm.272443

Genome annotation databases

EnsembliENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233
GeneIDi13544
KEGGimmu:13544
UCSCiuc007ypw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41285 mRNA Translation: AAB01761.1
AC087898 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97570.1
CCDSiCCDS37287.1
RefSeqiNP_031915.2, NM_007889.2
UniGeneiMm.247259
Mm.272443

3D structure databases

ProteinModelPortaliQ61062
SMRiQ61062
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199344, 9 interactors
CORUMiQ61062
IntActiQ61062, 15 interactors
MINTiQ61062
STRINGi10090.ENSMUSP00000003318

PTM databases

iPTMnetiQ61062
PhosphoSitePlusiQ61062

Proteomic databases

EPDiQ61062
MaxQBiQ61062
PaxDbiQ61062
PRIDEiQ61062

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003318; ENSMUSP00000003318; ENSMUSG00000003233
GeneIDi13544
KEGGimmu:13544
UCSCiuc007ypw.1 mouse

Organism-specific databases

CTDi1857
MGIiMGI:108100 Dvl3

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00390000013552
HOGENOMiHOG000017084
HOVERGENiHBG005542
InParanoidiQ61062
KOiK02353
OMAiTNQSDNC
TreeFamiTF318198

Enzyme and pathway databases

ReactomeiR-MMU-201688 WNT mediated activation of DVL
R-MMU-4086400 PCP/CE pathway
R-MMU-4641258 Degradation of DVL
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5663220 RHO GTPases Activate Formins

Miscellaneous databases

PROiPR:Q61062
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003233 Expressed in 78 organ(s), highest expression level in brain
CleanExiMM_DVL3
ExpressionAtlasiQ61062 baseline and differential
GenevisibleiQ61062 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01763 DISHEVELLED3
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDVL3_MOUSE
AccessioniPrimary (citable) accession number: Q61062
Secondary accession number(s): G5E820
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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