Stip1

Functionⁱ

Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90.By similarity

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Reactomeⁱ

R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Stress-induced-phosphoprotein 1 Short name: STI1 Short name: mSTI1 Alternative name(s): Hsc70/Hsp90-organizing protein Short name: Hop
Gene namesⁱ	Name:Stip1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:109130 Stip1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000106373	1 – 543	Stress-induced-phosphoprotein 1Add BLAST		543

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication	1
Modified residueⁱ	8	N6-acetyllysineBy similarity	1
Modified residueⁱ	16	PhosphoserineBy similarity	1
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	198	PhosphothreonineBy similarity	1
Cross-linkⁱ	210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	301	N6-acetyllysineBy similarity	1
Modified residueⁱ	312	N6-acetyllysineBy similarity	1
Modified residueⁱ	325	N6-acetyllysineCombined sources	1
Modified residueⁱ	332	PhosphothreonineBy similarity	1
Modified residueⁱ	344	N6-acetyllysineBy similarity	1
Modified residueⁱ	354	PhosphotyrosineBy similarity	1
Modified residueⁱ	446	N6-acetyllysineBy similarity	1
Modified residueⁱ	481	PhosphoserineBy similarity	1

Post-translational modificationⁱ

In vitro kinase assay failed to detect phosphorylation by MAPKAPK2.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q60864
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q60864
PaxDbⁱ	Q60864
PeptideAtlas More...PeptideAtlasⁱ	Q60864
PRIDEⁱ	Q60864

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00121514 Q60864
UCD-2DPAGEⁱ	Q60864

PTM databases

iPTMnetⁱ	Q60864
PhosphoSitePlusⁱ	Q60864
SwissPalmⁱ	Q60864

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024966 Expressed in 304 organ(s), highest expression level in morula
CleanExⁱ	MM_STIP1
Genevisibleⁱ	Q60864 MM

Interactionⁱ

Subunit structureⁱ

Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875). Interacts with PACRG. Interacts with METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203539, 7 interactors
IntActⁱ	Q60864, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q60864
STRINGⁱ	10090.ENSMUSP00000025918

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q60864
SMRⁱ	Q60864
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 37	TPR 1Add BLAST	34
Repeatⁱ	39 – 71	TPR 2Add BLAST	33
Repeatⁱ	73 – 105	TPR 3Add BLAST	33
Domainⁱ	130 – 169	STI1 1Add BLAST	40
Repeatⁱ	225 – 258	TPR 4Add BLAST	34
Repeatⁱ	260 – 292	TPR 5Add BLAST	33
Repeatⁱ	300 – 333	TPR 6Add BLAST	34
Repeatⁱ	360 – 393	TPR 7Add BLAST	34
Repeatⁱ	395 – 427	TPR 8Add BLAST	33
Repeatⁱ	428 – 461	TPR 9Add BLAST	34
Domainⁱ	492 – 531	STI1 2Add BLAST	40

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	222 – 239	Bipartite nuclear localization signalSequence analysisAdd BLAST		18

Domainⁱ

The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity).By similarity

Keywords - Domainⁱ

Repeat, TPR repeat

Phylogenomic databases

eggNOGⁱ	KOG0548 Eukaryota ENOG410XTCJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140989
HOGENOMⁱ	HOG000186562
HOVERGENⁱ	HBG057820
InParanoidⁱ	Q60864
KEGG Orthology (KO) More...KOⁱ	K09553
OMAⁱ	KDPAMRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E5W
PhylomeDBⁱ	Q60864
TreeFamⁱ	TF300478

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR006636 STI1_HS-bd IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR001440 TPR_1 IPR019734 TPR_repeat
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00515 TPR_1, 1 hit PF13181 TPR_8, 1 hit
SMARTⁱ	View protein in SMART SM00727 STI1, 2 hits SM00028 TPR, 9 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 9 hits PS50293 TPR_REGION, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q60864-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEQVNELKEK GNKALSAGNI DDALQCYSEA IKLDPQNHVL YSNRSAAYAK 
        60         70         80         90        100
KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK 
       110        120        130        140        150
HEANNLQLKE GLQNMEARLA ERKFMNPFNL PNLYQKLEND PRTRSLLSDP 
       160        170        180        190        200
TYRELIEQLQ NKPSDLGTKL QDPRVMTTLS VLLGVDLGSM DEEEEAATPP 
       210        220        230        240        250
PPPPPKKEPK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDKALKHYDR 
       260        270        280        290        300
AKELDPTNMT YITNQAAVHF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA 
       310        320        330        340        350
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE 
       360        370        380        390        400
RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PRDAKLYSNR 
       410        420        430        440        450
AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV 
       460        470        480        490        500
YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS 
       510        520        530        540 
DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR

Length:543

Mass (Da):62,582

Last modified:November 1, 1996 - v1

Checksum:ⁱB737FBA92B198D6C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15	L → P in BAC36100 (PubMed:16141072).Curated	1
Sequence conflictⁱ	106	L → V in AAH03794 (PubMed:15489334).Curated	1
Sequence conflictⁱ	274 – 279	DYNKCR → RLYKCT in BAC36100 (PubMed:16141072).Curated	6
Sequence conflictⁱ	288	V → S in BAC36100 (PubMed:16141072).Curated	1
Sequence conflictⁱ	305 – 310	RIGNSY → PNWQFL in BAC36100 (PubMed:16141072).Curated	6
Sequence conflictⁱ	316 – 317	YK → VQ in BAC36100 (PubMed:16141072).Curated	2
Sequence conflictⁱ	333 – 347	PDVLK…EKILK → QMCSRSASSQRNSE in BAC36100 (PubMed:16141072).CuratedAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U27830 mRNA Translation: AAC53267.1 AK075988 mRNA Translation: BAC36100.1 AK088494 mRNA Translation: BAC40389.1 AK149493 mRNA Translation: BAE28916.1 AK161645 mRNA Translation: BAE36509.1 AK167273 mRNA Translation: BAE39385.1 BC003794 mRNA Translation: AAH03794.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37901.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058017.1, NM_016737.2
UniGeneⁱ	Mm.258633

Genome annotation databases

Ensemblⁱ	ENSMUST00000025918; ENSMUSP00000025918; ENSMUSG00000024966
GeneIDⁱ	20867
KEGGⁱ	mmu:20867
UCSC genome browser More...UCSCⁱ	uc008gke.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q60864	Stress-induced-phosphoprotein 1	)	HUMAN		543	UniRef90_P31948
Stress-induced-phosphoprotein 1		RAT		543
Stress-induced-phosphoprotein 1		MACFA		543
Stress-induced-phosphoprotein 1		CRIGR		543
Stress-induced-phosphoprotein 1		BOVIN		543
+141

Protein	Similar proteins		Species	Score	Length	Source
Q60864	Stress-induced-phosphoprotein 1	)	HUMAN		543	UniRef50_P31948
Stress-induced-phosphoprotein 1		RAT		543
Stress-induced-phosphoprotein 1		MACFA		543
Stress-induced-phosphoprotein 1		CRIGR		543
Stress-induced-phosphoprotein 1		BOVIN		543
+253

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U27830 mRNA Translation: AAC53267.1 AK075988 mRNA Translation: BAC36100.1 AK088494 mRNA Translation: BAC40389.1 AK149493 mRNA Translation: BAE28916.1 AK161645 mRNA Translation: BAE36509.1 AK167273 mRNA Translation: BAE39385.1 BC003794 mRNA Translation: AAH03794.1
CCDSⁱ	CCDS37901.1
RefSeqⁱ	NP_058017.1, NM_016737.2
UniGeneⁱ	Mm.258633

3D structure databases

ProteinModelPortalⁱ	Q60864
SMRⁱ	Q60864
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203539, 7 interactors
IntActⁱ	Q60864, 7 interactors
MINTⁱ	Q60864
STRINGⁱ	10090.ENSMUSP00000025918

PTM databases

iPTMnetⁱ	Q60864
PhosphoSitePlusⁱ	Q60864
SwissPalmⁱ	Q60864

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00121514 Q60864
UCD-2DPAGEⁱ	Q60864

Proteomic databases

EPDⁱ	Q60864
MaxQBⁱ	Q60864
PaxDbⁱ	Q60864
PeptideAtlasⁱ	Q60864
PRIDEⁱ	Q60864

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025918; ENSMUSP00000025918; ENSMUSG00000024966
GeneIDⁱ	20867
KEGGⁱ	mmu:20867
UCSCⁱ	uc008gke.2 mouse

Organism-specific databases

CTDⁱ	10963
MGIⁱ	MGI:109130 Stip1

Phylogenomic databases

eggNOGⁱ	KOG0548 Eukaryota ENOG410XTCJ LUCA
GeneTreeⁱ	ENSGT00900000140989
HOGENOMⁱ	HOG000186562
HOVERGENⁱ	HBG057820
InParanoidⁱ	Q60864
KOⁱ	K09553
OMAⁱ	KDPAMRM
OrthoDBⁱ	EOG091G0E5W
PhylomeDBⁱ	Q60864
TreeFamⁱ	TF300478

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Reactomeⁱ

R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Miscellaneous databases

ChiTaRSⁱ	Stip1 mouse
Protein Ontology More...PROⁱ	PR:Q60864
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024966 Expressed in 304 organ(s), highest expression level in morula
CleanExⁱ	MM_STIP1
Genevisibleⁱ	Q60864 MM

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR006636 STI1_HS-bd IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR001440 TPR_1 IPR019734 TPR_repeat
Pfamⁱ	View protein in Pfam PF00515 TPR_1, 1 hit PF13181 TPR_8, 1 hit
SMARTⁱ	View protein in SMART SM00727 STI1, 2 hits SM00028 TPR, 9 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 9 hits PS50293 TPR_REGION, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STIP1_MOUSE
Accessionⁱ	Q60864Primary (citable) accession number: Q60864 Secondary accession number(s): Q3TT16, Q8BPH3, Q99L66
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q60864 (STIP1_MOUSE)

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Stress-induced-phosphoprotein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ