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Protein

Rho guanine nucleotide exchange factor 2

Gene

Arhgef2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 86Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Guanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Differentiation, Immunity, Innate immunity, Mitosis, Neurogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 2
Alternative name(s):
Guanine nucleotide exchange factor H1
Short name:
GEF-H1
LBC'S first cousin
Lymphoid blast crisis-like 1
Oncogene LFC
Rhobin
Gene namesi
Name:Arhgef2
Synonyms:Kiaa0651, Lbcl1, Lfc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:103264 Arhgef2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Microtubule, Tight junction

Pathology & Biotechi

Disruption phenotypei

Mice show reduced volume of the total brain, the cerebellum and the brainstem. Show complete lack of precerebellar pontin gray and reticulotegmental nuclei. Show impaired precerebellar neuron migration.1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809101 – 985Rho guanine nucleotide exchange factor 2Add BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei143Phosphoserine; by PAK4By similarity1
Modified residuei151PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei177PhosphoserineBy similarity1
Modified residuei354N6-acetyllysineBy similarity1
Modified residuei646PhosphoserineCombined sources1
Modified residuei649PhosphoserineBy similarity1
Modified residuei680Phosphothreonine; by MAPK1 or MAPK3By similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei710PhosphoserineBy similarity1
Modified residuei781PhosphoserineCombined sources1
Modified residuei795PhosphothreonineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei893PhosphotyrosineBy similarity1
Modified residuei895Phosphoserine; by PAK4By similarity1
Modified residuei931PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei944PhosphothreonineCombined sources1
Modified residuei946PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1
Modified residuei952PhosphoserineCombined sources1
Modified residuei955PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of Ser-885 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ60875
PeptideAtlasiQ60875
PRIDEiQ60875

PTM databases

iPTMnetiQ60875
PhosphoSitePlusiQ60875
SwissPalmiQ60875

Expressioni

Tissue specificityi

Ubiquitous, with the exception of liver tissue. Levels are high in hemopoietic tissues (thymus, spleen, bone marrow) as well as in kidney and lung. Expressed in the germinal zones of both the neocortex and the cerebellum and in the pontine gray nuclei (PubMed:28453519).1 Publication

Developmental stagei

Expressed in the neuroepithelium of telencephalon, diencephalon and rhombencephalon at 11 dpc (PubMed:28453519).1 Publication

Gene expression databases

BgeeiENSMUSG00000028059 Expressed in 260 organ(s), highest expression level in fibroblast
ExpressionAtlasiQ60875 baseline and differential
GenevisibleiQ60875 MM

Interactioni

Subunit structurei

Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-885. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1 (By similarity). Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ksr1Q610975EBI-772191,EBI-1536336

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201114, 13 interactors
IntActiQ60875, 15 interactors
MINTiQ60875
STRINGi10090.ENSMUSP00000029694

Structurei

Secondary structure

1985
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ60875
SMRiQ60875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 433DHPROSITE-ProRule annotationAdd BLAST198
Domaini473 – 572PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 161Interaction with DYNLT1By similarityAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili591 – 619Sequence analysisAdd BLAST29
Coiled coili797 – 866Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi493 – 496Poly-Leu4

Domaini

The DH (DBL-homology) domain promotes tyrosine phosphorylation of RIPK2 (By similarity). The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA.By similarity
The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes.By similarity
The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 86Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR0Y Eukaryota
ENOG410XT68 LUCA
GeneTreeiENSGT00760000119193
HOVERGENiHBG050566
InParanoidiQ60875
KOiK12791
OrthoDBiEOG091G00G7
TreeFamiTF325887

Family and domain databases

CDDicd00029 C1, 1 hit
cd13393 PH_ARHGEF2, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037806 ARHGEF2_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60875-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRIESLTRA RIDRSKEQAT KTREKEKMKE AKDARYTNGH LFTTISVSGM
60 70 80 90 100
TMCYACNKSI TAKEALICPT CNVTIHNRCK DTLANCTKVK QKQQKAALLR
110 120 130 140 150
NNTALQSVSL RSKTTTRERP TSAIYPSDSF RQSLLGSRRG LSSLSLAKSV
160 170 180 190 200
STTNIAGHFN DESPLGLRQI LSQSTDSLNM RNRTLSVESL IDEGVEVFYN
210 220 230 240 250
ELMSDFEMDE KDFEADSWSL AVDSSFLQQH KKEVMKKQDV IYELIQTELH
260 270 280 290 300
HVRTLKIMTR LFRTGMLEEL QMEPEVVQGL FPCVDELSDI HTRFLNQLLE
310 320 330 340 350
RRRQALCPGS TRNFVIHRLG DLLISQFSGS NAEQMRKTYS EFCSRHTKAL
360 370 380 390 400
KLYKELYARD KRFQQFIRKM TRSAVLKRHG VQECILLVTQ RITKYPVLIN
410 420 430 440 450
RILQNSHGVE EEYQDLASAL GLVKELLSNV DQDVHELEKE ARLQEIYNRM
460 470 480 490 500
DPRAQTPVPG KGPFGRDELL RRKLIHEGCL LWKTATGRFK DVLLLLMTDV
510 520 530 540 550
LVFLQEKDQK YIFTSLDKPS VVSLQNLIVR DIANQAKGMF LISSGPPEMY
560 570 580 590 600
EVHAASRDDR TTWIRVIQQS VRLCPSREDF PLIETEDKAY LRRIKTKLQQ
610 620 630 640 650
KNQALVELLQ KNVELFAEMV HFQALKAGFV GMPPPALPRG LFRLESFESL
660 670 680 690 700
RGERLLKDAL REVEGLKDLL LGPCVDLPMT SREPALPLDS DSGSCPGVTA
710 720 730 740 750
NGEARTFNGS IELCRADSDS SQKDRNGNQL RSPQEEVLQP LINLYGLLHG
760 770 780 790 800
LQAVVVQQER LMEALFPEGP ERWEKLSRAN SRDGEAGRAA VASVTPEKQA
810 820 830 840 850
TELALLQRQH TLLQEELRRC QRLGEERATE AGSLEARLRE SEQARALLER
860 870 880 890 900
EAEEIRRQLA ALGQNEPLPA EAPWARRPLD PRRRSLPAGD ALYLSFNPPQ
910 920 930 940 950
PSRGHDRLDL PVTVRSLHRP FDDREAQELG SPEDRLQDSS DPDTGSEEEV
960 970 980
SSRLSPPHSP RDFTRMQDIP EETESRDGEP TASES
Length:985
Mass (Da):111,974
Last modified:July 27, 2011 - v4
Checksum:i1A5EAB73F95005D1
GO
Isoform 2 (identifier: Q60875-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-985: Missing.

Show »
Length:573
Mass (Da):65,836
Checksum:i6BB5C323B6FE355A
GO
Isoform 3 (identifier: Q60875-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSRIESLTRARIDRSKEQATK → MSGNRRQPSRRGQ
     596-596: T → S
     597-985: Missing.

Show »
Length:588
Mass (Da):67,638
Checksum:i7224EA3E1C9EDCCB
GO
Isoform 4 (identifier: Q60875-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:958
Mass (Da):108,744
Checksum:i2C38027E3BB226B7
GO
Isoform 5 (identifier: Q60875-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     112-113: Missing.

Show »
Length:956
Mass (Da):108,528
Checksum:i07B245CA6CA2EF2D
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJ45H3BJ45_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
968Annotation score:
H3BKH9H3BKH9_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
983Annotation score:
H3BJ40H3BJ40_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2 mCG_8844
970Annotation score:
H3BJU7H3BJU7_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
956Annotation score:
H3BJX8H3BJX8_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
968Annotation score:
H3BL15H3BL15_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
257Annotation score:
H3BIX8H3BIX8_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
130Annotation score:
H3BJ59H3BJ59_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
208Annotation score:
H3BLF9H3BLF9_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
203Annotation score:
H3BJM4H3BJM4_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef2
84Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAC41438 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156A → V in CAA65067 (Ref. 2) Curated1
Sequence conflicti539M → V in AAG09271 (Ref. 3) Curated1
Sequence conflicti679M → T in AAG09271 (Ref. 3) Curated1
Sequence conflicti679M → T in BAC41438 (PubMed:12465718).Curated1
Sequence conflicti679M → T in AAH06589 (PubMed:15489334).Curated1
Sequence conflicti810H → Y in BAE42325 (PubMed:16141072).Curated1
Sequence conflicti941D → G in AAG09271 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349621 – 27Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_0226401 – 21MSRIE…EQATK → MSGNRRQPSRRGQ in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_034963112 – 113Missing in isoform 5. 1 Publication2
Alternative sequenceiVSP_022641574 – 985Missing in isoform 2. 1 PublicationAdd BLAST412
Alternative sequenceiVSP_022642596T → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_022643597 – 985Missing in isoform 3. 1 PublicationAdd BLAST389

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28495 mRNA Translation: AAC52234.1
X95761 mRNA Translation: CAA65067.1
AF177032 mRNA Translation: AAG09271.1
AB093254 mRNA Translation: BAC41438.1 Different initiation.
AK167628 mRNA Translation: BAE39679.1
AK171223 mRNA Translation: BAE42325.1
AC145168 Genomic DNA No translation available.
BC006589 mRNA Translation: AAH06589.1
CCDSiCCDS17481.1 [Q60875-1]
CCDS57221.1 [Q60875-5]
CCDS57222.1 [Q60875-4]
PIRiI49342
RefSeqiNP_001185840.1, NM_001198911.1
NP_001185841.1, NM_001198912.1 [Q60875-4]
NP_001185842.1, NM_001198913.1 [Q60875-5]
NP_032513.3, NM_008487.3 [Q60875-1]
XP_006501130.1, XM_006501067.3 [Q60875-4]
UniGeneiMm.239329
Mm.482396

Genome annotation databases

EnsembliENSMUST00000029694; ENSMUSP00000029694; ENSMUSG00000028059 [Q60875-1]
ENSMUST00000107510; ENSMUSP00000103134; ENSMUSG00000028059 [Q60875-4]
ENSMUST00000170653; ENSMUSP00000127843; ENSMUSG00000028059 [Q60875-5]
ENSMUST00000175911; ENSMUSP00000135428; ENSMUSG00000028059 [Q60875-3]
GeneIDi16800
KEGGimmu:16800
UCSCiuc008pvw.2 mouse [Q60875-1]
uc008pvy.2 mouse [Q60875-5]
uc008pwa.1 mouse [Q60875-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28495 mRNA Translation: AAC52234.1
X95761 mRNA Translation: CAA65067.1
AF177032 mRNA Translation: AAG09271.1
AB093254 mRNA Translation: BAC41438.1 Different initiation.
AK167628 mRNA Translation: BAE39679.1
AK171223 mRNA Translation: BAE42325.1
AC145168 Genomic DNA No translation available.
BC006589 mRNA Translation: AAH06589.1
CCDSiCCDS17481.1 [Q60875-1]
CCDS57221.1 [Q60875-5]
CCDS57222.1 [Q60875-4]
PIRiI49342
RefSeqiNP_001185840.1, NM_001198911.1
NP_001185841.1, NM_001198912.1 [Q60875-4]
NP_001185842.1, NM_001198913.1 [Q60875-5]
NP_032513.3, NM_008487.3 [Q60875-1]
XP_006501130.1, XM_006501067.3 [Q60875-4]
UniGeneiMm.239329
Mm.482396

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WI4X-ray2.00A/B/C139-164[»]
ProteinModelPortaliQ60875
SMRiQ60875
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201114, 13 interactors
IntActiQ60875, 15 interactors
MINTiQ60875
STRINGi10090.ENSMUSP00000029694

PTM databases

iPTMnetiQ60875
PhosphoSitePlusiQ60875
SwissPalmiQ60875

Proteomic databases

PaxDbiQ60875
PeptideAtlasiQ60875
PRIDEiQ60875

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029694; ENSMUSP00000029694; ENSMUSG00000028059 [Q60875-1]
ENSMUST00000107510; ENSMUSP00000103134; ENSMUSG00000028059 [Q60875-4]
ENSMUST00000170653; ENSMUSP00000127843; ENSMUSG00000028059 [Q60875-5]
ENSMUST00000175911; ENSMUSP00000135428; ENSMUSG00000028059 [Q60875-3]
GeneIDi16800
KEGGimmu:16800
UCSCiuc008pvw.2 mouse [Q60875-1]
uc008pvy.2 mouse [Q60875-5]
uc008pwa.1 mouse [Q60875-3]

Organism-specific databases

CTDi9181
MGIiMGI:103264 Arhgef2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IR0Y Eukaryota
ENOG410XT68 LUCA
GeneTreeiENSGT00760000119193
HOVERGENiHBG050566
InParanoidiQ60875
KOiK12791
OrthoDBiEOG091G00G7
TreeFamiTF325887

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRSiArhgef2 mouse
PROiPR:Q60875
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028059 Expressed in 260 organ(s), highest expression level in fibroblast
ExpressionAtlasiQ60875 baseline and differential
GenevisibleiQ60875 MM

Family and domain databases

CDDicd00029 C1, 1 hit
cd13393 PH_ARHGEF2, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037806 ARHGEF2_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARHG2_MOUSE
AccessioniPrimary (citable) accession number: Q60875
Secondary accession number(s): E9QNW9
, O09115, Q3TBI4, Q3TJ16, Q8CHE1, Q923E0, Q9ESG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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