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Protein

Forkhead box protein G1

Gene

Foxg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi172 – 263Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein G1
Short name:
FoxG1
Alternative name(s):
Brain factor 1
Short name:
BF-1
Short name:
BF1
Forkhead-related protein FKHL1
Gene namesi
Name:Foxg1
Synonyms:Fkhl1, Foxg1b, Hfhbf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1347464 Foxg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918371 – 481Forkhead box protein G1Add BLAST481

Proteomic databases

MaxQBiQ60987
PaxDbiQ60987
PRIDEiQ60987

PTM databases

iPTMnetiQ60987
PhosphoSitePlusiQ60987

Expressioni

Tissue specificityi

CNS, and nasal half of the retina.

Gene expression databases

BgeeiENSMUSG00000020950 Expressed in 140 organ(s), highest expression level in neocortex
CleanExiMM_FOXG1
ExpressionAtlasiQ60987 baseline and differential
GenevisibleiQ60987 MM

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXO3O435245EBI-11166131,EBI-1644164From Homo sapiens.

Protein-protein interaction databases

BioGridi200291, 5 interactors
IntActiQ60987, 4 interactors
STRINGi10090.ENSMUSP00000021333

Structurei

3D structure databases

ProteinModelPortaliQ60987
SMRiQ60987
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 398Interaction with KDM5BBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 56His-richAdd BLAST24
Compositional biasi57 – 83Pro-richAdd BLAST27
Compositional biasi70 – 75Poly-Gln6

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000112629
HOVERGENiHBG051645
InParanoidiQ60987
KOiK09385
OMAiLPYATHH
OrthoDBiEOG091G0JF7
PhylomeDBiQ60987
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q60987-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH
60 70 80 90 100
HHHHHHPPPP APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL
110 120 130 140 150
LLPPSTALDG AKADALGAKG EPGGGPAELA PVGPDEKEKG AGAGGEEKKG
160 170 180 190 200
AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA LIMMAIRQSP EKRLTLNGIY
210 220 230 240 250
EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD PGKGNYWMLD
260 270 280 290 300
PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW
310 320 330 340 350
PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST
360 370 380 390 400
ANGLSVDRLV NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN
410 420 430 440 450
LLAGQTSYFF PHVPHPSMTS QTSTSMSARA ASSSTSPQAP STLPCESLRP
460 470 480
SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H
Length:481
Mass (Da):51,625
Last modified:November 1, 1997 - v1
Checksum:iFF6786C3513AB452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36760 mRNA Translation: AAB42158.1
BC046958 mRNA Translation: AAH46958.2
CCDSiCCDS25899.1
RefSeqiNP_001153584.1, NM_001160112.1
NP_032267.1, NM_008241.2
UniGeneiMm.4704

Genome annotation databases

EnsembliENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950
ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950
GeneIDi15228
KEGGimmu:15228
UCSCiuc007nmf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36760 mRNA Translation: AAB42158.1
BC046958 mRNA Translation: AAH46958.2
CCDSiCCDS25899.1
RefSeqiNP_001153584.1, NM_001160112.1
NP_032267.1, NM_008241.2
UniGeneiMm.4704

3D structure databases

ProteinModelPortaliQ60987
SMRiQ60987
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200291, 5 interactors
IntActiQ60987, 4 interactors
STRINGi10090.ENSMUSP00000021333

PTM databases

iPTMnetiQ60987
PhosphoSitePlusiQ60987

Proteomic databases

MaxQBiQ60987
PaxDbiQ60987
PRIDEiQ60987

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950
ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950
GeneIDi15228
KEGGimmu:15228
UCSCiuc007nmf.2 mouse

Organism-specific databases

CTDi2290
MGIiMGI:1347464 Foxg1

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000112629
HOVERGENiHBG051645
InParanoidiQ60987
KOiK09385
OMAiLPYATHH
OrthoDBiEOG091G0JF7
PhylomeDBiQ60987
TreeFamiTF316127

Miscellaneous databases

ChiTaRSiFoxg1 mouse
PROiPR:Q60987
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020950 Expressed in 140 organ(s), highest expression level in neocortex
CleanExiMM_FOXG1
ExpressionAtlasiQ60987 baseline and differential
GenevisibleiQ60987 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXG1_MOUSE
AccessioniPrimary (citable) accession number: Q60987
Secondary accession number(s): Q80VP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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