UniProtKB - Q61029 (LAP2B_MOUSE)
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma
Tmpo
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: MGI
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gammaAlternative name(s): Thymopoietin isoforms beta/delta/epsilon/gamma Short name: TP beta/delta/epsilon/gamma |
Gene namesi | Name:Tmpo Synonyms:Lap2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106920, Tmpo |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Single-pass type II membrane protein By similarity
Other locations
- Chromosome By similarity
Note: Tightly associated with the nuclear lamina.By similarity
Nucleus
- nuclear envelope Source: MGI
- nuclear inner membrane Source: MGI
- nuclear membrane Source: MGI
- nucleus Source: MGI
Other locations
- chromatin Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 410 – 430 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 452 | LumenalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Chromosome, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206146 | 1 – 452 | Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gammaAdd BLAST | 452 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 59 | PhosphoserineBy similarity | 1 | |
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 74 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 79 | PhosphoserineBy similarity | 1 | |
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 85 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 87 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 153 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 155 | PhosphoserineCombined sources | 1 | |
Modified residuei | 158 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 163 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 176 | Phosphoserine1 Publication | 1 | |
Modified residuei | 179 | Phosphoserine; by PKC1 Publication | 1 | |
Modified residuei | 183 | PhosphoserineBy similarity | 1 | |
Modified residuei | 189 | PhosphoserineBy similarity | 1 | |
Modified residuei | 206 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 210 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 221 | PhosphoserineBy similarity | 1 | |
Modified residuei | 223 | PhosphoserineBy similarity | 1 | |
Modified residuei | 249 | PhosphoserineBy similarity | 1 | |
Modified residuei | 253 | PhosphoserineBy similarity | 1 | |
Modified residuei | 264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 305 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 311 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 314 | PhosphoserineBy similarity | 1 | |
Modified residuei | 319 | Citrulline1 Publication | 1 | |
Modified residuei | 361 | PhosphoserineCombined sources | 1 | |
Modified residuei | 377 | PhosphoserineBy similarity | 1 | |
Modified residuei | 384 | PhosphoserineBy similarity | 1 | |
Modified residuei | 388 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 400 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 401 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q61029 |
jPOSTi | Q61029 |
PeptideAtlasi | Q61029 |
PRIDEi | Q61029 |
TopDownProteomicsi | Q61029-1 [Q61029-1] |
PTM databases
iPTMneti | Q61029 |
PhosphoSitePlusi | Q61029 |
SwissPalmi | Q61029 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019961, Expressed in otic placode and 322 other tissues |
ExpressionAtlasi | Q61029, baseline and differential |
Genevisiblei | Q61029, MM |
Interactioni
Subunit structurei
Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes.
By similarityBinary interactionsi
Q61029
With | #Exp. | IntAct |
---|---|---|
Zbtb7b [Q64321] | 2 | EBI-6172136,EBI-642868 |
Protein-protein interaction databases
BioGRIDi | 204234, 10 interactors |
IntActi | Q61029, 5 interactors |
MINTi | Q61029 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 48 | LEM-likePROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 109 – 153 | LEMPROSITE-ProRule annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 409 | NucleoplasmicSequence analysisAdd BLAST | 409 | |
Regioni | 49 – 108 | LinkerAdd BLAST | 60 | |
Regioni | 137 – 242 | NAKAP95-binding NAdd BLAST | 106 | |
Regioni | 298 – 370 | Binds lamins BAdd BLAST | 73 | |
Regioni | 299 – 373 | NAKAP95-binding CAdd BLAST | 75 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000154098 |
HOGENOMi | CLU_032534_1_0_1 |
OMAi | LGDFRME |
Family and domain databases
Gene3Di | 1.10.720.40, 2 hits |
InterProi | View protein in InterPro IPR013146, LEM-like_dom IPR011015, LEM/LEM-like_dom_sf IPR003887, LEM_dom |
Pfami | View protein in Pfam PF03020, LEM, 1 hit PF08198, Thymopoietin, 1 hit |
SMARTi | View protein in SMART SM00540, LEM, 1 hit SM01261, Thymopoietin, 1 hit |
SUPFAMi | SSF63451, SSF63451, 2 hits |
PROSITEi | View protein in PROSITE PS50954, LEM, 1 hit PS50955, LEM_LIKE, 1 hit |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR
60 70 80 90 100
PPLAAGANSK GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK
110 120 130 140 150
PRLEDKDDLD VTELSNEELL DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE
160 170 180 190 200
QGTESRSSTP LPTVSSSAEN TRQNGSNDSD RYSDNDEDSK IELKLEKREP
210 220 230 240 250
LKGRAKTPVT LKQRRTEHNQ SYSQAGVTET EWTSGSSTGG PLQALTREST
260 270 280 290 300
RGSRRTPRKR VETSQHFRID GAVISESTPI AETIKASSNE SLVANRLTGN
310 320 330 340 350
FKHASSILPI TEFSDITRRT PKKPLTRAEV GEKTEERRVD RDILKEMFPY
360 370 380 390 400
EASTPTGISA SCRRPIKGAA GRPLELSDFR MEESFSSKYV PKYAPLADVK
410 420 430 440 450
SEKTKKRRSV PMWIKMLLFA LVAVFLFLVY QAMETNQGNP FTNFLQDTKI
SN
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
The sequence of this isoform differs from the canonical sequence as follows:
221-292: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
221-260: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
221-329: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 – 73 | EP → DA in AAC52574 (PubMed:8743987).Curated | 2 | |
Sequence conflicti | 72 – 73 | EP → DA in AAC52575 (PubMed:8743987).Curated | 2 | |
Sequence conflicti | 72 – 73 | EP → DA in AAC52576 (PubMed:8743987).Curated | 2 | |
Sequence conflicti | 72 – 73 | EP → DA in AAC52577 (PubMed:8743987).Curated | 2 | |
Sequence conflicti | 422 – 424 | VAV → GAC in AAC52574 (PubMed:8743987).Curated | 3 | |
Sequence conflicti | 422 – 424 | VAV → GAC in AAC52575 (PubMed:8743987).Curated | 3 | |
Sequence conflicti | 422 – 424 | VAV → GAC in AAC52576 (PubMed:8743987).Curated | 3 | |
Sequence conflicti | 422 – 424 | VAV → GAC in AAC52577 (PubMed:8743987).Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010132 | 221 – 329 | Missing in isoform Gamma. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_010131 | 221 – 292 | Missing in isoform Delta. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_010130 | 221 – 260 | Missing in isoform Epsilon. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39074 mRNA Translation: AAC52574.1 U39075 mRNA Translation: AAC52575.1 U39076 mRNA Translation: AAC52576.1 U39077 mRNA Translation: AAC52577.1 AK150305 mRNA Translation: BAE29455.1 AK150515 mRNA Translation: BAE29627.1 AK153281 mRNA Translation: BAE31865.1 AK165851 mRNA Translation: BAE38413.1 CH466539 Genomic DNA Translation: EDL21533.1 |
CCDSi | CCDS36032.1 [Q61029-4] CCDS36033.1 [Q61029-2] CCDS36034.1 [Q61029-3] CCDS36035.1 [Q61029-1] |
RefSeqi | NP_001073598.1, NM_001080129.2 [Q61029-1] NP_001073600.1, NM_001080131.2 [Q61029-2] NP_001073601.1, NM_001080132.2 [Q61029-4] |
Genome annotation databases
Ensembli | ENSMUST00000072239; ENSMUSP00000072092; ENSMUSG00000019961 [Q61029-1] ENSMUST00000092219; ENSMUSP00000089864; ENSMUSG00000019961 [Q61029-3] ENSMUST00000099355; ENSMUSP00000096956; ENSMUSG00000019961 [Q61029-2] ENSMUST00000105293; ENSMUSP00000100930; ENSMUSG00000019961 [Q61029-4] |
GeneIDi | 21917 |
KEGGi | mmu:21917 |
UCSCi | uc007gtq.2, mouse [Q61029-1] uc007gts.2, mouse [Q61029-2] uc007gtt.2, mouse [Q61029-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39074 mRNA Translation: AAC52574.1 U39075 mRNA Translation: AAC52575.1 U39076 mRNA Translation: AAC52576.1 U39077 mRNA Translation: AAC52577.1 AK150305 mRNA Translation: BAE29455.1 AK150515 mRNA Translation: BAE29627.1 AK153281 mRNA Translation: BAE31865.1 AK165851 mRNA Translation: BAE38413.1 CH466539 Genomic DNA Translation: EDL21533.1 |
CCDSi | CCDS36032.1 [Q61029-4] CCDS36033.1 [Q61029-2] CCDS36034.1 [Q61029-3] CCDS36035.1 [Q61029-1] |
RefSeqi | NP_001073598.1, NM_001080129.2 [Q61029-1] NP_001073600.1, NM_001080131.2 [Q61029-2] NP_001073601.1, NM_001080132.2 [Q61029-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204234, 10 interactors |
IntActi | Q61029, 5 interactors |
MINTi | Q61029 |
PTM databases
iPTMneti | Q61029 |
PhosphoSitePlusi | Q61029 |
SwissPalmi | Q61029 |
Proteomic databases
EPDi | Q61029 |
jPOSTi | Q61029 |
PeptideAtlasi | Q61029 |
PRIDEi | Q61029 |
TopDownProteomicsi | Q61029-1 [Q61029-1] |
Protocols and materials databases
Antibodypediai | 2387, 372 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000072239; ENSMUSP00000072092; ENSMUSG00000019961 [Q61029-1] ENSMUST00000092219; ENSMUSP00000089864; ENSMUSG00000019961 [Q61029-3] ENSMUST00000099355; ENSMUSP00000096956; ENSMUSG00000019961 [Q61029-2] ENSMUST00000105293; ENSMUSP00000100930; ENSMUSG00000019961 [Q61029-4] |
GeneIDi | 21917 |
KEGGi | mmu:21917 |
UCSCi | uc007gtq.2, mouse [Q61029-1] uc007gts.2, mouse [Q61029-2] uc007gtt.2, mouse [Q61029-4] |
Organism-specific databases
CTDi | 7112 |
MGIi | MGI:106920, Tmpo |
Phylogenomic databases
GeneTreei | ENSGT00940000154098 |
HOGENOMi | CLU_032534_1_0_1 |
OMAi | LGDFRME |
Miscellaneous databases
BioGRID-ORCSi | 21917, 1 hit in 17 CRISPR screens |
ChiTaRSi | Tmpo, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019961, Expressed in otic placode and 322 other tissues |
ExpressionAtlasi | Q61029, baseline and differential |
Genevisiblei | Q61029, MM |
Family and domain databases
Gene3Di | 1.10.720.40, 2 hits |
InterProi | View protein in InterPro IPR013146, LEM-like_dom IPR011015, LEM/LEM-like_dom_sf IPR003887, LEM_dom |
Pfami | View protein in Pfam PF03020, LEM, 1 hit PF08198, Thymopoietin, 1 hit |
SMARTi | View protein in SMART SM00540, LEM, 1 hit SM01261, Thymopoietin, 1 hit |
SUPFAMi | SSF63451, SSF63451, 2 hits |
PROSITEi | View protein in PROSITE PS50954, LEM, 1 hit PS50955, LEM_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAP2B_MOUSE | |
Accessioni | Q61029Primary (citable) accession number: Q61029 Secondary accession number(s): Q3UCI5 Q61032 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families