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Protein

Receptor expression-enhancing protein 5

Gene

Reep5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote functional cell surface expression of olfactory receptors.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 5
Alternative name(s):
GP106
Polyposis locus protein 1 homolog
Protein TB2 homolog
Gene namesi
Name:Reep5
Synonyms:Dp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1270152 Reep5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018161 – 185Receptor expression-enhancing protein 5Add BLAST185

Proteomic databases

EPDiQ60870
MaxQBiQ60870
PaxDbiQ60870
PeptideAtlasiQ60870
PRIDEiQ60870

PTM databases

iPTMnetiQ60870
SwissPalmiQ60870

Expressioni

Gene expression databases

CleanExiMM_REEP5

Interactioni

Subunit structurei

Interacts with ATL1 and ATL2 (PubMed:19665976). Interacts with ZFYVE27 (PubMed:24668814).2 Publications

Binary interactionsi

Protein-protein interaction databases

IntActiQ60870, 2 interactors
STRINGi10090.ENSMUSP00000006027

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1725 Eukaryota
COG5052 LUCA
HOVERGENiHBG000796
InParanoidiQ60870
PhylomeDBiQ60870

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q60870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRERFDRFLH EKNCMTDLLA KLEAKTGVNR SFIALGVIGL VALYLVFGYG
60 70 80 90 100
ASLLCNLIGF GYPAYISMKA IESPNKDDDT QWLTYWVVYG VFSIAEFFSD
110 120 130 140 150
LFLSWLPFYY MLKCGFLLWC MAPSPANGAE MLYRRIIRPI FLRHESQVDS
160 170 180
VVKDVKDKAK ETADAISKEV KKATVNLLGD VKKST
Length:185
Mass (Da):21,051
Last modified:November 1, 1997 - v1
Checksum:i706F03AB257D7D0C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8R0G3X8R0_MOUSE
Receptor expression-enhancing prote...
Reep5 mCG_121499
189Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28168 mRNA Translation: AAB07994.1
PIRiJC4667
UniGeneiMm.280075

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28168 mRNA Translation: AAB07994.1
PIRiJC4667
UniGeneiMm.280075

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60870, 2 interactors
STRINGi10090.ENSMUSP00000006027

PTM databases

iPTMnetiQ60870
SwissPalmiQ60870

Proteomic databases

EPDiQ60870
MaxQBiQ60870
PaxDbiQ60870
PeptideAtlasiQ60870
PRIDEiQ60870

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1270152 Reep5

Phylogenomic databases

eggNOGiKOG1725 Eukaryota
COG5052 LUCA
HOVERGENiHBG000796
InParanoidiQ60870
PhylomeDBiQ60870

Miscellaneous databases

PROiPR:Q60870
SOURCEiSearch...

Gene expression databases

CleanExiMM_REEP5

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREEP5_MOUSE
AccessioniPrimary (citable) accession number: Q60870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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