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Protein

Eukaryotic translation initiation factor 1A

Gene

Eif1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A
Short name:
eIF-1A
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eif1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:95298 Eif1a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001451061 – 144Eukaryotic translation initiation factor 1AAdd BLAST144

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q60872

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q60872

MaxQB - The MaxQuant DataBase

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MaxQBi
Q60872

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60872

PRoteomics IDEntifications database

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PRIDEi
Q60872

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q60872

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q60872

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q60872

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057561 Expressed in 290 organ(s), highest expression level in seminal vesicle

CleanEx database of gene expression profiles

More...
CleanExi
MM_EIF1A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60872 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q60872 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077223

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q60872

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q60872

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 96S1-likeAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-1A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3403 Eukaryota
COG0361 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000223675

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001131

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q60872

KEGG Orthology (KO)

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KOi
K03236

Identification of Orthologs from Complete Genome Data

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OMAi
DADIVHK

Database of Orthologous Groups

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OrthoDBi
1426335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q60872

TreeFam database of animal gene trees

More...
TreeFami
TF350394

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05793 S1_IF1A, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00216 aIF_1A, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
IPR018104 TIF_eIF-1A_CS

The PANTHER Classification System

More...
PANTHERi
PTHR21668 PTHR21668, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01176 eIF-1a, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD005579 TIF_eIF-1A, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00652 eIF1a, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00523 eIF-1A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01262 IF1A, 1 hit
PS50832 S1_IF1_TYPE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q60872-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM
60 70 80 90 100
CFDGVRRLCH IRGKLRKKVW INTSDIILIG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,502
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04D99384C0BBA6D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78L → W in AAB05664 (PubMed:8631492).Curated1
Sequence conflicti97A → P in AAB05664 (PubMed:8631492).Curated1
Sequence conflicti106Y → C in BAB31727 (PubMed:16141072).Curated1
Sequence conflicti118T → M in AAB05664 (PubMed:8631492).Curated1
Sequence conflicti130Q → V in AAB05664 (PubMed:8631492).Curated1
Sequence conflicti136D → E in AAB05664 (PubMed:8631492).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF026481 mRNA Translation: AAC63934.1
AK009026 mRNA Translation: BAB26034.1
AK013268 mRNA Translation: BAB28759.1
AK019451 mRNA Translation: BAB31727.1
BC027437 mRNA Translation: AAH27437.1
U28419 mRNA Translation: AAB05664.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29233.1

NCBI Reference Sequences

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RefSeqi
NP_034250.3, NM_010120.5

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.262037
Mm.423010

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000078079; ENSMUSP00000077223; ENSMUSG00000057561
ENSMUST00000168382; ENSMUSP00000132018; ENSMUSG00000057561

Database of genes from NCBI RefSeq genomes

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GeneIDi
13664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:13664

UCSC genome browser

More...
UCSCi
uc008evs.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026481 mRNA Translation: AAC63934.1
AK009026 mRNA Translation: BAB26034.1
AK013268 mRNA Translation: BAB28759.1
AK019451 mRNA Translation: BAB31727.1
BC027437 mRNA Translation: AAH27437.1
U28419 mRNA Translation: AAB05664.1
CCDSiCCDS29233.1
RefSeqiNP_034250.3, NM_010120.5
UniGeneiMm.262037
Mm.423010

3D structure databases

ProteinModelPortaliQ60872
SMRiQ60872
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077223

PTM databases

iPTMnetiQ60872
PhosphoSitePlusiQ60872
SwissPalmiQ60872

Proteomic databases

EPDiQ60872
jPOSTiQ60872
MaxQBiQ60872
PaxDbiQ60872
PRIDEiQ60872

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078079; ENSMUSP00000077223; ENSMUSG00000057561
ENSMUST00000168382; ENSMUSP00000132018; ENSMUSG00000057561
GeneIDi13664
KEGGimmu:13664
UCSCiuc008evs.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
13664
MGIiMGI:95298 Eif1a

Phylogenomic databases

eggNOGiKOG3403 Eukaryota
COG0361 LUCA
GeneTreeiENSGT00390000008256
HOGENOMiHOG000223675
HOVERGENiHBG001131
InParanoidiQ60872
KOiK03236
OMAiDADIVHK
OrthoDBi1426335at2759
PhylomeDBiQ60872
TreeFamiTF350394

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q60872

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057561 Expressed in 290 organ(s), highest expression level in seminal vesicle
CleanExiMM_EIF1A
ExpressionAtlasiQ60872 baseline and differential
GenevisibleiQ60872 MM

Family and domain databases

CDDicd05793 S1_IF1A, 1 hit
HAMAPiMF_00216 aIF_1A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
IPR018104 TIF_eIF-1A_CS
PANTHERiPTHR21668 PTHR21668, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005579 TIF_eIF-1A, 1 hit
SMARTiView protein in SMART
SM00652 eIF1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00523 eIF-1A, 1 hit
PROSITEiView protein in PROSITE
PS01262 IF1A, 1 hit
PS50832 S1_IF1_TYPE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF1A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60872
Secondary accession number(s): O88847
, Q8R2M4, Q9CX76, Q9DB61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Translation initiation factors
    List of translation initiation factor entries
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