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Entry version 155 (12 Aug 2020)
Sequence version 2 (10 Jan 2006)
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Protein

Deleted in malignant brain tumors 1 protein

Gene

Dmbt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5683826, Surfactant metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deleted in malignant brain tumors 1 protein
Alternative name(s):
Apactin
CRP-ductin
Glycoprotein 300
Short name:
gp300
Hensin
Mucin-like glycoprotein
Short name:
Muclin
Vomeroglandin
p80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmbt1
Synonyms:Crpd
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106210, Dmbt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2050 – 2070HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Variable phenotypes have been reported. In some studies mice display normal development and viability with impaired exocrine pancreatic function and no development of gastrointestinal tumors (PubMed:17983803 and PubMed:18202109). In other studies mice die between 4.5 dpc and 5.5 dpc due to defects in the differentiation of the primitive endoderm layer (PubMed:15452149).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2073T → A: Abolishes phosphorylation. 1 Publication1
Mutagenesisi2082S → A: Abolishes phosphorylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004538820 – 2085Deleted in malignant brain tumors 1 proteinAdd BLAST2066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi62 ↔ 126By similarity
Disulfide bondi75 ↔ 136By similarity
Disulfide bondi106 ↔ 116By similarity
Disulfide bondi211 ↔ 275By similarity
Disulfide bondi224 ↔ 285By similarity
Disulfide bondi255 ↔ 265By similarity
Disulfide bondi349 ↔ 413By similarity
Disulfide bondi362 ↔ 423By similarity
Disulfide bondi393 ↔ 403By similarity
Disulfide bondi488 ↔ 552By similarity
Disulfide bondi501 ↔ 562By similarity
Disulfide bondi532 ↔ 542By similarity
Disulfide bondi627 ↔ 691By similarity
Disulfide bondi640 ↔ 701By similarity
Disulfide bondi671 ↔ 681By similarity
Disulfide bondi766 ↔ 830By similarity
Disulfide bondi779 ↔ 840By similarity
Disulfide bondi810 ↔ 820By similarity
Disulfide bondi905 ↔ 969By similarity
Disulfide bondi918 ↔ 979By similarity
Disulfide bondi949 ↔ 959By similarity
Disulfide bondi1023 ↔ 1049By similarity
Disulfide bondi1074 ↔ 1096By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1139 ↔ 1165By similarity
Disulfide bondi1190 ↔ 1212By similarity
Glycosylationi1204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1265 ↔ 1291By similarity
Disulfide bondi1316 ↔ 1338By similarity
Glycosylationi1330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1381 ↔ 1407By similarity
Disulfide bondi1432 ↔ 1454By similarity
Glycosylationi1446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1504N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1514N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1535 ↔ 1599By similarity
Disulfide bondi1548 ↔ 1609By similarity
Disulfide bondi1579 ↔ 1589By similarity
Glycosylationi1630N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1633 ↔ 1659By similarity
Disulfide bondi1684 ↔ 1706By similarity
Glycosylationi1745N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1817N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1858N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1874N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1920 ↔ 1978By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2073Phosphothreonine1 Publication1
Modified residuei2082Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N- and O-glycosylated. The O-glycans are heavily sulfated. O-glycosylation and sulfation in pancreatic acinar cells are required for zymogen granule maturation. Glycoconjugate composition changes during development with fucose only acquired post-natally during weaning.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60997

PRoteomics IDEntifications database

More...
PRIDEi
Q60997

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q60997, 21 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q60997

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q60997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in acini and duct epithelial cells of the exocrine pancreas but not in the islets of Langerhans. Expressed in gall bladder, salivary glands and in the epithelium lining larger hepatic ducts, but not in the liver parenchyma, stomach or lung. Expressed along the intestinal tract including duodenum, jejunum, ileum and colon (at protein level). Expressed in glands associated with vomeronasal tissues. Expressed in the vomeronasal gland and posterior gland of nasal septum. Weakly expressed in lateral nasal gland. CFTR knockout mice show increased expression in pancreas, duodenum and small intestine but not in gall bladder. In pancreas and small intestine, increased expression occurs after the appearance of dilated lumina.6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in the 3.5 dpc blastocyst. Levels increase to a maximum between 18.5 dpc and birth and decrease gradually between birth and adulthood with the greatest decreases occurring between neonate and P1 and between P9 and P16 (at protein level). Expressed in the primitive endoderm at 4.5 dpc. At 9.5 dpc, expressed in midbrain, notochord, liver primordium, midgut and hindgut.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LGALS3. Binds SPAR in a calcium-dependent manner (By similarity). Binds SFTPD in a calcium-dependent manner.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
198900, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081556

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q60997, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q60997

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 137SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini186 – 286SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini324 – 424SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini463 – 563SRCR 4PROSITE-ProRule annotationAdd BLAST101
Domaini602 – 702SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini741 – 841SRCR 6PROSITE-ProRule annotationAdd BLAST101
Domaini880 – 980SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini1023 – 1132CUB 1PROSITE-ProRule annotationAdd BLAST110
Domaini1139 – 1248CUB 2PROSITE-ProRule annotationAdd BLAST110
Domaini1265 – 1374CUB 3PROSITE-ProRule annotationAdd BLAST110
Domaini1381 – 1490CUB 4PROSITE-ProRule annotationAdd BLAST110
Domaini1510 – 1610SRCR 8PROSITE-ProRule annotationAdd BLAST101
Domaini1633 – 1742CUB 5PROSITE-ProRule annotationAdd BLAST110
Domaini1751 – 1999ZPPROSITE-ProRule annotationAdd BLAST249

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi987 – 1018Thr-richAdd BLAST32

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SRCR domains mediate binding to bacteria.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DMBT1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RSDM, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q60997

KEGG Orthology (KO)

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KOi
K13912

Database of Orthologous Groups

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OrthoDBi
1095487at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q60997

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.290, 5 hits
3.10.250.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
IPR001507, ZP_dom
IPR017977, ZP_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 5 hits
PF00530, SRCR, 8 hits
PF00100, Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 5 hits
SM00202, SR, 8 hits
SM00241, ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 5 hits
SSF56487, SSF56487, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 5 hits
PS00420, SRCR_1, 8 hits
PS50287, SRCR_2, 8 hits
PS00682, ZP_1, 1 hit
PS51034, ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60997-1) [UniParc]FASTAAdd to basket
Also known as: CPR-ductin alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGISTVIFEI CLLWGQILST ASQTAVPTDG TDSGLAVRLV NGGDRCQGRV
60 70 80 90 100
EILYQGSWGT VCDDSWDLND ANVVCRQLGC GLAVSAPGNA RFGQGSGPIV
110 120 130 140 150
MDDVACGGYE DYLWRCSHRG WLSHNCGHQE DAGVICSDSQ TSSPTPGWWN
160 170 180 190 200
PGGTNNDVFY PTEQTTAEQT TIPDYTPIGT DSGLAVRLVN GGDRCQGRVE
210 220 230 240 250
ILYQGSWGTV CDDSWDVSDA NVVCRQLGCG WAVSAPGNAY FGQGQGPIVL
260 270 280 290 300
DDVACGGYEN YLWSCSHQGW LSHNCGHQED AGVICSASQS SSPTPGWWNP
310 320 330 340 350
GGTNNDVFYP TEQTTAGTDS GLAVRLVNGG DRCQGRVEIL YQGSWGTVCD
360 370 380 390 400
DSWDTNDANV VCRQLGCGWA VSAPGNAYFG PGSGSIVLDD VACTGHEDYL
410 420 430 440 450
WRCSHRGWLS HNCGHHEDAG VICSASQSSS PTPDVFYPTD QTTAEQTTVP
460 470 480 490 500
DYTPIGTDSG LAVRLVNGGD RCQGRVEILY QGSWGTVCDD SWDLNDANVV
510 520 530 540 550
CRQLGCGLAV SAPGSARFGQ GTGPIVMDDV ACGGYEDYLW RCSHRGWLSH
560 570 580 590 600
NCGHHEDAGV ICSASQSSSP TPDVFYPTDQ TTAEQTTVPD YTPIGTDSGL
610 620 630 640 650
AVRLVNGGDR CQGRVEILYQ GSWGTVCDDS WDLNDANVVC RQLGCGLAVS
660 670 680 690 700
APGSARFGQG TGPIVMDDVA CGGYEDYLWR CSHRGWLSHN CGHHEDAGVI
710 720 730 740 750
CSASQSSSPT PDVFYPTDQT TAEQTTVPDY TTIGTENSLA VRLENGGDRC
760 770 780 790 800
QGRVEILYQG SWGTVCDDSW DLNDANVVCR QLGCGLAVSA PGSARFGQGT
810 820 830 840 850
GPIVMDDVAC GGYEDYLWRC SHRGWLSHNC GHHEDAGVIC SASQSSSPTP
860 870 880 890 900
DVFYPTDQTT VEQTTVPDYT PIGTENSLAV RLENGGDRCQ GRVEILYQGS
910 920 930 940 950
WGTVCDDSWD TKDANVVCRQ LGCGWAVSAP GNAYFGPGSG SIVLDDVACT
960 970 980 990 1000
GHEDYLWSCS HRGWLSHNCG HHEDAGVICS DAQIQSTTRP DLWPTTTTPE
1010 1020 1030 1040 1050
TTTELLTTTP YFDWWTTTSD YSCGGLLTQP SGQFSSPYYP SNYPNNARCS
1060 1070 1080 1090 1100
WKIVLPNMNR VTVVFTDVQL EGGCNYDYIL VYDGPEYNSS LIARVCDGSN
1110 1120 1130 1140 1150
GSFTSTGNFM SVVFITDGSV TRRGFQAHYY STVSTNYSCG GLLTQPSGQF
1160 1170 1180 1190 1200
SSPYYPSNYP NNARCSWEIL VPNMNRVTVV FTDVQLEGGC NYDYILVYDG
1210 1220 1230 1240 1250
PQYNSSLIAR VCDGSNGSFT STGNFMSVVF ITDGSVTRRG FQAHYYSTVS
1260 1270 1280 1290 1300
TTPPVPIPTT DDYSCGGLLT LPSGQFSSPH YPSNYPNNAR CSWEILVPNM
1310 1320 1330 1340 1350
NRVTVAFTDV QLEGGCNYDY ILVYDGPEYN SSLIARVCDG SNGSFTSTGN
1360 1370 1380 1390 1400
FMSVVFITDG SVTRRGFQAH YYSTVSTNYS CGGLLTQPSG QFSSPHYPSN
1410 1420 1430 1440 1450
YPNNVRCSWE ILVPSMNRVT VAFTDVQLEG GCSFDYILVY DGPEYNSSLI
1460 1470 1480 1490 1500
APVCDGFNGS FTSTGNFMSV VFITDGSVTR RGFQAYYYST VSTPPSFHPN
1510 1520 1530 1540 1550
ITGNDSSLAL RLVNGSNRCE GRVEILYRGS WGTVCDDSWG ISDANVVCRQ
1560 1570 1580 1590 1600
LGCGSALSAP GNAWFGQGSG LIVLDDVSCS GYESHLWNCH HPGWLVHNCR
1610 1620 1630 1640 1650
HSEDAGVICA LPEVTSPSPG WWTTSPSYVN YTCGGFLTQP SGQFSSPFYP
1660 1670 1680 1690 1700
GNYPNNARCL WNIEVPNNYR VTVVFRDLQL ERGCSYDYIE IFDGPHHSSP
1710 1720 1730 1740 1750
LIARVCDGSL GSFTSTSNFM SIRFITDHSI TARGFQAHYY SDFDNNTTNL
1760 1770 1780 1790 1800
LCQSNHMQAS VSRSYLQSMG YSARDLVIPG WNSSYHCQPQ ITQREVIFTI
1810 1820 1830 1840 1850
PYTGCGTIKQ ADNETINYSN FLRAVVSNGI IKRRKDLNIH VSCKMLQNTW
1860 1870 1880 1890 1900
VNTMYITNNT VEIQEVQYGN FDVNISFYTS SSFLFPVTSS PYYVDLDQNL
1910 1920 1930 1940 1950
YLQAEILHSD ASLALFVDTC VASPHPNDFS SLTYDLIRSG CVRDDTYQSY
1960 1970 1980 1990 2000
SSPSPRVSRF KFSSFHFLNR FPSVYLQCKL VVCRAYDTSS RCYRGCVVRS
2010 2020 2030 2040 2050
KRDVGSYQEK VDVVLGPIQL QSPSKEKRSL DLAVEDVKKP ASSQAVYPTA
2060 2070 2080
AIFGGVFLAM VLAVAAFTLG RRTHIDRGQP PSTKL
Length:2,085
Mass (Da):226,815
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BE4E77D299B32ED
GO
Isoform 2 (identifier: Q60997-2) [UniParc]FASTAAdd to basket
Also known as: CPR-ductin beta

The sequence of this isoform differs from the canonical sequence as follows:
     2032-2085: Missing.

Show »
Length:2,031
Mass (Da):221,165
Checksum:i75B4ECA6D1304690
GO
Isoform 3 (identifier: Q60997-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: D → DEVSYTAEQSTE
     397-534: Missing.

Show »
Length:1,958
Mass (Da):213,435
Checksum:iA807608B561959AD
GO
Isoform 4 (identifier: Q60997-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-534: Missing.

Show »
Length:1,947
Mass (Da):212,209
Checksum:iC4DE1C161903C30A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPG8E9QPG8_MOUSE
Deleted in malignant brain tumors 1...
Dmbt1
1,946Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM72A0A1D5RM72_MOUSE
Deleted in malignant brain tumors 1...
Dmbt1
1,783Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LI59A0A140LI59_MOUSE
Deleted in malignant brain tumors 1...
Dmbt1
1,957Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHB2A0A140LHB2_MOUSE
Deleted in malignant brain tumors 1...
Dmbt1
423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC52505 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti247 – 248PI → L in AAC52505 (PubMed:8742698).Curated2
Sequence conflicti1494 – 1497PPSF → SLH in AAC52505 (PubMed:8742698).Curated4
Sequence conflicti2061V → G in BAA92266 (PubMed:10679193).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01685129D → DEVSYTAEQSTE in isoform 3. 1 Publication1
Alternative sequenceiVSP_016852397 – 534Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST138
Alternative sequenceiVSP_0168532032 – 2085Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U37438 mRNA Translation: AAC52505.1 Frameshift.
AB005909 mRNA Translation: BAA92266.1
BC049835 mRNA Translation: AAH49835.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42721

NCBI Reference Sequences

More...
RefSeqi
NP_001334561.1, NM_001347632.1
NP_031795.2, NM_007769.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12945

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12945

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37438 mRNA Translation: AAC52505.1 Frameshift.
AB005909 mRNA Translation: BAA92266.1
BC049835 mRNA Translation: AAH49835.1
PIRiT42721
RefSeqiNP_001334561.1, NM_001347632.1
NP_031795.2, NM_007769.2

3D structure databases

SMRiQ60997
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198900, 4 interactors
STRINGi10090.ENSMUSP00000081556

PTM databases

GlyGeniQ60997, 21 sites
iPTMnetiQ60997
PhosphoSitePlusiQ60997

Proteomic databases

PaxDbiQ60997
PRIDEiQ60997

Genome annotation databases

GeneIDi12945
KEGGimmu:12945

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1755
MGIiMGI:106210, Dmbt1

Phylogenomic databases

eggNOGiENOG502RSDM, Eukaryota
InParanoidiQ60997
KOiK13912
OrthoDBi1095487at2759
PhylomeDBiQ60997

Enzyme and pathway databases

ReactomeiR-MMU-5683826, Surfactant metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
12945, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dmbt1, mouse

Protein Ontology

More...
PROi
PR:Q60997
RNActiQ60997, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00041, CUB, 5 hits
Gene3Di2.60.120.290, 5 hits
3.10.250.10, 8 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
IPR001507, ZP_dom
IPR017977, ZP_dom_CS
PfamiView protein in Pfam
PF00431, CUB, 5 hits
PF00530, SRCR, 8 hits
PF00100, Zona_pellucida, 1 hit
PRINTSiPR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00042, CUB, 5 hits
SM00202, SR, 8 hits
SM00241, ZP, 1 hit
SUPFAMiSSF49854, SSF49854, 5 hits
SSF56487, SSF56487, 8 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 5 hits
PS00420, SRCR_1, 8 hits
PS50287, SRCR_2, 8 hits
PS00682, ZP_1, 1 hit
PS51034, ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMBT1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60997
Secondary accession number(s): Q80YC6, Q9JMJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: August 12, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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