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UniProtKB - Q61026 (NCOA2_MOUSE)

Entry version 196 (22 Apr 2020)
Sequence version 3 (27 Jul 2011)
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Protein

Nuclear receptor coactivator 2

Gene

Ncoa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:24529706).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-159418 Recycling of bile acids and salts
R-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-MMU-211976 Endogenous sterols
R-MMU-3214847 HATs acetylate histones
R-MMU-400206 Regulation of lipid metabolism by PPARalpha
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 2
Short name:
NCoA-2
Alternative name(s):
Glucocorticoid receptor-interacting protein 1
Short name:
GRIP-1
Steroid receptor coactivator 2
Short name:
SRC-2
Transcriptional intermediary factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncoa2
Synonyms:Grip1, Src2, Tif2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1276533 Ncoa2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Animals show a glycogenopathy resembling to Von Gierke's disease with impaired growth, fasting hypoglycemia, and an increase in concentrations of triglycerides, cholesterol, free fatty acids, ketone bodies, uric acid and lactic acid in the plasma during fating. They also have increased liver glycogen stores and hepatic steatosis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi644 – 645LL → AA: Abolishes interaction with RORC; when associated with 689-A--A-694 and 744-A--A-749. 1 Publication2
Mutagenesisi689 – 694ILHRLL → AAHRAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 744-A--A-749. 1 Publication6
Mutagenesisi744 – 749LLRYLL → AARAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 689-A--A-694. 1 Publication6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944032 – 1462Nuclear receptor coactivator 2Add BLAST1461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei29PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei338Asymmetric dimethylarginineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei499PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei565PhosphoserineCombined sources1
Modified residuei636N6-acetyllysineCombined sources1
Modified residuei640N6-acetyllysineCombined sources1
Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei682PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei736PhosphoserineBy similarity1
Modified residuei771PhosphoserineCombined sources1
Modified residuei780N6-acetyllysineCombined sources1
Modified residuei785N6-acetyllysine; alternateCombined sources1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei864Asymmetric dimethylarginineCombined sources1
Modified residuei874Asymmetric dimethylarginineCombined sources1
Modified residuei1173Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1190Asymmetric dimethylarginineCombined sources1
Modified residuei1196Asymmetric dimethylarginineBy similarity1
Modified residuei1203Asymmetric dimethylarginineCombined sources1
Modified residuei1221Asymmetric dimethylarginineCombined sources1
Modified residuei1240Asymmetric dimethylarginineCombined sources1
Modified residuei1259Omega-N-methylarginineBy similarity1
Modified residuei1264Asymmetric dimethylarginineBy similarity1
Cross-linki1452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q61026

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q61026

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q61026

PRoteomics IDEntifications database

More...PRIDEi		Q61026

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q61026

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q61026

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q61026

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expressed in a circadian manner in the liver, brown adipose tissue (BAT), white adipose tissue (WAT), heart, skeletal muscle and suprachiasmatic nucleus (SCN) of the brain. Shows a higher expression during the light phase compared with the dark phase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000005886 Expressed in retina and 267 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q61026 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q61026 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP.

Interacts (via C-terminus) with CREBBP.

Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300.

Interacts with CASP8AP2 and TTLL5/STAMP.

Interacts with PSMB9 and DDX5.

Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif).

Interacts with RWDD3.

Interacts with CLOCK and ARNTL/BMAL1.

Interacts with NR4A3; potentiates the activity of the NR4A3 (PubMed:12709428).

Interacts with NR1H3 (By similarity).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		201708, 14 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-703 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-818 RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex

Database of interacting proteins

More...DIPi		DIP-5979N

Protein interaction database and analysis system

More...IntActi		Q61026, 11 interactors

Molecular INTeraction database

More...MINTi		Q61026

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000006037

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q61026 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q61026

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q61026

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 83bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini119 – 183PASPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni691 – 743CASP8AP2-bindingAdd BLAST53
Regioni730 – 1121Interaction with ARNTL1 PublicationAdd BLAST392

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi641 – 645LXXLL motif 15
Motifi690 – 694LXXLL motif 25
Motifi745 – 749LXXLL motif 35
Motifi878 – 882LXXLL motif 45
Motifi1079 – 1087LLXXLXXXL motif9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (PubMed:16148126).1 Publication
The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.By similarity
Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183021

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q61026

KEGG Orthology (KO)

More...KOi		K11255

Identification of Orthologs from Complete Genome Data

More...OMAi		DQLYMAL

Database of Orthologous Groups

More...OrthoDBi		59971at2759

TreeFam database of animal gene trees

More...TreeFami		TF332652

Family and domain databases

Conserved Domains Database

More...CDDi		cd00083 HLH, 1 hit
cd00130 PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.1070, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL

The PANTHER Classification System

More...PANTHERi		PTHR10684 PTHR10684, 1 hit
PTHR10684:SF2 PTHR10684:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038181 Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA 
        60         70         80         90        100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 
       110        120        130        140        150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGSVVFVS ENVTQYLRYN 
       160        170        180        190        200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWSGEP PRRSSHTFNC 
       210        220        230        240        250
RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE EGEDLQSCLI 
       260        270        280        290        300
CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 
       310        320        330        340        350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 
       360        370        380        390        400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS 
       410        420        430        440        450
SSPAHQALCS GNPGQDMTLG SNINFPMNGP KEQMGMPMGR FGGSGGMNHV 
       460        470        480        490        500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QASSVLSPRQ RMSPGVAGSP 
       510        520        530        540        550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS 
       560        570        580        590        600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 
       610        620        630        640        650
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD 
       660        670        680        690        700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP 
       710        720        730        740        750
VDLAKLTAEA TGKELSQESS STAPGSEVTV KQEPASPKKK ENALLRYLLD 
       760        770        780        790        800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG 
       810        820        830        840        850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS 
       860        870        880        890        900
SPVPPAGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 
       910        920        930        940        950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRPSMP 
       960        970        980        990       1000
SGEWAPQSPA VRVTCAATTG AMNRPVQGGM IRNPTASIPM RANSQPGQRQ 
      1010       1020       1030       1040       1050
MLQSQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFAS 
      1060       1070       1080       1090       1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL 
      1110       1120       1130       1140       1150
GIPELVSQSQ AVDAEQFSSQ ESSIMLEQKP PVFPQQYASQ AQMAQGGYNP 
      1160       1170       1180       1190       1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 
      1210       1220       1230       1240       1250
QNRQPLMNQI SSVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR 
      1260       1270       1280       1290       1300
QMQQQVQQRT LMMRGQGLNV TPSMVAPAGL PAAMSNPRIP QANAQQFPFP 
      1310       1320       1330       1340       1350
PNYGISQQPD PGFTGATTPQ SPLMSPRMAH TQSPMMQQSQ ANPAYQPTSD 
      1360       1370       1380       1390       1400
MNGWAQGSMG GNSMFSQQSP PHFGQQANTS MYSNNMNISV SMATNTGGLS 
      1410       1420       1430       1440       1450
SMNQMTGQMS MTSVTSVPTS GLPSMGPEQV NDPALRGGNL FPNQLPGMDM 
      1460 
IKQEGDASRK YC
Length:1,462
Mass (Da):158,466
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i619462FF1ACC6067
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV80E9PV80_MOUSE
Nuclear receptor coactivator
Ncoa2
1,393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z4F6D3Z4F6_MOUSE
Nuclear receptor coactivator 2
Ncoa2
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB61575 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51E → D in AAC53151 (PubMed:9111344).Curated1
Sequence conflicti140 – 141SE → FR in AAB61575 (PubMed:9192892).Curated2
Sequence conflicti194S → T in AAC53151 (PubMed:9111344).Curated1
Sequence conflicti256V → I in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti286S → T in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti420G → S in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti512S → N in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti594E → K in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti607 – 608EE → KK in AAB61575 (PubMed:9192892).Curated2
Sequence conflicti864R → C in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti869T → S in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti884N → Y in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti972M → K in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti980M → K in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti991R → G in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti996P → L in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti1407G → C in AAC53151 (PubMed:9111344).Curated1
Sequence conflicti1446P → L in AAB61575 (PubMed:9192892).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U39060 mRNA Translation: AAC53151.1
AF000582 mRNA Translation: AAB61575.1 Frameshift.
AC091248 Genomic DNA No translation available.
AC121538 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35515.1

Protein sequence database of the Protein Information Resource

More...PIRi		T30193
T42639

NCBI Reference Sequences

More...RefSeqi		NP_032704.2, NM_008678.3
XP_006495528.1, XM_006495465.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000006037; ENSMUSP00000006037; ENSMUSG00000005886

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17978

UCSC genome browser

More...UCSCi		uc007aim.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39060 mRNA Translation: AAC53151.1
AF000582 mRNA Translation: AAB61575.1 Frameshift.
AC091248 Genomic DNA No translation available.
AC121538 Genomic DNA No translation available.
CCDSiCCDS35515.1
PIRiT30193
T42639
RefSeqiNP_032704.2, NM_008678.3
XP_006495528.1, XM_006495465.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L2IX-ray1.95C/D686-698[»]
1OSVX-ray2.50C/D/E741-752[»]
1WM0X-ray2.90Y684-697[»]
2Q6JX-ray2.70C/D686-698[»]
2QA6X-ray2.60C/D686-698[»]
2QA8X-ray1.85C/D686-698[»]
2QABX-ray1.89C/D686-698[»]
2QGTX-ray2.15C/D686-698[»]
2QGWX-ray2.39C/D686-698[»]
2QH6X-ray2.70C/D686-698[»]
2QPYX-ray2.50B744-753[»]
2QR9X-ray2.00C/D686-698[»]
2QSEX-ray1.85C/D686-698[»]
2QXMX-ray2.30C/D686-698[»]
2QZOX-ray1.72C/D686-698[»]
3MNEX-ray1.96B740-752[»]
3MNOX-ray1.55B740-752[»]
3MNPX-ray1.50B740-752[»]
SMRiQ61026
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi201708, 14 interactors
ComplexPortaliCPX-703 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-818 RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex
DIPiDIP-5979N
IntActiQ61026, 11 interactors
MINTiQ61026
STRINGi10090.ENSMUSP00000006037

PTM databases

iPTMnetiQ61026
PhosphoSitePlusiQ61026
SwissPalmiQ61026

Proteomic databases

EPDiQ61026
MaxQBiQ61026
PaxDbiQ61026
PRIDEiQ61026

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6252 289 antibodies

Genome annotation databases

EnsembliENSMUST00000006037; ENSMUSP00000006037; ENSMUSG00000005886
GeneIDi17978
KEGGimmu:17978
UCSCiuc007aim.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10499
MGIiMGI:1276533 Ncoa2

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00950000183021
InParanoidiQ61026
KOiK11255
OMAiDQLYMAL
OrthoDBi59971at2759
TreeFamiTF332652

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-MMU-211976 Endogenous sterols
R-MMU-3214847 HATs acetylate histones
R-MMU-400206 Regulation of lipid metabolism by PPARalpha
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ncoa2 mouse
EvolutionaryTraceiQ61026

Protein Ontology

More...PROi		PR:Q61026
RNActiQ61026 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000005886 Expressed in retina and 267 other tissues
ExpressionAtlasiQ61026 baseline and differential
GenevisibleiQ61026 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF2 PTHR10684:SF2, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61026
Secondary accession number(s): E9QMH9, O09001, P97759
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: April 22, 2020
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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