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Entry version 87 (12 Aug 2020)
Sequence version 3 (22 Sep 2009)
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Protein

Calcium-dependent secretion activator

Gene

unc-31

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by satiety. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. Plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-dependent secretion activator
Alternative name(s):
Uncoordinated protein 31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-31
ORF Names:CBG22310
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis briggsae
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6238 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008549 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome IV, Unassembled WGS sequence

Organism-specific databases

WormBase

More...
WormBasei
CBG22310a ; CBP40444 ; WBGene00040906 ; Cbr-unc-31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538701 – 1354Calcium-dependent secretion activatorAdd BLAST1354

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q60PC0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6238.CBG22310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q60PC0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini441 – 558C2PROSITE-ProRule annotationAdd BLAST118
Domaini580 – 686PHPROSITE-ProRule annotationAdd BLAST107
Domaini975 – 1106MHD1PROSITE-ProRule annotationAdd BLAST132

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain is essential for regulated exocytosis and binds phospholipids.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3543, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007068_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q60PC0

Identification of Orthologs from Complete Genome Data

More...
OMAi
YISADPC

Database of Orthologous Groups

More...
OrthoDBi
138870at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033227, CAPS
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR12166, PTHR12166, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06292, DUF1041, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01145, DUF1041, 1 hit
SM00233, PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS51258, MHD1, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q60PC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGASSSEEE DDDFQDDHES QLPIAQVKKR SLLSGAMTPR SSSPAPSDSV
60 70 80 90 100
SQTNSLKRNN SSSQARRKDS VHSQTPARSP MKMNSPSPMP QARTMSNVTR
110 120 130 140 150
PVLQNSQELD GEEIEETEGS GTMVASDDGG PSLSKEEQER IKAEKEEEEH
160 170 180 190 200
KKNLQMYVFI ARCVAYPFNG QQTGDMARRQ MKVNKPELAR IRERFAQFLR
210 220 230 240 250
GETNIAADEA FTKAIQSYTE VFLKSERVQK VVHAGGFSQH DFREVFRLII
260 270 280 290 300
EKRVRSLPDI EGLSKDTVLN SWLAKFDAII KGDETDQNRN ARGRSRNPNS
310 320 330 340 350
AMSADAVLGK EQLYDVFQQI LGVKKFEHQI IFNSLQLDNP DEQAAAIRRE
360 370 380 390 400
FATREEALKD PMKMKRLTPK FVVKDMETLY MDEVRMSINT LIGNLETVPV
410 420 430 440 450
TTRGQTVGKR KDKSRSRSIE DLSLFNSLKR RTSSGSLNKG DSDDGDVTLT
460 470 480 490 500
KSDVSLALSM EVVVMEVQGL KSIQPNKIVY CVMDVDGHKL ATDHAEASKP
510 520 530 540 550
KWDTQGDFTT KTPLPTVKVK LYTEVKSLVS FDDKELGKIM ITPTPNCSRN
560 570 580 590 600
PEWYTMTLPK NSQDSSLKIR IAIRIEKPPN LKYSGHCWCI GRNSWKKWKK
610 620 630 640 650
RFFCLVQVSQ YAFAVCSFRE KKADPTEFIQ LDGFTIDYMP ESDPELSAQG
660 670 680 690 700
GKHFFTAIKE GDELKFATDD ENERHLWVQA LYRATGQAYK PVPPKQSTIA
710 720 730 740 750
PKAQGFQDKA SKHGMDALIQ ADSINFDHDH LYSDIQRLTL DFRINEPICS
760 770 780 790 800
LGWFSPGQAF VLEEYSARYM VRGCFRHVTL LSNLLDKADD GLLIDPALIH
810 820 830 840 850
YSFAFCASHV HGNRCMPDRQ GPEGVGTVTL EEKEKFQEIK ERLRVLLEKQ
860 870 880 890 900
ITNFRYCFPF GRPEGALKGT LGLLERVLMK DVVSPVPPEE VRAVIRKCLE
910 920 930 940 950
DAALVNYTRI CNEAKIEQRM GNDVSPAQRI EDMIRVTEFC IDLLKENEEH
960 970 980 990 1000
HGEAFSWFSD LLSDHSEIFW SLYSVDLDSA LEVQPHDSWD SFPLFQMLND
1010 1020 1030 1040 1050
FLLSEPNLKG GIFHNKLVQQ FQPLVVRYID LMEHSIAQAI DKGFLKEKWE
1060 1070 1080 1090 1100
SRKEGCATSE DIYWKMDALH TFVIDLNWPE EDFRKYLQTK MKTLTSDLIS
1110 1120 1130 1140 1150
KVSDCTFTAF DSWMQKAKKS TDYMLPSEVC VQINVMFSSK SRAVRVTVDS
1160 1170 1180 1190 1200
GEYKYQSKLD ETLETMLKTM ESCIQEKLLG VLESVLSRLA RYDEGNPIGA
1210 1220 1230 1240 1250
ILNIAPKPAS IFNKLKTMAG DTSVQSSSST RQPLTAQQSS GQIGNSYVTF
1260 1270 1280 1290 1300
FHGCTELLRQ VIIDEIWVNG LFEHWYDNQM KAINDWLTER LQQSLSATQF
1310 1320 1330 1340 1350
ISLSNIVKKV YQDFAMQGID EERLNSKTYQ SISRRLQLEE SNSHIQEGIR

RLKT
Length:1,354
Mass (Da):154,108
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F279BE33DC3C157
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HE601241 Genomic DNA Translation: CAP38936.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601241 Genomic DNA Translation: CAP38936.2

3D structure databases

SMRiQ60PC0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6238.CBG22310

Proteomic databases

PRIDEiQ60PC0

Organism-specific databases

WormBaseiCBG22310a ; CBP40444 ; WBGene00040906 ; Cbr-unc-31

Phylogenomic databases

eggNOGiKOG3543, Eukaryota
HOGENOMiCLU_007068_0_0_1
InParanoidiQ60PC0
OMAiYISADPC
OrthoDBi138870at2759

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033227, CAPS
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR12166, PTHR12166, 1 hit
PfamiView protein in Pfam
PF06292, DUF1041, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM01145, DUF1041, 1 hit
SM00233, PH, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51258, MHD1, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPS_CAEBR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60PC0
Secondary accession number(s): A8Y216
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 22, 2009
Last modified: August 12, 2020
This is version 87 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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