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Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.74.1.1 the 4 tms multidrug endosomal transporter (met) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Alternative name(s):
Golgi 4-transmembrane-spanning transporter
Mouse transporter protein
Short name:
MTP
Gene namesi
Name:Laptm4a
Synonyms:Mtrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108017 Laptm4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000217831 – 233Lysosomal-associated transmembrane protein 4AAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ60961
PeptideAtlasiQ60961
PRIDEiQ60961

PTM databases

iPTMnetiQ60961
PhosphoSitePlusiQ60961
SwissPalmiQ60961

Expressioni

Gene expression databases

CleanExiMM_LAPTM4A

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020909

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Pro4

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGH Eukaryota
ENOG4111K1Z LUCA
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ60961
PhylomeDBiQ60961

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
PfamiView protein in Pfam
PF03821 Mtp, 2 hits
TIGRFAMsiTIGR00799 mtp, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: Q60961-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA
Length:233
Mass (Da):26,858
Last modified:November 1, 1996 - v1
Checksum:iCA409AC77ACE4D6E
GO
Isoform Short (identifier: Q60961-2) [UniParc]FASTAAdd to basket
Also known as: Truncated, MTP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:144
Mass (Da):16,781
Checksum:iD0F40FFCDB841AE5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLR3E9QLR3_MOUSE
Lysosomal-associated transmembrane ...
Laptm4a
308Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188211 – 89Missing in isoform Short. CuratedAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34259 mRNA Translation: AAB04938.1
UniGeneiMm.30071
Mm.401534

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34259 mRNA Translation: AAB04938.1
UniGeneiMm.30071
Mm.401534

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020909

Protein family/group databases

TCDBi2.A.74.1.1 the 4 tms multidrug endosomal transporter (met) family

PTM databases

iPTMnetiQ60961
PhosphoSitePlusiQ60961
SwissPalmiQ60961

Proteomic databases

PaxDbiQ60961
PeptideAtlasiQ60961
PRIDEiQ60961

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108017 Laptm4a

Phylogenomic databases

eggNOGiENOG410IEGH Eukaryota
ENOG4111K1Z LUCA
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ60961
PhylomeDBiQ60961

Miscellaneous databases

ChiTaRSiLaptm4a mouse
PROiPR:Q60961
SOURCEiSearch...

Gene expression databases

CleanExiMM_LAPTM4A

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
PfamiView protein in Pfam
PF03821 Mtp, 2 hits
TIGRFAMsiTIGR00799 mtp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAP4A_MOUSE
AccessioniPrimary (citable) accession number: Q60961
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 31, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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