Heart- and neural crest derivatives-expressed protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development."
    Anderson K.M., Anderson D.M., McAnally J.R., Shelton J.M., Bassel-Duby R., Olson E.N.
    Nature 539:433-436(2016) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
• DNA-binding transcription factor binding Source: MGI
• E-box binding Source: MGIInferred from direct assayⁱ
  • "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development."
    Holler K.L., Hendershot T.J., Troy S.E., Vincentz J.W., Firulli A.B., Howard M.J.
    Dev Biol 341:291-304(2010) [PubMed] [Europe PMC] [Abstract]
• minor groove of adenine-thymine-rich DNA binding Source: MGI
• protein homodimerization activity Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding."
    McFadden D.G., McAnally J., Richardson J.A., Charite J., Olson E.N.
    Development 129:3077-3088(2002) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription coactivator binding Source: BHF-UCL

GO - Biological processⁱ

• adult heart development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.4

    "Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND."
    Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N.
    Nat. Genet. 16:154-160(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• angiogenesis Source: UniProtKB-KW
• apoptotic process involved in heart morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation."
    Yamagishi H., Yamagishi C., Nakagawa O., Harvey R.P., Olson E.N., Srivastava D.
    Dev Biol 239:190-203(2001) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell differentiation Source: MGITraceable author statementⁱ
  • "Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development."
    Anderson K.M., Anderson D.M., McAnally J.R., Shelton J.M., Bassel-Duby R., Olson E.N.
    Nature 539:433-436(2016) [PubMed] [Europe PMC] [Abstract]
• cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ Res 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• cardiac neural crest cell migration involved in outflow tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development."
    Holler K.L., Hendershot T.J., Troy S.E., Vincentz J.W., Firulli A.B., Howard M.J.
    Dev Biol 341:291-304(2010) [PubMed] [Europe PMC] [Abstract]
• cardiac right ventricle formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart."
    McFadden D.G., Charite J., Richardson J.A., Srivastava D., Firulli A.B., Olson E.N.
    Development 127:5331-5341(2000) [PubMed] [Europe PMC] [Abstract]
• cardiac right ventricle morphogenesis Source: MGITraceable author statementⁱ
  • "Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development."
    Anderson K.M., Anderson D.M., McAnally J.R., Shelton J.M., Bassel-Duby R., Olson E.N.
    Nature 539:433-436(2016) [PubMed] [Europe PMC] [Abstract]
• cartilage morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev Biol 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• cell proliferation involved in outflow tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development."
    Holler K.L., Hendershot T.J., Troy S.E., Vincentz J.W., Firulli A.B., Howard M.J.
    Dev Biol 341:291-304(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: Ensembl
• cellular response to retinoic acid Source: Ensembl
• coronary artery morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development."
    Barnes R.M., Firulli B.A., VanDusen N.J., Morikawa Y., Conway S.J., Cserjesi P., Vincentz J.W., Firulli A.B.
    Circ Res 108:940-949(2011) [PubMed] [Europe PMC] [Abstract]
• determination of heart left/right asymmetry Source: MGIInferred from mutant phenotypeⁱ
  • "The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness."
    Thomas T., Yamagishi H., Overbeek P.A., Olson E.N., Srivastava D.
    Dev Biol 196:228-236(1998) [PubMed] [Europe PMC] [Abstract]
• developmental process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic digit morphogenesis Source: MGIInferred from direct assayⁱ
  • "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding."
    McFadden D.G., McAnally J., Richardson J.A., Charite J., Olson E.N.
    Development 129:3077-3088(2002) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system development Source: MGIInferred from genetic interactionⁱ
  • "An endothelin-1 switch specifies maxillomandibular identity."
    Sato T., Kurihara Y., Asai R., Kawamura Y., Tonami K., Uchijima Y., Heude E., Ekker M., Levi G., Kurihara H.
    Proc Natl Acad Sci U S A 105:18806-18811(2008) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from genetic interactionⁱ
  • "The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner."
    McFadden D.G., Barbosa A.C., Richardson J.A., Schneider M.D., Srivastava D., Olson E.N.
    Development 132:189-201(2005) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND."
    Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N.
    Nat. Genet. 16:154-160(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• heart morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation."
    Yamagishi H., Yamagishi C., Nakagawa O., Harvey R.P., Olson E.N., Srivastava D.
    Dev Biol 239:190-203(2001) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND."
    Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N.
    Nat. Genet. 16:154-160(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• mesenchymal cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 is required in the epithelium for palatogenesis in mice."
    Xiong W., He F., Morikawa Y., Yu X., Zhang Z., Lan Y., Jiang R., Cserjesi P., Chen Y.
    Dev Biol 330:131-141(2009) [PubMed] [Europe PMC] [Abstract]
• mesenchyme development Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev Biol 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 is required in the epithelium for palatogenesis in mice."
    Xiong W., He F., Morikawa Y., Yu X., Zhang Z., Lan Y., Jiang R., Cserjesi P., Chen Y.
    Dev Biol 330:131-141(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ Res 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: MGI
• negative regulation of osteoblast differentiation Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme."
    Thomas T., Kurihara H., Yamagishi H., Kurihara Y., Yazaki Y., Olson E.N., Srivastava D.
    Development 125:3005-3014(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• odontogenesis of dentin-containing tooth Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev Biol 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system neuron development Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development."
    Morikawa Y., Dai Y.S., Hao J., Bonin C., Hwang S., Cserjesi P.
    Dev Dyn 234:613-621(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle hypertrophy Source: MGI
• positive regulation of ERK1 and ERK2 cascade Source: MGI
• positive regulation of gene expression Source: MGI
• positive regulation of p38MAPK cascade Source: MGI
• positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ Res 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development."
    Morikawa Y., Dai Y.S., Hao J., Bonin C., Hwang S., Cserjesi P.
    Dev Dyn 234:613-621(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ Res 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription regulatory region DNA binding Source: MGI
• primary palate development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev Biol 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of secondary heart field cardioblast proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ Res 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of tissue remodeling Source: MGI
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Differential cooperation between dHAND and three different E-proteins."
    Murakami M., Kataoka K., Tominaga J., Nakagawa O., Kurihara H.
    Biochem Biophys Res Commun 323:168-174(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• roof of mouth development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev Biol 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
  • "Hand2 is required in the epithelium for palatogenesis in mice."
    Xiong W., He F., Morikawa Y., Yu X., Zhang Z., Lan Y., Jiang R., Cserjesi P., Chen Y.
    Dev Biol 330:131-141(2009) [PubMed] [Europe PMC] [Abstract]
• suckling behavior Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev Biol 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
• sympathetic nervous system development Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development."
    Morikawa Y., Dai Y.S., Hao J., Bonin C., Hwang S., Cserjesi P.
    Dev Dyn 234:613-621(2005) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ Res 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• tongue development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev Biol 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
• visceral serous pericardium development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development."
    Barnes R.M., Firulli B.A., VanDusen N.J., Morikawa Y., Conway S.J., Cserjesi P., Vincentz J.W., Firulli A.B.
    Circ Res 108:940-949(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• DNA-binding transcription factor binding Source: MGI
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator binding Source: BHF-UCL

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH 
        60         70         80         90        100
PEMSPPDYSM ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR 
       110        120        130        140        150
RGTANRKERR RTQSINSAFA ELRECIPNVP ADTKLSKIKT LRLATSYIAY 
       160        170        180        190        200
LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK RKKELNEILK STVSSNDKKT 
       210 
KGRTGWPQHV WALELKQ                                     

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot