UniProtKB - Q60928 (GGT1_MOUSE)

BLAST

>sp|Q60928|GGT1_MOUSE Glutathione hydrolase 1 proenzyme OS=Mus musculus OX=10090 GN=Ggt1 PE=1 SV=1
MKNRFLVLGLVAVVLVFVIIGLCIWLPYTSGKPDHVYSRAAVATDAKRCSEIGRDILQEG
GSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEVINAREVAPRLANTTMFNN
SKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLAIALDKK
RDVIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGAKAFYNGSLTAQIVKDI
QEAGGIMTVEDLNNYRAELIEHPMSIGLGDATLYVPSAPLSGPVLILILNILKGYNFSPK
SVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDE
TTHPAAYYEPEFYLQDDGGTAHLSAVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEM
DDFSSPNFINQFRVAPSPANFIKPGKQPLSSMCPSIILDKDGQVRMVVGASGGTQITTSV
ALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKDIDQVVTAGLKIRHHHTEVTPTFI
AVVQAVVRASGGWAAASDSRKGGEPAGY

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History
Entry version 158 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Glutathione hydrolase 1 proenzyme

Gene

Ggt1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Indirectly regulates multiple aspects of skeletal biology.1 Publication

Catalytic activityⁱ

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.By similarity

Glutathione + H₂O = L-cysteinylglycine + L-glutamate.By similarity

Leukotriene C₄ + H₂O = leukotriene D₄ + L-glutamate.By similarity

Activity regulationⁱ

Activated by autocatalytic cleavage.By similarity

Pathwayⁱ: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	106	GlutamateBy similarity	1
Active siteⁱ	380	NucleophileBy similarity	1
Binding siteⁱ	398	GlutamateBy similarity	1
Binding siteⁱ	419	GlutamateBy similarity	1

GO - Molecular functionⁱ

glutathione hydrolase activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 20622017
hypoglycin A gamma-glutamyl transpeptidase activity Source: UniProtKB-EC
leukotriene-C(4) hydrolase Source: MGI
leukotriene C4 gamma-glutamyl transferase activity Source: UniProtKB-EC
peptidyltransferase activity Source: MGI
transferase activity, transferring amino-acyl groups Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular amino acid metabolic process Source: MGI
cysteine biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12468440
fatty acid metabolic process Source: MGI
glutamate metabolic process Source: UniProtKB
glutathione biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12468440
glutathione catabolic process Source: UniProtKB
glutathione metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
leukotriene D4 biosynthetic process Source: MGI
peptide modification Source: MGI
proteolysis Source: MGI
regulation of immune system process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12468440
regulation of inflammatory response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12468440
response to estradiol
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to tumor necrosis factor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
spermatogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 9139708
zymogen activation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Hydrolase, Protease, Transferase
Biological process	Glutathione biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-174403 Glutathione synthesis and recycling R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-MMU-5423646 Aflatoxin activation and detoxification
UniPathwayⁱ	UPA00204

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutathione hydrolase 1 proenzyme (EC:3.4.19.13By similarity) Alternative name(s): Gamma-glutamyltransferase 1 Gamma-glutamyltranspeptidase 1 (EC:2.3.2.2By similarity) Short name: GGT 1 Leukotriene-C4 hydrolase (EC:3.4.19.14By similarity) CD_antigen: CD224 Cleaved into the following 2 chains: Glutathione hydrolase 1 heavy chain Glutathione hydrolase 1 light chain
Gene namesⁱ	Name:Ggt1 Synonyms:Ggt, Ggtp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:95706 Ggt1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 4	CytoplasmicSequence analysis	4
Transmembraneⁱ	5 – 26	Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST	22
Topological domainⁱ	27 – 568	ExtracellularSequence analysisAdd BLAST	542

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in Ggt1 are a cause of glutathionuria, severe growth failure, reduced life spans and infertility. Ggt1-deficient mice have multiple metabolic abnormalities and are dwarf. Some abnormalities can be ameliorated by N-acetylcysteine treatment.2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000011060	1 – 379	Glutathione hydrolase 1 heavy chainAdd BLAST		379
ChainⁱPRO_0000011061	380 – 568	Glutathione hydrolase 1 light chainAdd BLAST		189

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 73	By similarity
Glycosylationⁱ	94	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	191 ↔ 195	By similarity
Glycosylationⁱ	229	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	343	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	510	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

N-glycosylated on both chains.By similarity

Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q60928
PaxDbⁱ	Q60928
PRIDEⁱ	Q60928
TopDownProteomicsⁱ	Q60928

PTM databases

iPTMnetⁱ	Q60928
PhosphoSitePlusⁱ	Q60928

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000006345 Expressed in 126 organ(s), highest expression level in jejunum
CleanExⁱ	MM_GGT1
ExpressionAtlasⁱ	Q60928 baseline and differential
Genevisibleⁱ	Q60928 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer composed of the light and heavy chains. The active site is located in the light chain.By similarity

Protein-protein interaction databases

IntActⁱ	Q60928, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q60928
STRINGⁱ	10090.ENSMUSP00000006508

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q60928
SMRⁱ	Q60928
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	450 – 451	Glutamate bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2410 Eukaryota COG0405 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074591
HOGENOMⁱ	HOG000175620
HOVERGENⁱ	HBG005835
InParanoidⁱ	Q60928
KEGG Orthology (KO) More...KOⁱ	K18592
OMAⁱ	TKNMFLD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03Y3
PhylomeDBⁱ	Q60928
TreeFamⁱ	TF313608

Family and domain databases

InterProⁱ	View protein in InterPro IPR000101 GGT_peptidase IPR029055 Ntn_hydrolases_N
PANTHERⁱ	PTHR11686 PTHR11686, 1 hit
SUPFAMⁱ	SSF56235 SSF56235, 1 hit
TIGRFAMsⁱ	TIGR00066 g_glut_trans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00462 G_GLU_TRANSPEPTIDASE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show all Align All

Q60928-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKNRFLVLGL VAVVLVFVII GLCIWLPYTS GKPDHVYSRA AVATDAKRCS 
        60         70         80         90        100
EIGRDILQEG GSVVDAAIAS LLCMGLMNAH SMGIGGGLFF TIYNSTTGKV 
       110        120        130        140        150
EVINAREVAP RLANTTMFNN SKDSEEGGLS VAVPGEIRGY ELAHQRHGRL 
       160        170        180        190        200
PWARLFQPSI QLARHGFPVG KGLAIALDKK RDVIEKTPAL CEVFCRQGKV 
       210        220        230        240        250
LQEGETVTMP KLADTLQILA QEGAKAFYNG SLTAQIVKDI QEAGGIMTVE 
       260        270        280        290        300
DLNNYRAELI EHPMSIGLGD ATLYVPSAPL SGPVLILILN ILKGYNFSPK 
       310        320        330        340        350
SVATPEQKAL TYHRIVEAFR FAYAKRTMLG DPKFVDVSQV IRNMSSEFYA 
       360        370        380        390        400
TQLRARITDE TTHPAAYYEP EFYLQDDGGT AHLSAVSEDG SAVAATSTIN 
       410        420        430        440        450
LYFGSKVLSR VSGILFNDEM DDFSSPNFIN QFRVAPSPAN FIKPGKQPLS 
       460        470        480        490        500
SMCPSIILDK DGQVRMVVGA SGGTQITTSV ALAIINSLWF GYDVKRAVEE 
       510        520        530        540        550
PRLHNQLLPN TTTVEKDIDQ VVTAGLKIRH HHTEVTPTFI AVVQAVVRAS 
       560 
GGWAAASDSR KGGEPAGY

Length:568

Mass (Da):61,563

Last modified:November 1, 1996 - v1

Checksum:ⁱ293C6E224FDC0766

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	D3Z266	D3Z266_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	243	Annotation score:
	D3YVY4	D3YVY4_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	237	Annotation score:
	D3YWW2	D3YWW2_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	189	Annotation score:
	D3YWW4	D3YWW4_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	190	Annotation score:
	D3Z4Q6	D3Z4Q6_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	235	Annotation score:
	D3YVX1	D3YVX1_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	88	Annotation score:
	D3YY79	D3YY79_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	209	Annotation score:
	D3Z2C6	D3Z2C6_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	60	Annotation score:
	D3YXV6	D3YXV6_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	126	Annotation score:
	D3YYH6	D3YYH6_MOUSE	Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme	Ggt1	110	Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30509 mRNA Translation: AAA97395.1 BC012969 mRNA Translation: AAH12969.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23927.1
PIRⁱ	JC4570
NCBI Reference Sequences More...RefSeqⁱ	NP_001292921.1, NM_001305992.1 NP_032142.1, NM_008116.3 XP_006513293.1, XM_006513230.3 XP_006513294.1, XM_006513231.3
UniGeneⁱ	Mm.4559 Mm.486584

Genome annotation databases

Ensemblⁱ	ENSMUST00000006508; ENSMUSP00000006508; ENSMUSG00000006345 ENSMUST00000134503; ENSMUSP00000121312; ENSMUSG00000006345
GeneIDⁱ	14598
KEGGⁱ	mmu:14598
UCSC genome browser More...UCSCⁱ	uc007fqo.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q60928	Gamma-glutamyltransferase 1, isoform CRA_a		MOUSE		568	UniRef100_Q60928
Glutathione hydrolase 1 proenzyme (Fragment)		MOUSE		235
Glutathione hydrolase 1 proenzyme (Fragment)		MOUSE		243
Glutathione hydrolase 1 proenzyme (Fragment)		MOUSE		237
Glutathione hydrolase 1 proenzyme (Fragment)		MOUSE		209
+2

Protein	Similar proteins		Species	Score	Length	Source
Q60928	Gamma-glutamyltransferase 1, isoform CRA_a		MOUSE		568	UniRef90_Q60928
UPI000A311A81		MUSPA		573
UPI000A314CE9		MUSCR		573
Glutathione hydrolase 1 proenzyme (Fragment)		MOUSE		235
Glutathione hydrolase 1 proenzyme (Fragment)		MOUSE		243
+10

Protein	Similar proteins		Species	Score	Length	Source
Q60928	Glutathione hydrolase 1 proenzyme	)	HUMAN		569	UniRef50_P19440
Glutathione hydrolase 1 proenzyme		PIG		568
Glutathione hydrolase 1 proenzyme		RAT		568
GGT1 isoform 21		PANTR		225
Uncharacterized protein		MACMU		569
+541

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30509 mRNA Translation: AAA97395.1 BC012969 mRNA Translation: AAH12969.1
CCDSⁱ	CCDS23927.1
PIRⁱ	JC4570
RefSeqⁱ	NP_001292921.1, NM_001305992.1 NP_032142.1, NM_008116.3 XP_006513293.1, XM_006513230.3 XP_006513294.1, XM_006513231.3
UniGeneⁱ	Mm.4559 Mm.486584

3D structure databases

ProteinModelPortalⁱ	Q60928
SMRⁱ	Q60928
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q60928, 2 interactors
MINTⁱ	Q60928
STRINGⁱ	10090.ENSMUSP00000006508

PTM databases

iPTMnetⁱ	Q60928
PhosphoSitePlusⁱ	Q60928

Proteomic databases

MaxQBⁱ	Q60928
PaxDbⁱ	Q60928
PRIDEⁱ	Q60928
TopDownProteomicsⁱ	Q60928

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006508; ENSMUSP00000006508; ENSMUSG00000006345 ENSMUST00000134503; ENSMUSP00000121312; ENSMUSG00000006345
GeneIDⁱ	14598
KEGGⁱ	mmu:14598
UCSCⁱ	uc007fqo.2 mouse

Organism-specific databases

CTDⁱ	2678
MGIⁱ	MGI:95706 Ggt1

Phylogenomic databases

eggNOGⁱ	KOG2410 Eukaryota COG0405 LUCA
GeneTreeⁱ	ENSGT00550000074591
HOGENOMⁱ	HOG000175620
HOVERGENⁱ	HBG005835
InParanoidⁱ	Q60928
KOⁱ	K18592
OMAⁱ	TKNMFLD
OrthoDBⁱ	EOG091G03Y3
PhylomeDBⁱ	Q60928
TreeFamⁱ	TF313608

Enzyme and pathway databases

UniPathwayⁱ	UPA00204
Reactomeⁱ	R-MMU-174403 Glutathione synthesis and recycling R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-MMU-5423646 Aflatoxin activation and detoxification

Miscellaneous databases

ChiTaRSⁱ	Ggt1 mouse
Protein Ontology More...PROⁱ	PR:Q60928
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000006345 Expressed in 126 organ(s), highest expression level in jejunum
CleanExⁱ	MM_GGT1
ExpressionAtlasⁱ	Q60928 baseline and differential
Genevisibleⁱ	Q60928 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000101 GGT_peptidase IPR029055 Ntn_hydrolases_N
PANTHERⁱ	PTHR11686 PTHR11686, 1 hit
SUPFAMⁱ	SSF56235 SSF56235, 1 hit
TIGRFAMsⁱ	TIGR00066 g_glut_trans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00462 G_GLU_TRANSPEPTIDASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GGT1_MOUSE
Accessionⁱ	Q60928Primary (citable) accession number: Q60928
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q60928 (GGT1_MOUSE)

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Glutathione hydrolase 1 proenzyme

Ggt1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glutathione metabolism

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: glutathione metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ