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Protein

Myosin-3

Gene

myo-3

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells.By similarity

Miscellaneous

MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 186ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-3
Alternative name(s):
Myosin heavy chain A
Short name:
MHC A
Gene namesi
Name:myo-3By similarity
ORF Names:CBG23416
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome V, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG23416 ; CBP46195 ; WBGene00041777 ; Cbr-myo-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062451 – 1969Myosin-3Add BLAST1969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130N6,N6,N6-trimethyllysineSequence analysis1

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ60LV4

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6238.CBG23416

Structurei

3D structure databases

ProteinModelPortaliQ60LV4
SMRiQ60LV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 82Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini86 – 791Myosin motorPROSITE-ProRule annotationAdd BLAST706
Domaini794 – 823IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni667 – 689Actin-bindingBy similarityAdd BLAST23
Regioni770 – 784Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili853 – 1941Sequence analysisAdd BLAST1089

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.Sequence analysis

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
HOGENOMiHOG000173959
InParanoidiQ60LV4
KOiK10352
OMAiTIQWNIR
OrthoDBiEOG091G07UM

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q60LV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGNPDAFEN DPGFPFLGMS REAKAASAAR PFDSKKNCWI PDPEDGFVAA
60 70 80 90 100
EIQSTTGDQV TVVTVKGNQI TVKKDQCQEM NPPKFDKTED MANLTFLNEA
110 120 130 140 150
SVLGNLKDRY KDLMIYTYSG LFCVVINPYK RLPIYSESVI KHFMGKRRNE
160 170 180 190 200
MPPHLFAVSD EAYRNMVQDK ENQSMLITGE SGAGKTENTK KVISYFAIVG
210 220 230 240 250
ATQAAAGGKK EEGKKGGTLE EQIVQTNPVL EAFGNAKTVR NNNSSRFGKF
260 270 280 290 300
IRTHFSGSGK LAGGDIEHYL LEKSRVVRQA PGERCYHIFY QIMSGNDASL
310 320 330 340 350
RGKLKLNNDI TYYHFCSQAE LTIEGMDDKE EMRLTQEAFD IMGFEDQETM
360 370 380 390 400
DLYRSTAGIM HMGEMKFKQR PREEQAEPDG EEDALNAAAM LGINAEEFLK
410 420 430 440 450
ALTKPRVRVG TEWVNKGQNL EQVSWAVSGL AKAIYARMFK WIINRCNKTL
460 470 480 490 500
DAKEIERKHF IGVLDIAGFE IFDLNSFEQL WINFVNERLQ QFFNHHMFVL
510 520 530 540 550
EQEEYKREGI AWTFIDFGLD LQACIELIEK PLGIISILDE ECIVPKATDM
560 570 580 590 600
TYAQKLLDQH LGKHPNFQKP KPPKGKQGDA HFAIVHYAGT VRYNANNFLE
610 620 630 640 650
KNKDPLNDTA VALLKHSVDN NLMLDIWQDY QTQEEAAEAA KAGQSGGGKR
660 670 680 690 700
GKSSSFATVS MIYRESLNNL MNMLYQTHPH FIRCIIPNEK KASGVIDSAL
710 720 730 740 750
VLNQLTCNGV LEGIRICRKG FPNRMLYPDF KHRYAILAAD AAKDSDPKKA
760 770 780 790 800
SVGILDKIAN DGNLTDEEFK IGETKIFFKA GVLAKLEDLR DEILSRIVTM
810 820 830 840 850
FQSRIRSYLA KAEVRRRYEQ QTGLLIVQRN VRAWCTLRTW EWFKLFGKVK
860 870 880 890 900
PMLKAGKEQE AMGELAEKIQ KLEEAVQRGE IARSQLETQV ADLVEEKNAL
910 920 930 940 950
FLSLETEKAN LADAEERNEK LNQLKATLES KLTDITGQLE DMQERHEDLT
960 970 980 990 1000
RQKKKTEQEL SDTKKHVQDL ELTLRKAEQE KQSRDHQIRS LQDEMANQDE
1010 1020 1030 1040 1050
SVAKLNKEKK HQEESNRKLN EDLQSEEDKV NHLEKIRNKL EQQMDELEET
1060 1070 1080 1090 1100
IDREKRSRSD IEKSKRKVEG DLKVAQENID EITKQKQDVE NTLKRKEDDL
1110 1120 1130 1140 1150
HHASTKLAEE QALAAKLQRQ IKELQARIAE LEEELESERN SRQKADRTRN
1160 1170 1180 1190 1200
ELQRELEEIS ERLEQQGGFS AAQLEANKKR EAEIAKLRRE KEEDALNHET
1210 1220 1230 1240 1250
AVSSLRKRQV DAVAELTEQL ETLQKLKAKG DAERAKLQRD LEEAQHATDS
1260 1270 1280 1290 1300
EVRARQEVEK SYKTIEVQFS ELQTKADEQS RQLQDFAALK NRLNNENGDL
1310 1320 1330 1340 1350
NRTLEEMDNQ VNSLHRLKST LQSQLDETRR NFEEESRERQ ALAATAKNLE
1360 1370 1380 1390 1400
HENEILREHL DEEAESKADL TRQISKLNAE IQQWKARFDS EGLNKLEEIE
1410 1420 1430 1440 1450
AAKKALQLKV QELSDTNEGL FAKIASQEKV RHKLMQDLDD AQSDVEKAAA
1460 1470 1480 1490 1500
QVAYYEKHRR QFEKIVEEWK KKTDDLASEL DAAQRDNRQL STDLFKAKTA
1510 1520 1530 1540 1550
NDELAEYLDS TRRENKSLAQ EVKDLTDQLG EGGRSVAELQ KIVRRLEVEK
1560 1570 1580 1590 1600
EELQKALDEA EAALEAEEAK VLRAQIEVSQ IRSEIEKRIQ EKEEEFENTR
1610 1620 1630 1640 1650
RNHQRALESM QATLEAETKQ KEEALRIKKK LESDINDLEI ALDHANRANA
1660 1670 1680 1690 1700
DAQKTIKKYM ETVRELQVQI EEEQRQKDEL REQFLASEKR NGILQAEKDE
1710 1720 1730 1740 1750
LAQQAEAAER ARRNAEADCI ELREQNNDLS NQVSSLTGWR RKLEGELLAV
1760 1770 1780 1790 1800
HAELEELVTE LKNAQEQGQK ASADAARLAE ELRQEQEHSM HIERIRKGLE
1810 1820 1830 1840 1850
LQIKEMQIRL DDAENAALKG GKKIIAQLEA RIRAIEQELD GEQRRHQDTE
1860 1870 1880 1890 1900
KNWRKAERRV KEVEFQVIEE KKNEERLTEL VDKLQTKLKI FKRQVEEAEE
1910 1920 1930 1940 1950
VAASNLNKYK VLQAQFEQAD ERAEIAENAL SKMRNKIRAS ASVIPPDGFP
1960
LAQSPSSALV RSASNARFL
Length:1,969
Mass (Da):225,901
Last modified:November 23, 2004 - v1
Checksum:iF4E140250CE57847
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601533 Genomic DNA Translation: CAP39610.1
RefSeqiXP_002636698.1, XM_002636652.1

Genome annotation databases

GeneIDi8578694
KEGGicbr:CBG23416

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601533 Genomic DNA Translation: CAP39610.1
RefSeqiXP_002636698.1, XM_002636652.1

3D structure databases

ProteinModelPortaliQ60LV4
SMRiQ60LV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG23416

Proteomic databases

PRIDEiQ60LV4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8578694
KEGGicbr:CBG23416

Organism-specific databases

CTDi8578694
WormBaseiCBG23416 ; CBP46195 ; WBGene00041777 ; Cbr-myo-3

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
HOGENOMiHOG000173959
InParanoidiQ60LV4
KOiK10352
OMAiTIQWNIR
OrthoDBiEOG091G07UM

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO3_CAEBR
AccessioniPrimary (citable) accession number: Q60LV4
Secondary accession number(s): A8Y3Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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