Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropeptide Y receptor type 4

Gene

Npy4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.

GO - Molecular functioni

  • pancreatic polypeptide receptor activity Source: MGI
  • peptide binding Source: MGI
  • peptide YY receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 4
Short name:
NPY4-R
Alternative name(s):
NPYR-D
Pancreatic polypeptide receptor 1
Short name:
PP1
Gene namesi
Name:Npy4r
Synonyms:Ppyr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:105374 Npy4r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 78CytoplasmicSequence analysisAdd BLAST18
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini100 – 116ExtracellularSequence analysisAdd BLAST17
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 155CytoplasmicSequence analysisAdd BLAST18
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 211ExtracellularSequence analysisAdd BLAST35
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 266CytoplasmicSequence analysisAdd BLAST34
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini288 – 301ExtracellularSequence analysisAdd BLAST14
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 375CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi307

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699361 – 375Neuropeptide Y receptor type 4Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi340S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ61041
PRIDEiQ61041

PTM databases

PhosphoSitePlusiQ61041

Expressioni

Tissue specificityi

Heart, detected in small intestine.

Gene expression databases

BgeeiENSMUSG00000048337
CleanExiMM_PPYR1
GenevisibleiQ61041 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056576

Structurei

3D structure databases

ProteinModelPortaliQ61041
SMRiQ61041
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148949
HOGENOMiHOG000050229
HOVERGENiHBG105676
InParanoidiQ61041
KOiK04206
OMAiIYTIMDY
OrthoDBiEOG091G0HOS
TreeFamiTF315303

Family and domain databases

CDDicd15397 7tmA_NPY4R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001933 NPY4_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR43916:SF4 PTHR43916:SF4, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01015 NRPEPTIDEY4R
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSHFLAPL FPGSLQGKNG TNPLDSPYNF SDGCQDSAEL LAFIITTYSI
60 70 80 90 100
ETILGVLGNL CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT
110 120 130 140 150
YTIMDYWIFG EVLCKMLTFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSIFQAYLGI VVIWFVSCFL SLPFLANSTL NDLFHYNHSK VVEFLEDKVV
210 220 230 240 250
CFVSWSSDHH RLIYTTFLLL FQYCIPLAFI LVCYIRIYQR LQRQKHVFHA
260 270 280 290 300
HACSSRAGQM KRINSMLMTM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG
310 320 330 340 350
NLIFLMCHLL AMASTCVNPF IYGFLNINFK KDIKALVLTC HCRSPRGESE
360 370
HLPLSTVHTD LSKGSMRMGS KSNFI
Length:375
Mass (Da):42,648
Last modified:July 27, 2011 - v2
Checksum:i6E04552C0E7F656E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166V → I in AAC52442 (PubMed:8641440).Curated1
Sequence conflicti346R → Q in AAC52442 (PubMed:8641440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40189 Genomic DNA Translation: AAC52442.1
AK144461 mRNA Translation: BAE25901.1
BC132395 mRNA Translation: AAI32396.1
BC145981 mRNA Translation: AAI45982.1
CCDSiCCDS26933.1
PIRiS63685
RefSeqiNP_032945.3, NM_008919.4
UniGeneiMm.57059

Genome annotation databases

EnsembliENSMUST00000052164; ENSMUSP00000056576; ENSMUSG00000048337
GeneIDi19065
KEGGimmu:19065
UCSCiuc007tak.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNPY4R_MOUSE
AccessioniPrimary (citable) accession number: Q61041
Secondary accession number(s): Q3UN46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 18, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health