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Protein

Muscle, skeletal receptor tyrosine-protein kinase

Gene

Musk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.5 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mg2+By similarity

Activity regulationi

Positively regulated by CK2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei608ATPPROSITE-ProRule annotation1
Active sitei724Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi580 – 588ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Muscle protein, Receptor, Transferase, Tyrosine-protein kinase
Biological processDifferentiation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle, skeletal receptor tyrosine-protein kinase (EC:2.7.10.1)
Alternative name(s):
Muscle-specific tyrosine-protein kinase receptor
Short name:
MuSK
Short name:
Muscle-specific kinase receptor
Gene namesi
Name:Musk
Synonyms:Nsk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:103581 Musk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 494ExtracellularSequence analysisAdd BLAST473
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 868CytoplasmicSequence analysisAdd BLAST353

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice die perinatally being unable to take a breath and to respond to tail or leg pinch. Despite the presence of apparently normal skeletal muscle, the absence of differentiated nerve terminals is sufficient to account for this phenotype. Every aspect of NMJ formation examined is absent in these mice. Branches of the main intramuscular nerve do not establish normal contacts with the muscle, do not form correctly positioned or specialized nerve terminals, and are apparently not given appropriate signals to stop their wandering aimlessly across the muscle. Furthermore, postsynaptic differentiation is absent, muscle-derived proteins normally localized to the synaptic basal lamina or the postsynaptic membrane being uniformly distributed in myofibers.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi553Y → F: Loss of interaction with DOK7. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002444722 – 868Muscle, skeletal receptor tyrosine-protein kinaseAdd BLAST847

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 99By similarity
Disulfide bondi98 ↔ 112By similarity
Disulfide bondi142 ↔ 190By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 282By similarity
Disulfide bondi317 ↔ 382By similarity
Disulfide bondi325 ↔ 375By similarity
Glycosylationi338N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi366 ↔ 406By similarity
Disulfide bondi394 ↔ 447By similarity
Disulfide bondi398 ↔ 434By similarity
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei553Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei680Phosphoserine; by CK21 Publication1
Modified residuei697Phosphoserine; by CK21 Publication1
Modified residuei754Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.1 Publication
Phosphorylated (PubMed:16818610). Phosphorylation is induced by AGRIN (PubMed:8653787, PubMed:18848351). Autophosphorylated. Autophosphorylation at Tyr-553 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (PubMed:16794080, PubMed:20603078).5 Publications
Neddylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61006
PRIDEiQ61006

PTM databases

iPTMnetiQ61006
PhosphoSitePlusiQ61006

Expressioni

Tissue specificityi

Expressed preferentially in skeletal muscle.1 Publication

Developmental stagei

Skeletal myogenesis is a major site of expression during normal embryogenesis. In addition, the ganglia of the developing peripheral nervous system and various embryonic epithelia, including those of kidney, lung and gut are also sites of expression.1 Publication

Gene expression databases

BgeeiENSMUSG00000057280 Expressed in 81 organ(s), highest expression level in skeletal muscle organ
CleanExiMM_MUSK
ExpressionAtlasiQ61006 baseline and differential
GenevisibleiQ61006 MM

Interactioni

Subunit structurei

Monomer. Homodimer (Probable). Interacts with LRP4; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which facilitates MUSK trans-autophosphorylation on tyrosine residue and activation. Interacts (via cytoplasmic part) with DOK7 (via IRS-type PTB domain); requires MUSK phosphorylation. Interacts with DVL1 (via DEP domain); the interaction is direct and mediates the formation of a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with FNTA; the interaction is direct and mediates AGRIN-induced phosphorylation and activation of FNTA. Interacts with CSNK2B; mediates regulation by CK2. Interacts (via the cytoplasmic domain) with DNAJA3. Interacts with NSF; may regulate MUSK endocytosis and activity. Interacts with CAV3; may regulate MUSK signaling. Interacts with RNF31.Curated11 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201860, 5 interactors
ELMiQ61006
IntActiQ61006, 4 interactors
STRINGi10090.ENSMUSP00000095665

Structurei

Secondary structure

1868
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61006
SMRiQ61006
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61006

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 116Ig-like 1Add BLAST89
Domaini121 – 205Ig-like 2Add BLAST85
Domaini212 – 302Ig-like 3Add BLAST91
Domaini312 – 450FZPROSITE-ProRule annotationAdd BLAST139
Domaini574 – 855Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMMJ Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000044461
HOVERGENiHBG052539
InParanoidiQ61006
KOiK05129
TreeFamiTF106465

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61006-1) [UniParc]FASTAAdd to basket
Also known as: MLK2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA
60 70 80 90 100
VESYPQPEIS WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI
110 120 130 140 150
ANNGVGGAVE SCGALQVKMK PKITRPPINV KIIEGLKAVL PCTTMGNPKP
160 170 180 190 200
SVSWIKGDNA LRENSRIAVL ESGSLRIHNV QKEDAGQYRC VAKNSLGTAY
210 220 230 240 250
SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGIPV PTISWIENGN
260 270 280 290 300
AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT
310 320 330 340 350
VSIAEWSKSQ KDSQGYCAQY RGEVCDAVLA KDALVFFNTS YRDPEDAQEL
360 370 380 390 400
LIHTAWNELK AVSPLCRPAA EALLCNHLFQ ECSPGVVPTP MPICREYCLA
410 420 430 440 450
VKELFCAKEW QAMEGKAHRG LYRSGMHLLP VPECSKLPSM HRDPTACTRL
460 470 480 490 500
PYLDYKKENI TTFPSITSSR PSADIPNLPA STSSFAVSPA YSMTVIISIV
510 520 530 540 550
SSFALFALLT IATLYCCRRR KEWKNKKRES TAVTLTTLPS ELLLDRLHPN
560 570 580 590 600
PMYQRMPLLL NPKLLSLEYP RNNIEYVRDI GEGAFGRVFQ ARAPGLLPYE
610 620 630 640 650
PFTMVAVKML KEEASADMQA DFQREAALMA EFDNPNIVKL LGVCAVGKPM
660 670 680 690 700
CLLFEYMAYG DLNEFLRSMS PHTVCSLSHS DLSTRARVSS PGPPPLSCAE
710 720 730 740 750
QLCIARQVAA GMAYLSERKF VHRDLATRNC LVGETMVVKI ADFGLSRNIY
760 770 780 790 800
SADYYKADGN DAIPIRWMPP ESIFYNRYTT ESDVWAYGVV LWEIFSYGLQ
810 820 830 840 850
PYYGMAHEEV IYYVRDGNIL ACPENCPLEL YNLMRLCWSK LPADRPSFCS
860
IHRILQRMCE RAEGTVGV
Length:868
Mass (Da):96,693
Last modified:November 1, 1996 - v1
Checksum:iAFE4E644C6869933
GO
Isoform 2 (identifier: Q61006-2) [UniParc]FASTAAdd to basket
Also known as: MLK1

The sequence of this isoform differs from the canonical sequence as follows:
     454-462: DYKKENITT → A

Note: No experimental confirmation available.
Show »
Length:860
Mass (Da):95,671
Checksum:iA837F8299BD7494C
GO
Isoform 3 (identifier: Q61006-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-338: VCDAVLAKDALVFFN → GVLMQGPGEKMLLVFLPT

Note: No experimental confirmation available.
Show »
Length:871
Mass (Da):96,998
Checksum:iAA8D8D17E2F04722
GO
Isoform 4 (identifier: Q61006-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     866-868: VGV → TDGRAHFFWPHQY

Note: No experimental confirmation available.
Show »
Length:878
Mass (Da):98,081
Checksum:iA08686F5F939B8BC
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PVV8E9PVV8_MOUSE
Muscle, skeletal receptor tyrosine-...
Musk
893Annotation score:
Q497X0Q497X0_MOUSE
Muscle, skeletal receptor tyrosine-...
Musk
870Annotation score:
K3W4P7K3W4P7_MOUSE
Muscle, skeletal receptor tyrosine-...
Musk
868Annotation score:
F6WVU1F6WVU1_MOUSE
Muscle, skeletal receptor tyrosine-...
Musk
870Annotation score:
J3QPS3J3QPS3_MOUSE
Muscle, skeletal receptor tyrosine-...
Musk
878Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31T → A in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti31T → A in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti169V → A in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti169V → A in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti211 – 212FA → LG in CAA60165 (PubMed:7624144).Curated2
Sequence conflicti211 – 212FA → LG in CAA60166 (PubMed:7624144).Curated2
Sequence conflicti235A → E in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti235A → E in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti341Y → H in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti341Y → H in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti376N → Y in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti376N → Y in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti380Q → L in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti380Q → L in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti435S → R in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti435S → R in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti503F → L in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti503F → L in CAA60166 (PubMed:7624144).Curated1
Sequence conflicti512A → V in CAA60165 (PubMed:7624144).Curated1
Sequence conflicti512A → V in CAA60166 (PubMed:7624144).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010785324 – 338VCDAV…LVFFN → GVLMQGPGEKMLLVFLPT in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_010784454 – 462DYKKENITT → A in isoform 2. 1 Publication9
Alternative sequenceiVSP_010786866 – 868VGV → TDGRAHFFWPHQY in isoform 4. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37708 mRNA Translation: AAA79203.1
U37709 mRNA Translation: AAA79204.1
X86444 mRNA Translation: CAA60165.1
X86445 Genomic DNA Translation: CAA60166.1
CCDSiCCDS18210.1 [Q61006-2]
CCDS18211.1 [Q61006-1]
PIRiI48696
I48697
RefSeqiNP_001032205.1, NM_001037128.1
NP_001032206.1, NM_001037129.1
NP_001032207.1, NM_001037130.1 [Q61006-2]
NP_035074.2, NM_010944.2 [Q61006-1]
UniGeneiMm.16148

Genome annotation databases

EnsembliENSMUST00000084578; ENSMUSP00000081625; ENSMUSG00000057280 [Q61006-1]
ENSMUST00000102893; ENSMUSP00000099957; ENSMUSG00000057280 [Q61006-2]
GeneIDi18198
KEGGimmu:18198
UCSCiuc033icg.1 mouse [Q61006-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37708 mRNA Translation: AAA79203.1
U37709 mRNA Translation: AAA79204.1
X86444 mRNA Translation: CAA60165.1
X86445 Genomic DNA Translation: CAA60166.1
CCDSiCCDS18210.1 [Q61006-2]
CCDS18211.1 [Q61006-1]
PIRiI48696
I48697
RefSeqiNP_001032205.1, NM_001037128.1
NP_001032206.1, NM_001037129.1
NP_001032207.1, NM_001037130.1 [Q61006-2]
NP_035074.2, NM_010944.2 [Q61006-1]
UniGeneiMm.16148

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ML4X-ray2.60E/F/G/H544-556[»]
ProteinModelPortaliQ61006
SMRiQ61006
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201860, 5 interactors
ELMiQ61006
IntActiQ61006, 4 interactors
STRINGi10090.ENSMUSP00000095665

PTM databases

iPTMnetiQ61006
PhosphoSitePlusiQ61006

Proteomic databases

PaxDbiQ61006
PRIDEiQ61006

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084578; ENSMUSP00000081625; ENSMUSG00000057280 [Q61006-1]
ENSMUST00000102893; ENSMUSP00000099957; ENSMUSG00000057280 [Q61006-2]
GeneIDi18198
KEGGimmu:18198
UCSCiuc033icg.1 mouse [Q61006-1]

Organism-specific databases

CTDi4593
MGIiMGI:103581 Musk

Phylogenomic databases

eggNOGiENOG410IMMJ Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000044461
HOVERGENiHBG052539
InParanoidiQ61006
KOiK05129
TreeFamiTF106465

Enzyme and pathway databases

BRENDAi2.7.10.1 3474

Miscellaneous databases

EvolutionaryTraceiQ61006
PROiPR:Q61006
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057280 Expressed in 81 organ(s), highest expression level in skeletal muscle organ
CleanExiMM_MUSK
ExpressionAtlasiQ61006 baseline and differential
GenevisibleiQ61006 MM

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMUSK_MOUSE
AccessioniPrimary (citable) accession number: Q61006
Secondary accession number(s): Q61005, Q61987, Q61988
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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