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Protein

Interleukin-17A

Gene

IL17A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Gene namesi
Name:IL17A
Synonyms:IL17
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000022750124 – 153Interleukin-17AAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 142By similarity
Disulfide bondi97 ↔ 144By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60I29
PRIDEiQ60I29

Expressioni

Tissue specificityi

Highly expressed in adult heart, skin, and intestinal tissues, such as jejunum and ileum.1 Publication

Interactioni

Subunit structurei

Homodimer. Heterodimer with IL17F.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001905

Structurei

3D structure databases

ProteinModelPortaliQ60I29
SMRiQ60I29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P Eukaryota
ENOG410YS4N LUCA
HOGENOMiHOG000064520
HOVERGENiHBG006143
InParanoidiQ60I29
KOiK05489

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60I29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPVRSSSLS LLLLLSLVAL VKAGIMIPQS PGCPKTEDKN FPQHVRVNLN
60 70 80 90 100
ILNRSTPARR PSDYSKRFTS PWTLQRNEDP ERYSSVIWEA KCSHSGCINA
110 120 130 140 150
EGKEDHHMNS VPIQQEILVL RREPRHCPNS FRLEKVMVTV GCTCVTPIVR

HIS
Length:153
Mass (Da):17,312
Last modified:November 23, 2004 - v1
Checksum:i1C7D32185E31E67E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102693 mRNA Translation: BAD52431.1
RefSeqiNP_001005729.1, NM_001005729.1
UniGeneiSsc.42770

Genome annotation databases

GeneIDi449530
KEGGissc:449530

Similar proteinsi

Entry informationi

Entry nameiIL17_PIG
AccessioniPrimary (citable) accession number: Q60I29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: May 10, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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