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Protein

Psychosine receptor

Gene

Gpr65

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (By similarity). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (PubMed:8599842).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Psychosine receptor
Alternative name(s):
G-protein coupled receptor 65
T-cell death-associated gene 8 protein
Gene namesi
Name:Gpr65
Synonyms:Gpcr25, Tdag8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108031 Gpr65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 52CytoplasmicSequence analysisAdd BLAST14
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 91ExtracellularSequence analysisAdd BLAST18
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 131CytoplasmicSequence analysisAdd BLAST19
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 182ExtracellularSequence analysisAdd BLAST30
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 229CytoplasmicSequence analysisAdd BLAST26
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 273ExtracellularSequence analysisAdd BLAST23
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 337CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are healthy with no signs of spontaneous colitis or inflammation, however are more susceptible to bacteria-induced colitis in comparison to the wild type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700881 – 337Psychosine receptorAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 172PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61038
PRIDEiQ61038

PTM databases

iPTMnetiQ61038
PhosphoSitePlusiQ61038

Expressioni

Tissue specificityi

Detected in thymus and at low levels in spleen.

Inductioni

By glucocorticoids, during apoptosis of immature thymocytes.

Gene expression databases

CleanExiMM_GPR65

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074581

Structurei

3D structure databases

ProteinModelPortaliQ61038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000004801
HOVERGENiHBG101118
InParanoidiQ61038
KOiK08416
PhylomeDBiQ61038
TreeFamiTF331803

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005464 Psych_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01649 PSYCHOSINER
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMNSMCIEE QHHLEHYLFP VVYIIVFIVS VPANIGSLCV SFLQAKKENE
60 70 80 90 100
LGIYLFSLSL SDLLYALTLP LWINYTWNKD NWTFSPTLCK GSVFFTYMNF
110 120 130 140 150
YSSTAFLTCI ALDRYLAVVY PLKFSFLRTR RFAFITSLSI WILESFFNSM
160 170 180 190 200
LLWKDETSVE YCDSDKSNFT LCYDKYPLEK WQINLNLFRT CMGYAIPLIT
210 220 230 240 250
IMICNHKVYR AVRHNQATEN SEKRRIIKLL ASITLTFVLC FTPFHVMVLI
260 270 280 290 300
RCVLERDMNV NDKSGWQTFT VYRVTVALTS LNCVADPILY CFVTETGRAD
310 320 330
MWNILKLCTR KHNRHQGQKR DILSVSTRDA VELEIID
Length:337
Mass (Da):39,388
Last modified:October 3, 2003 - v2
Checksum:i61A1ADE6E0D09273
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0Y2A0A0R4J0Y2_MOUSE
G-protein coupled receptor 65
Gpr65 mCG_122280
337Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12H → R in AAB02188 (PubMed:8599842).Curated1
Sequence conflicti318Q → K in AAB02188 (PubMed:8599842).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39827 mRNA Translation: AAB02188.1
BC011332 mRNA Translation: AAH11332.1
CCDSiCCDS26096.1
RefSeqiNP_032178.1, NM_008152.3
UniGeneiMm.378924

Genome annotation databases

GeneIDi14744
KEGGimmu:14744

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39827 mRNA Translation: AAB02188.1
BC011332 mRNA Translation: AAH11332.1
CCDSiCCDS26096.1
RefSeqiNP_032178.1, NM_008152.3
UniGeneiMm.378924

3D structure databases

ProteinModelPortaliQ61038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074581

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ61038
PhosphoSitePlusiQ61038

Proteomic databases

PaxDbiQ61038
PRIDEiQ61038

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14744
KEGGimmu:14744

Organism-specific databases

CTDi8477
MGIiMGI:108031 Gpr65

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000004801
HOVERGENiHBG101118
InParanoidiQ61038
KOiK08416
PhylomeDBiQ61038
TreeFamiTF331803

Miscellaneous databases

PROiPR:Q61038
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR65

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005464 Psych_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01649 PSYCHOSINER
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSYR_MOUSE
AccessioniPrimary (citable) accession number: Q61038
Secondary accession number(s): Q921N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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