UniProtKB - Q61041 (NPY4R_MOUSE)
Protein
Neuropeptide Y receptor type 4
Gene
Npy4r
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.1 Publication
GO - Molecular functioni
- pancreatic polypeptide receptor activity Source: MGI
- peptide binding Source: MGI
- peptide YY receptor activity Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide Y receptor type 4Short name: NPY4-R Alternative name(s): NPYR-D Pancreatic polypeptide receptor 1 Short name: PP1 |
Gene namesi | Name:Npy4r Synonyms:Ppyr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105374, Npy4r |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 60 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 61 – 78 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 79 – 99 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 100 – 116 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 117 – 137 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 155 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 156 – 176 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 211 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 212 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 266 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 267 – 287 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 301 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 302 – 322 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 323 – 375 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069936 | 1 – 375 | Neuropeptide Y receptor type 4Add BLAST | 375 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 19 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 201 | PROSITE-ProRule annotation | ||
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 340 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q61041 |
PRIDEi | Q61041 |
PTM databases
GlyGeni | Q61041, 4 sites |
PhosphoSitePlusi | Q61041 |
Expressioni
Tissue specificityi
Heart, detected in small intestine.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000048337, Expressed in adult mammalian kidney and 27 other tissues |
Genevisiblei | Q61041, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000056576 |
Chemistry databases
BindingDBi | Q61041 |
Miscellaneous databases
RNActi | Q61041, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161927 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | Q61041 |
OMAi | CYLRIYL |
OrthoDBi | 609835at2759 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001933, NPY4_rcpt IPR000611, NPY_rcpt |
PANTHERi | PTHR24235:SF25, PTHR24235:SF25, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01015, NRPEPTIDEY4R PR01012, NRPEPTIDEYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q61041-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI
60 70 80 90 100
ETILGVLGNL CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT
110 120 130 140 150
YTIMDYWIFG EVLCKMLTFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSIFQAYLGI VVIWFVSCFL SLPFLANSTL NDLFHYNHSK VVEFLEDKVV
210 220 230 240 250
CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR LQRQKHVFHA
260 270 280 290 300
HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG
310 320 330 340 350
NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE
360 370
HLPLSTVHTD LSKGSMRMGS KSNFI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 166 | V → I in AAC52442 (PubMed:8641440).Curated | 1 | |
Sequence conflicti | 346 | R → Q in AAC52442 (PubMed:8641440).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40189 Genomic DNA Translation: AAC52442.1 AK144461 mRNA Translation: BAE25901.1 BC132395 mRNA Translation: AAI32396.1 BC145981 mRNA Translation: AAI45982.1 |
CCDSi | CCDS26933.1 |
PIRi | S63685 |
RefSeqi | NP_032945.3, NM_008919.4 |
Genome annotation databases
Ensembli | ENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337 |
GeneIDi | 19065 |
KEGGi | mmu:19065 |
UCSCi | uc007tak.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40189 Genomic DNA Translation: AAC52442.1 AK144461 mRNA Translation: BAE25901.1 BC132395 mRNA Translation: AAI32396.1 BC145981 mRNA Translation: AAI45982.1 |
CCDSi | CCDS26933.1 |
PIRi | S63685 |
RefSeqi | NP_032945.3, NM_008919.4 |
3D structure databases
SMRi | Q61041 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000056576 |
Chemistry databases
BindingDBi | Q61041 |
ChEMBLi | CHEMBL4105736 |
GuidetoPHARMACOLOGYi | 307 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q61041, 4 sites |
PhosphoSitePlusi | Q61041 |
Proteomic databases
PaxDbi | Q61041 |
PRIDEi | Q61041 |
Genome annotation databases
Ensembli | ENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337 |
GeneIDi | 19065 |
KEGGi | mmu:19065 |
UCSCi | uc007tak.2, mouse |
Organism-specific databases
CTDi | 5540 |
MGIi | MGI:105374, Npy4r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161927 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | Q61041 |
OMAi | CYLRIYL |
OrthoDBi | 609835at2759 |
TreeFami | TF315303 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 19065, 1 hit in 17 CRISPR screens |
PROi | PR:Q61041 |
RNActi | Q61041, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048337, Expressed in adult mammalian kidney and 27 other tissues |
Genevisiblei | Q61041, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001933, NPY4_rcpt IPR000611, NPY_rcpt |
PANTHERi | PTHR24235:SF25, PTHR24235:SF25, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01015, NRPEPTIDEY4R PR01012, NRPEPTIDEYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPY4R_MOUSE | |
Accessioni | Q61041Primary (citable) accession number: Q61041 Secondary accession number(s): Q3UN46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families