UniProtKB - Q61026 (NCOA2_MOUSE)
Nuclear receptor coactivator 2
Ncoa2
Functioni
Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140, PubMed:31851938).
Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).
Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).
Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).
Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140).
Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:24529706).
6 PublicationsGO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- chromatin binding Source: MGI
- DNA polymerase binding Source: MGI
- estrogen receptor binding Source: MGI
- glucocorticoid receptor binding Source: MGI
- nuclear receptor binding Source: MGI
- nuclear receptor coactivator activity Source: MGI
- PDZ domain binding Source: MGI
- progesterone receptor binding Source: MGI
- protein-containing complex binding Source: MGI
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: MGI
- retinoic acid receptor binding Source: MGI
- retinoid X receptor binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: UniProtKB
- signaling receptor binding Source: MGI
- thyroid hormone receptor binding Source: MGI
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- cellular response to hormone stimulus Source: GO_Central
- cellular response to Thyroglobulin triiodothyronine Source: MGI
- circadian regulation of gene expression Source: UniProtKB
- circadian rhythm Source: UniProtKB
- locomotor rhythm Source: UniProtKB
- mRNA transcription by RNA polymerase II Source: ComplexPortal
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- peroxisome proliferator activated receptor signaling pathway Source: ComplexPortal
- positive regulation of adipose tissue development Source: ComplexPortal
- positive regulation of female receptivity Source: MGI
- positive regulation of glucocorticoid receptor signaling pathway Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cellular response to insulin stimulus Source: ComplexPortal
- regulation of gene expression Source: MGI
- regulation of glucose metabolic process Source: UniProtKB
- regulation of transcription, DNA-templated Source: MGI
- response to progesterone Source: MGI
Keywordsi
Molecular function | Activator |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-159418, Recycling of bile acids and salts R-MMU-192105, Synthesis of bile acids and bile salts R-MMU-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-MMU-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-MMU-211976, Endogenous sterols R-MMU-3214847, HATs acetylate histones R-MMU-400206, Regulation of lipid metabolism by PPARalpha R-MMU-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-MMU-9018519, Estrogen-dependent gene expression R-MMU-9707564, Cytoprotection by HMOX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 2Short name: NCoA-2 Alternative name(s): Glucocorticoid receptor-interacting protein 11 Publication Short name: GRIP-11 Publication Steroid receptor coactivator 2 Short name: SRC-2 Transcriptional intermediary factor 2 |
Gene namesi | Name:Ncoa2 Synonyms:Grip11 Publication, Src2, Tif2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1276533, Ncoa2 |
VEuPathDBi | HostDB:ENSMUSG00000005886 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- microtubule Source: MGI
Endoplasmic reticulum
- rough endoplasmic reticulum Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- cytoplasm Source: MGI
- dendrite Source: MGI
- dendritic spine Source: MGI
- neuronal cell body Source: MGI
- postsynaptic density Source: MGI
- presynaptic active zone Source: MGI
- protein-containing complex Source: MGI
- transcription regulator complex Source: ComplexPortal
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 644 – 645 | LL → AA: Abolishes interaction with RORC; when associated with 689-A--A-694 and 744-A--A-749. 1 Publication | 2 | |
Mutagenesisi | 689 – 694 | ILHRLL → AAHRAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 744-A--A-749. 1 Publication | 6 | |
Mutagenesisi | 744 – 749 | LLRYLL → AARAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 689-A--A-694. 1 Publication | 6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000094403 | 2 – 1462 | Nuclear receptor coactivator 2Add BLAST | 1461 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 29 | PhosphoserineBy similarity | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 338 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 487 | PhosphoserineCombined sources | 1 | |
Modified residuei | 493 | PhosphoserineCombined sources | 1 | |
Modified residuei | 499 | PhosphoserineBy similarity | 1 | |
Modified residuei | 554 | PhosphoserineBy similarity | 1 | |
Modified residuei | 565 | PhosphoserineCombined sources | 1 | |
Modified residuei | 636 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 640 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 648 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 682 | PhosphoserineBy similarity | 1 | |
Modified residuei | 699 | PhosphoserineCombined sources | 1 | |
Cross-linki | 705 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 731 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 736 | PhosphoserineBy similarity | 1 | |
Modified residuei | 771 | PhosphoserineCombined sources | 1 | |
Modified residuei | 780 | N6-acetyllysineCombined sources1 Publication | 1 | |
Modified residuei | 785 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 785 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 864 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 874 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1173 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1177 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1190 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1196 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1203 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1221 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1240 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1259 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1264 | Asymmetric dimethylarginineBy similarity | 1 | |
Cross-linki | 1452 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q61026 |
jPOSTi | Q61026 |
MaxQBi | Q61026 |
PaxDbi | Q61026 |
PRIDEi | Q61026 |
ProteomicsDBi | 287453 |
PTM databases
iPTMneti | Q61026 |
PhosphoSitePlusi | Q61026 |
SwissPalmi | Q61026 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000005886, Expressed in retina and 290 other tissues |
Genevisiblei | Q61026, MM |
Interactioni
Subunit structurei
Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP.
Interacts (via C-terminus) with CREBBP.
Interacts with ESR1, HIF1A, NCOA1, APEX1, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300.
Interacts with CASP8AP2 and TTLL5/STAMP.
Interacts with PSMB9 and DDX5.
Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif).
Interacts with RWDD3.
Interacts with CLOCK and ARNTL/BMAL1.
Interacts with NR4A3; potentiates the activity of the NR4A3 (PubMed:12709428).
Interacts with NR1H3 (By similarity).
By similarity8 PublicationsBinary interactionsi
Q61026
With | #Exp. | IntAct |
---|---|---|
KMT5B - isoform 1 [Q4FZB7-1] from Homo sapiens. | 4 | EBI-688662,EBI-15746366 |
NR3C1 - isoform Alpha [P04150-1] from Homo sapiens. | 3 | EBI-688662,EBI-15750116 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- DNA polymerase binding Source: MGI
- estrogen receptor binding Source: MGI
- glucocorticoid receptor binding Source: MGI
- nuclear receptor binding Source: MGI
- PDZ domain binding Source: MGI
- progesterone receptor binding Source: MGI
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: MGI
- retinoic acid receptor binding Source: MGI
- retinoid X receptor binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: UniProtKB
- signaling receptor binding Source: MGI
- thyroid hormone receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201708, 17 interactors |
ComplexPortali | CPX-643, RXRalpha-NCOA2 activated retinoic acid receptor complex CPX-668, RARalpha-NCOA2 activated retinoic acid receptor complex CPX-703, PPARgamma-NCOA2 activated nuclear receptor complex CPX-818, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex |
DIPi | DIP-5979N |
IntActi | Q61026, 12 interactors |
MINTi | Q61026 |
STRINGi | 10090.ENSMUSP00000006037 |
Miscellaneous databases
RNActi | Q61026, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q61026 |
SMRi | Q61026 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q61026 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 83 | bHLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 119 – 183 | PASPROSITE-ProRule annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 467 – 513 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 557 – 636 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 648 – 742 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 691 – 743 | CASP8AP2-binding1 PublicationAdd BLAST | 53 | |
Regioni | 730 – 1121 | Interaction with ARNTL1 PublicationAdd BLAST | 392 | |
Regioni | 1051 – 1071 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1309 – 1328 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 641 – 645 | LXXLL motif 1 | 5 | |
Motifi | 690 – 694 | LXXLL motif 2 | 5 | |
Motifi | 745 – 749 | LXXLL motif 3 | 5 | |
Motifi | 878 – 882 | LXXLL motif 4 | 5 | |
Motifi | 1079 – 1087 | LLXXLXXXL motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 40 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 467 – 490 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 557 – 572 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 596 – 620 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 648 – 678 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 712 – 729 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
InParanoidi | Q61026 |
OMAi | DSNMPPV |
OrthoDBi | 59971at2759 |
PhylomeDBi | Q61026 |
TreeFami | TF332652 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.20, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032565, DUF4927 IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028822, NCOA2 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF2, PTHR10684:SF2, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 1 hit PF16279, DUF4927, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 1 hit SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA
60 70 80 90 100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS
110 120 130 140 150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGSVVFVS ENVTQYLRYN
160 170 180 190 200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWSGEP PRRSSHTFNC
210 220 230 240 250
RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE EGEDLQSCLI
260 270 280 290 300
CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV
310 320 330 340 350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ
360 370 380 390 400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS
410 420 430 440 450
SSPAHQALCS GNPGQDMTLG SNINFPMNGP KEQMGMPMGR FGGSGGMNHV
460 470 480 490 500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QASSVLSPRQ RMSPGVAGSP
510 520 530 540 550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS
560 570 580 590 600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA
610 620 630 640 650
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD
660 670 680 690 700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP
710 720 730 740 750
VDLAKLTAEA TGKELSQESS STAPGSEVTV KQEPASPKKK ENALLRYLLD
760 770 780 790 800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG
810 820 830 840 850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS
860 870 880 890 900
SPVPPAGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG
910 920 930 940 950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRPSMP
960 970 980 990 1000
SGEWAPQSPA VRVTCAATTG AMNRPVQGGM IRNPTASIPM RANSQPGQRQ
1010 1020 1030 1040 1050
MLQSQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFAS
1060 1070 1080 1090 1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL
1110 1120 1130 1140 1150
GIPELVSQSQ AVDAEQFSSQ ESSIMLEQKP PVFPQQYASQ AQMAQGGYNP
1160 1170 1180 1190 1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ
1210 1220 1230 1240 1250
QNRQPLMNQI SSVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR
1260 1270 1280 1290 1300
QMQQQVQQRT LMMRGQGLNV TPSMVAPAGL PAAMSNPRIP QANAQQFPFP
1310 1320 1330 1340 1350
PNYGISQQPD PGFTGATTPQ SPLMSPRMAH TQSPMMQQSQ ANPAYQPTSD
1360 1370 1380 1390 1400
MNGWAQGSMG GNSMFSQQSP PHFGQQANTS MYSNNMNISV SMATNTGGLS
1410 1420 1430 1440 1450
SMNQMTGQMS MTSVTSVPTS GLPSMGPEQV NDPALRGGNL FPNQLPGMDM
1460
IKQEGDASRK YC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PV80 | E9PV80_MOUSE | Nuclear receptor coactivator | Ncoa2 | 1,393 | Annotation score: | ||
D3Z4F6 | D3Z4F6_MOUSE | Nuclear receptor coactivator 2 | Ncoa2 | 114 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 51 | E → D in AAC53151 (PubMed:9111344).Curated | 1 | |
Sequence conflicti | 140 – 141 | SE → FR in AAB61575 (PubMed:9192892).Curated | 2 | |
Sequence conflicti | 194 | S → T in AAC53151 (PubMed:9111344).Curated | 1 | |
Sequence conflicti | 256 | V → I in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 286 | S → T in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 420 | G → S in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 512 | S → N in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 594 | E → K in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 607 – 608 | EE → KK in AAB61575 (PubMed:9192892).Curated | 2 | |
Sequence conflicti | 864 | R → C in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 869 | T → S in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 884 | N → Y in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 972 | M → K in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 980 | M → K in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 991 | R → G in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 996 | P → L in AAB61575 (PubMed:9192892).Curated | 1 | |
Sequence conflicti | 1407 | G → C in AAC53151 (PubMed:9111344).Curated | 1 | |
Sequence conflicti | 1446 | P → L in AAB61575 (PubMed:9192892).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39060 mRNA Translation: AAC53151.1 AF000582 mRNA Translation: AAB61575.1 Frameshift. AC091248 Genomic DNA No translation available. AC121538 Genomic DNA No translation available. |
CCDSi | CCDS35515.1 |
PIRi | T30193 T42639 |
RefSeqi | NP_032704.2, NM_008678.3 XP_006495528.1, XM_006495465.3 |
Genome annotation databases
Ensembli | ENSMUST00000006037; ENSMUSP00000006037; ENSMUSG00000005886 |
GeneIDi | 17978 |
KEGGi | mmu:17978 |
UCSCi | uc007aim.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39060 mRNA Translation: AAC53151.1 AF000582 mRNA Translation: AAB61575.1 Frameshift. AC091248 Genomic DNA No translation available. AC121538 Genomic DNA No translation available. |
CCDSi | CCDS35515.1 |
PIRi | T30193 T42639 |
RefSeqi | NP_032704.2, NM_008678.3 XP_006495528.1, XM_006495465.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1L2I | X-ray | 1.95 | C/D | 686-698 | [»] | |
1OSV | X-ray | 2.50 | C/D/E | 741-752 | [»] | |
1WM0 | X-ray | 2.90 | Y | 684-697 | [»] | |
2Q6J | X-ray | 2.70 | C/D | 686-698 | [»] | |
2QA6 | X-ray | 2.60 | C/D | 686-698 | [»] | |
2QA8 | X-ray | 1.85 | C/D | 686-698 | [»] | |
2QAB | X-ray | 1.89 | C/D | 686-698 | [»] | |
2QGT | X-ray | 2.15 | C/D | 686-698 | [»] | |
2QGW | X-ray | 2.39 | C/D | 686-698 | [»] | |
2QH6 | X-ray | 2.70 | C/D | 686-698 | [»] | |
2QPY | X-ray | 2.50 | B | 744-753 | [»] | |
2QR9 | X-ray | 2.00 | C/D | 686-698 | [»] | |
2QSE | X-ray | 1.85 | C/D | 686-698 | [»] | |
2QXM | X-ray | 2.30 | C/D | 686-698 | [»] | |
2QZO | X-ray | 1.72 | C/D | 686-698 | [»] | |
3MNE | X-ray | 1.96 | B | 740-752 | [»] | |
3MNO | X-ray | 1.55 | B | 740-752 | [»] | |
3MNP | X-ray | 1.50 | B | 740-752 | [»] | |
AlphaFoldDBi | Q61026 | |||||
SMRi | Q61026 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201708, 17 interactors |
ComplexPortali | CPX-643, RXRalpha-NCOA2 activated retinoic acid receptor complex CPX-668, RARalpha-NCOA2 activated retinoic acid receptor complex CPX-703, PPARgamma-NCOA2 activated nuclear receptor complex CPX-818, RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex |
DIPi | DIP-5979N |
IntActi | Q61026, 12 interactors |
MINTi | Q61026 |
STRINGi | 10090.ENSMUSP00000006037 |
PTM databases
iPTMneti | Q61026 |
PhosphoSitePlusi | Q61026 |
SwissPalmi | Q61026 |
Proteomic databases
EPDi | Q61026 |
jPOSTi | Q61026 |
MaxQBi | Q61026 |
PaxDbi | Q61026 |
PRIDEi | Q61026 |
ProteomicsDBi | 287453 |
Protocols and materials databases
Antibodypediai | 6252, 301 antibodies from 31 providers |
DNASUi | 17978 |
Genome annotation databases
Ensembli | ENSMUST00000006037; ENSMUSP00000006037; ENSMUSG00000005886 |
GeneIDi | 17978 |
KEGGi | mmu:17978 |
UCSCi | uc007aim.2, mouse |
Organism-specific databases
CTDi | 10499 |
MGIi | MGI:1276533, Ncoa2 |
VEuPathDBi | HostDB:ENSMUSG00000005886 |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
InParanoidi | Q61026 |
OMAi | DSNMPPV |
OrthoDBi | 59971at2759 |
PhylomeDBi | Q61026 |
TreeFami | TF332652 |
Enzyme and pathway databases
Reactomei | R-MMU-159418, Recycling of bile acids and salts R-MMU-192105, Synthesis of bile acids and bile salts R-MMU-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-MMU-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-MMU-211976, Endogenous sterols R-MMU-3214847, HATs acetylate histones R-MMU-400206, Regulation of lipid metabolism by PPARalpha R-MMU-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-MMU-9018519, Estrogen-dependent gene expression R-MMU-9707564, Cytoprotection by HMOX1 |
Miscellaneous databases
BioGRID-ORCSi | 17978, 3 hits in 77 CRISPR screens |
ChiTaRSi | Ncoa2, mouse |
EvolutionaryTracei | Q61026 |
PROi | PR:Q61026 |
RNActi | Q61026, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005886, Expressed in retina and 290 other tissues |
Genevisiblei | Q61026, MM |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.20, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032565, DUF4927 IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028822, NCOA2 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF2, PTHR10684:SF2, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 1 hit PF16279, DUF4927, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 1 hit SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA2_MOUSE | |
Accessioni | Q61026Primary (citable) accession number: Q61026 Secondary accession number(s): E9QMH9, O09001, P97759 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families