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Entry version 156 (17 Jun 2020)
Sequence version 4 (25 Apr 2018)
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Protein

Ninein

Gene

Nin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15784680, PubMed:10934040). May also act as a centrosome maturation factor (By similarity). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15784680). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (By similarity). Required for centriole organization and microtubule anchoring at the mother centriole (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi245 – 252GTPSequence analysis8
Nucleotide bindingi300 – 304GTPSequence analysis5
Nucleotide bindingi420 – 423GTPSequence analysis4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ninein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NinImported
Synonyms:Kiaa1565Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:105108 Nin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000968451 – 2113NineinAdd BLAST2113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei152PhosphoserineBy similarity1
Modified residuei269PhosphoserineCombined sources1
Modified residuei1540PhosphoserineBy similarity1
Modified residuei1826PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/Aurora kinase B.

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q61043

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q61043

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61043

PRoteomics IDEntifications database

More...
PRIDEi
Q61043

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61043

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61043

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in spleen, bone marrow and skin. Weakly expressed in liver and small intestine. Expressed in brain.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Associated with the centrosome throughout the cell cycle (PubMed:8834802). During mitosis, it is associated with the centrosome and the mitotic spindle (PubMed:8834802). At anaphase, it is only localized to centrosomes (PubMed:8834802). Isoform 4 is highly expressed in postmitotic cortical neurons during neurogenesis (PubMed:27565344).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021068 Expressed in mesenteric lymph node and 262 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q61043 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q61043 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (By similarity).

Interacts with GSK3B/GSK3-beta via its C-terminal domain (By similarity).

Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3B (By similarity).

Interacts with AUNIP (via N-terminus) (By similarity).

Identified in a complex with AUNIP and AURKA (By similarity).

Interacts with CCDC120 (By similarity).

Interacts (via C-terminus) with CEP250 (PubMed:27565344).

Interacts with CEP170 (PubMed:27565344).

Interacts (via N-terminus) with the gamma-tubulin ring complex component TUBGCP3 (PubMed:15784680).

Interacts with gamma-tubulin (PubMed:15784680). Isoform 4 does not interact with CEP170 or CEP250 (PubMed:27565344).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
201772, 3 interactors

Protein interaction database and analysis system

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IntActi
Q61043, 3 interactors

Molecular INTeraction database

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MINTi
Q61043

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000082422

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q61043 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q61043

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini42 – 77EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini182 – 217EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini219 – 252EF-hand 4PROSITE-ProRule annotationAdd BLAST34
Domaini317 – 352EF-hand 5PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni798 – 1495Important for interaction with CEP1701 PublicationAdd BLAST698

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili358 – 570Sequence analysisAdd BLAST213
Coiled coili620 – 926Sequence analysisAdd BLAST307
Coiled coili958 – 1008Sequence analysisAdd BLAST51
Coiled coili1175 – 1323Sequence analysisAdd BLAST149
Coiled coili1425 – 1806Sequence analysisAdd BLAST382
Coiled coili1852 – 1910Sequence analysisAdd BLAST59
Coiled coili1971 – 2093Sequence analysisAdd BLAST123

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

There is conflicting information regarding the regions required for centrosomal localization (PubMed:15784680). One study shows that the region 1591-1671 is necessary and sufficient for targeting to the centrosome (By similarity). Another study shows that a separate region within the coiled-coil domain, 1279-1565, is important for centrosomal localization (By similarity). However, a third study shows that the coiled-coil region (373-1874) is not sufficient for centrosomal localization and instead localizes to cytoplasmic speckles (PubMed:15784680). The observed differences might be due to oligomerization of the longer coiled-coil domain-containing sequence, which would mask the shorter centrosomal targeting sequences (PubMed:15784680).By similarity1 Publication
The N-terminal domain is important for targeting to the mother centriole, although it is not sufficient by itself for centrosomal localization.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK59 Eukaryota
ENOG410Z1RR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00660000095541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001462_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q61043

KEGG Orthology (KO)

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KOi
K16476

Database of Orthologous Groups

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OrthoDBi
95801at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325139

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR029664 NIN

The PANTHER Classification System

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PANTHERi
PTHR18905:SF11 PTHR18905:SF11, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61043-3) [UniParc]FASTAAdd to basket
Also known as: NPC-CT1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEVEEDQHE ARLKELFDSF DTLGTGSLGQ EELTDLCHVL CLEDVGPVLQ
60 70 80 90 100
QTLLQDNLLG RVHFDQFKEA LILILSRTLS SEEHFEESDC SPEAQPKYVR
110 120 130 140 150
GGKRYGRRSL PEFQESGEEI EEVTVLEPLE EEARSSPIPA GDCGEHWKTQ
160 170 180 190 200
RSEEYEAEGQ LRFWNPDDLN ASHGGSCPPP DWIEEKLQEV CEDLGITRDG
210 220 230 240 250
HLNRKKLVSI CEQYGLQNVD GAMLEEVFLS LDPDGTMSVE DFFYGLFKTG
260 270 280 290 300
KSLTPSASTP YRQLKRHLSM QSFDESGRRT ATSSAMTSTI GFRVFSCLDD
310 320 330 340 350
GMGQASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL
360 370 380 390 400
LVTKNGIHQA ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM
410 420 430 440 450
ASEVDDHHAA IERRNEYNLR KLDEEYKERI AALKNELRQE REQMLQQVGK
460 470 480 490 500
QRVELEQEIQ KAKTEENYIR DRLALSLKEN NRLETELLEN AEKLAEYESL
510 520 530 540 550
TQKLQRSLEN VLAEKFGDLD PSSAEFFLQE ERLAQMRNEY EQQCRLLQDQ
560 570 580 590 600
VDELQSELEE YQAQGRVLRL PLKNSLSEEL DGHSGGIEPD QGPGSEECNP
610 620 630 640 650
LNMSIEAELV IEQMKEQHHR DLCHLRLELE DKVRHYEKQL DDTRVASEQE
660 670 680 690 700
QAAMKQKYEQ GVHTLEKRVS ELRSEIADLE GQAAVLREAH HKASCRHEEE
710 720 730 740 750
KRQLQMAFDE EKAQLQEELR QEHERELQAR LQQAAESFRQ EREGLAQAAW
760 770 780 790 800
TEEKVRGLEQ SYQEQLLSLE EKHALEKEEL REELSEHHRR ELQEGREEME
810 820 830 840 850
TECNRRVSQI EAQCQADCEK VTEHCEQTLQ SLEVRHRQEL RDLLDQHLEE
860 870 880 890 900
RSQWEFEKDE LTQECTDAQE QLKEALQRER ATAAAMKQEQ EILERTYKDR
910 920 930 940 950
LNILSTERKQ LLQDLKDLQN ASESQHGLLS GQILELKRSQ ERELRDQGQA
960 970 980 990 1000
LCQTGVSEQL ASQQLERLRV EHEQERREMT GKLAALESAH RASLERADQE
1010 1020 1030 1040 1050
KAEMSTEICR LQNTVKDMQQ AASLLMLQGG CQATAGEEAE GDGAMSLLQQ
1060 1070 1080 1090 1100
GEQLLEENGD VLISLQRAHE HAVKENAKMA TEISRLQQRL KKLEPGSVIS
1110 1120 1130 1140 1150
SCLEEGTSEI SGSSREQVEP IMKQGPATKH FLSDLGDHEA RDLASTGTSS
1160 1170 1180 1190 1200
VQRQECKTEA SEASLDCFSE LENSEDTRTE SWDLKSQISQ LREQLTVLRA
1210 1220 1230 1240 1250
DCDRASERKQ DLLFDISVLK KKLKMLERLP EASSRYKVLY EDAARENSCL
1260 1270 1280 1290 1300
QEELRLVETR YEESLDSNKE LTAEVYRLQD EMKKMEEVME TFLSLEKSYD
1310 1320 1330 1340 1350
EVKVENEELR ALVLRLQGKM EKVLGRAALQ GDSYALWEAP SENLEVASDE
1360 1370 1380 1390 1400
KMLELRQTPK ECTPKVVSMH HIIEECTQET QCCEQGSTKL LARIKAHEIA
1410 1420 1430 1440 1450
WFHRAIKTHP EKPSAQNRVI PEGSAALLGL QDKHLQQEAT IAELELEKQK
1460 1470 1480 1490 1500
LQELTRNLRE RVTALVRQKD APSQGQKEEE LKAMMQDLQI TCGEMQRKVE
1510 1520 1530 1540 1550
LLRYESEKLQ EENSILRNEI TTLNEEDSIS NLKLEELNGS QEELWQKIET
1560 1570 1580 1590 1600
IEQEKASIQT MVEKLKKQVS DLKIKNQQLD SENIELSQKN SQNKEELKTL
1610 1620 1630 1640 1650
NQRLAEMLCQ REEPGACTSE KWEQENASLK EELDHYKVQT STLVSSLEAE
1660 1670 1680 1690 1700
LSEVKLQTHV MEQENLLLKD ELERLKQLHR CPDLSDFQQK MSSILSYNEK
1710 1720 1730 1740 1750
LLKEKEVLSE ELKSCADKLA ESSLLEHRIA TMKQEQTAWE EQSESLKSQL
1760 1770 1780 1790 1800
AVSQAKVQNL EDVLQNVNLQ MAEIESDLQV TRQEKEALKQ EVMSLHRQLQ
1810 1820 1830 1840 1850
NAIDKDWVSE TAPHLSGLRG QQRRLSWDKL DHLMNEEPQL LCQESKRLQT
1860 1870 1880 1890 1900
VVQNTQADLT HSREKVRQLE SNLLPTKHQK QLNQPCTVKS TEQEKLTLKR
1910 1920 1930 1940 1950
ECEQSQKEQS PTSRKVGQMG SLERGLETIH LENEGLKKKQ MQPLRSTVTR
1960 1970 1980 1990 2000
SPSSHWDLQL LQQQACPMVP REQFLQLQQQ LLQAEKRSQH LQEELENRTS
2010 2020 2030 2040 2050
ETNTPQGNQE HLVNLMEERM IEVEQKLKLV KRLLQEKVNQ LKEQLCKNTK
2060 2070 2080 2090 2100
TDAVVKDLYV ENAQLLKALE MTEQRQKTAE KRNFLLEEKI ASLSTIVRNL
2110
APAPLTSMPP LRS
Length:2,113
Mass (Da):243,718
Last modified:April 25, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3A2EEBD3E9FC826
GO
Isoform 2 (identifier: Q61043-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2007-2026: GNQEHLVNLMEERMIEVEQK → ALLLEQRAVHADSCRRIGHL
     2027-2113: Missing.

Show »
Length:2,026
Mass (Da):233,608
Checksum:iE7E37BD4108D2560
GO
Isoform 3 (identifier: Q61043-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1940-1940: Q → QVRLDEKLME
     2007-2026: GNQEHLVNLMEERMIEVEQK → ALLLEQRAVHADSCRRIGHL
     2027-2113: Missing.

Show »
Length:2,035
Mass (Da):234,723
Checksum:iF92C1E77C1365D19
GO
Isoform 4 (identifier: Q61043-4) [UniParc]FASTAAdd to basket
Also known as: Neuron1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     797-1503: Missing.
     1941-1979: MQPLRSTVTR...PREQFLQLQQ → VRLDEKLMES...DAAPEVHCDA
     1980-2113: Missing.

Show »
Length:1,272
Mass (Da):146,753
Checksum:i9807EC9ADFD01C46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VNC5A0A1Y7VNC5_MOUSE
Ninein
Nin
1,979Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJC3A0A1Y7VJC3_MOUSE
Ninein
Nin
996Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VIQ3A0A1Y7VIQ3_MOUSE
Ninein
Nin
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJS5A0A1Y7VJS5_MOUSE
Ninein
Nin
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A668KL94A0A668KL94_MOUSE
Ninein
Nin
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA83234 differs from that shown. Reason: Frameshift.Curated
The sequence AAA83234 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC98204 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145 – 146EH → DD in AAA83234 (PubMed:8834802).Curated2
Sequence conflicti341 – 342EL → DV in AAA83234 (PubMed:8834802).Curated2
Sequence conflicti383 – 394KEKLR…LDKAE → RRAYGRTWTSR in AAA83234 (PubMed:8834802).CuratedAdd BLAST12
Sequence conflicti506R → A in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti561Y → H in BAC98204 (PubMed:14621295).Curated1
Sequence conflicti675E → K in AAS87211 (PubMed:15784680).Curated1
Sequence conflicti737S → T in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti862T → A in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti909K → E in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti909K → E in BAC98204 (PubMed:14621295).Curated1
Sequence conflicti909K → E in AAI37790 (PubMed:15489334).Curated1
Sequence conflicti909K → E in AAI44914 (PubMed:15489334).Curated1
Sequence conflicti909K → E in AAS87211 (PubMed:15784680).Curated1
Sequence conflicti963 – 964QQ → PE in AAA83234 (PubMed:8834802).Curated2
Sequence conflicti1084 – 1085SR → YQ in AAA83234 (PubMed:8834802).Curated2
Sequence conflicti1084 – 1085SR → YQ in AAS87211 (PubMed:15784680).Curated2
Sequence conflicti1084S → Y in BAC98204 (PubMed:14621295).Curated1
Sequence conflicti1084S → Y in AAI37790 (PubMed:15489334).Curated1
Sequence conflicti1084S → Y in AAI44914 (PubMed:15489334).Curated1
Sequence conflicti1155E → K in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti1155E → K in AAS87211 (PubMed:15784680).Curated1
Sequence conflicti1182Missing in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti1327A → P in AAS87211 (PubMed:15784680).Curated1
Sequence conflicti1336 – 1339LWEA → SGKP in AAA83234 (PubMed:8834802).Curated4
Sequence conflicti1487 – 1490DLQI → PAV in AAA83234 (PubMed:8834802).Curated4
Sequence conflicti1653 – 1654EV → RI in AAA83234 (PubMed:8834802).Curated2
Sequence conflicti1687F → L in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti1694I → V in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti1759N → D in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti1788L → V in AAA83234 (PubMed:8834802).Curated1
Sequence conflicti1841L → F in AAI44914 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059551797 – 1503Missing in isoform 4. Add BLAST707
Alternative sequenceiVSP_0595521940Q → QVRLDEKLME in isoform 3. 1
Alternative sequenceiVSP_0595531941 – 1979MQPLR…LQLQQ → VRLDEKLMESSVVGSSRAGR SSVPELACEDAAPEVHCDA in isoform 4. Add BLAST39
Alternative sequenceiVSP_0595541980 – 2113Missing in isoform 4. Add BLAST134
Alternative sequenceiVSP_0595552007 – 2026GNQEH…EVEQK → ALLLEQRAVHADSCRRIGHL in isoform 2 and isoform 3. Add BLAST20
Alternative sequenceiVSP_0595562027 – 2113Missing in isoform 2 and isoform 3. Add BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U40342 mRNA Translation: AAA83234.1 Sequence problems.
AY515727 mRNA Translation: AAS87211.1
AK129394 mRNA Translation: BAC98204.1 Different initiation.
AC112146 Genomic DNA No translation available.
AC116574 Genomic DNA No translation available.
BC137789 mRNA Translation: AAI37790.1
BC144913 mRNA Translation: AAI44914.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36468.1 [Q61043-3]
CCDS36469.1 [Q61043-1]

Protein sequence database of the Protein Information Resource

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PIRi
T30171

NCBI Reference Sequences

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RefSeqi
NP_001074922.1, NM_001081453.1 [Q61043-3]
NP_001273008.1, NM_001286079.2 [Q61043-1]
NP_001273009.1, NM_001286080.2 [Q61043-2]
NP_032723.2, NM_008697.4 [Q61043-1]
XP_011242311.1, XM_011244009.1 [Q61043-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000021468; ENSMUSP00000021468; ENSMUSG00000021068 [Q61043-1]
ENSMUST00000085314; ENSMUSP00000082422; ENSMUSG00000021068 [Q61043-3]
ENSMUST00000095666; ENSMUSP00000093327; ENSMUSG00000021068 [Q61043-1]
ENSMUST00000169074; ENSMUSP00000129648; ENSMUSG00000021068 [Q61043-1]
ENSMUST00000220689; ENSMUSP00000152530; ENSMUSG00000021068 [Q61043-4]
ENSMUST00000222237; ENSMUSP00000152240; ENSMUSG00000021068 [Q61043-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18080

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18080

UCSC genome browser

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UCSCi
uc007ntf.1 mouse
uc007ntg.2 mouse [Q61043-3]
uc007nth.2 mouse [Q61043-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40342 mRNA Translation: AAA83234.1 Sequence problems.
AY515727 mRNA Translation: AAS87211.1
AK129394 mRNA Translation: BAC98204.1 Different initiation.
AC112146 Genomic DNA No translation available.
AC116574 Genomic DNA No translation available.
BC137789 mRNA Translation: AAI37790.1
BC144913 mRNA Translation: AAI44914.1
CCDSiCCDS36468.1 [Q61043-3]
CCDS36469.1 [Q61043-1]
PIRiT30171
RefSeqiNP_001074922.1, NM_001081453.1 [Q61043-3]
NP_001273008.1, NM_001286079.2 [Q61043-1]
NP_001273009.1, NM_001286080.2 [Q61043-2]
NP_032723.2, NM_008697.4 [Q61043-1]
XP_011242311.1, XM_011244009.1 [Q61043-3]

3D structure databases

SMRiQ61043
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201772, 3 interactors
IntActiQ61043, 3 interactors
MINTiQ61043
STRINGi10090.ENSMUSP00000082422

PTM databases

iPTMnetiQ61043
PhosphoSitePlusiQ61043

Proteomic databases

jPOSTiQ61043
MaxQBiQ61043
PaxDbiQ61043
PRIDEiQ61043

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23688 136 antibodies

Genome annotation databases

EnsembliENSMUST00000021468; ENSMUSP00000021468; ENSMUSG00000021068 [Q61043-1]
ENSMUST00000085314; ENSMUSP00000082422; ENSMUSG00000021068 [Q61043-3]
ENSMUST00000095666; ENSMUSP00000093327; ENSMUSG00000021068 [Q61043-1]
ENSMUST00000169074; ENSMUSP00000129648; ENSMUSG00000021068 [Q61043-1]
ENSMUST00000220689; ENSMUSP00000152530; ENSMUSG00000021068 [Q61043-4]
ENSMUST00000222237; ENSMUSP00000152240; ENSMUSG00000021068 [Q61043-3]
GeneIDi18080
KEGGimmu:18080
UCSCiuc007ntf.1 mouse
uc007ntg.2 mouse [Q61043-3]
uc007nth.2 mouse [Q61043-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51199
MGIiMGI:105108 Nin

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IK59 Eukaryota
ENOG410Z1RR LUCA
GeneTreeiENSGT00660000095541
HOGENOMiCLU_001462_1_1_1
InParanoidiQ61043
KOiK16476
OrthoDBi95801at2759
TreeFamiTF325139

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
18080 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nin mouse

Protein Ontology

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PROi
PR:Q61043
RNActiQ61043 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021068 Expressed in mesenteric lymph node and 262 other tissues
ExpressionAtlasiQ61043 baseline and differential
GenevisibleiQ61043 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR029664 NIN
PANTHERiPTHR18905:SF11 PTHR18905:SF11, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61043
Secondary accession number(s): A0A1Y7VJL5
, B2RQ73, B7ZMZ9, E9Q488, E9Q4S3, Q674R4, Q6ZPM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 25, 2018
Last modified: June 17, 2020
This is version 156 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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