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Protein

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

  • cation channel activity Source: MGI
  • inositol 1,4,5 trisphosphate binding Source: MGI
  • ion channel binding Source: MGI
  • store-operated calcium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Short name:
mTrp1
Trp-related protein 1
Gene namesi
Name:Trpc1
Synonyms:Trp1, Trrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109528 Trpc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 386CytoplasmicSequence analysisAdd BLAST386
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 415ExtracellularSequence analysis8
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 495CytoplasmicSequence analysisAdd BLAST59
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 539ExtracellularSequence analysisAdd BLAST23
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Topological domaini561 – 586CytoplasmicSequence analysisAdd BLAST26
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 616ExtracellularSequence analysis9
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 793CytoplasmicSequence analysisAdd BLAST156

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153041 – 793Short transient receptor potential channel 1Add BLAST793

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61056
PRIDEiQ61056

PTM databases

iPTMnetiQ61056
PhosphoSitePlusiQ61056

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC4 and/or TRPC5 (By similarity). Interacts with TRPC3, TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with FKBP4 (By similarity). Interacts with TRPC4AP.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204327, 2 interactors
CORUMiQ61056
DIPiDIP-33928N
IntActiQ61056, 3 interactors
STRINGi10090.ENSMUSP00000057640

Structurei

3D structure databases

ProteinModelPortaliQ61056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 75ANK 1Add BLAST30
Repeati83 – 111ANK 2Add BLAST29
Repeati112 – 138ANK 3Add BLAST27
Repeati158 – 187ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiQ61056
KOiK04964

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005457 TRPC1_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF56 PTHR10117:SF56, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01642 TRPCHANNEL1
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q61056-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL
110 120 130 140 150
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
160 170 180 190 200
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
210 220 230 240 250
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV
260 270 280 290 300
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL
310 320 330 340 350
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
360 370 380 390 400
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
410 420 430 440 450
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
460 470 480 490 500
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG
510 520 530 540 550
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS
560 570 580 590 600
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
610 620 630 640 650
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ
660 670 680 690 700
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
710 720 730 740 750
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM
760 770 780 790
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN
Length:793
Mass (Da):91,213
Last modified:May 3, 2011 - v5
Checksum:iCBECB08C0D72E5DF
GO
Isoform Beta (identifier: Q61056-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,618
Checksum:i92FFA669703237BE
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RPS7B2RPS7_MOUSE
Short transient receptor potential ...
Trpc1 mCG_10244
809Annotation score:
B7ZMP6B7ZMP6_MOUSE
Short transient receptor potential ...
Trpc1 mCG_10244
775Annotation score:
A0A087WSD0A0A087WSD0_MOUSE
Short transient receptor potential ...
Trpc1
255Annotation score:
A0A087WP07A0A087WP07_MOUSE
Short transient receptor potential ...
Trpc1
99Annotation score:
A0A087WRB2A0A087WRB2_MOUSE
Short transient receptor potential ...
Trpc1
84Annotation score:

Sequence cautioni

The sequence AAB50622 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC53162 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF05725 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006561110 – 143Missing in isoform Beta. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73625 mRNA Translation: AAB50622.1 Different initiation.
U95167 mRNA Translation: AAC53162.1 Different initiation.
AF191551 mRNA Translation: AAF05725.1 Different initiation.
U40980 mRNA Translation: AAC52699.1
RefSeqiNP_001298052.1, NM_001311123.1
NP_035773.1, NM_011643.3
UniGeneiMm.149633
Mm.398522

Genome annotation databases

GeneIDi22063
KEGGimmu:22063
UCSCiuc009rbj.1 mouse [Q61056-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73625 mRNA Translation: AAB50622.1 Different initiation.
U95167 mRNA Translation: AAC53162.1 Different initiation.
AF191551 mRNA Translation: AAF05725.1 Different initiation.
U40980 mRNA Translation: AAC52699.1
RefSeqiNP_001298052.1, NM_001311123.1
NP_035773.1, NM_011643.3
UniGeneiMm.149633
Mm.398522

3D structure databases

ProteinModelPortaliQ61056
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204327, 2 interactors
CORUMiQ61056
DIPiDIP-33928N
IntActiQ61056, 3 interactors
STRINGi10090.ENSMUSP00000057640

PTM databases

iPTMnetiQ61056
PhosphoSitePlusiQ61056

Proteomic databases

PaxDbiQ61056
PRIDEiQ61056

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22063
KEGGimmu:22063
UCSCiuc009rbj.1 mouse [Q61056-1]

Organism-specific databases

CTDi7220
MGIiMGI:109528 Trpc1

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiQ61056
KOiK04964

Miscellaneous databases

PROiPR:Q61056
SOURCEiSearch...

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005457 TRPC1_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF56 PTHR10117:SF56, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01642 TRPCHANNEL1
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC1_MOUSE
AccessioniPrimary (citable) accession number: Q61056
Secondary accession number(s): O35722
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 3, 2011
Last modified: November 7, 2018
This is version 166 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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