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Protein

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Gene

Gngt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-202040 G-protein activation
R-MMU-2485179 Activation of the phototransduction cascade
R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-381753 Olfactory Signaling Pathway
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Alternative name(s):
Transducin gamma chain
Gene namesi
Name:Gngt1
Synonyms:Gng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109165 Gngt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126072 – 71Guanine nucleotide-binding protein G(T) subunit gamma-T1Add BLAST70
PropeptideiPRO_000001260872 – 74Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71Cysteine methyl ester1 Publication1
Lipidationi71S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61012
PaxDbiQ61012
PRIDEiQ61012

PTM databases

PhosphoSitePlusiQ61012

Expressioni

Tissue specificityi

Retinal rod outer segment.

Gene expression databases

BgeeiENSMUSG00000029663 Expressed in 219 organ(s), highest expression level in retina
GenevisibleiQ61012 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiQ61012, 1 interactor
STRINGi10090.ENSMUSP00000031673

Structurei

3D structure databases

ProteinModelPortaliQ61012
SMRiQ61012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOVERGENiHBG014983
InParanoidiQ61012
KOiK04548
OMAiTSKCCEE
OrthoDBiEOG091G17J0
PhylomeDBiQ61012
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61012-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVINIEDLT EKDKLKMEVD QLKKEVTLER MMVSKCCEEV RDYIEERSGE
60 70
DPLVKGIPED KNPFKELKGG CVIS
Length:74
Mass (Da):8,528
Last modified:January 23, 2007 - v3
Checksum:i3ABB43EF45CE02F4
GO

Mass spectrometryi

Molecular mass is 8314.5±0.1 Da from positions 2 - 71. Determined by ESI. Includes farnesylation and methylation.1 Publication
Molecular mass is 695.5±0.1 Da from positions 67 - 71. Determined by MALDI. Includes farnesylation and methylation.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020863 mRNA Translation: BAB32232.1
AK020903 mRNA Translation: BAB32247.1
BC025929 mRNA Translation: AAH25929.1
U38495 mRNA Translation: AAB01726.1
CCDSiCCDS39418.1
RefSeqiNP_034444.1, NM_010314.2
XP_006505049.1, XM_006504986.1
XP_017176877.1, XM_017321388.1
XP_017176878.1, XM_017321389.1
UniGeneiMm.95398

Genome annotation databases

EnsembliENSMUST00000031673; ENSMUSP00000031673; ENSMUSG00000029663
GeneIDi14699
KEGGimmu:14699
UCSCiuc009avi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020863 mRNA Translation: BAB32232.1
AK020903 mRNA Translation: BAB32247.1
BC025929 mRNA Translation: AAH25929.1
U38495 mRNA Translation: AAB01726.1
CCDSiCCDS39418.1
RefSeqiNP_034444.1, NM_010314.2
XP_006505049.1, XM_006504986.1
XP_017176877.1, XM_017321388.1
XP_017176878.1, XM_017321389.1
UniGeneiMm.95398

3D structure databases

ProteinModelPortaliQ61012
SMRiQ61012
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61012, 1 interactor
STRINGi10090.ENSMUSP00000031673

PTM databases

PhosphoSitePlusiQ61012

Proteomic databases

MaxQBiQ61012
PaxDbiQ61012
PRIDEiQ61012

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031673; ENSMUSP00000031673; ENSMUSG00000029663
GeneIDi14699
KEGGimmu:14699
UCSCiuc009avi.1 mouse

Organism-specific databases

CTDi2792
MGIiMGI:109165 Gngt1

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOVERGENiHBG014983
InParanoidiQ61012
KOiK04548
OMAiTSKCCEE
OrthoDBiEOG091G17J0
PhylomeDBiQ61012
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-202040 G-protein activation
R-MMU-2485179 Activation of the phototransduction cascade
R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-381753 Olfactory Signaling Pathway
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

ChiTaRSiGngt1 mouse
PROiPR:Q61012
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029663 Expressed in 219 organ(s), highest expression level in retina
GenevisibleiQ61012 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG1_MOUSE
AccessioniPrimary (citable) accession number: Q61012
Secondary accession number(s): Q9CR01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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