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Entry version 124 (16 Oct 2019)
Sequence version 1 (23 Nov 2004)
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Protein
Submitted name:

Filamin-A

Gene

FLNA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Filamin-AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3754 FLNA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28172

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q60FE5

PRoteomics IDEntifications database

More...
PRIDEi
Q60FE5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20518

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q60FE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196924 Expressed in 239 organ(s), highest expression level in esophagogastric junction muscularis propria

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60FE5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q60FE5, 4 interactors

Molecular INTeraction database

More...
MINTi
Q60FE5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 122Calponin-homology (CH)InterPro annotationAdd BLAST107
Domaini139 – 242Calponin-homology (CH)InterPro annotationAdd BLAST104
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati249 – 347FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati349 – 447FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati448 – 543FilaminPROSITE-ProRule annotationAdd BLAST96
Repeati544 – 636FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati640 – 736FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati737 – 839FilaminPROSITE-ProRule annotationAdd BLAST103
Repeati840 – 938FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati939 – 1034FilaminPROSITE-ProRule annotationAdd BLAST96
Repeati1035 – 1127FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1128 – 1222FilaminPROSITE-ProRule annotationAdd BLAST95
Repeati1223 – 1322FilaminPROSITE-ProRule annotationAdd BLAST100
Repeati1323 – 1415FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1416 – 1512FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati1513 – 1609FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati1622 – 1713FilaminPROSITE-ProRule annotationAdd BLAST92
Repeati1752 – 1833FilaminPROSITE-ProRule annotationAdd BLAST82
Repeati1833 – 1925FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1923 – 2012FilaminPROSITE-ProRule annotationAdd BLAST90
Repeati2015 – 2107FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati2105 – 2203FilaminPROSITE-ProRule annotationAdd BLAST99
Repeati2206 – 2298FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati2300 – 2393FilaminPROSITE-ProRule annotationAdd BLAST94
Repeati2397 – 2489FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati2525 – 2619FilaminPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni244 – 267DisorderedSequence analysisAdd BLAST24
Regioni1334 – 1355DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1336 – 1351PolarSequence analysisAdd BLAST16

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0518 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153588

KEGG Orthology (KO)

More...
KOi
K04437

Database of Orthologous Groups

More...
OrthoDBi
35998at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.60.40.10, 24 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF00630 Filamin, 23 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00557 IG_FLMN, 24 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF81296 SSF81296, 24 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50194 FILAMIN_REPEAT, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q60FE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVSKRIANL QTDLSDGLRL
60 70 80 90 100
IALLEVLSQK KMHRKHNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK
110 120 130 140 150
AIVDGNLKLI LGLIWTLILH YSISMPMWDE EEDEEAKKQT PKQRLLGWIQ
160 170 180 190 200
NKLPQLPITN FSRDWQSGRA LGALVDSCAP GLCPDWDSWD ASKPVTNARE
210 220 230 240 250
AMQQADDWLG IPQVITPEEI VDPNVDEHSV MTYLSQFPKA KLKPGAPLRP
260 270 280 290 300
KLNPKKARAY GPGIEPTGNM VKKRAEFTVE TRSAGQGEVL VYVEDPAGHQ
310 320 330 340 350
EEAKVTANND KNRTFSVWYV PEVTGTHKVT VLFAGQHIAK SPFEVYVDKS
360 370 380 390 400
QGDASKVTAQ GPGLEPSGNI ANKTTYFEIF TAGAGTGEVE VVIQDPMGQK
410 420 430 440 450
GTVEPQLEAR GDSTYRCSYQ PTMEGVHTVH VTFAGVPIPR SPYTVTVGQA
460 470 480 490 500
CNPSACRAVG RGLQPKGVRV KETADFKVYT KGAGSGELKV TVKGPKGEER
510 520 530 540 550
VKQKDLGDGV YGFEYYPMVP GTYIVTITWG GQNIGRSPFE VKVGTECGNQ
560 570 580 590 600
KVRAWGPGLE GGVVGKSADF VVEAIGDDVG TLGFSVEGPS QAKIECDDKG
610 620 630 640 650
DGSCDVRYWP QEAGEYAVHV LCNSEDIRLS PFMADIRDAP QDFHPDRVKA
660 670 680 690 700
RGPGLEKTGV AVNKPAEFTV DAKHGGKAPL RVQVQDNEGC PVEALVKDNG
710 720 730 740 750
NGTYSCSYVP RKPVKHTAMV SWGGVSIPNS PFRVNVGAGS HPNKVKVYGP
760 770 780 790 800
GVAKTGLKAH EPTYFTVDCA EAGQGDVSIG IKCAPGVVGP AEADIDFDII
810 820 830 840 850
RNDNDTFTVK YTPRGAGSYT IMVLFADQAT PTSPIRVKVE PSHDASKVKA
860 870 880 890 900
EGPGLSRTGV ELGKPTHFTV NAKAAGKGKL DVQFSGLTKG DAVRDVDIID
910 920 930 940 950
HHDNTYTVKY TPVQQGPVGV NVTYGGDPIP KSPFSVAVSP SLDLSKIKVS
960 970 980 990 1000
GLGEKVDVGK DQEFTVKSKG AGGQGKVASK IVGPSGAAVP CKVEPGLGAD
1010 1020 1030 1040 1050
NSVVRFLPRE EGPYEVEVTY DGVPVPGSPF PLEAVAPTKP SKVKAFGPGL
1060 1070 1080 1090 1100
QGGSAGSPAR FTIDTKGAGT GGLGLTVEGP CEAQLECLDN GDGTCSVSYV
1110 1120 1130 1140 1150
PTEPGDYNIN ILFADTHIPG SPFKAHVVPC FDASKVKCSG PGLERATAGE
1160 1170 1180 1190 1200
VGQFQVDCSS AGSAELTIEI CSEAGLPAEV YIQDHGDGTH TITYIPLCPG
1210 1220 1230 1240 1250
AYTVTIKYGG QPVPNFPSKL QVEPAVDTSG VQCYGPGIEG QGVFREATTE
1260 1270 1280 1290 1300
FSVDARALTQ TGGPHVKARV ANPSGNLTET YVQDRGDGMY KVEYTPYEEG
1310 1320 1330 1340 1350
LHSVDVTYDG SPVPSSPFQV PVTEGCDPSR VRVHGPGIQS GTTNKPNKFT
1360 1370 1380 1390 1400
VETRGAGTGG LGLAVEGPSE AKMSCMDNKD GSCSVEYIPY EAGTYSLNVT
1410 1420 1430 1440 1450
YGGHQVPGSP FKVPVHDVTD ASKVKCSGPG LSPGMVRANL PQSFQVDTSK
1460 1470 1480 1490 1500
AGVAPLQVKV QGPKGLVEPV DVVDNADGTQ TVNYVPSREG PYSISVLYGD
1510 1520 1530 1540 1550
EEVPRSPFKV KVLPTHDASK VKASGPGLNT TGVPASLPVE FTIDAKDAGE
1560 1570 1580 1590 1600
GLLAVQITDP EGKPKKTHIQ DNHDGTYTVA YVPDVTGRYT ILIKYGGDEI
1610 1620 1630 1640 1650
PFSPYRVRAV PTGDASKCTV TVSIGGHGLG AGIGPTIQIG EETVITVDTK
1660 1670 1680 1690 1700
AAGKGKVTCT VCTPDGSEVD VDVVENEDGT FDIFYTAPQP GKYVICVRFG
1710 1720 1730 1740 1750
GEHVPNSPFQ VTALAGDQPS VQPPLRSQQL APQYTYAQGG QQTWAPERPL
1760 1770 1780 1790 1800
VGVNGLDVTS LRPFDLVIPF TIKKGEITGE VRMPSGKVAQ PTITDNKDGT
1810 1820 1830 1840 1850
VTVRYAPSEA GLHEMDIRYD NMHIPGSPLQ FYVDYVNCGH VTAYGPGLTH
1860 1870 1880 1890 1900
GVVNKPATFT VNTKDAGEGG LSLAIEGPSK AEISCTDNQD GTCSVSYLPV
1910 1920 1930 1940 1950
LPGDYSILVK YNEQHVPGSP FTARVTGDDS MRMSHLKVGS AADIPINISE
1960 1970 1980 1990 2000
TDLSLLTATV VPPSGREEPC LLKRLRNGHV GISFVPKETG EHLVHVKKNG
2010 2020 2030 2040 2050
QHVASSPIPV VISQSEIGDA SRVRVSGQGL HEGHTFEPAE FIIDTRDAGY
2060 2070 2080 2090 2100
GGLSLSIEGP SKVDINTEDL EDGTCRVTYC PTEPGNYIIN IKFADQHVPG
2110 2120 2130 2140 2150
SPFSVKVTGE GRVKESITRR RRAPSVANVG SHCDLSLKIP EISIQDMTAQ
2160 2170 2180 2190 2200
VTSPSGKTHE AEIVEGENHT YCIRFVPAEM GTHTVSVKYK GQHVPGSPFQ
2210 2220 2230 2240 2250
FTVGPLGEGG AHKVRAGGPG LERAEAGVPA EFSIWTREAG AGGLAIAVEG
2260 2270 2280 2290 2300
PSKAEISFED RKDGSCGVAY VVQEPGDYEV SVKFNEEHIP DSPFVVPVAS
2310 2320 2330 2340 2350
PSGDARRLTV SSLQESGLKV NQPASFAVSL NGAKGAIDAK VHSPSGALEE
2360 2370 2380 2390 2400
CYVTEIDQDK YAVRFIPREN GVYLIDVKFN GTHIPGSPFK IRVGEPGHGG
2410 2420 2430 2440 2450
DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID GPSKVKMDCQ
2460 2470 2480 2490 2500
ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT GPRLVSNHSL
2510 2520 2530 2540 2550
HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL SKAYVGQKSS
2560 2570 2580 2590 2600
FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT
2610 2620
LVVKWGDEHI PGSPYRVVVP
Length:2,620
Mass (Da):278,226
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1ABFC44B1B32B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P21333FLNA_HUMAN
Filamin-A
FLNA FLN, FLN1
2,647Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWY3A0A087WWY3_HUMAN
Filamin-A
FLNA
2,315Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5F3H0Y5F3_HUMAN
Filamin-A
FLNA
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE98F8WE98_HUMAN
Filamin-A
FLNA
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5C6H0Y5C6_HUMAN
Filamin-A
FLNA
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2E7H7C2E7_HUMAN
Filamin-A
FLNA
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC245140 Genomic DNA No translation available.
AB191260 mRNA Translation: BAD52436.1
AB371574 mRNA Translation: BAG48303.1
AB371576 mRNA Translation: BAG48305.1

NCBI Reference Sequences

More...
RefSeqi
NP_001104026.1, NM_001110556.1
NP_001447.2, NM_001456.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369856; ENSP00000358872; ENSG00000196924

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2316

UCSC genome browser

More...
UCSCi
uc065cca.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245140 Genomic DNA No translation available.
AB191260 mRNA Translation: BAD52436.1
AB371574 mRNA Translation: BAG48303.1
AB371576 mRNA Translation: BAG48305.1
RefSeqiNP_001104026.1, NM_001110556.1
NP_001447.2, NM_001456.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ60FE5, 4 interactors
MINTiQ60FE5

PTM databases

SwissPalmiQ60FE5

Proteomic databases

PeptideAtlasiQ60FE5
PRIDEiQ60FE5
ProteomicsDBi20518

Genome annotation databases

EnsembliENST00000369856; ENSP00000358872; ENSG00000196924
GeneIDi2316
KEGGihsa:2316
UCSCiuc065cca.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2316
HGNCiHGNC:3754 FLNA
OpenTargetsiENSG00000196924
PharmGKBiPA28172

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG0518 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000153588
KOiK04437
OrthoDBi35998at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FLNA human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2316

Gene expression databases

BgeeiENSG00000196924 Expressed in 239 organ(s), highest expression level in esophagogastric junction muscularis propria
ExpressionAtlasiQ60FE5 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.60.40.10, 24 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00630 Filamin, 23 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00557 IG_FLMN, 24 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF81296 SSF81296, 24 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50194 FILAMIN_REPEAT, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ60FE5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60FE5
Secondary accession number(s): E9PHF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 16, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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