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UniProtKB - Q61001 (LAMA5_MOUSE)

Entry version 190 (11 Dec 2019)
Sequence version 4 (27 Jul 2011)
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Protein

Laminin subunit alpha-5

Gene

Lama5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3000157 Laminin interactions
R-MMU-8874081 MET activates PTK2 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit alpha-5
Alternative name(s):
Laminin-10 subunit alpha
Laminin-11 subunit alpha
Laminin-15 subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lama5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:105382 Lama5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 401 PublicationAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001706341 – 3718Laminin subunit alpha-5Add BLAST3678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi305 ↔ 314By similarity
Disulfide bondi307 ↔ 327By similarity
Disulfide bondi329 ↔ 338By similarity
Disulfide bondi341 ↔ 361By similarity
Disulfide bondi364 ↔ 373By similarity
Disulfide bondi366 ↔ 398By similarity
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 410By similarity
Disulfide bondi413 ↔ 431By similarity
Disulfide bondi434 ↔ 445By similarity
Disulfide bondi436 ↔ 452By similarity
Disulfide bondi454 ↔ 463By similarity
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi466 ↔ 476By similarity
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 512By similarity
Disulfide bondi502 ↔ 521By similarity
Disulfide bondi523 ↔ 532By similarity
Disulfide bondi535 ↔ 544By similarity
Disulfide bondi547 ↔ 559By similarity
Disulfide bondi549 ↔ 566By similarity
Disulfide bondi568 ↔ 577By similarity
Disulfide bondi580 ↔ 590By similarity
Disulfide bondi593 ↔ 605By similarity
Disulfide bondi595 ↔ 611By similarity
Disulfide bondi613 ↔ 622By similarity
Disulfide bondi625 ↔ 635By similarity
Disulfide bondi638 ↔ 650By similarity
Disulfide bondi640 ↔ 656By similarity
Disulfide bondi658 ↔ 667By similarity
Disulfide bondi670 ↔ 680By similarity
Disulfide bondi683 ↔ 695By similarity
Disulfide bondi685 ↔ 702By similarity
Disulfide bondi704 ↔ 713By similarity
Disulfide bondi716 ↔ 731By similarity
Disulfide bondi752 ↔ 761By similarity
Disulfide bondi764 ↔ 779By similarity
Disulfide bondi782 ↔ 796By similarity
Disulfide bondi784 ↔ 802By similarity
Disulfide bondi804 ↔ 813By similarity
Disulfide bondi816 ↔ 831By similarity
Disulfide bondi834 ↔ 846By similarity
Disulfide bondi836 ↔ 853By similarity
Disulfide bondi855 ↔ 864By similarity
Glycosylationi905N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi926N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1335N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1443 ↔ 1455By similarity
Disulfide bondi1445 ↔ 1462By similarity
Disulfide bondi1464 ↔ 1473By similarity
Disulfide bondi1476 ↔ 1486By similarity
Disulfide bondi1489 ↔ 1496By similarity
Disulfide bondi1491 ↔ 1503By similarity
Disulfide bondi1505 ↔ 1514By similarity
Disulfide bondi1517 ↔ 1530By similarity
Disulfide bondi1533 ↔ 1548By similarity
Glycosylationi1534N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1535 ↔ 1555By similarity
Disulfide bondi1557 ↔ 1566By similarity
Disulfide bondi1569 ↔ 1579By similarity
Disulfide bondi1582 ↔ 1594By similarity
Disulfide bondi1584 ↔ 1601By similarity
Disulfide bondi1603 ↔ 1612By similarity
Disulfide bondi1615 ↔ 1630By similarity
Disulfide bondi1865 ↔ 1874By similarity
Disulfide bondi1867 ↔ 1881By similarity
Disulfide bondi1884 ↔ 1893By similarity
Disulfide bondi1896 ↔ 1912By similarity
Disulfide bondi1915 ↔ 1930By similarity
Disulfide bondi1917 ↔ 1939By similarity
Disulfide bondi1941 ↔ 1950By similarity
Disulfide bondi1953 ↔ 1968By similarity
Disulfide bondi1971 ↔ 1986By similarity
Disulfide bondi1973 ↔ 1993By similarity
Disulfide bondi1996 ↔ 2005By similarity
Disulfide bondi2008 ↔ 2022By similarity
Glycosylationi2021N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2025 ↔ 2035By similarity
Disulfide bondi2027 ↔ 2042By similarity
Disulfide bondi2044 ↔ 2053By similarity
Disulfide bondi2056 ↔ 2069By similarity
Disulfide bondi2072 ↔ 2083By similarity
Disulfide bondi2074 ↔ 2090By similarity
Disulfide bondi2092 ↔ 2101By similarity
Disulfide bondi2104 ↔ 2116By similarity
Disulfide bondi2119 ↔ 2126By similarity
Disulfide bondi2121 ↔ 2133By similarity
Disulfide bondi2135 ↔ 2144By similarity
Disulfide bondi2147 ↔ 2166By similarity
Disulfide bondi2169InterchainCurated
Disulfide bondi2172InterchainCurated
Glycosylationi2198N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2211N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2395N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2425N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2503N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2570N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2709N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2903 ↔ 2933By similarity
Disulfide bondi3094 ↔ 3119By similarity
Glycosylationi3111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3261N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3265 ↔ 3296By similarity
Glycosylationi3291N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3488 ↔ 3511By similarity
Glycosylationi3623N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3661 ↔ 3689By similarity
Glycosylationi3673N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q61001

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q61001

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q61001

PeptideAtlas

More...PeptideAtlasi		Q61001

PRoteomics IDEntifications database

More...PRIDEi		Q61001

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2458

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q61001

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q61001

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adult, high levels in heart, lung, and kidney; lower in brain, muscle and testis; very low in liver, gut and skin. Expressed in many tissues in embryonic day 11.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000015647 Expressed in 240 organ(s), highest expression level in decidua

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q61001 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		201100, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3016 Laminin-511 complex
CPX-3017 Laminin-521 complex
CPX-3020 Laminin-522 complex
CPX-3021 Laminin-523 complex

Protein interaction database and analysis system

More...IntActi		Q61001, 4 interactors

Molecular INTeraction database

More...MINTi		Q61001

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000015791

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q61001 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13718
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q61001

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q61001

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 304Laminin N-terminalPROSITE-ProRule annotationAdd BLAST259
Domaini305 – 363Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST59
Domaini364 – 433Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST70
Domaini434 – 479Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST46
Domaini500 – 546Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST47
Domaini547 – 592Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST46
Domaini593 – 637Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST45
Domaini638 – 682Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST45
Domaini683 – 728Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST46
Domaini729 – 781Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST53
Domaini782 – 833Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini834 – 855Laminin EGF-like 11; truncatedPROSITE-ProRule annotationAdd BLAST22
Domaini1443 – 1488Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST46
Domaini1489 – 1532Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST44
Domaini1533 – 1581Laminin EGF-like 14PROSITE-ProRule annotationAdd BLAST49
Domaini1582 – 1632Laminin EGF-like 15PROSITE-ProRule annotationAdd BLAST51
Domaini1633 – 1642Laminin EGF-like 16; first partPROSITE-ProRule annotation10
Domaini1646 – 1831Laminin IV type APROSITE-ProRule annotationAdd BLAST186
Domaini1832 – 1864Laminin EGF-like 16; second partPROSITE-ProRule annotationAdd BLAST33
Domaini1865 – 1914Laminin EGF-like 17PROSITE-ProRule annotationAdd BLAST50
Domaini1915 – 1970Laminin EGF-like 18PROSITE-ProRule annotationAdd BLAST56
Domaini1971 – 2024Laminin EGF-like 19PROSITE-ProRule annotationAdd BLAST54
Domaini2025 – 2071Laminin EGF-like 20PROSITE-ProRule annotationAdd BLAST47
Domaini2072 – 2118Laminin EGF-like 21PROSITE-ProRule annotationAdd BLAST47
Domaini2119 – 2168Laminin EGF-like 22PROSITE-ProRule annotationAdd BLAST50
Domaini2736 – 2933Laminin G-like 1PROSITE-ProRule annotationAdd BLAST198
Domaini2947 – 3119Laminin G-like 2PROSITE-ProRule annotationAdd BLAST173
Domaini3128 – 3296Laminin G-like 3PROSITE-ProRule annotationAdd BLAST169
Domaini3337 – 3511Laminin G-like 4PROSITE-ProRule annotationAdd BLAST175
Domaini3518 – 3689Laminin G-like 5PROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni856 – 1442Domain IV 1 (domain IV B)Add BLAST587
Regioni2169 – 2735Domain II and IAdd BLAST567

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2205 – 2257Sequence analysisAdd BLAST53
Coiled coili2330 – 2464Sequence analysisAdd BLAST135
Coiled coili2604 – 2621Sequence analysisAdd BLAST18
Coiled coili2639 – 2705Sequence analysisAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1723 – 1725Cell attachment siteSequence analysis3
Motifi1839 – 1841Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI, IV and G are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231235

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q61001

KEGG Orthology (KO)

More...KOi		K06240

Identification of Orthologs from Complete Genome Data

More...OMAi		RCDCSPC

Database of Orthologous Groups

More...OrthoDBi		2342at2759

TreeFam database of animal gene trees

More...TreeFami		TF335359

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 19 hits
PF02210 Laminin_G_2, 5 hits
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 15 hits
SM00180 EGF_Lam, 22 hits
SM00281 LamB, 1 hit
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899 SSF49899, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 19 hits
PS01186 EGF_2, 4 hits
PS01248 EGF_LAM_1, 19 hits
PS50027 EGF_LAM_2, 21 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q61001-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRGGQLCA GSAPGALGPR SPAPRPLLLL LAGLALVGEA RTPGGDGFSL 
        60         70         80         90        100
HPPYFNLAEG ARITASATCG EEAPTRSVSR PTEDLYCKLV GGPVAGGDPN 
       110        120        130        140        150
QTIQGQYCDI CTAANSNKAH PVSNAIDGTE RWWQSPPLSR GLEYNEVNVT 
       160        170        180        190        200
LDLGQVFHVA YVLIKFANSP RPDLWVLERS TDFGHTYQPW QFFASSKRDC 
       210        220        230        240        250
LERFGPRTLE RITQDDDVIC TTEYSRIVPL ENGEIVVSLV NGRPGALNFS 
       260        270        280        290        300
YSPLLRDFTK ATNIRLRFLR TNTLLGHLMG KALRDPTVTR RYYYSIKDIS 
       310        320        330        340        350
IGGRCVCHGH ADVCDAKDPL DPFRLQCACQ HNTCGGSCDR CCPGFNQQPW 
       360        370        380        390        400
KPATTDSANE CQSCNCHGHA YDCYYDPEVD RRNASQNQDN VYQGGGVCLD 
       410        420        430        440        450
CQHHTTGINC ERCLPGFFRA PDQPLDSPHV CRPCDCESDF TDGTCEDLTG 
       460        470        480        490        500
RCYCRPNFTG ELCAACAEGY TDFPHCYPLP SFPHNDTREQ VLPAGQIVNC 
       510        520        530        540        550
DCNAAGTQGN ACRKDPRLGR CVCKPNFRGA HCELCAPGFH GPSCHPCQCS 
       560        570        580        590        600
SPGVANSLCD PESGQCMCRT GFEGDRCDHC ALGYFHFPLC QLCGCSPAGT 
       610        620        630        640        650
LPEGCDEAGR CQCRPGFDGP HCDRCLPGYH GYPDCHACAC DPRGALDQQC 
       660        670        680        690        700
GVGGLCHCRP GYTGATCQEC SPGFYGFPSC IPCHCSADGS LHTTCDPTTG 
       710        720        730        740        750
QCRCRPRVTG LHCDMCVPGA YNFPYCEAGS CHPAGLAPAN PALPETQAPC 
       760        770        780        790        800
MCRAHVEGPS CDRCKPGYWG LSASNPEGCT RCSCDPRGTL GGVTECQGNG 
       810        820        830        840        850
QCFCKAHVCG KTCAACKDGF FGLDYADYFG CRSCRCDVGG ALGQGCEPKT 
       860        870        880        890        900
GACRCRPNTQ GPTCSEPAKD HYLPDLHHMR LELEEAATPE GHAVRFGFNP 
       910        920        930        940        950
LEFENFSWRG YAHMMAIQPR IVARLNVTSP DLFRLVFRYV NRGSTSVNGQ 
       960        970        980        990       1000
ISVREEGKLS SCTNCTEQSQ PVAFPPSTEP AFVTVPQRGF GEPFVLNPGI 
      1010       1020       1030       1040       1050
WALLVEAEGV LLDYVVLLPS TYYEAALLQH RVTEACTYRP SALHSTENCL 
      1060       1070       1080       1090       1100
VYAHLPLDGF PSAAGTEALC RHDNSLPRPC PTEQLSPSHP PLATCFGSDV 
      1110       1120       1130       1140       1150
DIQLEMAVPQ PGQYVLVVEY VGEDSHQEMG VAVHTPQRAP QQGVLNLHPC 
      1160       1170       1180       1190       1200
PYSSLCRSPA RDTQHHLAIF YLDSEASIRL TAEQAHFFLH SVTLVPVEEF 
      1210       1220       1230       1240       1250
STEFVEPRVF CVSSHGTFNP SSAACLASRF PKPPQPIILK DCQVLPLPPD 
      1260       1270       1280       1290       1300
LPLTQSQELS PGAPPEGPQP RPPTAVDPNA EPTLLRHPQG TVVFTTQVPT 
      1310       1320       1330       1340       1350
LGRYAFLLHG YQPVHPSFPV EVLINGGRIW QGHANASFCP HGYGCRTLVL 
      1360       1370       1380       1390       1400
CEGQTMLDVT DNELTVTVRV PEGRWLWLDY VLIVPEDAYS SSYLQEEPLD 
      1410       1420       1430       1440       1450
KSYDFISHCA TQGYHISPSS SSPFCRNAAT SLSLFYNNGA LPCGCHEVGA 
      1460       1470       1480       1490       1500
VSPTCEPFGG QCPCRGHVIG RDCSRCATGY WGFPNCRPCD CGARLCDELT 
      1510       1520       1530       1540       1550
GQCICPPRTV PPDCLVCQPQ SFGCHPLVGC EECNCSGPGV QELTDPTCDM 
      1560       1570       1580       1590       1600
DSGQCRCRPN VAGRRCDTCA PGFYGYPSCR PCDCHEAGTM ASVCDPLTGQ 
      1610       1620       1630       1640       1650
CHCKENVQGS RCDQCRVGTF SLDAANPKGC TRCFCFGATE RCGNSNLARH 
      1660       1670       1680       1690       1700
EFVDMEGWVL LSSDRQVVPH EHRPEIELLH ADLRSVADTF SELYWQAPPS 
      1710       1720       1730       1740       1750
YLGDRVSSYG GTLHYELHSE TQRGDIFIPY ESRPDVVLQG NQMSIAFLEL 
      1760       1770       1780       1790       1800
AYPPPGQVHR GQLQLVEGNF RHLETHNPVS REELMMVLAG LEQLQIRALF 
      1810       1820       1830       1840       1850
SQTSSSVSLR RVVLEVASEA GRGPPASNVE LCMCPANYRG DSCQECAPGY 
      1860       1870       1880       1890       1900
YRDTKGLFLG RCVPCQCHGH SDRCLPGSGI CVGCQHNTEG DQCERCRPGF 
      1910       1920       1930       1940       1950
VSSDPSNPAS PCVSCPCPLA VPSNNFADGC VLRNGRTQCL CRPGYAGASC 
      1960       1970       1980       1990       2000
ERCAPGFFGN PLVLGSSCQP CDCSGNGDPN MIFSDCDPLT GACRGCLRHT 
      2010       2020       2030       2040       2050
TGPHCERCAP GFYGNALLPG NCTRCDCSPC GTETCDPQSG RCLCKAGVTG 
      2060       2070       2080       2090       2100
QRCDRCLEGY FGFEQCQGCR PCACGPAAKG SECHPQSGQC HCQPGTTGPQ 
      2110       2120       2130       2140       2150
CLECAPGYWG LPEKGCRRCQ CPRGHCDPHT GHCTCPPGLS GERCDTCSQQ 
      2160       2170       2180       2190       2200
HQVPVPGKPG GHGIHCEVCD HCVVLLLDDL ERAGALLPAI REQLQGINAS 
      2210       2220       2230       2240       2250
SAAWARLHRL NASIADLQSK LRSPPGPRYQ AAQQLQTLEQ QSISLQQDTE 
      2260       2270       2280       2290       2300
RLGSQATGVQ GQAGQLLDTT ESTLGRAQKL LESVRAVGRA LNELASRMGQ 
      2310       2320       2330       2340       2350
GSPGDALVPS GEQLRWALAE VERLLWDMRT RDLGAQGAVA EAELAEAQRL 
      2360       2370       2380       2390       2400
MARVQEQLTS FWEENQSLAT HIRDQLAQYE SGLMDLREAL NQAVNTTREA 
      2410       2420       2430       2440       2450
EELNSRNQER LKEALQWKQE LSQDNATLKA TLQAASLILG HVSELLQGID 
      2460       2470       2480       2490       2500
QAKEDLEHLA ASLDGAWTPL LKRMQAFSPA SSKVDLVEAA EAHAQKLNQL 
      2510       2520       2530       2540       2550
AINLSGIILG INQDRFIQRA VEASNAYSSI LQAVQAAEDA AGQALRQASR 
      2560       2570       2580       2590       2600
TWEMVVQRGL AAGARQLLAN SSALEETILG HQGRLGLAQG RLQAAGIQLH 
      2610       2620       2630       2640       2650
NVWARKNQLA AQIQEAQAML AMDTSETSEK IAHAKAVAAE ALSTATHVQS 
      2660       2670       2680       2690       2700
QLQGMQKNVE RWQSQLGGLQ GQDLSQVERD ASSSVSTLEK TLPQLLAKLS 
      2710       2720       2730       2740       2750
RLENRGVHNA SLALSANIGR VRKLIAQARS AASKVKVSMK FNGRSGVRLR 
      2760       2770       2780       2790       2800
TPRDLADLAA YTALKFHIQS PVPAPEPGKN TGDHFVLYMG SRQATGDYMG 
      2810       2820       2830       2840       2850
VSLRNQKVHW VYRLGKAGPT TLSIDENIGE QFAAVSIDRT LQFGHMSVTV 
      2860       2870       2880       2890       2900
EKQMVHEIKG DTVAPGSEGL LNLHPDDFVF YVGGYPSNFT PPEPLRFPGY 
      2910       2920       2930       2940       2950
LGCIEMETLN EEVVSLYNFE QTFMLDTAVD KPCARSKATG DPWLTDGSYL 
      2960       2970       2980       2990       3000
DGSGFARISF EKQFSNTKRF DQELRLVSYN GIIFFLKQES QFLCLAVQEG 
      3010       3020       3030       3040       3050
TLVLFYDFGS GLKKADPLQP PQALTAASKA IQVFLLAGNR KRVLVRVERA 
      3060       3070       3080       3090       3100
TVFSVDQDNM LEMADAYYLG GVPPEQLPLS LRQLFPSGGS VRGCIKGIKA 
      3110       3120       3130       3140       3150
LGKYVDLKRL NTTGISFGCT ADLLVGRTMT FHGHGFLPLA LPDVAPITEV 
      3160       3170       3180       3190       3200
VYSGFGFRGT QDNNLLYYRT SPDGPYQVSL REGHVTLRFM NQEVETQRVF 
      3210       3220       3230       3240       3250
ADGAPHYVAF YSNVTGVWLY VDDQLQLVKS HERTTPMLQL QPEEPSRLLL 
      3260       3270       3280       3290       3300
GGLPVSGTFH NFSGCISNVF VQRLRGPQRV FDLHQNMGSV NVSVGCTPAQ 
      3310       3320       3330       3340       3350
LIETSRATAQ KVSRRSRQPS QDLACTTPWL PGTIQDAYQF GGPLPSYLQF 
      3360       3370       3380       3390       3400
VGISPSHRNR LHLSMLVRPH AASQGLLLST APMSGRSPSL VLFLNHGHFV 
      3410       3420       3430       3440       3450
AQTEGPGPRL QVQSRQHSRA GQWHRVSVRW GMQQIQLVVD GSQTWSQKAL 
      3460       3470       3480       3490       3500
HHRVPRAERP QPYTLSVGGL PASSYSSKLP VSVGFSGCLK KLQLDKRPLR 
      3510       3520       3530       3540       3550
TPTQMVGVTP CVSGPLEDGL FFPGSEGVVT LELPKAKMPY VSLELEMRPL 
      3560       3570       3580       3590       3600
AAAGLIFHLG QALATPYMQL KVLTEQVLLQ ANDGAGEFST WVTYPKLCDG 
      3610       3620       3630       3640       3650
RWHRVAVIMG RDTLRLEVDT QSNHTTGRLP ESLAGSPALL HLGSLPKSST 
      3660       3670       3680       3690       3700
ARPELPAYRG CLRKLLINGA PVNVTASVQI QGAVGMRGCP SGTLALSKQG 
      3710 
KALTQRQAKP SVSPLLWH
Length:3,718
Mass (Da):404,054
Last modified:July 27, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18542A9661BA82E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti662Y → N in AAC53430 (PubMed:7499364).Curated1
Sequence conflicti1171Y → H in AAC53430 (PubMed:7499364).Curated1
Sequence conflicti2223S → R in AAC53430 (PubMed:7499364).Curated1
Sequence conflicti2411L → V in AAC53430 (PubMed:7499364).Curated1
Sequence conflicti2751T → P in AAC53430 (PubMed:7499364).Curated1
Sequence conflicti3497R → Q in AAC53430 (PubMed:7499364).Curated1
Sequence conflicti3707Q → H in AAC53430 (PubMed:7499364).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL663027 Genomic DNA No translation available.
AJ293593 mRNA Translation: CAB99255.1
U37501 mRNA Translation: AAC53430.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38375.1

Protein sequence database of the Protein Information Resource

More...PIRi		T10053

NCBI Reference Sequences

More...RefSeqi		NP_001074640.1, NM_001081171.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000015791; ENSMUSP00000015791; ENSMUSG00000015647

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:16776

UCSC genome browser

More...UCSCi		uc008oip.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663027 Genomic DNA No translation available.
AJ293593 mRNA Translation: CAB99255.1
U37501 mRNA Translation: AAC53430.1
CCDSiCCDS38375.1
PIRiT10053
RefSeqiNP_001074640.1, NM_001081171.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y38X-ray2.90A44-433[»]
SMRiQ61001
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi201100, 1 interactor
ComplexPortaliCPX-3016 Laminin-511 complex
CPX-3017 Laminin-521 complex
CPX-3020 Laminin-522 complex
CPX-3021 Laminin-523 complex
IntActiQ61001, 4 interactors
MINTiQ61001
STRINGi10090.ENSMUSP00000015791

PTM databases

GlyConnecti2458
iPTMnetiQ61001
PhosphoSitePlusiQ61001

Proteomic databases

EPDiQ61001
MaxQBiQ61001
PaxDbiQ61001
PeptideAtlasiQ61001
PRIDEiQ61001

Genome annotation databases

EnsembliENSMUST00000015791; ENSMUSP00000015791; ENSMUSG00000015647
GeneIDi16776
KEGGimmu:16776
UCSCiuc008oip.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3911
MGIiMGI:105382 Lama5

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000156537
HOGENOMiHOG000231235
InParanoidiQ61001
KOiK06240
OMAiRCDCSPC
OrthoDBi2342at2759
TreeFamiTF335359

Enzyme and pathway databases

ReactomeiR-MMU-3000157 Laminin interactions
R-MMU-8874081 MET activates PTK2 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Lama5 mouse
EvolutionaryTraceiQ61001

Protein Ontology

More...PROi		PR:Q61001
RNActiQ61001 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000015647 Expressed in 240 organ(s), highest expression level in decidua
GenevisibleiQ61001 MM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 19 hits
PF02210 Laminin_G_2, 5 hits
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 15 hits
SM00180 EGF_Lam, 22 hits
SM00281 LamB, 1 hit
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 19 hits
PS01186 EGF_2, 4 hits
PS01248 EGF_LAM_1, 19 hits
PS50027 EGF_LAM_2, 21 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMA5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61001
Secondary accession number(s): A2ABW7, Q9JHQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: December 11, 2019
This is version 190 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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