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Protein

Max dimerization protein 4

Gene

Mxd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Max dimerization protein 4
Short name:
Max dimerizer 4
Alternative name(s):
Max-associated protein 4
Max-interacting transcriptional repressor MAD4
Gene namesi
Name:Mxd4
Synonyms:Mad4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104991 Mxd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272671 – 209Max dimerization protein 4Add BLAST209

Proteomic databases

MaxQBiQ60948
PaxDbiQ60948
PRIDEiQ60948

PTM databases

PhosphoSitePlusiQ60948

Expressioni

Developmental stagei

Expressed during neural and epidermal differentiation. Primarily expressed in growth-arrested differentiating cells. In the spinal cord at embryonic day 10.5, a strong expression seen in the differentiating cells of the intermediate zone at the ventral part of the neural tube and weakly in the ventricular zone. At 11.5 and 12.5 dpc, highly expressed in the intermediate zone and at reduced levels in the ventricular zone that mostly persists in the dorsal part of the neural tube. At 14.5 dpc, expressed throughout the spinal cord. In the developing epidermis, expressed in the dermis, hair follicles and in some differentiating cells in the upper layers of the epidermis.1 Publication

Gene expression databases

CleanExiMM_MXD4

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039071

Structurei

3D structure databases

ProteinModelPortaliQ60948
SMRiQ60948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 23Interaction with SIN3A and SIN3B1 PublicationAdd BLAST18

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111V1C LUCA
HOVERGENiHBG006314
InParanoidiQ60948

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q60948-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELNSLLLLL EAAEYLERRD REAEHGYASM LPFDGDFARK KTKTAGLVRK
60 70 80 90 100
GPNNRSSHNE LEKHRRAKLR LYLEQLKQLG PLGPDSTRHT TLSLLKRAKM
110 120 130 140 150
HIKKLEEQDR RALSIKEQLQ REHRFLKRRL EQLSVQSVER VRTDSTGSAV
160 170 180 190 200
STDDSEQEVD IEGMEFGPGE LDSAGSSSDA DDHYSLQSSG CSDSSYGHPC

RRPGCPGLS
Length:209
Mass (Da):23,590
Last modified:November 1, 1996 - v1
Checksum:iC8FB5A56AFE3B27C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91VN7Q91VN7_MOUSE
Max dimerization protein 4
Mxd4
209Annotation score:
Q3UZ22Q3UZ22_MOUSE
Max dimerization protein 4
Mxd4
199Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32395 mRNA Translation: AAB02795.1
CCDSiCCDS19212.1
UniGeneiMm.259260
Mm.391777

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32395 mRNA Translation: AAB02795.1
CCDSiCCDS19212.1
UniGeneiMm.259260
Mm.391777

3D structure databases

ProteinModelPortaliQ60948
SMRiQ60948
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039071

PTM databases

PhosphoSitePlusiQ60948

Proteomic databases

MaxQBiQ60948
PaxDbiQ60948
PRIDEiQ60948

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104991 Mxd4

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111V1C LUCA
HOVERGENiHBG006314
InParanoidiQ60948

Miscellaneous databases

ChiTaRSiMxd4 mouse
PROiPR:Q60948
SOURCEiSearch...

Gene expression databases

CleanExiMM_MXD4

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAD4_MOUSE
AccessioniPrimary (citable) accession number: Q60948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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