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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene

Gngt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Alternative name(s):
G gamma-C
G-gamma-8
Gene namesi
Name:Gngt2
Synonyms:Gng8, Gngt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:893584 Gngt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126471 – 66Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2Add BLAST66
PropeptideiPRO_000001264867 – 69Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66Cysteine methyl esterBy similarity1
Lipidationi66S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ61017
MaxQBiQ61017
PaxDbiQ61017
PRIDEiQ61017

Expressioni

Gene expression databases

BgeeiENSMUSG00000038811 Expressed in 138 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ61017 baseline and differential
GenevisibleiQ61017 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

CORUMiQ61017
STRINGi10090.ENSMUSP00000047586

Structurei

3D structure databases

ProteinModelPortaliQ61017
SMRiQ61017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiQ61017
KOiK04549
OMAiKNERQMV
OrthoDBiEOG091G17J0
PhylomeDBiQ61017
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61017-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQDLSEKEL LRMEVEQLKK EVKNPRDLIS KTGKEIKDYV EAQAGTDPLL
60
KGIPEDKNPF KEKGTCVLS
Length:69
Mass (Da):7,802
Last modified:September 27, 2004 - v2
Checksum:i80A9586CD56BB304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA Translation: BAB27023.1
U38500 mRNA Translation: AAB01731.1
CCDSiCCDS25284.1
RefSeqiNP_001033753.2, NM_001038664.2
NP_001271322.1, NM_001284393.1
NP_001271326.1, NM_001284397.1
NP_075610.1, NM_023121.2
XP_006532294.1, XM_006532231.3
XP_011247039.1, XM_011248737.1
XP_017169763.1, XM_017314274.1
UniGeneiMm.46299

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811
GeneIDi14710
KEGGimmu:14710
UCSCiuc007lau.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA Translation: BAB27023.1
U38500 mRNA Translation: AAB01731.1
CCDSiCCDS25284.1
RefSeqiNP_001033753.2, NM_001038664.2
NP_001271322.1, NM_001284393.1
NP_001271326.1, NM_001284397.1
NP_075610.1, NM_023121.2
XP_006532294.1, XM_006532231.3
XP_011247039.1, XM_011248737.1
XP_017169763.1, XM_017314274.1
UniGeneiMm.46299

3D structure databases

ProteinModelPortaliQ61017
SMRiQ61017
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ61017
STRINGi10090.ENSMUSP00000047586

Proteomic databases

EPDiQ61017
MaxQBiQ61017
PaxDbiQ61017
PRIDEiQ61017

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811
GeneIDi14710
KEGGimmu:14710
UCSCiuc007lau.1 mouse

Organism-specific databases

CTDi2793
MGIiMGI:893584 Gngt2

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiQ61017
KOiK04549
OMAiKNERQMV
OrthoDBiEOG091G17J0
PhylomeDBiQ61017
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

PROiPR:Q61017
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038811 Expressed in 138 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ61017 baseline and differential
GenevisibleiQ61017 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBGT2_MOUSE
AccessioniPrimary (citable) accession number: Q61017
Secondary accession number(s): Q9CWL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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