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Entry version 153 (23 Feb 2022)
Sequence version 4 (27 Jul 2011)
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Protein

Centrosome-associated protein CEP250

Gene

Cep250

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosome-associated protein CEP250
Alternative name(s):
250 kDa centrosomal protein
Short name:
Cep250
Centrosomal Nek2-associated protein 1
Short name:
C-Nap1
Centrosomal protein 2
Intranuclear matrix protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep250
Synonyms:Cep2, Inmp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108084, Cep250

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000038241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi187 – 2414Missing : Knockin mutant mice show retinal morphological anomalies and altered electroretinographic responses to light stimuli. 1 PublicationAdd BLAST2228

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894881 – 2414Centrosome-associated protein CEP250Add BLAST2414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2292PhosphoserineBy similarity1
Modified residuei2389Phosphoserine; by NEK2By similarity1
Modified residuei2393Phosphoserine; by NEK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

C-terminal part is phosphorylated by NEK2. Dephosphorylated in vitro by the PP1 phosphatase (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q60952

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q60952

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q60952

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60952

PeptideAtlas

More...
PeptideAtlasi
Q60952

PRoteomics IDEntifications database

More...
PRIDEi
Q60952

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
283438

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q60952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q60952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038241, Expressed in retinal neural layer and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60952, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q60952, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (Probable).

Forms a complex in vitro with both NEK2 kinase and the PPP1CC catalytic subunit of protein phosphatase 1 (PP1) (By similarity).

Interacts with CEP135 (By similarity).

Interacts with CROCC/rootletin (PubMed:16339073).

Interacts with CNTLN (By similarity).

Interacts with NIN (via C-terminus) (PubMed:27565344).

By similarityCurated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
200766, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q60952, 8 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105248

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q60952, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q60952

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni356 – 384DisorderedSequence analysisAdd BLAST29
Regioni672 – 707DisorderedSequence analysisAdd BLAST36
Regioni1191 – 1212DisorderedSequence analysisAdd BLAST22
Regioni1269 – 1303DisorderedSequence analysisAdd BLAST35
Regioni2050 – 2071DisorderedSequence analysisAdd BLAST22
Regioni2194 – 2238DisorderedSequence analysisAdd BLAST45
Regioni2275 – 2317DisorderedSequence analysisAdd BLAST43
Regioni2390 – 2414DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili91 – 153Sequence analysisAdd BLAST63
Coiled coili248 – 357Sequence analysisAdd BLAST110
Coiled coili400 – 1165Sequence analysisAdd BLAST766
Coiled coili1237 – 2200Sequence analysisAdd BLAST964
Coiled coili2231 – 2290Sequence analysisAdd BLAST60
Coiled coili2320 – 2345Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 379Polar residuesSequence analysisAdd BLAST24
Compositional biasi677 – 707Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1269 – 1287Polar residuesSequence analysisAdd BLAST19
Compositional biasi1288 – 1303Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2194 – 2226Polar residuesSequence analysisAdd BLAST33
Compositional biasi2275 – 2290Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2294 – 2317Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTBY, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161056

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q60952

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q60952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METGSPGLNM KPQSLQLVLE GQVLALQQQM AENQAASWRK LKNSQEAQKR
60 70 80 90 100
QATLVRKLQA KVLQYRSWCQ DLEKRLEATG GLIPQRWESV EEPNLEQLLI
110 120 130 140 150
RLEEEQQRCE SLVEVNTELR LHMEKADVVN KALQEDVEKL TVDWSRARDE
160 170 180 190 200
LVRKESQWRM EQEFFKGYLR GEHGRLLNLW REVVTFRRHF LKMKSATDRD
210 220 230 240 250
LTELKAEHAR LSGSLLTCCL RLTLRAQSRE SSGSGRTEES EPARLLLLVA
260 270 280 290 300
KTQALEKEAH EKSQELMQLK SHGDLEKAEL QDRVTELSAL LTQSQKQNED
310 320 330 340 350
YEKMVKALRE TMEILETNHA ELMEHEASLS RNAQEEKLSL QQVIKAITQA
360 370 380 390 400
LASVEEEDTV TQSSGHEDSL QSDCNGLSQF DPQDPDRALT LVQSVLTRRQ
410 420 430 440 450
QAVQDLRQQL SGCQEAMSFL QQQHDQWEEE GRALREKLQK LTGERDALAG
460 470 480 490 500
QTVGLQGEVD SLSRERELLQ KARGELQQQL EVLEQEAWRL RRMNMELQLQ
510 520 530 540 550
GDSAQGEKLE QQEELHLAVR ERERLQETLV GLEAKQSESL SELLTLREAL
560 570 580 590 600
ESSRLEGELL KQERVEVAAA LARAEQSIVE LSGSENSLKA EVADLRAAAV
610 620 630 640 650
KLGALNEALA LDKVELNQQL LQLEQENQSL CSRVEAAEQL RSALQVDLAE
660 670 680 690 700
AERRREALWE KKTQLETQLQ KAEEAGAELQ AELRGTREEK EELKDKLSEA
710 720 730 740 750
HHQQETATAH LEQLHQDAER QEETLARAVQ EKEALVRERA ALEVRLQAVE
760 770 780 790 800
RDRQDLTEHV LGLRSAKEQL ESNLFEAQQQ NSVIQVTKGQ LEVQIQTIIQ
810 820 830 840 850
AKEVIQGEVK CLKLELDAER TRAEQEWDAV ARQLAQAEQE GQASLERQKV
860 870 880 890 900
AHEEEVNRLQ EKWEKERSWL QQELDKTLET LERERAELET KLREQQTEME
910 920 930 940 950
AIRAQREEER SQADSALYQM QLETEKERVS LLETLLRTQK ELADASQQLE
960 970 980 990 1000
RLRQDMKIQK LKEQETTGML QAQLQETQQE LKEAAQQHRD DLAAFQKDKL
1010 1020 1030 1040 1050
DLQKQVEDLM SQLVAHDDSQ RLVKEEIEEK VKVAQECSRI QKELEKENAS
1060 1070 1080 1090 1100
LALSLVEKEK RLLILQEADS VRQQELSSLR QDIQEAQEGQ RELGVQVELL
1110 1120 1130 1140 1150
RQEVKEKEAD FVAREAQLLE ELEASRVAEQ QLRASLWAQE AKATQLQLQL
1160 1170 1180 1190 1200
RSTESQLEAL VAEQQPENQA QAQLASLCSV LQQALGSACE SRPELRGGGD
1210 1220 1230 1240 1250
SAPTLWGPDP DQNGASRLFK RWSLPTALSP EAVALALQKL HQDVWKARQA
1260 1270 1280 1290 1300
RDDLRDQVQK LVQRLTDTEA QKSQVHSELQ DLQRQLSQSQ EEKSKWEGRQ
1310 1320 1330 1340 1350
NSLESELRDL HETAASLQSR LRQAELQKME AQNDRELLQA SKEKLSAQVE
1360 1370 1380 1390 1400
HLQACVAEAQ AQADAAAVLE EDLRTARSAL KLKNEELESE RERAQALQEQ
1410 1420 1430 1440 1450
GELKVAQGKA LQENLALLAQ TLSNREREVE TLQAEVQELE KQREMQKAAL
1460 1470 1480 1490 1500
ELLSLDLKKR SREVDLQQEQ IQELEQCRSV LEHLPMAVQE REQKLSVQRD
1510 1520 1530 1540 1550
QIRELENDRE AQRSVLEHQL LDLEQKAQVI ESQRGQIQDL KKQLGTLECL
1560 1570 1580 1590 1600
ALELEESHHK VESQQKMITE LEGQREMQRV ALTHLTLDLE ERSQELQAQS
1610 1620 1630 1640 1650
SQLHELENHS THLAKELQER DQEVTSQRQQ IDELQKQQEQ LAQALERKGQ
1660 1670 1680 1690 1700
ELVLQKERIQ VLEDQRTLQT KILEEDLEQI KHSLRERSQE LASQWQLVHE
1710 1720 1730 1740 1750
RADDGKSPSK GQRGSLEHLK LILRDKEKEV ECQQERIQEL QGHMGQLEQQ
1760 1770 1780 1790 1800
LQGLHRKVGE TSLLLTHREQ ETATLQQHLQ EAKEQGELRE QVLQGQLEEA
1810 1820 1830 1840 1850
QRDLAQRDHE LETLRQEKQQ TQDQEESMKL KTSALQAALE QAHATLKERQ
1860 1870 1880 1890 1900
GELEEHREQV RRLQEELEVE GRQVRALEEV LGDLRAESRE HEKAVLALQQ
1910 1920 1930 1940 1950
RCAEQAQEHE AEARTLQDSW LQAQATLTEQ EQELAALRAE NQYSRRQEEA
1960 1970 1980 1990 2000
AVSQAEALQE ALSKAQAALQ EKEQSLLEQA ELSHTLEAST AALQATLDTC
2010 2020 2030 2040 2050
QASARQLEEA LRIREGEIQA QALQHHEVTQ HLQQELCQKK EELRQLLEKA
2060 2070 2080 2090 2100
GARRSQENGI QEKQSLEQER QEETRRLLES LKELQLTVAQ REEEILMLRE
2110 2120 2130 2140 2150
ASSPRHRALP AEKPALQPLP AQQELERLQT ALRQTEAREI EWREKAQDLA
2160 2170 2180 2190 2200
LSLAQSKASI SSLQEITMFL QASVLERESE QQRLQEELVL SRQALEEQQS
2210 2220 2230 2240 2250
GGPHSTSRAD QGPKVGQGSQ SGEVETEPSP GVEEKERLTQ RLERLQQAVA
2260 2270 2280 2290 2300
ELEVDRSKLQ CHNAQLRTAL EQVERERRKL KRDSVRASRA GSLEARETMT
2310 2320 2330 2340 2350
SSPTQQDGRG SQRGSSDSVL VVELQREVAL LRAQLALERK QRQDYIARSV
2360 2370 2380 2390 2400
QTSRELAGLH HSLSHSLLTV AQAPEATVLE AETRKLDESL NQSLTSPGPC
2410
LLHPSLDTTQ NTHR
Length:2,414
Mass (Da):276,814
Last modified:July 27, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B76E9E781D731CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A3KGJ7A3KGJ7_MOUSE
Centrosome-associated protein CEP25...
Cep250
2,435Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5A8E9Q5A8_MOUSE
Centrosome-associated protein CEP25...
Cep250
2,434Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCN3B7ZCN3_MOUSE
Centrosome-associated protein CEP25...
Cep250
706Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QCB4F6QCB4_MOUSE
Centrosome-associated protein CEP25...
Cep250
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BUJ0F7BUJ0_MOUSE
Centrosome-associated protein CEP25...
Cep250
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BZX9Q8BZX9_MOUSE
Centrosome-associated protein CEP25...
Cep250 Cep2
338Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB41824 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91E → K in BAC32417 (PubMed:16141072).Curated1
Sequence conflicti369S → L in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti424H → R in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti437K → R in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti454G → D in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti508K → R in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti615E → G in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti645Q → R in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti1837A → P in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti1864Q → R in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti1924 – 1925QA → RP in AAB41824 (PubMed:8950169).Curated2
Sequence conflicti1966Q → E in BAE23916 (PubMed:16141072).Curated1
Sequence conflicti1974Q → H in AAH57582 (PubMed:15489334).Curated1
Sequence conflicti2003S → R in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti2003S → R in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti2040K → E in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti2040K → E in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti2105R → S in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti2105R → S in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti2192R → S in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti2218G → E in AAB41824 (PubMed:8950169).Curated1
Sequence conflicti2221S → P in ABA29340 (PubMed:16339073).Curated1
Sequence conflicti2221S → P in AAB41824 (PubMed:8950169).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ148475 mRNA Translation: ABA29340.1
AL833786 Genomic DNA No translation available.
AK045557 mRNA Translation: BAC32417.1
AK139187 mRNA Translation: BAE23916.1
U33198 mRNA Translation: AAB41824.1 Frameshift.
BC057582 mRNA Translation: AAH57582.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS50771.1

NCBI Reference Sequences

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RefSeqi
NP_001123471.1, NM_001129999.1
NP_032409.3, NM_008383.3
NP_796191.2, NM_177217.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000094421; ENSMUSP00000091988; ENSMUSG00000038241

Database of genes from NCBI RefSeq genomes

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GeneIDi
16328

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16328

UCSC genome browser

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UCSCi
uc008nlu.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ148475 mRNA Translation: ABA29340.1
AL833786 Genomic DNA No translation available.
AK045557 mRNA Translation: BAC32417.1
AK139187 mRNA Translation: BAE23916.1
U33198 mRNA Translation: AAB41824.1 Frameshift.
BC057582 mRNA Translation: AAH57582.1
CCDSiCCDS50771.1
RefSeqiNP_001123471.1, NM_001129999.1
NP_032409.3, NM_008383.3
NP_796191.2, NM_177217.3

3D structure databases

SMRiQ60952
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200766, 14 interactors
IntActiQ60952, 8 interactors
STRINGi10090.ENSMUSP00000105248

PTM databases

iPTMnetiQ60952
PhosphoSitePlusiQ60952

Proteomic databases

EPDiQ60952
jPOSTiQ60952
MaxQBiQ60952
PaxDbiQ60952
PeptideAtlasiQ60952
PRIDEiQ60952
ProteomicsDBi283438

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26072, 83 antibodies from 20 providers

Genome annotation databases

EnsembliENSMUST00000094421; ENSMUSP00000091988; ENSMUSG00000038241
GeneIDi16328
KEGGimmu:16328
UCSCiuc008nlu.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11190
MGIiMGI:108084, Cep250
VEuPathDBiHostDB:ENSMUSG00000038241

Phylogenomic databases

eggNOGiENOG502QTBY, Eukaryota
GeneTreeiENSGT00940000161056
InParanoidiQ60952

Enzyme and pathway databases

ReactomeiR-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
16328, 2 hits in 66 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cep250, mouse

Protein Ontology

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PROi
PR:Q60952
RNActiQ60952, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038241, Expressed in retinal neural layer and 175 other tissues
ExpressionAtlasiQ60952, baseline and differential
GenevisibleiQ60952, MM

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP250_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60952
Secondary accession number(s): E9QMB2
, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: February 23, 2022
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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