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UniProtKB - Q61026 (NCOA2_MOUSE)

Protein

Nuclear receptor coactivator 2

Gene

Ncoa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:24529706).5 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-MMU-211976 Endogenous sterols
R-MMU-3214847 HATs acetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 2
Short name:
NCoA-2
Alternative name(s):
Glucocorticoid receptor-interacting protein 1
Short name:
GRIP-1
Steroid receptor coactivator 2
Short name:
SRC-2
Transcriptional intermediary factor 2
Gene namesi
Name:Ncoa2
Synonyms:Grip1, Src2, Tif2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1276533 Ncoa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Animals show a glycogenopathy resembling to Von Gierke's disease with impaired growth, fasting hypoglycemia, and an increase in concentrations of triglycerides, cholesterol, free fatty acids, ketone bodies, uric acid and lactic acid in the plasma during fating. They also have increased liver glycogen stores and hepatic steatosis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi644 – 645LL → AA: Abolishes interaction with RORC; when associated with 689-A--A-694 and 744-A--A-749. 1 Publication2
Mutagenesisi689 – 694ILHRLL → AAHRAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 744-A--A-749. 1 Publication6
Mutagenesisi744 – 749LLRYLL → AARAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 689-A--A-694. 1 Publication6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000944032 – 1462Nuclear receptor coactivator 2Add BLAST1461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei29PhosphoserineBy similarity1
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei338Asymmetric dimethylarginineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei499PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei565PhosphoserineCombined sources1
Modified residuei636N6-acetyllysineCombined sources1
Modified residuei640N6-acetyllysineCombined sources1
Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei682PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei736PhosphoserineBy similarity1
Modified residuei771PhosphoserineCombined sources1
Modified residuei780N6-acetyllysineCombined sources1
Modified residuei785N6-acetyllysine; alternateCombined sources1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei864Asymmetric dimethylarginineCombined sources1
Modified residuei874Asymmetric dimethylarginineCombined sources1
Modified residuei1173Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1190Asymmetric dimethylarginineCombined sources1
Modified residuei1196Asymmetric dimethylarginineBy similarity1
Modified residuei1203Asymmetric dimethylarginineCombined sources1
Modified residuei1221Asymmetric dimethylarginineCombined sources1
Modified residuei1240Asymmetric dimethylarginineCombined sources1
Modified residuei1259Omega-N-methylarginineBy similarity1
Modified residuei1264Asymmetric dimethylarginineBy similarity1
Cross-linki1452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61026
MaxQBiQ61026
PaxDbiQ61026
PRIDEiQ61026

PTM databases

iPTMnetiQ61026
PhosphoSitePlusiQ61026
SwissPalmiQ61026

Expressioni

Tissue specificityi

Ubiquitous.

Inductioni

Expressed in a circadian manner in the liver, brown adipose tissue (BAT), white adipose tissue (WAT), heart, skeletal muscle and suprachiasmatic nucleus (SCN) of the brain. Shows a higher expression during the light phase compared with the dark phase.1 Publication

Gene expression databases

BgeeiENSMUSG00000005886 Expressed in 268 organ(s), highest expression level in retina
CleanExiMM_GRIP1
MM_NCOA2
ExpressionAtlasiQ61026 baseline and differential
GenevisibleiQ61026 MM

Interactioni

Subunit structurei

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1. Interacts with NR4A3; potentiates the activity of the NR4A3 (PubMed:12709428). Interacts with NR1H3 (By similarity).By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KMT5BQ4FZB7-14EBI-688662,EBI-15746366From a different organism.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi201708, 14 interactors
ComplexPortaliCPX-703 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-818 RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex
DIPiDIP-5979N
IntActiQ61026, 11 interactors
MINTiQ61026
STRINGi10090.ENSMUSP00000006037

Structurei

Secondary structure

11462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61026
SMRiQ61026
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61026

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 83bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini119 – 183PASPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni691 – 743CASP8AP2-bindingAdd BLAST53
Regioni730 – 1121Interaction with ARNTL1 PublicationAdd BLAST392

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi641 – 645LXXLL motif 15
Motifi690 – 694LXXLL motif 25
Motifi745 – 749LXXLL motif 35
Motifi878 – 882LXXLL motif 45
Motifi1079 – 1087LLXXLXXXL motif9

Domaini

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (PubMed:16148126).1 Publication
The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.By similarity
Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.By similarity

Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
HOGENOMiHOG000230947
HOVERGENiHBG052583
InParanoidiQ61026
KOiK11255
OMAiVNMNPPQ
OrthoDBiEOG091G00US
TreeFamiTF332652

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF2 PTHR10684:SF2, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA 
        60         70         80         90        100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 
       110        120        130        140        150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGSVVFVS ENVTQYLRYN 
       160        170        180        190        200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWSGEP PRRSSHTFNC 
       210        220        230        240        250
RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE EGEDLQSCLI 
       260        270        280        290        300
CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 
       310        320        330        340        350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 
       360        370        380        390        400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS 
       410        420        430        440        450
SSPAHQALCS GNPGQDMTLG SNINFPMNGP KEQMGMPMGR FGGSGGMNHV 
       460        470        480        490        500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QASSVLSPRQ RMSPGVAGSP 
       510        520        530        540        550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS 
       560        570        580        590        600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 
       610        620        630        640        650
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD 
       660        670        680        690        700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP 
       710        720        730        740        750
VDLAKLTAEA TGKELSQESS STAPGSEVTV KQEPASPKKK ENALLRYLLD 
       760        770        780        790        800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG 
       810        820        830        840        850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS 
       860        870        880        890        900
SPVPPAGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 
       910        920        930        940        950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRPSMP 
       960        970        980        990       1000
SGEWAPQSPA VRVTCAATTG AMNRPVQGGM IRNPTASIPM RANSQPGQRQ 
      1010       1020       1030       1040       1050
MLQSQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFAS 
      1060       1070       1080       1090       1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL 
      1110       1120       1130       1140       1150
GIPELVSQSQ AVDAEQFSSQ ESSIMLEQKP PVFPQQYASQ AQMAQGGYNP 
      1160       1170       1180       1190       1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 
      1210       1220       1230       1240       1250
QNRQPLMNQI SSVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR 
      1260       1270       1280       1290       1300
QMQQQVQQRT LMMRGQGLNV TPSMVAPAGL PAAMSNPRIP QANAQQFPFP 
      1310       1320       1330       1340       1350
PNYGISQQPD PGFTGATTPQ SPLMSPRMAH TQSPMMQQSQ ANPAYQPTSD 
      1360       1370       1380       1390       1400
MNGWAQGSMG GNSMFSQQSP PHFGQQANTS MYSNNMNISV SMATNTGGLS 
      1410       1420       1430       1440       1450
SMNQMTGQMS MTSVTSVPTS GLPSMGPEQV NDPALRGGNL FPNQLPGMDM 
      1460 
IKQEGDASRK YC
Length:1,462
Mass (Da):158,466
Last modified:July 27, 2011 - v3
Checksum:i619462FF1ACC6067
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV80E9PV80_MOUSE
Nuclear receptor coactivator
Ncoa2
1,393Annotation score:
D3Z4F6D3Z4F6_MOUSE
Nuclear receptor coactivator 2
Ncoa2
114Annotation score:

Sequence cautioni

The sequence AAB61575 differs from that shown. Reason: Frameshift at positions 251, 256, 302, 321, 959, 964 and 983.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51E → D in AAC53151 (PubMed:9111344).Curated1
Sequence conflicti140 – 141SE → FR in AAB61575 (PubMed:9192892).Curated2
Sequence conflicti194S → T in AAC53151 (PubMed:9111344).Curated1
Sequence conflicti256V → I in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti286S → T in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti420G → S in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti512S → N in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti594E → K in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti607 – 608EE → KK in AAB61575 (PubMed:9192892).Curated2
Sequence conflicti864R → C in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti869T → S in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti884N → Y in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti972M → K in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti980M → K in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti991R → G in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti996P → L in AAB61575 (PubMed:9192892).Curated1
Sequence conflicti1407G → C in AAC53151 (PubMed:9111344).Curated1
Sequence conflicti1446P → L in AAB61575 (PubMed:9192892).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39060 mRNA Translation: AAC53151.1
AF000582 mRNA Translation: AAB61575.1 Frameshift.
AC091248 Genomic DNA No translation available.
AC121538 Genomic DNA No translation available.
CCDSiCCDS35515.1
PIRiT30193
T42639
RefSeqiNP_032704.2, NM_008678.3
XP_006495528.1, XM_006495465.3
UniGeneiMm.2537

Genome annotation databases

EnsembliENSMUST00000006037; ENSMUSP00000006037; ENSMUSG00000005886
GeneIDi17978
KEGGimmu:17978
UCSCiuc007aim.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39060 mRNA Translation: AAC53151.1
AF000582 mRNA Translation: AAB61575.1 Frameshift.
AC091248 Genomic DNA No translation available.
AC121538 Genomic DNA No translation available.
CCDSiCCDS35515.1
PIRiT30193
T42639
RefSeqiNP_032704.2, NM_008678.3
XP_006495528.1, XM_006495465.3
UniGeneiMm.2537

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L2IX-ray1.95C/D686-698[»]
1OSVX-ray2.50C/D/E741-752[»]
1WM0X-ray2.90Y684-697[»]
2Q6JX-ray2.70C/D686-698[»]
2QA6X-ray2.60C/D686-698[»]
2QA8X-ray1.85C/D686-698[»]
2QABX-ray1.89C/D686-698[»]
2QGTX-ray2.15C/D686-698[»]
2QGWX-ray2.39C/D686-698[»]
2QH6X-ray2.70C/D686-698[»]
2QPYX-ray2.50B744-753[»]
2QR9X-ray2.00C/D686-698[»]
2QSEX-ray1.85C/D686-698[»]
2QXMX-ray2.30C/D686-698[»]
2QZOX-ray1.72C/D686-698[»]
3MNEX-ray1.96B740-752[»]
3MNOX-ray1.55B740-752[»]
3MNPX-ray1.50B740-752[»]
ProteinModelPortaliQ61026
SMRiQ61026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201708, 14 interactors
ComplexPortaliCPX-703 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-818 RXRalpha-RARalpha-NCOA2 retinoic acid receptor complex
DIPiDIP-5979N
IntActiQ61026, 11 interactors
MINTiQ61026
STRINGi10090.ENSMUSP00000006037

PTM databases

iPTMnetiQ61026
PhosphoSitePlusiQ61026
SwissPalmiQ61026

Proteomic databases

EPDiQ61026
MaxQBiQ61026
PaxDbiQ61026
PRIDEiQ61026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006037; ENSMUSP00000006037; ENSMUSG00000005886
GeneIDi17978
KEGGimmu:17978
UCSCiuc007aim.2 mouse

Organism-specific databases

CTDi10499
MGIiMGI:1276533 Ncoa2

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
HOGENOMiHOG000230947
HOVERGENiHBG052583
InParanoidiQ61026
KOiK11255
OMAiVNMNPPQ
OrthoDBiEOG091G00US
TreeFamiTF332652

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-MMU-211976 Endogenous sterols
R-MMU-3214847 HATs acetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

EvolutionaryTraceiQ61026
PROiPR:Q61026
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005886 Expressed in 268 organ(s), highest expression level in retina
CleanExiMM_GRIP1
MM_NCOA2
ExpressionAtlasiQ61026 baseline and differential
GenevisibleiQ61026 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028822 NCOA2
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF2 PTHR10684:SF2, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA2_MOUSE
AccessioniPrimary (citable) accession number: Q61026
Secondary accession number(s): E9QMH9, O09001, P97759
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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