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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi381 – 388ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCAP243233:G1G0X-960-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:MCA0964
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
Proteomesi
  • UP000006821 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 190HelicalUniRule annotationAdd BLAST20
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21
Transmembranei283 – 303HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925881 – 601Lipid A export ATP-binding/permease protein MsbAAdd BLAST601

Proteomic databases

PRIDEiQ60AA3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243233.MCA0964

Structurei

3D structure databases

ProteinModelPortaliQ60AA3
SMRiQ60AA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 315ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini347 – 583ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK11085
OMAiGDLMNRI
OrthoDBiPOG091H00DB

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q60AA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHSASESKP LSSGLAIYRR LLRYGFPYWR SFCVAVVAMI AYAAITPFFA
60 70 80 90 100
KLIQPLIDGS FIDNDPTVLR QVSLMLIGLS VLRGIAGFLS EYCSGSVGRR
110 120 130 140 150
VIADLRRDIF DQLLNLPCSF YDNASGGQLL SKLLYNTEQV SASLQQGIIT
160 170 180 190 200
CIREGFTVIG LMALMVYQNP VLSLVFLVLG PVLGLSVRFV SKRFRRLSMR
210 220 230 240 250
IQESMGKVSH VTQEVIDAQR IVKVFNGKDY EAAKFATEND RNQKRQMKLI
260 270 280 290 300
ATDALGGGVI HLISVAGVAG ILYVVSLDSV RQTITPGSLM AFIAAMAMML
310 320 330 340 350
SPIRRLSQVV SVMQRGIAAG DSIFAMLDLP RERDRGRISL KRARGSIEYR
360 370 380 390 400
HVSLVYDDRH GAAVDDVSLV IPAGKTVALV GQSGSGKTSL VRLLPRLYEA
410 420 430 440 450
TAGEILIDGH DIRELTLESL RRQIAYVGQE VTLFNDTVAS NIAYGCLDRV
460 470 480 490 500
GLDAVREAAR AANALDFIET LPQGFDTLVG QQGIVLSGGQ RQRIAIARAL
510 520 530 540 550
LKNAPILILD EATSALDAES ERYVQQALEV LMQNRTTLVI AHRLSTIQNA
560 570 580 590 600
DQICVMRGGR IIECGTHAQL MAARGGYADL YAMQFGYSSV PEAVAVHAVR

R
Length:601
Mass (Da):65,686
Last modified:November 23, 2004 - v1
Checksum:i290174A90ACBD2C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA Translation: AAU92729.1
RefSeqiWP_010960270.1, NC_002977.6

Genome annotation databases

EnsemblBacteriaiAAU92729; AAU92729; MCA0964
KEGGimca:MCA0964

Similar proteinsi

Entry informationi

Entry nameiMSBA_METCA
AccessioniPrimary (citable) accession number: Q60AA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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