UniProtKB - Q60864 (STIP1_MOUSE)
Stress-induced-phosphoprotein 1
Stip1
Functioni
GO - Molecular functioni
- chaperone binding Source: MGI
- Hsp70 protein binding Source: MGI
- Hsp90 protein binding Source: MGI
- protein C-terminus binding Source: MGI
GO - Biological processi
- cellular response to interleukin-7 Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) |
Names & Taxonomyi
Protein namesi | Recommended name: Stress-induced-phosphoprotein 1Short name: STI1 Short name: mSTI1 Alternative name(s): Hsc70/Hsp90-organizing protein Short name: Hop |
Gene namesi | Name:Stip1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109130, Stip1 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chaperone complex Source: MGI
- myelin sheath Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106373 | 1 – 543 | Stress-induced-phosphoprotein 1Add BLAST | 543 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 8 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineBy similarity | 1 | |
Cross-linki | 123 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 123 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 198 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 210 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 210 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 301 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 312 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 325 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 332 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 344 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 354 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 446 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 481 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | non-CPTAC-3673 non-CPTAC-3674 |
EPDi | Q60864 |
jPOSTi | Q60864 |
MaxQBi | Q60864 |
PaxDbi | Q60864 |
PeptideAtlasi | Q60864 |
PRIDEi | Q60864 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00121514 Q60864 |
UCD-2DPAGEi | Q60864 |
PTM databases
iPTMneti | Q60864 |
PhosphoSitePlusi | Q60864 |
SwissPalmi | Q60864 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024966, Expressed in morula and 317 other tissues |
Genevisiblei | Q60864, MM |
Interactioni
Subunit structurei
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity).
Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875).
Interacts with PACRG.
Interacts with METTL21B.
Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction.
Interacts with FLCN, FNIP1 and FNIP2.
Interacts with HSPA8/HSC70 (By similarity).
Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity).
By similarity1 PublicationGO - Molecular functioni
- chaperone binding Source: MGI
- Hsp70 protein binding Source: MGI
- Hsp90 protein binding Source: MGI
- protein C-terminus binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203539, 26 interactors |
IntActi | Q60864, 7 interactors |
MINTi | Q60864 |
STRINGi | 10090.ENSMUSP00000025918 |
Miscellaneous databases
RNActi | Q60864, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 37 | TPR 1Add BLAST | 34 | |
Repeati | 39 – 71 | TPR 2Add BLAST | 33 | |
Repeati | 73 – 105 | TPR 3Add BLAST | 33 | |
Domaini | 130 – 169 | STI1 1Add BLAST | 40 | |
Repeati | 225 – 258 | TPR 4Add BLAST | 34 | |
Repeati | 260 – 292 | TPR 5Add BLAST | 33 | |
Repeati | 300 – 333 | TPR 6Add BLAST | 34 | |
Repeati | 360 – 393 | TPR 7Add BLAST | 34 | |
Repeati | 395 – 427 | TPR 8Add BLAST | 33 | |
Repeati | 428 – 461 | TPR 9Add BLAST | 34 | |
Domaini | 492 – 531 | STI1 2Add BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 222 – 239 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 18 |
Domaini
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0548, Eukaryota |
GeneTreei | ENSGT00940000154911 |
HOGENOMi | CLU_000134_46_5_1 |
InParanoidi | Q60864 |
OMAi | KDPAMRM |
OrthoDBi | 933764at2759 |
PhylomeDBi | Q60864 |
TreeFami | TF300478 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR041243, STI1 IPR006636, STI1_HS-bd IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF17830, STI1, 2 hits PF00515, TPR_1, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00028, TPR, 9 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 9 hits PS50293, TPR_REGION, 2 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MEQVNELKEK GNKALSAGNI DDALQCYSEA IKLDPQNHVL YSNRSAAYAK
60 70 80 90 100
KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK
110 120 130 140 150
HEANNLQLKE GLQNMEARLA ERKFMNPFNL PNLYQKLEND PRTRSLLSDP
160 170 180 190 200
TYRELIEQLQ NKPSDLGTKL QDPRVMTTLS VLLGVDLGSM DEEEEAATPP
210 220 230 240 250
PPPPPKKEPK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDKALKHYDR
260 270 280 290 300
AKELDPTNMT YITNQAAVHF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA
310 320 330 340 350
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE
360 370 380 390 400
RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PRDAKLYSNR
410 420 430 440 450
AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV
460 470 480 490 500
YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS
510 520 530 540
DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | L → P in BAC36100 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 106 | L → V in AAH03794 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 274 – 279 | DYNKCR → RLYKCT in BAC36100 (PubMed:16141072).Curated | 6 | |
Sequence conflicti | 288 | V → S in BAC36100 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 305 – 310 | RIGNSY → PNWQFL in BAC36100 (PubMed:16141072).Curated | 6 | |
Sequence conflicti | 316 – 317 | YK → VQ in BAC36100 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 333 – 347 | PDVLK…EKILK → QMCSRSASSQRNSE in BAC36100 (PubMed:16141072).CuratedAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27830 mRNA Translation: AAC53267.1 AK075988 mRNA Translation: BAC36100.1 AK088494 mRNA Translation: BAC40389.1 AK149493 mRNA Translation: BAE28916.1 AK161645 mRNA Translation: BAE36509.1 AK167273 mRNA Translation: BAE39385.1 BC003794 mRNA Translation: AAH03794.1 |
CCDSi | CCDS37901.1 |
RefSeqi | NP_058017.1, NM_016737.2 |
Genome annotation databases
Ensembli | ENSMUST00000025918; ENSMUSP00000025918; ENSMUSG00000024966 |
GeneIDi | 20867 |
KEGGi | mmu:20867 |
UCSCi | uc008gke.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27830 mRNA Translation: AAC53267.1 AK075988 mRNA Translation: BAC36100.1 AK088494 mRNA Translation: BAC40389.1 AK149493 mRNA Translation: BAE28916.1 AK161645 mRNA Translation: BAE36509.1 AK167273 mRNA Translation: BAE39385.1 BC003794 mRNA Translation: AAH03794.1 |
CCDSi | CCDS37901.1 |
RefSeqi | NP_058017.1, NM_016737.2 |
3D structure databases
SMRi | Q60864 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203539, 26 interactors |
IntActi | Q60864, 7 interactors |
MINTi | Q60864 |
STRINGi | 10090.ENSMUSP00000025918 |
PTM databases
iPTMneti | Q60864 |
PhosphoSitePlusi | Q60864 |
SwissPalmi | Q60864 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00121514 Q60864 |
UCD-2DPAGEi | Q60864 |
Proteomic databases
CPTACi | non-CPTAC-3673 non-CPTAC-3674 |
EPDi | Q60864 |
jPOSTi | Q60864 |
MaxQBi | Q60864 |
PaxDbi | Q60864 |
PeptideAtlasi | Q60864 |
PRIDEi | Q60864 |
Protocols and materials databases
Antibodypediai | 15273, 413 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025918; ENSMUSP00000025918; ENSMUSG00000024966 |
GeneIDi | 20867 |
KEGGi | mmu:20867 |
UCSCi | uc008gke.2, mouse |
Organism-specific databases
CTDi | 10963 |
MGIi | MGI:109130, Stip1 |
Phylogenomic databases
eggNOGi | KOG0548, Eukaryota |
GeneTreei | ENSGT00940000154911 |
HOGENOMi | CLU_000134_46_5_1 |
InParanoidi | Q60864 |
OMAi | KDPAMRM |
OrthoDBi | 933764at2759 |
PhylomeDBi | Q60864 |
TreeFami | TF300478 |
Enzyme and pathway databases
Reactomei | R-MMU-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) |
Miscellaneous databases
BioGRID-ORCSi | 20867, 4 hits in 17 CRISPR screens |
ChiTaRSi | Stip1, mouse |
PROi | PR:Q60864 |
RNActi | Q60864, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024966, Expressed in morula and 317 other tissues |
Genevisiblei | Q60864, MM |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR041243, STI1 IPR006636, STI1_HS-bd IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF17830, STI1, 2 hits PF00515, TPR_1, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00028, TPR, 9 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 9 hits PS50293, TPR_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STIP1_MOUSE | |
Accessioni | Q60864Primary (citable) accession number: Q60864 Secondary accession number(s): Q3TT16, Q8BPH3, Q99L66 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot