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Protein

Guanine nucleotide exchange factor VAV2

Gene

Vav2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri513 – 562Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: MGI
  • guanyl-nucleotide exchange factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • phosphotyrosine residue binding Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processAngiogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2424491 DAP12 signaling
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-3928665 EPH-ephrin mediated repulsion of cells
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445144 Signal transduction by L1
R-MMU-5218920 VEGFR2 mediated vascular permeability

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor VAV2
Short name:
VAV-2
Gene namesi
Name:Vav2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102718 Vav2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809851 – 868Guanine nucleotide exchange factor VAV2Add BLAST868

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142Phosphotyrosine; by EGFRBy similarity1
Modified residuei159Phosphotyrosine; by EGFRBy similarity1
Modified residuei172Phosphotyrosine; by EGFRBy similarity1
Modified residuei566PhosphoserineBy similarity1
Modified residuei616PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues in response to FGR activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60992
PaxDbiQ60992
PeptideAtlasiQ60992
PRIDEiQ60992

PTM databases

iPTMnetiQ60992
PhosphoSitePlusiQ60992

Expressioni

Gene expression databases

BgeeiENSMUSG00000009621 Expressed in 219 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_VAV2
ExpressionAtlasiQ60992 baseline and differential
GenevisibleiQ60992 MM

Interactioni

Subunit structurei

Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with NEK3 and PRLR and this interaction is prolactin-dependent (By similarity). Interacts with SSX2IP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ60992, 4 interactors
STRINGi10090.ENSMUSP00000062782

Structurei

3D structure databases

ProteinModelPortaliQ60992
SMRiQ60992
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 120Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST120
Domaini193 – 371DHPROSITE-ProRule annotationAdd BLAST179
Domaini400 – 502PHPROSITE-ProRule annotationAdd BLAST103
Domaini576 – 642SH3 1PROSITE-ProRule annotationAdd BLAST67
Domaini663 – 757SH2PROSITE-ProRule annotationAdd BLAST95
Domaini806 – 867SH3 2PROSITE-ProRule annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri513 – 562Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
GeneTreeiENSGT00930000150930
HOGENOMiHOG000234364
HOVERGENiHBG018066
InParanoidiQ60992
KOiK05730
OMAiVTPPCKI
OrthoDBiEOG091G01O3
PhylomeDBiQ60992
TreeFamiTF316171

Family and domain databases

CDDicd00029 C1, 1 hit
cd00014 CH, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd10406 SH2_Vav2, 1 hit
cd11980 SH3_VAV2_1, 1 hit
cd11977 SH3_VAV2_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035880 VAV2_SH2
IPR035733 VAV2_SH3_1
IPR035732 VAV2_SH3_2
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF07653 SH3_2, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q60992-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL
60 70 80 90 100
SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF
110 120 130 140 150
DVRDFGKVIS AVSRLSLHSI AQSKGIRPFP SEETAENDDD VYRSLEELAD
160 170 180 190 200
EHDLGEDIYD CVPCEDEGDD IYEDIIKVEV QQPMKMGMTE DDKRSCCLLE
210 220 230 240 250
IQETEAKYYR TLEDIEKNYM GPLRLVLSPA DMAAVFINLE DLIKVHHSFL
260 270 280 290 300
RAIDVSMMAG GSTLAKVFLE FKERLLIYGE YCSHMEHAQS TLNQLLASRE
310 320 330 340 350
DFRQKVEECT LRVQDGKFKL QDLLVVPMQR VLKYHLLLKE LLSHSADRPE
360 370 380 390 400
RQQLKEALEA MQDLAMYINE VKRDKETLKK ISEFQCSIEN LQVKLEEFGR
410 420 430 440 450
PKIDGELKVR SIVNHTKQDR YLFLFDKVVI VCKRKGYSYE LKEVIELLFH
460 470 480 490 500
KMTDDPMHNK DIKKWSYGFY LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA
510 520 530 540 550
MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC KMFLRGTFYQ GYLCTRCGVG
560 570 580 590 600
AHKECLEVIP PCKMSSPADV DAPGAGPGPK MVAVQNYHGN PAPPGKPVLT
610 620 630 640 650
FQTGDVIELL RGDPDSPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPTGR
660 670 680 690 700
PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS
710 720 730 740 750
IKFNDEVKHI KVVEKDSWIH ITEAKKFESL LELVEYYQCH SLKESFKQLD
760 770 780 790 800
TTLKFPYKSR ERTTSRASSR SPASCASYNF SFLSPQGLSF APQAPSAPFW
810 820 830 840 850
SVFTPRVIGT AVARYNFAAR DMRELSLREG DVVKIYSRIG GDQGWWKGET
860
NGRIGWFPST YVEEEGVQ
Length:868
Mass (Da):99,915
Last modified:November 1, 1997 - v1
Checksum:iD18581E7EEB2DBC2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TSI6Q7TSI6_MOUSE
Guanine nucleotide exchange factor ...
Vav2 VAV2
829Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37017 mRNA Translation: AAC52761.1
AL731552, AL772282 Genomic DNA Translation: CAM13732.1
AL772282, AL731552 Genomic DNA Translation: CAM21000.1
CCDSiCCDS15827.1
RefSeqiNP_033526.1, NM_009500.2
UniGeneiMm.179011

Genome annotation databases

EnsembliENSMUST00000056176; ENSMUSP00000062782; ENSMUSG00000009621
GeneIDi22325
KEGGimmu:22325
UCSCiuc008ixh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37017 mRNA Translation: AAC52761.1
AL731552, AL772282 Genomic DNA Translation: CAM13732.1
AL772282, AL731552 Genomic DNA Translation: CAM21000.1
CCDSiCCDS15827.1
RefSeqiNP_033526.1, NM_009500.2
UniGeneiMm.179011

3D structure databases

ProteinModelPortaliQ60992
SMRiQ60992
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60992, 4 interactors
STRINGi10090.ENSMUSP00000062782

PTM databases

iPTMnetiQ60992
PhosphoSitePlusiQ60992

Proteomic databases

MaxQBiQ60992
PaxDbiQ60992
PeptideAtlasiQ60992
PRIDEiQ60992

Protocols and materials databases

DNASUi22325
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056176; ENSMUSP00000062782; ENSMUSG00000009621
GeneIDi22325
KEGGimmu:22325
UCSCiuc008ixh.1 mouse

Organism-specific databases

CTDi7410
MGIiMGI:102718 Vav2

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
GeneTreeiENSGT00930000150930
HOGENOMiHOG000234364
HOVERGENiHBG018066
InParanoidiQ60992
KOiK05730
OMAiVTPPCKI
OrthoDBiEOG091G01O3
PhylomeDBiQ60992
TreeFamiTF316171

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2424491 DAP12 signaling
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-3928665 EPH-ephrin mediated repulsion of cells
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445144 Signal transduction by L1
R-MMU-5218920 VEGFR2 mediated vascular permeability

Miscellaneous databases

ChiTaRSiVav2 mouse
PROiPR:Q60992
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009621 Expressed in 219 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_VAV2
ExpressionAtlasiQ60992 baseline and differential
GenevisibleiQ60992 MM

Family and domain databases

CDDicd00029 C1, 1 hit
cd00014 CH, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd10406 SH2_Vav2, 1 hit
cd11980 SH3_VAV2_1, 1 hit
cd11977 SH3_VAV2_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035880 VAV2_SH2
IPR035733 VAV2_SH3_1
IPR035732 VAV2_SH3_2
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF07653 SH3_2, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAV2_MOUSE
AccessioniPrimary (citable) accession number: Q60992
Secondary accession number(s): A2AH49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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