Heart- and neural crest derivatives-expressed protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: BHF-UCL
• AT DNA binding Source: MGI
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
• E-box binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development."
    Holler K.L., Hendershot T.J., Troy S.E., Vincentz J.W., Firulli A.B., Howard M.J.
    Dev. Biol. 341:291-304(2010) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J. Biol. Chem. 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding."
    McFadden D.G., McAnally J., Richardson J.A., Charite J., Olson E.N.
    Development 129:3077-3088(2002) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J. Biol. Chem. 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adult heart development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.4

    "Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND."
    Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N.
    Nat. Genet. 16:154-160(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• angiogenesis Source: UniProtKB-KW
• apoptotic process involved in heart morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation."
    Yamagishi H., Yamagishi C., Nakagawa O., Harvey R.P., Olson E.N., Srivastava D.
    Dev. Biol. 239:190-203(2001) [PubMed] [Europe PMC] [Abstract]
• cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ. Res. 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• cardiac neural crest cell migration involved in outflow tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development."
    Holler K.L., Hendershot T.J., Troy S.E., Vincentz J.W., Firulli A.B., Howard M.J.
    Dev. Biol. 341:291-304(2010) [PubMed] [Europe PMC] [Abstract]
• cardiac right ventricle formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart."
    McFadden D.G., Charite J., Richardson J.A., Srivastava D., Firulli A.B., Olson E.N.
    Development 127:5331-5341(2000) [PubMed] [Europe PMC] [Abstract]
• cartilage morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev. Biol. 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• cell proliferation involved in outflow tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development."
    Holler K.L., Hendershot T.J., Troy S.E., Vincentz J.W., Firulli A.B., Howard M.J.
    Dev. Biol. 341:291-304(2010) [PubMed] [Europe PMC] [Abstract]
• coronary artery morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development."
    Barnes R.M., Firulli B.A., VanDusen N.J., Morikawa Y., Conway S.J., Cserjesi P., Vincentz J.W., Firulli A.B.
    Circ. Res. 108:940-949(2011) [PubMed] [Europe PMC] [Abstract]
• determination of heart left/right asymmetry Source: MGIInferred from mutant phenotypeⁱ
  • "The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness."
    Thomas T., Yamagishi H., Overbeek P.A., Olson E.N., Srivastava D.
    Dev. Biol. 196:228-236(1998) [PubMed] [Europe PMC] [Abstract]
• embryonic digit morphogenesis Source: MGIInferred from direct assayⁱ
  • "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding."
    McFadden D.G., McAnally J., Richardson J.A., Charite J., Olson E.N.
    Development 129:3077-3088(2002) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from genetic interactionⁱ
  • "The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner."
    McFadden D.G., Barbosa A.C., Richardson J.A., Schneider M.D., Srivastava D., Olson E.N.
    Development 132:189-201(2005) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND."
    Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N.
    Nat. Genet. 16:154-160(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• heart morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation."
    Yamagishi H., Yamagishi C., Nakagawa O., Harvey R.P., Olson E.N., Srivastava D.
    Dev. Biol. 239:190-203(2001) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND."
    Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N.
    Nat. Genet. 16:154-160(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• mesenchymal cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 is required in the epithelium for palatogenesis in mice."
    Xiong W., He F., Morikawa Y., Yu X., Zhang Z., Lan Y., Jiang R., Cserjesi P., Chen Y.
    Dev. Biol. 330:131-141(2009) [PubMed] [Europe PMC] [Abstract]
• mesenchyme development Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev. Biol. 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 is required in the epithelium for palatogenesis in mice."
    Xiong W., He F., Morikawa Y., Yu X., Zhang Z., Lan Y., Jiang R., Cserjesi P., Chen Y.
    Dev. Biol. 330:131-141(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ. Res. 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: MGI
• negative regulation of osteoblast differentiation Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme."
    Thomas T., Kurihara H., Yamagishi H., Kurihara Y., Yazaki Y., Olson E.N., Srivastava D.
    Development 125:3005-3014(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• odontogenesis of dentin-containing tooth Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev. Biol. 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system neuron development Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development."
    Morikawa Y., Dai Y.S., Hao J., Bonin C., Hwang S., Cserjesi P.
    Dev. Dyn. 234:613-621(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle hypertrophy Source: MGI
• positive regulation of ERK1 and ERK2 cascade Source: MGI
• positive regulation of gene expression Source: MGI
• positive regulation of p38MAPK cascade Source: MGI
• positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ. Res. 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J. Biol. Chem. 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J. Biol. Chem. 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ. Res. 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription regulatory region DNA binding Source: MGI
• primary palate development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev. Biol. 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of secondary heart field cardioblast proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ. Res. 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of tissue remodeling Source: MGI
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Differential cooperation between dHAND and three different E-proteins."
    Murakami M., Kataoka K., Tominaga J., Nakagawa O., Kurihara H.
    Biochem. Biophys. Res. Commun. 323:168-174(2004) [PubMed] [Europe PMC] [Abstract]
• roof of mouth development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev. Biol. 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
  • "Hand2 is required in the epithelium for palatogenesis in mice."
    Xiong W., He F., Morikawa Y., Yu X., Zhang Z., Lan Y., Jiang R., Cserjesi P., Chen Y.
    Dev. Biol. 330:131-141(2009) [PubMed] [Europe PMC] [Abstract]
• suckling behavior Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev. Biol. 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
• sympathetic nervous system development Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development."
    Morikawa Y., Dai Y.S., Hao J., Bonin C., Hwang S., Cserjesi P.
    Dev. Dyn. 234:613-621(2005) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac neural crest expression of Hand2 regulates outflow and second heart field development."
    Morikawa Y., Cserjesi P.
    Circ. Res. 103:1422-1429(2008) [PubMed] [Europe PMC] [Abstract]
• tongue development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system."
    Morikawa Y., D'Autreaux F., Gershon M.D., Cserjesi P.
    Dev. Biol. 307:114-126(2007) [PubMed] [Europe PMC] [Abstract]
• visceral serous pericardium development Source: MGIInferred from mutant phenotypeⁱ
  • "Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development."
    Barnes R.M., Firulli B.A., VanDusen N.J., Morikawa Y., Conway S.J., Cserjesi P., Vincentz J.W., Firulli A.B.
    Circ. Res. 108:940-949(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: BHF-UCL
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J. Biol. Chem. 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J. Biol. Chem. 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH 
        60         70         80         90        100
PEMSPPDYSM ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR 
       110        120        130        140        150
RGTANRKERR RTQSINSAFA ELRECIPNVP ADTKLSKIKT LRLATSYIAY 
       160        170        180        190        200
LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK RKKELNEILK STVSSNDKKT 
       210 
KGRTGWPQHV WALELKQ                                     

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot