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UniProtKB - Q60FE5 (Q60FE5_HUMAN)

Entry version 132 (10 Feb 2021)
Sequence version 1 (23 Nov 2004)
Previous versions | rss
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Protein
Submitted name:

Filamin-A

Gene

FLNA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Filamin-AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3754, FLNA

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196924.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000196924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28172

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q60FE5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20518

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q60FE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196924, Expressed in esophagogastric junction muscularis propria and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q60FE5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q60FE5, 4 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 122Calponin-homology (CH)InterPro annotationAdd BLAST107
Domaini139 – 242Calponin-homology (CH)InterPro annotationAdd BLAST104
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati249 – 347FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati349 – 447FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati448 – 543FilaminPROSITE-ProRule annotationAdd BLAST96
Repeati544 – 636FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati640 – 736FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati737 – 839FilaminPROSITE-ProRule annotationAdd BLAST103
Repeati840 – 938FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati939 – 1034FilaminPROSITE-ProRule annotationAdd BLAST96
Repeati1035 – 1127FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1128 – 1222FilaminPROSITE-ProRule annotationAdd BLAST95
Repeati1223 – 1322FilaminPROSITE-ProRule annotationAdd BLAST100
Repeati1323 – 1415FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1416 – 1512FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati1513 – 1609FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati1622 – 1713FilaminPROSITE-ProRule annotationAdd BLAST92
Repeati1752 – 1833FilaminPROSITE-ProRule annotationAdd BLAST82
Repeati1833 – 1925FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1923 – 2012FilaminPROSITE-ProRule annotationAdd BLAST90
Repeati2015 – 2107FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati2105 – 2203FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati2206 – 2298FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati2300 – 2393FilaminPROSITE-ProRule annotationAdd BLAST94
Repeati2397 – 2489FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati2525 – 2619FilaminPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni244 – 267DisorderedSequence analysisAdd BLAST24
Regioni1334 – 1355DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1336 – 1351PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the filamin family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153588

Database of Orthologous Groups

More...OrthoDBi		35998at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
2.60.40.10, 24 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF00630, Filamin, 23 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00557, IG_FLMN, 24 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit
SSF81296, SSF81296, 24 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50194, FILAMIN_REPEAT, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q60FE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVSKRIANL QTDLSDGLRL 
        60         70         80         90        100
IALLEVLSQK KMHRKHNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK 
       110        120        130        140        150
AIVDGNLKLI LGLIWTLILH YSISMPMWDE EEDEEAKKQT PKQRLLGWIQ 
       160        170        180        190        200
NKLPQLPITN FSRDWQSGRA LGALVDSCAP GLCPDWDSWD ASKPVTNARE 
       210        220        230        240        250
AMQQADDWLG IPQVITPEEI VDPNVDEHSV MTYLSQFPKA KLKPGAPLRP 
       260        270        280        290        300
KLNPKKARAY GPGIEPTGNM VKKRAEFTVE TRSAGQGEVL VYVEDPAGHQ 
       310        320        330        340        350
EEAKVTANND KNRTFSVWYV PEVTGTHKVT VLFAGQHIAK SPFEVYVDKS 
       360        370        380        390        400
QGDASKVTAQ GPGLEPSGNI ANKTTYFEIF TAGAGTGEVE VVIQDPMGQK 
       410        420        430        440        450
GTVEPQLEAR GDSTYRCSYQ PTMEGVHTVH VTFAGVPIPR SPYTVTVGQA 
       460        470        480        490        500
CNPSACRAVG RGLQPKGVRV KETADFKVYT KGAGSGELKV TVKGPKGEER 
       510        520        530        540        550
VKQKDLGDGV YGFEYYPMVP GTYIVTITWG GQNIGRSPFE VKVGTECGNQ 
       560        570        580        590        600
KVRAWGPGLE GGVVGKSADF VVEAIGDDVG TLGFSVEGPS QAKIECDDKG 
       610        620        630        640        650
DGSCDVRYWP QEAGEYAVHV LCNSEDIRLS PFMADIRDAP QDFHPDRVKA 
       660        670        680        690        700
RGPGLEKTGV AVNKPAEFTV DAKHGGKAPL RVQVQDNEGC PVEALVKDNG 
       710        720        730        740        750
NGTYSCSYVP RKPVKHTAMV SWGGVSIPNS PFRVNVGAGS HPNKVKVYGP 
       760        770        780        790        800
GVAKTGLKAH EPTYFTVDCA EAGQGDVSIG IKCAPGVVGP AEADIDFDII 
       810        820        830        840        850
RNDNDTFTVK YTPRGAGSYT IMVLFADQAT PTSPIRVKVE PSHDASKVKA 
       860        870        880        890        900
EGPGLSRTGV ELGKPTHFTV NAKAAGKGKL DVQFSGLTKG DAVRDVDIID 
       910        920        930        940        950
HHDNTYTVKY TPVQQGPVGV NVTYGGDPIP KSPFSVAVSP SLDLSKIKVS 
       960        970        980        990       1000
GLGEKVDVGK DQEFTVKSKG AGGQGKVASK IVGPSGAAVP CKVEPGLGAD 
      1010       1020       1030       1040       1050
NSVVRFLPRE EGPYEVEVTY DGVPVPGSPF PLEAVAPTKP SKVKAFGPGL 
      1060       1070       1080       1090       1100
QGGSAGSPAR FTIDTKGAGT GGLGLTVEGP CEAQLECLDN GDGTCSVSYV 
      1110       1120       1130       1140       1150
PTEPGDYNIN ILFADTHIPG SPFKAHVVPC FDASKVKCSG PGLERATAGE 
      1160       1170       1180       1190       1200
VGQFQVDCSS AGSAELTIEI CSEAGLPAEV YIQDHGDGTH TITYIPLCPG 
      1210       1220       1230       1240       1250
AYTVTIKYGG QPVPNFPSKL QVEPAVDTSG VQCYGPGIEG QGVFREATTE 
      1260       1270       1280       1290       1300
FSVDARALTQ TGGPHVKARV ANPSGNLTET YVQDRGDGMY KVEYTPYEEG 
      1310       1320       1330       1340       1350
LHSVDVTYDG SPVPSSPFQV PVTEGCDPSR VRVHGPGIQS GTTNKPNKFT 
      1360       1370       1380       1390       1400
VETRGAGTGG LGLAVEGPSE AKMSCMDNKD GSCSVEYIPY EAGTYSLNVT 
      1410       1420       1430       1440       1450
YGGHQVPGSP FKVPVHDVTD ASKVKCSGPG LSPGMVRANL PQSFQVDTSK 
      1460       1470       1480       1490       1500
AGVAPLQVKV QGPKGLVEPV DVVDNADGTQ TVNYVPSREG PYSISVLYGD 
      1510       1520       1530       1540       1550
EEVPRSPFKV KVLPTHDASK VKASGPGLNT TGVPASLPVE FTIDAKDAGE 
      1560       1570       1580       1590       1600
GLLAVQITDP EGKPKKTHIQ DNHDGTYTVA YVPDVTGRYT ILIKYGGDEI 
      1610       1620       1630       1640       1650
PFSPYRVRAV PTGDASKCTV TVSIGGHGLG AGIGPTIQIG EETVITVDTK 
      1660       1670       1680       1690       1700
AAGKGKVTCT VCTPDGSEVD VDVVENEDGT FDIFYTAPQP GKYVICVRFG 
      1710       1720       1730       1740       1750
GEHVPNSPFQ VTALAGDQPS VQPPLRSQQL APQYTYAQGG QQTWAPERPL 
      1760       1770       1780       1790       1800
VGVNGLDVTS LRPFDLVIPF TIKKGEITGE VRMPSGKVAQ PTITDNKDGT 
      1810       1820       1830       1840       1850
VTVRYAPSEA GLHEMDIRYD NMHIPGSPLQ FYVDYVNCGH VTAYGPGLTH 
      1860       1870       1880       1890       1900
GVVNKPATFT VNTKDAGEGG LSLAIEGPSK AEISCTDNQD GTCSVSYLPV 
      1910       1920       1930       1940       1950
LPGDYSILVK YNEQHVPGSP FTARVTGDDS MRMSHLKVGS AADIPINISE 
      1960       1970       1980       1990       2000
TDLSLLTATV VPPSGREEPC LLKRLRNGHV GISFVPKETG EHLVHVKKNG 
      2010       2020       2030       2040       2050
QHVASSPIPV VISQSEIGDA SRVRVSGQGL HEGHTFEPAE FIIDTRDAGY 
      2060       2070       2080       2090       2100
GGLSLSIEGP SKVDINTEDL EDGTCRVTYC PTEPGNYIIN IKFADQHVPG 
      2110       2120       2130       2140       2150
SPFSVKVTGE GRVKESITRR RRAPSVANVG SHCDLSLKIP EISIQDMTAQ 
      2160       2170       2180       2190       2200
VTSPSGKTHE AEIVEGENHT YCIRFVPAEM GTHTVSVKYK GQHVPGSPFQ 
      2210       2220       2230       2240       2250
FTVGPLGEGG AHKVRAGGPG LERAEAGVPA EFSIWTREAG AGGLAIAVEG 
      2260       2270       2280       2290       2300
PSKAEISFED RKDGSCGVAY VVQEPGDYEV SVKFNEEHIP DSPFVVPVAS 
      2310       2320       2330       2340       2350
PSGDARRLTV SSLQESGLKV NQPASFAVSL NGAKGAIDAK VHSPSGALEE 
      2360       2370       2380       2390       2400
CYVTEIDQDK YAVRFIPREN GVYLIDVKFN GTHIPGSPFK IRVGEPGHGG 
      2410       2420       2430       2440       2450
DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID GPSKVKMDCQ 
      2460       2470       2480       2490       2500
ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT GPRLVSNHSL 
      2510       2520       2530       2540       2550
HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL SKAYVGQKSS 
      2560       2570       2580       2590       2600
FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT 
      2610       2620
LVVKWGDEHI PGSPYRVVVP
Length:2,620
Mass (Da):278,226
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1ABFC44B1B32B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P21333FLNA_HUMAN
Filamin-A
FLNA FLN, FLN1
2,647Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWY3A0A087WWY3_HUMAN
Filamin-A
FLNA
2,315Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5F3H0Y5F3_HUMAN
Filamin-A
FLNA
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE98F8WE98_HUMAN
Filamin-A
FLNA
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5C6H0Y5C6_HUMAN
Filamin-A
FLNA
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KBC6A0A669KBC6_HUMAN
Filamin-A
FLNA
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2E7H7C2E7_HUMAN
Filamin-A
FLNA
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC245140 Genomic DNA No translation available.
AB191260 mRNA Translation: BAD52436.1
AB371574 mRNA Translation: BAG48303.1
AB371576 mRNA Translation: BAG48305.1

NCBI Reference Sequences

More...RefSeqi		NP_001104026.1, NM_001110556.1
NP_001447.2, NM_001456.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369856; ENSP00000358872; ENSG00000196924

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2316

UCSC genome browser

More...UCSCi		uc065cca.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245140 Genomic DNA No translation available.
AB191260 mRNA Translation: BAD52436.1
AB371574 mRNA Translation: BAG48303.1
AB371576 mRNA Translation: BAG48305.1
RefSeqiNP_001104026.1, NM_001110556.1
NP_001447.2, NM_001456.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ60FE5, 4 interactors

PTM databases

SwissPalmiQ60FE5

Proteomic databases

PRIDEiQ60FE5
ProteomicsDBi20518

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		341, 641 antibodies

Genome annotation databases

EnsembliENST00000369856; ENSP00000358872; ENSG00000196924
GeneIDi2316
KEGGihsa:2316
UCSCiuc065cca.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2316
HGNCiHGNC:3754, FLNA
OpenTargetsiENSG00000196924
PharmGKBiPA28172
VEuPathDBiHostDB:ENSG00000196924.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000153588
OrthoDBi35998at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2316, 4 hits in 500 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FLNA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2316

Gene expression databases

BgeeiENSG00000196924, Expressed in esophagogastric junction muscularis propria and 250 other tissues
ExpressionAtlasiQ60FE5, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.60.40.10, 24 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00630, Filamin, 23 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00557, IG_FLMN, 24 hits
SUPFAMiSSF47576, SSF47576, 1 hit
SSF81296, SSF81296, 24 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50194, FILAMIN_REPEAT, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ60FE5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60FE5
Secondary accession number(s): E9PHF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: February 10, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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