UniProtKB - Q60FE5 (Q60FE5_HUMAN)
Protein
Submitted name:
Filamin-A
Gene
FLNA
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Filamin-AImported |
Gene namesi | Name:FLNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3754, FLNA |
VEuPathDBi | HostDB:ENSG00000196924.14 |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000196924, Expressed in esophagogastric junction muscularis propria and 250 other tissues |
ExpressionAtlasi | Q60FE5, baseline and differential |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | Q60FE5, 4 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 122 | Calponin-homology (CH)InterPro annotationAdd BLAST | 107 | |
Domaini | 139 – 242 | Calponin-homology (CH)InterPro annotationAdd BLAST | 104 | |
Repeati | 249 – 347 | FilaminPROSITE-ProRule annotationAdd BLAST | 99 | |
Repeati | 349 – 447 | FilaminPROSITE-ProRule annotationAdd BLAST | 99 | |
Repeati | 448 – 543 | FilaminPROSITE-ProRule annotationAdd BLAST | 96 | |
Repeati | 544 – 636 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 640 – 736 | FilaminPROSITE-ProRule annotationAdd BLAST | 97 | |
Repeati | 737 – 839 | FilaminPROSITE-ProRule annotationAdd BLAST | 103 | |
Repeati | 840 – 938 | FilaminPROSITE-ProRule annotationAdd BLAST | 99 | |
Repeati | 939 – 1034 | FilaminPROSITE-ProRule annotationAdd BLAST | 96 | |
Repeati | 1035 – 1127 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 1128 – 1222 | FilaminPROSITE-ProRule annotationAdd BLAST | 95 | |
Repeati | 1223 – 1322 | FilaminPROSITE-ProRule annotationAdd BLAST | 100 | |
Repeati | 1323 – 1415 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 1416 – 1512 | FilaminPROSITE-ProRule annotationAdd BLAST | 97 | |
Repeati | 1513 – 1609 | FilaminPROSITE-ProRule annotationAdd BLAST | 97 | |
Repeati | 1622 – 1713 | FilaminPROSITE-ProRule annotationAdd BLAST | 92 | |
Repeati | 1752 – 1833 | FilaminPROSITE-ProRule annotationAdd BLAST | 82 | |
Repeati | 1833 – 1925 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 1923 – 2012 | FilaminPROSITE-ProRule annotationAdd BLAST | 90 | |
Repeati | 2015 – 2107 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 2105 – 2203 | FilaminPROSITE-ProRule annotationAdd BLAST | 99 | |
Repeati | 2206 – 2298 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 2300 – 2393 | FilaminPROSITE-ProRule annotationAdd BLAST | 94 | |
Repeati | 2397 – 2489 | FilaminPROSITE-ProRule annotationAdd BLAST | 93 | |
Repeati | 2525 – 2619 | FilaminPROSITE-ProRule annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 244 – 267 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1334 – 1355 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1336 – 1351 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the filamin family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153588 |
OrthoDBi | 35998at2759 |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits 2.60.40.10, 24 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR017868, Filamin/ABP280_repeat-like IPR001298, Filamin/ABP280_rpt IPR013783, Ig-like_fold IPR014756, Ig_E-set |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF00630, Filamin, 23 hits |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00557, IG_FLMN, 24 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF81296, SSF81296, 24 hits |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50194, FILAMIN_REPEAT, 24 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q60FE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVSKRIANL QTDLSDGLRL
60 70 80 90 100
IALLEVLSQK KMHRKHNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK
110 120 130 140 150
AIVDGNLKLI LGLIWTLILH YSISMPMWDE EEDEEAKKQT PKQRLLGWIQ
160 170 180 190 200
NKLPQLPITN FSRDWQSGRA LGALVDSCAP GLCPDWDSWD ASKPVTNARE
210 220 230 240 250
AMQQADDWLG IPQVITPEEI VDPNVDEHSV MTYLSQFPKA KLKPGAPLRP
260 270 280 290 300
KLNPKKARAY GPGIEPTGNM VKKRAEFTVE TRSAGQGEVL VYVEDPAGHQ
310 320 330 340 350
EEAKVTANND KNRTFSVWYV PEVTGTHKVT VLFAGQHIAK SPFEVYVDKS
360 370 380 390 400
QGDASKVTAQ GPGLEPSGNI ANKTTYFEIF TAGAGTGEVE VVIQDPMGQK
410 420 430 440 450
GTVEPQLEAR GDSTYRCSYQ PTMEGVHTVH VTFAGVPIPR SPYTVTVGQA
460 470 480 490 500
CNPSACRAVG RGLQPKGVRV KETADFKVYT KGAGSGELKV TVKGPKGEER
510 520 530 540 550
VKQKDLGDGV YGFEYYPMVP GTYIVTITWG GQNIGRSPFE VKVGTECGNQ
560 570 580 590 600
KVRAWGPGLE GGVVGKSADF VVEAIGDDVG TLGFSVEGPS QAKIECDDKG
610 620 630 640 650
DGSCDVRYWP QEAGEYAVHV LCNSEDIRLS PFMADIRDAP QDFHPDRVKA
660 670 680 690 700
RGPGLEKTGV AVNKPAEFTV DAKHGGKAPL RVQVQDNEGC PVEALVKDNG
710 720 730 740 750
NGTYSCSYVP RKPVKHTAMV SWGGVSIPNS PFRVNVGAGS HPNKVKVYGP
760 770 780 790 800
GVAKTGLKAH EPTYFTVDCA EAGQGDVSIG IKCAPGVVGP AEADIDFDII
810 820 830 840 850
RNDNDTFTVK YTPRGAGSYT IMVLFADQAT PTSPIRVKVE PSHDASKVKA
860 870 880 890 900
EGPGLSRTGV ELGKPTHFTV NAKAAGKGKL DVQFSGLTKG DAVRDVDIID
910 920 930 940 950
HHDNTYTVKY TPVQQGPVGV NVTYGGDPIP KSPFSVAVSP SLDLSKIKVS
960 970 980 990 1000
GLGEKVDVGK DQEFTVKSKG AGGQGKVASK IVGPSGAAVP CKVEPGLGAD
1010 1020 1030 1040 1050
NSVVRFLPRE EGPYEVEVTY DGVPVPGSPF PLEAVAPTKP SKVKAFGPGL
1060 1070 1080 1090 1100
QGGSAGSPAR FTIDTKGAGT GGLGLTVEGP CEAQLECLDN GDGTCSVSYV
1110 1120 1130 1140 1150
PTEPGDYNIN ILFADTHIPG SPFKAHVVPC FDASKVKCSG PGLERATAGE
1160 1170 1180 1190 1200
VGQFQVDCSS AGSAELTIEI CSEAGLPAEV YIQDHGDGTH TITYIPLCPG
1210 1220 1230 1240 1250
AYTVTIKYGG QPVPNFPSKL QVEPAVDTSG VQCYGPGIEG QGVFREATTE
1260 1270 1280 1290 1300
FSVDARALTQ TGGPHVKARV ANPSGNLTET YVQDRGDGMY KVEYTPYEEG
1310 1320 1330 1340 1350
LHSVDVTYDG SPVPSSPFQV PVTEGCDPSR VRVHGPGIQS GTTNKPNKFT
1360 1370 1380 1390 1400
VETRGAGTGG LGLAVEGPSE AKMSCMDNKD GSCSVEYIPY EAGTYSLNVT
1410 1420 1430 1440 1450
YGGHQVPGSP FKVPVHDVTD ASKVKCSGPG LSPGMVRANL PQSFQVDTSK
1460 1470 1480 1490 1500
AGVAPLQVKV QGPKGLVEPV DVVDNADGTQ TVNYVPSREG PYSISVLYGD
1510 1520 1530 1540 1550
EEVPRSPFKV KVLPTHDASK VKASGPGLNT TGVPASLPVE FTIDAKDAGE
1560 1570 1580 1590 1600
GLLAVQITDP EGKPKKTHIQ DNHDGTYTVA YVPDVTGRYT ILIKYGGDEI
1610 1620 1630 1640 1650
PFSPYRVRAV PTGDASKCTV TVSIGGHGLG AGIGPTIQIG EETVITVDTK
1660 1670 1680 1690 1700
AAGKGKVTCT VCTPDGSEVD VDVVENEDGT FDIFYTAPQP GKYVICVRFG
1710 1720 1730 1740 1750
GEHVPNSPFQ VTALAGDQPS VQPPLRSQQL APQYTYAQGG QQTWAPERPL
1760 1770 1780 1790 1800
VGVNGLDVTS LRPFDLVIPF TIKKGEITGE VRMPSGKVAQ PTITDNKDGT
1810 1820 1830 1840 1850
VTVRYAPSEA GLHEMDIRYD NMHIPGSPLQ FYVDYVNCGH VTAYGPGLTH
1860 1870 1880 1890 1900
GVVNKPATFT VNTKDAGEGG LSLAIEGPSK AEISCTDNQD GTCSVSYLPV
1910 1920 1930 1940 1950
LPGDYSILVK YNEQHVPGSP FTARVTGDDS MRMSHLKVGS AADIPINISE
1960 1970 1980 1990 2000
TDLSLLTATV VPPSGREEPC LLKRLRNGHV GISFVPKETG EHLVHVKKNG
2010 2020 2030 2040 2050
QHVASSPIPV VISQSEIGDA SRVRVSGQGL HEGHTFEPAE FIIDTRDAGY
2060 2070 2080 2090 2100
GGLSLSIEGP SKVDINTEDL EDGTCRVTYC PTEPGNYIIN IKFADQHVPG
2110 2120 2130 2140 2150
SPFSVKVTGE GRVKESITRR RRAPSVANVG SHCDLSLKIP EISIQDMTAQ
2160 2170 2180 2190 2200
VTSPSGKTHE AEIVEGENHT YCIRFVPAEM GTHTVSVKYK GQHVPGSPFQ
2210 2220 2230 2240 2250
FTVGPLGEGG AHKVRAGGPG LERAEAGVPA EFSIWTREAG AGGLAIAVEG
2260 2270 2280 2290 2300
PSKAEISFED RKDGSCGVAY VVQEPGDYEV SVKFNEEHIP DSPFVVPVAS
2310 2320 2330 2340 2350
PSGDARRLTV SSLQESGLKV NQPASFAVSL NGAKGAIDAK VHSPSGALEE
2360 2370 2380 2390 2400
CYVTEIDQDK YAVRFIPREN GVYLIDVKFN GTHIPGSPFK IRVGEPGHGG
2410 2420 2430 2440 2450
DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID GPSKVKMDCQ
2460 2470 2480 2490 2500
ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT GPRLVSNHSL
2510 2520 2530 2540 2550
HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL SKAYVGQKSS
2560 2570 2580 2590 2600
FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT
2610 2620
LVVKWGDEHI PGSPYRVVVP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP21333 | FLNA_HUMAN | Filamin-A | FLNA FLN, FLN1 | 2,647 | Annotation score: | ||
A0A087WWY3 | A0A087WWY3_HUMAN | Filamin-A | FLNA | 2,315 | Annotation score: | ||
H0Y5F3 | H0Y5F3_HUMAN | Filamin-A | FLNA | 232 | Annotation score: | ||
F8WE98 | F8WE98_HUMAN | Filamin-A | FLNA | 604 | Annotation score: | ||
H0Y5C6 | H0Y5C6_HUMAN | Filamin-A | FLNA | 281 | Annotation score: | ||
A0A669KBC6 | A0A669KBC6_HUMAN | Filamin-A | FLNA | 73 | Annotation score: | ||
H7C2E7 | H7C2E7_HUMAN | Filamin-A | FLNA | 90 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC245140 Genomic DNA No translation available. AB191260 mRNA Translation: BAD52436.1 AB371574 mRNA Translation: BAG48303.1 AB371576 mRNA Translation: BAG48305.1 |
RefSeqi | NP_001104026.1, NM_001110556.1 NP_001447.2, NM_001456.3 |
Genome annotation databases
Ensembli | ENST00000369856; ENSP00000358872; ENSG00000196924 |
GeneIDi | 2316 |
KEGGi | hsa:2316 |
UCSCi | uc065cca.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC245140 Genomic DNA No translation available. AB191260 mRNA Translation: BAD52436.1 AB371574 mRNA Translation: BAG48303.1 AB371576 mRNA Translation: BAG48305.1 |
RefSeqi | NP_001104026.1, NM_001110556.1 NP_001447.2, NM_001456.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q60FE5, 4 interactors |
PTM databases
SwissPalmi | Q60FE5 |
Proteomic databases
PRIDEi | Q60FE5 |
ProteomicsDBi | 20518 |
Protocols and materials databases
Antibodypediai | 341, 641 antibodies |
Genome annotation databases
Ensembli | ENST00000369856; ENSP00000358872; ENSG00000196924 |
GeneIDi | 2316 |
KEGGi | hsa:2316 |
UCSCi | uc065cca.1, human |
Organism-specific databases
CTDi | 2316 |
HGNCi | HGNC:3754, FLNA |
OpenTargetsi | ENSG00000196924 |
PharmGKBi | PA28172 |
VEuPathDBi | HostDB:ENSG00000196924.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153588 |
OrthoDBi | 35998at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2316, 4 hits in 500 CRISPR screens |
ChiTaRSi | FLNA, human |
GenomeRNAii | 2316 |
Gene expression databases
Bgeei | ENSG00000196924, Expressed in esophagogastric junction muscularis propria and 250 other tissues |
ExpressionAtlasi | Q60FE5, baseline and differential |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits 2.60.40.10, 24 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR017868, Filamin/ABP280_repeat-like IPR001298, Filamin/ABP280_rpt IPR013783, Ig-like_fold IPR014756, Ig_E-set |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF00630, Filamin, 23 hits |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00557, IG_FLMN, 24 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF81296, SSF81296, 24 hits |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50194, FILAMIN_REPEAT, 24 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q60FE5_HUMAN | |
Accessioni | Q60FE5Primary (citable) accession number: Q60FE5 Secondary accession number(s): E9PHF0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |