Tmpo

Functionⁱ

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity).By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- Ref.6
  "Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)."
  Nili E., Cojocaru G.S., Kalma Y., Ginsberg D., Copeland N.G., Gilbert D.J., Jenkins N.A., Berger R., Shaklai S., Amariglio N., Brok-Simoni F., Simon A.J., Rechavi G.
  J. Cell Sci. 114:3297-3307(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: INTERACTION WITH GMCL.

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Reactomeⁱ

R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma Alternative name(s): Thymopoietin isoforms beta/delta/epsilon/gamma Short name: TP beta/delta/epsilon/gamma
Gene namesⁱ	Name:Tmpo Synonyms:Lap2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:106920 Tmpo

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	410 – 430	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST		21
Topological domainⁱ	431 – 452	LumenalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Chromosome, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206146	1 – 452	Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gammaAdd BLAST		452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	59	PhosphoserineBy similarity	1
Modified residueⁱ	66	PhosphoserineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Modified residueⁱ	74	PhosphothreonineCombined sources1 Publication	1
Modified residueⁱ	79	PhosphoserineBy similarity	1
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	85	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	87	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	153	PhosphothreonineCombined sources	1
Modified residueⁱ	155	PhosphoserineCombined sources	1
Modified residueⁱ	158	PhosphoserineCombined sources	1
Modified residueⁱ	159	PhosphothreonineCombined sources1 Publication	1
Modified residueⁱ	163	PhosphothreonineBy similarity	1
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	167	PhosphoserineCombined sources	1
Modified residueⁱ	176	Phosphoserine1 Publication	1
Modified residueⁱ	179	Phosphoserine; by PKC1 Publication	1
Modified residueⁱ	183	PhosphoserineBy similarity	1
Modified residueⁱ	189	PhosphoserineBy similarity	1
Modified residueⁱ	206	N6-acetyllysineCombined sources	1
Modified residueⁱ	210	PhosphothreonineBy similarity	1
Modified residueⁱ	221	PhosphoserineBy similarity	1
Modified residueⁱ	223	PhosphoserineBy similarity	1
Modified residueⁱ	249	PhosphoserineBy similarity	1
Modified residueⁱ	253	PhosphoserineBy similarity	1
Modified residueⁱ	264	PhosphoserineBy similarity	1
Modified residueⁱ	291	PhosphoserineBy similarity	1
Modified residueⁱ	305	PhosphoserineCombined sources	1
Modified residueⁱ	306	PhosphoserineCombined sources	1
Modified residueⁱ	311	PhosphothreonineBy similarity	1
Modified residueⁱ	314	PhosphoserineBy similarity	1
Modified residueⁱ	319	Citrulline1 Publication	1
Modified residueⁱ	361	PhosphoserineCombined sources	1
Modified residueⁱ	377	PhosphoserineBy similarity	1
Modified residueⁱ	384	PhosphoserineBy similarity	1
Modified residueⁱ	388	N6-acetyllysineCombined sources	1
Cross-linkⁱ	400	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	401	PhosphoserineBy similarity	1
Isoform Zeta (identifier: Q61033-2)
Modified residueⁱ	206	N6-acetyllysine	1

Post-translational modificationⁱ

Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.By similarity

Citrullinated by PADI4.1 Publication

Keywords - PTMⁱ

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q61029
jPOSTⁱ	Q61029
PeptideAtlas More...PeptideAtlasⁱ	Q61029
PRIDEⁱ	Q61029
TopDownProteomicsⁱ	Q61029-1 [Q61029-1]

PTM databases

iPTMnetⁱ	Q61029
PhosphoSitePlusⁱ	Q61029
SwissPalmⁱ	Q61029

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000019961 Expressed in 310 organ(s), highest expression level in cochlea
ExpressionAtlasⁱ	Q61029 baseline and differential
Genevisibleⁱ	Q61029 MM

Interactionⁱ

Subunit structureⁱ

Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Zbtb7b	Q64321	2	EBI-6172136,EBI-642868

With

Entry

#Exp.

IntAct

Notes

Zbtb7b

Q64321

2

EBI-6172136,EBI-642868

Protein-protein interaction databases

BioGridⁱ	204234, 6 interactors
IntActⁱ	Q61029, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q61029

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61029
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 48	LEM-likePROSITE-ProRule annotationAdd BLAST		44
Domainⁱ	109 – 153	LEMPROSITE-ProRule annotationAdd BLAST		45

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 409	NucleoplasmicSequence analysisAdd BLAST	409
Regionⁱ	49 – 108	LinkerAdd BLAST	60
Regionⁱ	137 – 242	NAKAP95-binding NAdd BLAST	106
Regionⁱ	298 – 370	Binds lamins BAdd BLAST	73
Regionⁱ	299 – 373	NAKAP95-binding CAdd BLAST	75

Domainⁱ

Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the LEM family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IT7C Eukaryota ENOG4111J0N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154098
HOGENOMⁱ	HOG000113280
HOVERGENⁱ	HBG000166
OMAⁱ	FKHAAPT
Database of Orthologous Groups More...OrthoDBⁱ	323585at2759

Family and domain databases

Gene3Dⁱ	1.10.720.40, 2 hits
InterProⁱ	View protein in InterPro IPR013146 LEM-like_dom IPR011015 LEM/LEM-like_dom_sf IPR003887 LEM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03020 LEM, 1 hit PF08198 Thymopoietin, 1 hit
SMARTⁱ	View protein in SMART SM00540 LEM, 1 hit SM01261 Thymopoietin, 1 hit
SUPFAMⁱ	SSF63451 SSF63451, 2 hits
PROSITEⁱ	View protein in PROSITE PS50954 LEM, 1 hit PS50955 LEM_LIKE, 1 hit

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform Beta (identifier: Q61029-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR 
        60         70         80         90        100
PPLAAGANSK GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK 
       110        120        130        140        150
PRLEDKDDLD VTELSNEELL DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE 
       160        170        180        190        200
QGTESRSSTP LPTVSSSAEN TRQNGSNDSD RYSDNDEDSK IELKLEKREP 
       210        220        230        240        250
LKGRAKTPVT LKQRRTEHNQ SYSQAGVTET EWTSGSSTGG PLQALTREST 
       260        270        280        290        300
RGSRRTPRKR VETSQHFRID GAVISESTPI AETIKASSNE SLVANRLTGN 
       310        320        330        340        350
FKHASSILPI TEFSDITRRT PKKPLTRAEV GEKTEERRVD RDILKEMFPY 
       360        370        380        390        400
EASTPTGISA SCRRPIKGAA GRPLELSDFR MEESFSSKYV PKYAPLADVK 
       410        420        430        440        450
SEKTKKRRSV PMWIKMLLFA LVAVFLFLVY QAMETNQGNP FTNFLQDTKI 

SN

Length:452

Mass (Da):50,373

Last modified:July 27, 2011 - v4

Checksum:ⁱ132AF11B458DCFBA

GO

Isoform Alpha (identifier: Q61033-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q61033.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:693

Mass (Da):75,168

GO

Isoform Zeta (identifier: Q61033-2) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q61033.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:225

Mass (Da):24,990

GO

Isoform Delta (identifier: Q61029-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
221-292: Missing.

« Hide

        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR 
        60         70         80         90        100
PPLAAGANSK GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK 
       110        120        130        140        150
PRLEDKDDLD VTELSNEELL DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE 
       160        170        180        190        200
QGTESRSSTP LPTVSSSAEN TRQNGSNDSD RYSDNDEDSK IELKLEKREP 
       210        220        230        240        250
LKGRAKTPVT LKQRRTEHNQ VANRLTGNFK HASSILPITE FSDITRRTPK 
       260        270        280        290        300
KPLTRAEVGE KTEERRVDRD ILKEMFPYEA STPTGISASC RRPIKGAAGR 
       310        320        330        340        350
PLELSDFRME ESFSSKYVPK YAPLADVKSE KTKKRRSVPM WIKMLLFALV 
       360        370        380
AVFLFLVYQA METNQGNPFT NFLQDTKISN

Show »

Length:380

Mass (Da):42,650

Checksum:ⁱF2BE6B5556030A49

GO

Isoform Epsilon (identifier: Q61029-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
221-260: Missing.

« Hide

        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR 
        60         70         80         90        100
PPLAAGANSK GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK 
       110        120        130        140        150
PRLEDKDDLD VTELSNEELL DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE 
       160        170        180        190        200
QGTESRSSTP LPTVSSSAEN TRQNGSNDSD RYSDNDEDSK IELKLEKREP 
       210        220        230        240        250
LKGRAKTPVT LKQRRTEHNQ VETSQHFRID GAVISESTPI AETIKASSNE 
       260        270        280        290        300
SLVANRLTGN FKHASSILPI TEFSDITRRT PKKPLTRAEV GEKTEERRVD 
       310        320        330        340        350
RDILKEMFPY EASTPTGISA SCRRPIKGAA GRPLELSDFR MEESFSSKYV 
       360        370        380        390        400
PKYAPLADVK SEKTKKRRSV PMWIKMLLFA LVAVFLFLVY QAMETNQGNP 
       410 
FTNFLQDTKI SN

Show »

Length:412

Mass (Da):46,050

Checksum:ⁱC54639DAB8788CEE

GO

Isoform Gamma (identifier: Q61029-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
221-329: Missing.

« Hide

        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR 
        60         70         80         90        100
PPLAAGANSK GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK 
       110        120        130        140        150
PRLEDKDDLD VTELSNEELL DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE 
       160        170        180        190        200
QGTESRSSTP LPTVSSSAEN TRQNGSNDSD RYSDNDEDSK IELKLEKREP 
       210        220        230        240        250
LKGRAKTPVT LKQRRTEHNQ VGEKTEERRV DRDILKEMFP YEASTPTGIS 
       260        270        280        290        300
ASCRRPIKGA AGRPLELSDF RMEESFSSKY VPKYAPLADV KSEKTKKRRS 
       310        320        330        340 
VPMWIKMLLF ALVAVFLFLV YQAMETNQGN PFTNFLQDTK ISN

Show »

Length:343

Mass (Da):38,502

Checksum:ⁱBA62B6D869B0FDAD

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	72 – 73	EP → DA in AAC52574 (PubMed:8743987).Curated	2
Sequence conflictⁱ	72 – 73	EP → DA in AAC52575 (PubMed:8743987).Curated	2
Sequence conflictⁱ	72 – 73	EP → DA in AAC52576 (PubMed:8743987).Curated	2
Sequence conflictⁱ	72 – 73	EP → DA in AAC52577 (PubMed:8743987).Curated	2
Sequence conflictⁱ	422 – 424	VAV → GAC in AAC52574 (PubMed:8743987).Curated	3
Sequence conflictⁱ	422 – 424	VAV → GAC in AAC52575 (PubMed:8743987).Curated	3
Sequence conflictⁱ	422 – 424	VAV → GAC in AAC52576 (PubMed:8743987).Curated	3
Sequence conflictⁱ	422 – 424	VAV → GAC in AAC52577 (PubMed:8743987).Curated	3

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010132	221 – 329	Missing in isoform Gamma. 1 PublicationAdd BLAST	109
Alternative sequenceⁱVSP_010131	221 – 292	Missing in isoform Delta. 1 PublicationAdd BLAST	72
Alternative sequenceⁱVSP_010130	221 – 260	Missing in isoform Epsilon. 1 PublicationAdd BLAST	40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39074 mRNA Translation: AAC52574.1 U39075 mRNA Translation: AAC52575.1 U39076 mRNA Translation: AAC52576.1 U39077 mRNA Translation: AAC52577.1 AK150305 mRNA Translation: BAE29455.1 AK150515 mRNA Translation: BAE29627.1 AK153281 mRNA Translation: BAE31865.1 AK165851 mRNA Translation: BAE38413.1 CH466539 Genomic DNA Translation: EDL21533.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36032.1 [Q61029-4] CCDS36033.1 [Q61029-2] CCDS36034.1 [Q61029-3] CCDS36035.1 [Q61029-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073598.1, NM_001080129.2 [Q61029-1] NP_001073600.1, NM_001080131.2 [Q61029-2] NP_001073601.1, NM_001080132.2 [Q61029-4]
UniGeneⁱ	Mm.159684 Mm.439157

Genome annotation databases

Ensemblⁱ	ENSMUST00000072239; ENSMUSP00000072092; ENSMUSG00000019961 [Q61029-1] ENSMUST00000092219; ENSMUSP00000089864; ENSMUSG00000019961 [Q61029-3] ENSMUST00000099355; ENSMUSP00000096956; ENSMUSG00000019961 [Q61029-2] ENSMUST00000105293; ENSMUSP00000100930; ENSMUSG00000019961 [Q61029-4]
GeneIDⁱ	21917
KEGGⁱ	mmu:21917
UCSC genome browser More...UCSCⁱ	uc007gtq.2 mouse [Q61029-1] uc007gts.2 mouse [Q61029-2] uc007gtt.2 mouse [Q61029-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61029	Lamina-associated polypeptide (Fragment)		Daphnia magna		323	UniRef100_Q61029
Q61029-3	Uncharacterized protein		MOUSE		412	UniRef100_Q3TNH0

Protein	Similar proteins		Species	Score	Length	Source
Q61029	Lamina-associated polypeptide 2, isoforms beta/gamma		HUMAN		454	UniRef90_P42167
Uncharacterized protein		PANPA		454
Uncharacterized protein		Cebus capucinus imitator		454
thymopoietin isoform X2		ODORO		454
thymopoietin isoform X2		DELLE		454
+69
Q61033-2	Isoform Zeta of Lamina-associated polypeptide 2, isoforms beta/gamma		HUMAN		248	UniRef90_P42167-3
TMPO isoform 7		PONAB		248
TMPO isoform 7		PANTR		248
Uncharacterized protein		CERAT		248
Uncharacterized protein		RHIRO		248
+7
Q61029-2	lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma isoform X4		CALUR		382	UniRef90_Q61029-2
thymopoietin isoform X4		Ursus arctos horribilis		382
Uncharacterized protein		Cebus capucinus imitator		382
thymopoietin isoform X4		ODORO		382
Uncharacterized protein		BOVIN		382
+38
Q61029-3	Lamina-associated polypeptide 2, isoforms beta/gamma		HUMAN		414	UniRef90_G5E972
Uncharacterized protein		PANPA		414
TMPO isoform 3		PANTR		414
lamina-associated polypeptide 2, isoforms beta/gamma isoform X3		CALUR		414
thymopoietin isoform X3		Ursus arctos horribilis		414
+31
Q61029-4	Thymopoietin, isoform CRA_a		HUMAN		345	UniRef90_Q61029-4
Uncharacterized protein		PANPA		345
Uncharacterized protein		Cebus capucinus imitator		345
Thymopoietin		GORGO		345
Uncharacterized protein		PROCO		345
+59

Protein	Similar proteins		Species	Score	Length	Source
Q61029	Lamina-associated polypeptide 2, isoforms beta/gamma		HUMAN		454	UniRef50_P42167
Uncharacterized protein		PANPA		454
Thymopoietin isoform beta		CALJA		454
Uncharacterized protein		RHIRO		454
Uncharacterized protein		RHIBE		107
+173
Q61033-2	Isoform Zeta of Lamina-associated polypeptide 2, isoforms beta/gamma		HUMAN		248	UniRef50_P42167-3
TMPO isoform 7		PANTR		248
Uncharacterized protein		RHIRO		248
Uncharacterized protein		RHIBE		248
Uncharacterized protein		PAPAN		248
+10
Q61029-2	thymopoietin isoform X4		ODORO		382	UniRef50_Q61029-2
Uncharacterized protein		Cebus capucinus imitator		382
lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma isoform X3		LIPVE		382
thymopoietin isoform X4		Ursus arctos horribilis		382
Uncharacterized protein		FELCA		382
+44
Q61029-3	Lamina-associated polypeptide 2, isoforms beta/gamma		HUMAN		414	UniRef50_G5E972
Uncharacterized protein		PANPA		414
thymopoietin isoform X3		Ursus arctos horribilis		414
Thymopoietin		GORGO		414
Uncharacterized protein		FELCA		414
+90
Q61029-4	thymopoietin isoform X3		Yangtze finless porpoise		345	UniRef50_Q61029-4
Uncharacterized protein		BOVIN		345
Uncharacterized protein		CERAT		345
Thymopoietin		GORGO		345
Thymopoietin isoform gamma		CALJA		345
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39074 mRNA Translation: AAC52574.1 U39075 mRNA Translation: AAC52575.1 U39076 mRNA Translation: AAC52576.1 U39077 mRNA Translation: AAC52577.1 AK150305 mRNA Translation: BAE29455.1 AK150515 mRNA Translation: BAE29627.1 AK153281 mRNA Translation: BAE31865.1 AK165851 mRNA Translation: BAE38413.1 CH466539 Genomic DNA Translation: EDL21533.1
CCDSⁱ	CCDS36032.1 [Q61029-4] CCDS36033.1 [Q61029-2] CCDS36034.1 [Q61029-3] CCDS36035.1 [Q61029-1]
RefSeqⁱ	NP_001073598.1, NM_001080129.2 [Q61029-1] NP_001073600.1, NM_001080131.2 [Q61029-2] NP_001073601.1, NM_001080132.2 [Q61029-4]
UniGeneⁱ	Mm.159684 Mm.439157

3D structure databases

ProteinModelPortalⁱ	Q61029
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204234, 6 interactors
IntActⁱ	Q61029, 5 interactors
MINTⁱ	Q61029

PTM databases

iPTMnetⁱ	Q61029
PhosphoSitePlusⁱ	Q61029
SwissPalmⁱ	Q61029

Proteomic databases

EPDⁱ	Q61029
jPOSTⁱ	Q61029
PeptideAtlasⁱ	Q61029
PRIDEⁱ	Q61029
TopDownProteomicsⁱ	Q61029-1 [Q61029-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000072239; ENSMUSP00000072092; ENSMUSG00000019961 [Q61029-1] ENSMUST00000092219; ENSMUSP00000089864; ENSMUSG00000019961 [Q61029-3] ENSMUST00000099355; ENSMUSP00000096956; ENSMUSG00000019961 [Q61029-2] ENSMUST00000105293; ENSMUSP00000100930; ENSMUSG00000019961 [Q61029-4]
GeneIDⁱ	21917
KEGGⁱ	mmu:21917
UCSCⁱ	uc007gtq.2 mouse [Q61029-1] uc007gts.2 mouse [Q61029-2] uc007gtt.2 mouse [Q61029-4]

Organism-specific databases

CTDⁱ	7112
MGIⁱ	MGI:106920 Tmpo

Phylogenomic databases

eggNOGⁱ	ENOG410IT7C Eukaryota ENOG4111J0N LUCA
GeneTreeⁱ	ENSGT00940000154098
HOGENOMⁱ	HOG000113280
HOVERGENⁱ	HBG000166
OMAⁱ	FKHAAPT
OrthoDBⁱ	323585at2759

Enzyme and pathway databases

Reactomeⁱ	R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Reactomeⁱ

R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Miscellaneous databases

ChiTaRSⁱ	Tmpo mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019961 Expressed in 310 organ(s), highest expression level in cochlea
ExpressionAtlasⁱ	Q61029 baseline and differential
Genevisibleⁱ	Q61029 MM

Family and domain databases

Gene3Dⁱ	1.10.720.40, 2 hits
InterProⁱ	View protein in InterPro IPR013146 LEM-like_dom IPR011015 LEM/LEM-like_dom_sf IPR003887 LEM_dom
Pfamⁱ	View protein in Pfam PF03020 LEM, 1 hit PF08198 Thymopoietin, 1 hit
SMARTⁱ	View protein in SMART SM00540 LEM, 1 hit SM01261 Thymopoietin, 1 hit
SUPFAMⁱ	SSF63451 SSF63451, 2 hits
PROSITEⁱ	View protein in PROSITE PS50954 LEM, 1 hit PS50955 LEM_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LAP2B_MOUSE
Accessionⁱ	Q61029Primary (citable) accession number: Q61029 Secondary accession number(s): Q3UCI5 , Q61030, Q61031, Q61032
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	July 27, 2011
	Last modified:	February 13, 2019
	This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61029 (LAP2B_MOUSE)

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Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ