Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Intraflagellar transport protein 20 homolog

Gene

Ift20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.2 Publications

Miscellaneous

Cells that stably express short interference RNAs targeting IFT20 show reduced centriolar IFT20 and lack primary cilia.

GO - Molecular functioni

  • opsin binding Source: MGI
  • Rab GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 20 homolog
Short name:
mIFT20
Gene namesi
Name:Ift20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915585 Ift20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493041 – 132Intraflagellar transport protein 20 homologAdd BLAST132

Proteomic databases

PaxDbiQ61025
PeptideAtlasiQ61025
PRIDEiQ61025

PTM databases

PhosphoSitePlusiQ61025

Expressioni

Tissue specificityi

Expressed in testis, kidney and retina.2 Publications

Gene expression databases

BgeeiENSMUSG00000001105 Expressed in 286 organ(s), highest expression level in brain
ExpressionAtlasiQ61025 baseline and differential
GenevisibleiQ61025 MM

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:12821668, PubMed:16775004, PubMed:19253336). Interacts directly with IFT57 and KIF3B/Kinesin II subunit (PubMed:12821668). Interacts with IFT88 (PubMed:19253336). Interacts with CEP83 (By similarity). Interacts with SPEF2 (via C-terminus) (PubMed:19889948).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Atg16l1Q8C0J22EBI-16077253,EBI-769195

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207750, 4 interactors
DIPiDIP-60602N
IntActiQ61025, 1 interactor
STRINGi10090.ENSMUSP00000103910

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 132IFT57-bindingAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 116Sequence analysisAdd BLAST43

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IW7Z Eukaryota
ENOG4111NRP LUCA
GeneTreeiENSGT00390000003413
HOGENOMiHOG000230527
HOVERGENiHBG081781
InParanoidiQ61025
KOiK16473
OMAiIEADQNE
OrthoDBiEOG091G0VSN
PhylomeDBiQ61025
TreeFamiTF319434

Family and domain databases

InterProiView protein in InterPro
IPR028172 FT20
PANTHERiPTHR31978 PTHR31978, 1 hit
PfamiView protein in Pfam
PF14931 IFT20, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61025-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKDILGEAG LHFDELNKLR VLDPEVTQQT VELKEECKDF VDKIGQFQKI
60 70 80 90 100
VGGLIELVDQ LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK
110 120 130
KTQLERYRVE YEALCKVEAE QNEFIDQFIF QK
Length:132
Mass (Da):15,237
Last modified:November 1, 1996 - v1
Checksum:iA0E797D01CFD001D
GO
Isoform 2 (identifier: Q61025-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-132: Missing.

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):12,014
Checksum:iF3CC2F8B99067BE4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YJL9Z4YJL9_MOUSE
Intraflagellar transport protein 20...
Ift20
111Annotation score:

Sequence cautioni

The sequence CAI25553 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020392107 – 132Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082613 mRNA Translation: AAL99202.1
U38981 mRNA Translation: AAA81518.1
AK002397 mRNA Translation: BAB22069.1
AK139942 mRNA Translation: BAE24189.1
AL591177 Genomic DNA Translation: CAI25553.1 Sequence problems.
AL591177 Genomic DNA Translation: CAI25554.1
BC002040 mRNA Translation: AAH02040.1
CCDSiCCDS25111.1 [Q61025-1]
RefSeqiNP_061342.1, NM_018854.4 [Q61025-1]
UniGeneiMm.358671

Genome annotation databases

EnsembliENSMUST00000108275; ENSMUSP00000103910; ENSMUSG00000001105 [Q61025-1]
ENSMUST00000128788; ENSMUSP00000118015; ENSMUSG00000001105 [Q61025-1]
GeneIDi55978
KEGGimmu:55978
UCSCiuc007kjs.1 mouse [Q61025-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082613 mRNA Translation: AAL99202.1
U38981 mRNA Translation: AAA81518.1
AK002397 mRNA Translation: BAB22069.1
AK139942 mRNA Translation: BAE24189.1
AL591177 Genomic DNA Translation: CAI25553.1 Sequence problems.
AL591177 Genomic DNA Translation: CAI25554.1
BC002040 mRNA Translation: AAH02040.1
CCDSiCCDS25111.1 [Q61025-1]
RefSeqiNP_061342.1, NM_018854.4 [Q61025-1]
UniGeneiMm.358671

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207750, 4 interactors
DIPiDIP-60602N
IntActiQ61025, 1 interactor
STRINGi10090.ENSMUSP00000103910

PTM databases

PhosphoSitePlusiQ61025

Proteomic databases

PaxDbiQ61025
PeptideAtlasiQ61025
PRIDEiQ61025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108275; ENSMUSP00000103910; ENSMUSG00000001105 [Q61025-1]
ENSMUST00000128788; ENSMUSP00000118015; ENSMUSG00000001105 [Q61025-1]
GeneIDi55978
KEGGimmu:55978
UCSCiuc007kjs.1 mouse [Q61025-1]

Organism-specific databases

CTDi90410
MGIiMGI:1915585 Ift20

Phylogenomic databases

eggNOGiENOG410IW7Z Eukaryota
ENOG4111NRP LUCA
GeneTreeiENSGT00390000003413
HOGENOMiHOG000230527
HOVERGENiHBG081781
InParanoidiQ61025
KOiK16473
OMAiIEADQNE
OrthoDBiEOG091G0VSN
PhylomeDBiQ61025
TreeFamiTF319434

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Miscellaneous databases

PROiPR:Q61025
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001105 Expressed in 286 organ(s), highest expression level in brain
ExpressionAtlasiQ61025 baseline and differential
GenevisibleiQ61025 MM

Family and domain databases

InterProiView protein in InterPro
IPR028172 FT20
PANTHERiPTHR31978 PTHR31978, 1 hit
PfamiView protein in Pfam
PF14931 IFT20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFT20_MOUSE
AccessioniPrimary (citable) accession number: Q61025
Secondary accession number(s): Q5SYG9, Q99M35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again