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Protein

Serpin B6

Gene

Serpinb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei343 – 344Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.030

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B6
Alternative name(s):
Placental thrombin inhibitor
Proteinase inhibitor 6
Short name:
PI-6
Gene namesi
Name:Serpinb6
Synonyms:Serpinb6a, Spi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103123 Serpinb6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941071 – 378Serpin B6Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Modified residuei197N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ60854
MaxQBiQ60854
PaxDbiQ60854
PRIDEiQ60854

PTM databases

iPTMnetiQ60854
PhosphoSitePlusiQ60854
SwissPalmiQ60854

Expressioni

Tissue specificityi

Expressed in the inner ear hair cells, keratinocytes of hair follicles and epidermis in abdominal skin.2 Publications

Developmental stagei

At E13.5, weakly detected in utricle sensory epithelium but not in hair cells. At E16.5, more prominently detected in crista hair cells. Hair cell expression is sustained in postnatal mice. In cochlea, detected in cochlear hair cells in embryo and in hair cells and the greater epithelial ridge (GER) region in early postnatal age.1 Publication

Gene expression databases

BgeeiENSMUSG00000060147 Expressed in 298 organ(s), highest expression level in female gonad
ExpressionAtlasiQ60854 baseline and differential
GenevisibleiQ60854 MM

Interactioni

Subunit structurei

Forms a complex with the monomeric form of beta-tryptase.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203444, 1 interactor
IntActiQ60854, 2 interactors
MINTiQ60854
STRINGi10090.ENSMUSP00000017188

Structurei

3D structure databases

ProteinModelPortaliQ60854
SMRiQ60854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ60854
KOiK13963
PhylomeDBiQ60854

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q60854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLQEANGT FALNLLKILG EDSSKNVFLS PMSISSALAM VFMGAKGTTA
60 70 80 90 100
SQMAQALALD KCSGNGGGDV HQGFQSLLTE VNKTGTQYLL RTANRLFGDK
110 120 130 140 150
TCDLLASFKD SCLKFYEAEL EELDFQGATE ESRQHINTWV AKKTEDKIKE
160 170 180 190 200
VLSPGTVNSD TSLVLVNAIY FKGNWEKQFN KEHTREMPFK VSKNEEKPVQ
210 220 230 240 250
MMFKKSTFKM TYIGEIFTKI LLLPYVSSEL NMIIMLPDEH VELSTVEKEV
260 270 280 290 300
TYEKFIEWTR LDKMDEEEVE VFLPKFKLEE NYNMNDALYK LGMTDAFGGR
310 320 330 340 350
ADFSGMSSKQ GLFLSKVVHK AFVEVNEEGT EAAAATAGMM TVRCMRFTPR
360 370
FCADHPFLFF IHHVKTNGIL FCGRFSSP
Length:378
Mass (Da):42,599
Last modified:November 1, 1996 - v1
Checksum:i4B0F5E1A030BBDF6
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIV2F8WIV2_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
399Annotation score:
K7E6F1K7E6F1_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
228Annotation score:
E9Q0P9E9Q0P9_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
193Annotation score:
E9Q6X2E9Q6X2_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
162Annotation score:
E9PYY0E9PYY0_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
120Annotation score:
E9PZQ9E9PZQ9_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
68Annotation score:
E9Q3Y1E9Q3Y1_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
144Annotation score:
E9Q108E9Q108_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
187Annotation score:
E9Q4R2E9Q4R2_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
72Annotation score:
E9Q5Q5E9Q5Q5_MOUSE
Serine (or cysteine) peptidase inhi...
Serpinb6a
18Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25844 mRNA Translation: AAA79684.1
BC006766 mRNA Translation: AAH06766.1
BC057950 mRNA Translation: AAH57950.1
CCDSiCCDS26441.1
PIRiA57488
RefSeqiNP_001157590.1, NM_001164118.1
NP_001230121.1, NM_001243192.1
NP_033280.1, NM_009254.3
XP_006516686.1, XM_006516623.1
XP_011242601.1, XM_011244299.1
XP_011242602.1, XM_011244300.2
XP_011242603.1, XM_011244301.1
UniGeneiMm.252210
Mm.374799
Mm.486427

Genome annotation databases

EnsembliENSMUST00000043552; ENSMUSP00000041016; ENSMUSG00000060147
ENSMUST00000076532; ENSMUSP00000075848; ENSMUSG00000060147
ENSMUST00000167163; ENSMUSP00000131115; ENSMUSG00000060147
GeneIDi20719
KEGGimmu:20719
UCSCiuc007qap.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25844 mRNA Translation: AAA79684.1
BC006766 mRNA Translation: AAH06766.1
BC057950 mRNA Translation: AAH57950.1
CCDSiCCDS26441.1
PIRiA57488
RefSeqiNP_001157590.1, NM_001164118.1
NP_001230121.1, NM_001243192.1
NP_033280.1, NM_009254.3
XP_006516686.1, XM_006516623.1
XP_011242601.1, XM_011244299.1
XP_011242602.1, XM_011244300.2
XP_011242603.1, XM_011244301.1
UniGeneiMm.252210
Mm.374799
Mm.486427

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M37model-A1-378[»]
ProteinModelPortaliQ60854
SMRiQ60854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203444, 1 interactor
IntActiQ60854, 2 interactors
MINTiQ60854
STRINGi10090.ENSMUSP00000017188

Protein family/group databases

MEROPSiI04.030

PTM databases

iPTMnetiQ60854
PhosphoSitePlusiQ60854
SwissPalmiQ60854

Proteomic databases

EPDiQ60854
MaxQBiQ60854
PaxDbiQ60854
PRIDEiQ60854

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043552; ENSMUSP00000041016; ENSMUSG00000060147
ENSMUST00000076532; ENSMUSP00000075848; ENSMUSG00000060147
ENSMUST00000167163; ENSMUSP00000131115; ENSMUSG00000060147
GeneIDi20719
KEGGimmu:20719
UCSCiuc007qap.2 mouse

Organism-specific databases

CTDi20719
MGIiMGI:103123 Serpinb6a

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ60854
KOiK13963
PhylomeDBiQ60854

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-75205 Dissolution of Fibrin Clot

Miscellaneous databases

ChiTaRSiSerpinb6a mouse
PROiPR:Q60854
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060147 Expressed in 298 organ(s), highest expression level in female gonad
ExpressionAtlasiQ60854 baseline and differential
GenevisibleiQ60854 MM

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB6_MOUSE
AccessioniPrimary (citable) accession number: Q60854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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