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Protein

D site-binding protein

Gene

Dbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity).By similarity

Miscellaneous

Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

GO - Molecular functioni

GO - Biological processi

  • circadian rhythm Source: MGI
  • liver development Source: Ensembl
  • multicellular organism development Source: GO_Central
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Gene namesi
Name:Dbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:94866 Dbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765081 – 325D site-binding proteinAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ60925
PRIDEiQ60925

PTM databases

iPTMnetiQ60925
PhosphoSitePlusiQ60925
SwissPalmiQ60925

Expressioni

Tissue specificityi

Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Inductioni

Accumulates according to a robust circadian rhythm in liver and kidney. In liver nuclei, the amplitude of daily oscillation has been estimated to be >50-fold, and 2-fold in the brain.

Gene expression databases

BgeeiENSMUSG00000059824
CleanExiMM_DBP
ExpressionAtlasiQ60925 baseline and differential
GenevisibleiQ60925 MM

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF (By similarity).By similarity

Protein-protein interaction databases

BioGridi199060, 7 interactors
STRINGi10090.ENSMUSP00000079693

Structurei

3D structure databases

ProteinModelPortaliQ60925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 318bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 279Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni283 – 297Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 135Poly-Pro7
Compositional biasi156 – 161Poly-Ser6
Compositional biasi188 – 239Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated

Phylogenomic databases

eggNOGiENOG410KDK1 Eukaryota
ENOG410YAPB LUCA
GeneTreeiENSGT00440000039070
HOGENOMiHOG000234383
HOVERGENiHBG004983
InParanoidiQ60925
KOiK09056
OMAiYQAQHGT
OrthoDBiEOG091G0EO0
PhylomeDBiQ60925
TreeFamiTF315869

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029830 DBP
PANTHERiPTHR11988:SF7 PTHR11988:SF7, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q60925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK
60 70 80 90 100
EKERKATLPS APVPGPGLET AGPADAPSGA VSGGGSPRGR SGPVAGPSLF
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP
160 170 180 190 200
SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGTL
Length:325
Mass (Da):34,380
Last modified:May 10, 2004 - v2
Checksum:iB2B2A3E091845A16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60S → T in AAA73924 (Ref. 1) Curated1
Sequence conflicti109L → F in AAA73924 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29762 Genomic DNA Translation: AAA73924.1
BC018323 mRNA Translation: AAH18323.1
CCDSiCCDS21260.1
RefSeqiNP_058670.2, NM_016974.3
UniGeneiMm.24222
Mm.378235

Genome annotation databases

EnsembliENSMUST00000080885; ENSMUSP00000079693; ENSMUSG00000059824
GeneIDi13170
KEGGimmu:13170
UCSCiuc009gws.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDBP_MOUSE
AccessioniPrimary (citable) accession number: Q60925
Secondary accession number(s): Q8VCX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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