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Entry version 158 (12 Aug 2020)
Sequence version 3 (27 Jul 2011)
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Protein

TBC1 domain family member 1

Gene

Tbc1d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tbc1d1
Synonyms:Kiaa1108, Tbc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1889508, Tbc1d1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080231 – 1255TBC1 domain family member 1Add BLAST1255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146Phosphoserine1 Publication1
Modified residuei229Phosphoserine; by PKB/AKT11 Publication1
Modified residuei231Phosphoserine; by AMPK1 Publication1
Modified residuei489Phosphoserine; by PKB/AKT11 Publication1
Modified residuei497PhosphoserineCombined sources1 Publication1
Modified residuei499Phosphothreonine; by PKB/AKT11 Publication1
Modified residuei501PhosphoserineCombined sources1 Publication1
Modified residuei519Phosphoserine1 Publication1
Modified residuei521Phosphoserine1 Publication1
Modified residuei559PhosphoserineCombined sources1 Publication1
Modified residuei560PhosphoserineCombined sources1
Modified residuei564PhosphoserineBy similarity1
Modified residuei565Phosphoserine1 Publication1
Modified residuei579PhosphoserineBy similarity1
Modified residuei590PhosphothreonineCombined sources1 Publication1
Modified residuei608Phosphoserine1 Publication1
Modified residuei621Phosphoserine; by PKB/AKT1Combined sources1 Publication1
Modified residuei660PhosphoserineCombined sources1 Publication1
Modified residuei661Phosphoserine1 Publication1
Modified residuei697Phosphoserine; by PKB/AKT11 Publication1
Modified residuei698Phosphoserine1 Publication1
Modified residuei699Phosphoserine1 Publication1
Modified residuei700Phosphoserine; by AMPKCombined sources1 Publication1
Modified residuei782PhosphoserineCombined sources1
Modified residuei1028Phosphoserine1 Publication1
Modified residuei1039Phosphotyrosine1 Publication1
Modified residuei1218Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Insulin-stimulated phosphorylation by AKT family kinases stimulates SLC2A4/GLUT4 translocation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q60949

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60949

PRoteomics IDEntifications database

More...
PRIDEi
Q60949

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q60949

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q60949

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in highest levels in hematopoietic cells, testis and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029174, Expressed in spermatocyte and 267 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q60949, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APPL2 (via BAR domain); interaction is dependent of TBC1D1 phosphorylation at Ser-229; interaction diminishes the phosphorylation of TBC1D1 at Thr-590, resulting in inhibition of SLC2A4/GLUT4 translocation and glucose uptake.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
208365, 2 interactors

Protein interaction database and analysis system

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IntActi
Q60949, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044577

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q60949, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini238 – 398PIDPROSITE-ProRule annotationAdd BLAST161
Domaini887 – 1081Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST195

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4436, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157949

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005350_13_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q60949

KEGG Orthology (KO)

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KOi
K18341

Identification of Orthologs from Complete Genome Data

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OMAi
EVTLIWE

Database of Orthologous Groups

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OrthoDBi
323342at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021785, DUF3350
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11830, DUF3350, 1 hit
PF00640, PID, 1 hit
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462, PTB, 2 hits
SM00164, TBC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179, PID, 1 hit
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60949-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAITFTARK HPFPNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL
60 70 80 90 100
SGQCSKKEPR TKQVRLWVSP SGLRCEPDLE KSQPWDPLIC SSIFECKPQR
110 120 130 140 150
VHKLIHNSHD PSYFACLIKE DAAHRQSLCY VFKADDQTKV PEIISSIRQA
160 170 180 190 200
GKIARQEELR CPSEFDDTFA KKFEVLFCGR VTVAHKKAPP ALIDECIEKF
210 220 230 240 250
NHVSCGRRTD WEAPTGQPSA PGPRPMRKSF SQPGLRSLAF RKEFQDASLR
260 270 280 290 300
SSTFSSFDND IENHLIGGHN VVQPTDMEEN RTMLFTIGQS EVYLISPDTK
310 320 330 340 350
KIALEKNFKE ISFCSQGIRH VDHFGFICRE CSGGGSGGFH FVCYVFQCTN
360 370 380 390 400
EALVDEIMMT LKQAFTVAAV QQTAKAPAQL CEGCPLQGLH KLCERIEGMN
410 420 430 440 450
SSKTKLELQK HLTTLTNQEQ ATIFEEVQKL RPRNEQRENE LIISFLRCLY
460 470 480 490 500
EEKQKEHSHT GEPKQTLQVA AENIGSDLPP SASRFRLDSL KNRAKRSLTE
510 520 530 540 550
SLESILSRGN KARGLQDHSA SVDLDSSTSS TLSNTSKELS MGDKEAFPVS
560 570 580 590 600
ETSFKLLGSS DDLSSDSEGH IAEESALLSP QQAFRRRANT LSHFPVECPA
610 620 630 640 650
PPEPAQSSPG VSQRKLMRYH SVSTETPHER NVDHLPGGES QGCPGQPSAP
660 670 680 690 700
PPPRLNPSAS SPNFFKYLKH NSSGEQSGNA VPKSVSYRNA LRKKLHSSSS
710 720 730 740 750
VPNFLKFLAP VDENNTCDFK NTNRDFESKA NHLGDTDGTP VKTRRHSWRQ
760 770 780 790 800
QIFLRVATPQ KACDSPSRYE DYSELGELPP RSPLEPVCED GPFGPVQEEK
810 820 830 840 850
RKTSRELREL WKKAILQQIL LLRMEKENQK LQASENDLLN KRLKLDYEEI
860 870 880 890 900
TPCLKEVTTV WEKMLSTPGR SKIKFDMEKV HSAVGQGVPR HHRGEIWKFL
910 920 930 940 950
AEQFHLKHPF PSKQQPKDVP YKELLKKLTS QQHAILIDLG RTFPTHPYFS
960 970 980 990 1000
AQLGAGQLSL YNILKAYSLL DQEVGYCQGL SFVAGILLLH MSEEEAFKML
1010 1020 1030 1040 1050
KFLMFDMGLR KQYRPDMIIL QIQMYQLSRL LHDYHRDLYN HLEEHEIGPS
1060 1070 1080 1090 1100
LYAAPWFLTV FASQFPLGFV ARVFDMIFLQ GSEVIFKVAL SLLGSHKPLI
1110 1120 1130 1140 1150
LQHENLETIV DFIKNTLPNL GLVQMEKTIS QVFEMDIAKQ LQAYEVEYHV
1160 1170 1180 1190 1200
LQEELIESSP LSDNQRMEKL EKTNSSLRKQ NLDLLEQLQV ANARIQSLEA
1210 1220 1230 1240 1250
TVEKLLTSES KLKQAALTLE VERSALLQMV EELRRQSARP STPEPDCTQL

EPTGD
Length:1,255
Mass (Da):142,026
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AC3121224B310D2
GO
Isoform 2 (identifier: Q60949-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     631-724: NVDHLPGGES...NTCDFKNTNR → K

Show »
Length:1,162
Mass (Da):132,008
Checksum:iA839A42715918549
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6L4E9Q6L4_MOUSE
TBC1 domain family member 1
Tbc1d1
1,033Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QUA9F6QUA9_MOUSE
TBC1 domain family member 1
Tbc1d1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG72A0A0G2JG72_MOUSE
TBC1 domain family member 1
Tbc1d1
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA85223 differs from that shown. Reason: Frameshift.Curated
The sequence BAC65727 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti174E → K in BAC65727 (PubMed:12693553).Curated1
Sequence conflicti289Q → P in AAA85223 (PubMed:7566974).Curated1
Sequence conflicti462E → A in AAA85223 (PubMed:7566974).Curated1
Sequence conflicti848E → D in AAH04675 (PubMed:15489334).Curated1
Sequence conflicti1047I → T in AAA85223 (PubMed:7566974).Curated1
Sequence conflicti1050 – 1051SL → PT in AAA85223 (PubMed:7566974).Curated2
Sequence conflicti1143A → P in AAH04675 (PubMed:15489334).Curated1
Sequence conflicti1151L → V in AAA85223 (PubMed:7566974).Curated1
Sequence conflicti1176S → T in AAA85223 (PubMed:7566974).Curated1
Sequence conflicti1215A → R in AAA85223 (PubMed:7566974).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008473631 – 724NVDHL…KNTNR → K in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33005 mRNA Translation: AAA85223.1 Frameshift.
AK122445 mRNA Translation: BAC65727.1 Different initiation.
AC131679 Genomic DNA No translation available.
AC132271 Genomic DNA No translation available.
BC004675 mRNA Translation: AAH04675.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39094.1 [Q60949-2]
CCDS80287.1 [Q60949-1]

Protein sequence database of the Protein Information Resource

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PIRi
T29104

NCBI Reference Sequences

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RefSeqi
NP_001297540.1, NM_001310611.1 [Q60949-1]
XP_011239059.1, XM_011240757.2 [Q60949-1]
XP_011239060.1, XM_011240758.2 [Q60949-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043893; ENSMUSP00000044577; ENSMUSG00000029174 [Q60949-1]
ENSMUST00000101195; ENSMUSP00000098756; ENSMUSG00000029174 [Q60949-2]
ENSMUST00000121370; ENSMUSP00000112493; ENSMUSG00000029174 [Q60949-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57915

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:57915

UCSC genome browser

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UCSCi
uc008xmm.2, mouse [Q60949-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33005 mRNA Translation: AAA85223.1 Frameshift.
AK122445 mRNA Translation: BAC65727.1 Different initiation.
AC131679 Genomic DNA No translation available.
AC132271 Genomic DNA No translation available.
BC004675 mRNA Translation: AAH04675.1
CCDSiCCDS39094.1 [Q60949-2]
CCDS80287.1 [Q60949-1]
PIRiT29104
RefSeqiNP_001297540.1, NM_001310611.1 [Q60949-1]
XP_011239059.1, XM_011240757.2 [Q60949-1]
XP_011239060.1, XM_011240758.2 [Q60949-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi208365, 2 interactors
IntActiQ60949, 1 interactor
STRINGi10090.ENSMUSP00000044577

PTM databases

iPTMnetiQ60949
PhosphoSitePlusiQ60949

Proteomic databases

jPOSTiQ60949
PaxDbiQ60949
PRIDEiQ60949

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10398, 201 antibodies

Genome annotation databases

EnsembliENSMUST00000043893; ENSMUSP00000044577; ENSMUSG00000029174 [Q60949-1]
ENSMUST00000101195; ENSMUSP00000098756; ENSMUSG00000029174 [Q60949-2]
ENSMUST00000121370; ENSMUSP00000112493; ENSMUSG00000029174 [Q60949-2]
GeneIDi57915
KEGGimmu:57915
UCSCiuc008xmm.2, mouse [Q60949-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23216
MGIiMGI:1889508, Tbc1d1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG4436, Eukaryota
GeneTreeiENSGT00940000157949
HOGENOMiCLU_005350_13_0_1
InParanoidiQ60949
KOiK18341
OMAiEVTLIWE
OrthoDBi323342at2759
TreeFamiTF317184

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57915, 2 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tbc1d1, mouse

Protein Ontology

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PROi
PR:Q60949
RNActiQ60949, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000029174, Expressed in spermatocyte and 267 other tissues
GenevisibleiQ60949, MM

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR021785, DUF3350
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF11830, DUF3350, 1 hit
PF00640, PID, 1 hit
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 2 hits
SM00164, TBC, 1 hit
SUPFAMiSSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS01179, PID, 1 hit
PS50086, TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBCD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60949
Secondary accession number(s): E9QLW9, Q80TJ9, Q923F8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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