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Entry version 178 (18 Sep 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Epidermal growth factor receptor substrate 15-like 1

Gene

Eps15l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi172 – 183PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-182971 EGFR downregulation
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epidermal growth factor receptor substrate 15-like 1
Alternative name(s):
Epidermal growth factor receptor pathway substrate 15-related sequence
Short name:
Eps15-rs
Eps15-related protein
Short name:
Eps15R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eps15l1
Synonyms:Eps15-rs, Eps15R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104582 Eps15l1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001461192 – 907Epidermal growth factor receptor substrate 15-like 1Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei74PhosphotyrosineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei229PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei259PhosphoserineBy similarity1
Modified residuei360PhosphoserineCombined sources1
Modified residuei364PhosphothreonineCombined sources1
Modified residuei369PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei558PhosphoserineBy similarity1
Modified residuei562PhosphotyrosineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei664PhosphoserineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei695PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei791PhosphoserineBy similarity1
Modified residuei795PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by EGFR.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q60902

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q60902

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60902

PeptideAtlas

More...
PeptideAtlasi
Q60902

PRoteomics IDEntifications database

More...
PRIDEi
Q60902

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q60902

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q60902

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000006276 Expressed in 241 organ(s), highest expression level in primary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60902 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q60902 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2).

Interacts with FCHO1 (By similarity).

Interacts with FCHO2.

Interacts (via EH domains) with DAB2.

Interacts with UBQLN1 (via ubiquitin-like domain).

Interacts with CAVIN3 (via leucine-zipper domain) (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
199490, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q60902, 10 interactors

Molecular INTeraction database

More...
MINTi
Q60902

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000129739

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q60902

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 104EH 1PROSITE-ProRule annotationAdd BLAST90
Domaini127 – 215EH 2PROSITE-ProRule annotationAdd BLAST89
Domaini159 – 194EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini273 – 363EH 3PROSITE-ProRule annotationAdd BLAST91
Domaini863 – 882UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini889 – 907UIM 2PROSITE-ProRule annotationAdd BLAST19

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 368Interaction with DAB21 PublicationAdd BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili384 – 551Sequence analysisAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi748 – 848Pro-richAdd BLAST101

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0998 Eukaryota
ENOG410XTDR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155438

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004804

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q60902

KEGG Orthology (KO)

More...
KOi
K12472

Identification of Orthologs from Complete Genome Data

More...
OMAi
QELHTDP

Database of Orthologous Groups

More...
OrthoDBi
597979at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324293

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052 EH, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR003903 UIM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12763 EF-hand_4, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits
SM00027 EH, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
PS50031 EH, 3 hits
PS50330 UIM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60902-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD
60 70 80 90 100
IILGKIWDLA DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP
110 120 130 140 150
PKFHDTSSPL MATQSSAETH WAVRVEEKAK FDGIFESLLP VNGLLSGDKV
160 170 180 190 200
KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD RDEFAVAMHL VYRALEKEPV
210 220 230 240 250
PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP SHGSVSSLNS
260 270 280 290 300
TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI
310 320 330 340 350
FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ
360 370 380 390 400
VLSPDMVPPS ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS
410 420 430 440 450
LEQDIREKEE AIRQKTSEVQ ELQNDLDRET SSLQELEAQK QDAQDRLDEM
460 470 480 490 500
DQQKAKLRDM LSDVRQKCQD ETQTISSLKT QIQSQESDLK SQEDDLNRAK
510 520 530 540 550
SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ ARSKLSQLQE
560 570 580 590 600
SHLEAHRSLE QYDQVPDGVS GTSLPDLATL NEGILLAERG GFGAMDDPFK
610 620 630 640 650
NKALLFSNNS QELHPDPFQA EDPFKSDPFK GADPFKGDPF QSDPFSEQQT
660 670 680 690 700
AATDPFGGDP FKESDPFHSS SSDDFFKKQT KNDPFTSDPF TKNPSLPSKL
710 720 730 740 750
DPFESSDPFS SSSISSKGSD PFGTLDPFGS SSFSSAEGFA DFSQMSKPPP
760 770 780 790 800
SGPFSSSLGG TGFSDDPFKS KQDTPALPPK KPAPPRPKPP SGQSTPVSQL
810 820 830 840 850
GSSDFPESPD PFQPLGADSG DPFQNKKGFG DPFSGKDPFA PSSSAKPPKT
860 870 880 890 900
SSSGFADFTS FGNEEQQLAW AKRESEKAEQ ERLARLRRQE QEDLELAIAL

SKADMPA
Length:907
Mass (Da):99,309
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5AF1A89B445E8A7
GO
Isoform 2 (identifier: Q60902-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     794-819: STPVSQLGSSDFPESPDPFQPLGADS → YASSSRGTRRWGQGGGHRAPPLSSPE
     820-907: Missing.

Show »
Length:819
Mass (Da):89,728
Checksum:iD46667729E593945
GO
Isoform 3 (identifier: Q60902-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-599: DDPF → VKVE
     600-819: Missing.

Show »
Length:687
Mass (Da):75,877
Checksum:iF30E20D19F47A4DA
GO
Isoform 4 (identifier: Q60902-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     565-595: Missing.
     748-860: Missing.

Note: No experimental confirmation available.
Show »
Length:763
Mass (Da):84,752
Checksum:i1739157C3A8045B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLS1A0A1D5RLS1_MOUSE
Epidermal growth factor receptor su...
Eps15l1
599Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14G → S in AAA87202 (PubMed:7568168).Curated1
Sequence conflicti14G → S in AAH15259 (PubMed:15489334).Curated1
Sequence conflicti29A → P in AAA87202 (PubMed:7568168).Curated1
Sequence conflicti170L → V in BAE31350 (PubMed:16141072).Curated1
Sequence conflicti413R → K in AAA87202 (PubMed:7568168).Curated1
Sequence conflicti413R → K in AAH15259 (PubMed:15489334).Curated1
Sequence conflicti726D → H in BAC29523 (PubMed:16141072).Curated1
Sequence conflicti821D → E in AAA87202 (PubMed:7568168).Curated1
Sequence conflicti850T → A in AAA87202 (PubMed:7568168).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022638565 – 595Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_010681596 – 599DDPF → VKVE in isoform 3. 2 Publications4
Alternative sequenceiVSP_010682600 – 819Missing in isoform 3. 2 PublicationsAdd BLAST220
Alternative sequenceiVSP_022639748 – 860Missing in isoform 4. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_010683794 – 819STPVS…LGADS → YASSSRGTRRWGQGGGHRAP PLSSPE in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_010684820 – 907Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U29156 mRNA Translation: AAA87202.1
AK036662 mRNA Translation: BAC29523.1
AK036728 mRNA Translation: BAC29554.1
AK146781 mRNA Translation: BAE27427.1
AK152602 mRNA Translation: BAE31350.1
CH466525 Genomic DNA Translation: EDL10796.1
BC015259 mRNA Translation: AAH15259.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52597.1 [Q60902-1]
CCDS85561.1 [Q60902-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001116304.1, NM_001122832.1
NP_001276788.1, NM_001289859.1 [Q60902-4]
NP_031970.2, NM_007944.3 [Q60902-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000163643; ENSMUSP00000129739; ENSMUSG00000006276 [Q60902-1]
ENSMUST00000212121; ENSMUSP00000148468; ENSMUSG00000006276 [Q60902-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
13859

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13859

UCSC genome browser

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UCSCi
uc009mfr.3 mouse [Q60902-1]
uc009mfs.3 mouse [Q60902-4]
uc009mft.2 mouse [Q60902-2]
uc009mfu.2 mouse [Q60902-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29156 mRNA Translation: AAA87202.1
AK036662 mRNA Translation: BAC29523.1
AK036728 mRNA Translation: BAC29554.1
AK146781 mRNA Translation: BAE27427.1
AK152602 mRNA Translation: BAE31350.1
CH466525 Genomic DNA Translation: EDL10796.1
BC015259 mRNA Translation: AAH15259.1
CCDSiCCDS52597.1 [Q60902-1]
CCDS85561.1 [Q60902-4]
RefSeqiNP_001116304.1, NM_001122832.1
NP_001276788.1, NM_001289859.1 [Q60902-4]
NP_031970.2, NM_007944.3 [Q60902-1]

3D structure databases

SMRiQ60902
ModBaseiSearch...

Protein-protein interaction databases

BioGridi199490, 10 interactors
IntActiQ60902, 10 interactors
MINTiQ60902
STRINGi10090.ENSMUSP00000129739

PTM databases

iPTMnetiQ60902
PhosphoSitePlusiQ60902

Proteomic databases

EPDiQ60902
jPOSTiQ60902
PaxDbiQ60902
PeptideAtlasiQ60902
PRIDEiQ60902

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163643; ENSMUSP00000129739; ENSMUSG00000006276 [Q60902-1]
ENSMUST00000212121; ENSMUSP00000148468; ENSMUSG00000006276 [Q60902-4]
GeneIDi13859
KEGGimmu:13859
UCSCiuc009mfr.3 mouse [Q60902-1]
uc009mfs.3 mouse [Q60902-4]
uc009mft.2 mouse [Q60902-2]
uc009mfu.2 mouse [Q60902-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58513
MGIiMGI:104582 Eps15l1

Phylogenomic databases

eggNOGiKOG0998 Eukaryota
ENOG410XTDR LUCA
GeneTreeiENSGT00940000155438
HOGENOMiHOG000004804
InParanoidiQ60902
KOiK12472
OMAiQELHTDP
OrthoDBi597979at2759
TreeFamiTF324293

Enzyme and pathway databases

ReactomeiR-MMU-182971 EGFR downregulation
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Eps15l1 mouse

Protein Ontology

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PROi
PR:Q60902

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000006276 Expressed in 241 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ60902 baseline and differential
GenevisibleiQ60902 MM

Family and domain databases

CDDicd00052 EH, 3 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR003903 UIM_dom
PfamiView protein in Pfam
PF12763 EF-hand_4, 3 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00027 EH, 3 hits
SUPFAMiSSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
PS50031 EH, 3 hits
PS50330 UIM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEP15R_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60902
Secondary accession number(s): Q3U7L9
, Q3UIS9, Q8CB60, Q8CB70, Q91WH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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