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Protein

ELAV-like protein 2

Gene

Elavl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
ELAV-like neuronal protein 1
Hu-antigen B
Short name:
HuB
Nervous system-specific RNA-binding protein Mel-N1
Gene namesi
Name:Elavl2
Synonyms:Hub
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1100887 Elavl2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815801 – 360ELAV-like protein 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60899
PaxDbiQ60899
PRIDEiQ60899

PTM databases

iPTMnetiQ60899
PhosphoSitePlusiQ60899

Expressioni

Tissue specificityi

Brain; neural-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000008489 Expressed in 244 organ(s), highest expression level in superior cervical ganglion
ExpressionAtlasiQ60899 baseline and differential
GenevisibleiQ60899 MM

Interactioni

Subunit structurei

Interacts with IGF2BP1.By similarity

Protein-protein interaction databases

BioGridi200483, 4 interactors
IntActiQ60899, 4 interactors
MINTiQ60899
STRINGi10090.ENSMUSP00000099863

Structurei

3D structure databases

ProteinModelPortaliQ60899
SMRiQ60899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini277 – 355RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ60899
KOiK13208

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q60899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METQLSNGPT CNNTANGPTT VNNNCSSPVD SGNTEDSKTN LIVNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
SRFSPMTIDG MTSLAGINIP GHPGTGWCIF VYNLAPDADE SILWQMFGPF
310 320 330 340 350
GAVTNVKVIR DFNTNKCKGF GFVTMTNYDE AAMAIASLNG YRLGDRVLQV
360
SFKTNKTHKA
Length:360
Mass (Da):39,577
Last modified:November 1, 1996 - v1
Checksum:i780CDD07F2E97D74
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AXZ5B1AXZ5_MOUSE
ELAV-like protein
Elavl2
389Annotation score:
B1AXZ4B1AXZ4_MOUSE
ELAV-like protein
Elavl2
388Annotation score:
Q80Y51Q80Y51_MOUSE
ELAV-like protein
Elavl2
373Annotation score:
Q80UJ0Q80UJ0_MOUSE
ELAV-like protein
Elavl2
347Annotation score:
Q3UR02Q3UR02_MOUSE
ELAV-like protein
Elavl2
359Annotation score:
B1AXZ0B1AXZ0_MOUSE
ELAV-like protein
Elavl2
346Annotation score:
B1AXZ6B1AXZ6_MOUSE
ELAV-like protein
Elavl2
376Annotation score:
H3BLG7H3BLG7_MOUSE
ELAV-like protein 2
Elavl2
125Annotation score:
B1AXZ3B1AXZ3_MOUSE
ELAV-like protein 2
Elavl2
83Annotation score:
H3BJL9H3BJL9_MOUSE
ELAV-like protein 2
Elavl2
23Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29088 mRNA Translation: AAC52644.1
CCDSiCCDS18355.1
PIRiJC6057
RefSeqiNP_034616.1, NM_010486.2
XP_006502852.1, XM_006502789.2
XP_006502853.1, XM_006502790.2
XP_006502854.1, XM_006502791.2
UniGeneiMm.318042

Genome annotation databases

EnsembliENSMUST00000008633; ENSMUSP00000008633; ENSMUSG00000008489
GeneIDi15569
KEGGimmu:15569
UCSCiuc008ton.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29088 mRNA Translation: AAC52644.1
CCDSiCCDS18355.1
PIRiJC6057
RefSeqiNP_034616.1, NM_010486.2
XP_006502852.1, XM_006502789.2
XP_006502853.1, XM_006502790.2
XP_006502854.1, XM_006502791.2
UniGeneiMm.318042

3D structure databases

ProteinModelPortaliQ60899
SMRiQ60899
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200483, 4 interactors
IntActiQ60899, 4 interactors
MINTiQ60899
STRINGi10090.ENSMUSP00000099863

PTM databases

iPTMnetiQ60899
PhosphoSitePlusiQ60899

Proteomic databases

MaxQBiQ60899
PaxDbiQ60899
PRIDEiQ60899

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008633; ENSMUSP00000008633; ENSMUSG00000008489
GeneIDi15569
KEGGimmu:15569
UCSCiuc008ton.2 mouse

Organism-specific databases

CTDi1993
MGIiMGI:1100887 Elavl2

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ60899
KOiK13208

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q60899
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008489 Expressed in 244 organ(s), highest expression level in superior cervical ganglion
ExpressionAtlasiQ60899 baseline and differential
GenevisibleiQ60899 MM

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiELAV2_MOUSE
AccessioniPrimary (citable) accession number: Q60899
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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