UniProtKB - Q60848 (HELLS_MOUSE)

BLAST

>sp|Q60848|HELLS_MOUSE Lymphocyte-specific helicase OS=Mus musculus OX=10090 GN=Hells PE=1 SV=2
MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSN
IYSKFLLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESY
NISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKF
FFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQ
CIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKNIH
KRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADN
KLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVL
HMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEK
ETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESEVN
LKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHK
VLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAG
GLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAA
AKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDL
ELLLDRSDLIDQMKASRPIKGKTGIFKILENSEDSSAECLF

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History
Entry version 144 (12 Sep 2018)
Sequence version 2 (01 Mar 2001)
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Protein

Lymphocyte-specific helicase

Gene

Hells

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.9 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	231 – 238	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 15448183
helicase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cellular response to leukemia inhibitory factor
Source: MGI
Inferred from expression patternⁱ
- 20439489
chromatin silencing
Source: MGI
Inferred from mutant phenotypeⁱ
- 15448183
DNA methylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 11711429
lymphocyte differentiation
Source: MGI
Traceable author statementⁱ
- 11325543
lymphocyte proliferation
Source: UniProtKB
Inferred from expression patternⁱ
- 10781083
maintenance of DNA methylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15105378
methylation-dependent chromatin silencing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15647320
multicellular organism development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11325543
negative regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 11325543
negative regulation of intrinsic apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 11325543
pericentric heterochromatin assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14612388
transcription, DNA-templated Source: UniProtKB-KW
urogenital system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 11325543

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Helicase, Hydrolase
Biological process	Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lymphocyte-specific helicase (EC:3.6.4.-) Alternative name(s): Proliferation-associated SNF2-like protein
Gene namesⁱ	Name:HellsImported Synonyms:Lsh1 Publication, PasgImported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:106209 Hells

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000260052	1 – 821	Lymphocyte-specific helicaseAdd BLAST		821

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	486	PhosphoserineBy similarity		1
Modified residueⁱ	498	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q60848
PeptideAtlas More...PeptideAtlasⁱ	Q60848
PRIDEⁱ	Q60848

PTM databases

iPTMnetⁱ	Q60848
PhosphoSitePlusⁱ	Q60848

Expressionⁱ

Tissue specificityⁱ

Highly expressed in thymus, bone marrow, and testis. Not detected in heart, brain, liver, kidney, skeletal muscle, spleen, peripheral blood lymphocytes, small intestine, colon, prostate or ovary.3 Publications

Developmental stageⁱ

Differentially expressed during embryonic development, with highest expression in developing face, limbs, skeletal muscle, heart, and tail. Highly expressed in fetal thymocytes from day 14 to 16 of gestation, and expressed at much lower levels in adult thymus.3 Publications

Inductionⁱ

By concanavalin or lipopolysaccharide in unactivated splenocytes.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000025001 Expressed in 232 organ(s), highest expression level in embryonic stem cell
CleanExⁱ	MM_HELLS
ExpressionAtlasⁱ	Q60848 baseline and differential
Genevisibleⁱ	Q60848 MM

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Bmi1	P25916	2	EBI-3043887,EBI-927401
Cbx2	P30658	2	EBI-3043887,EBI-360174
Dnmt3a	O88508	4	EBI-3043887,EBI-995154
Dnmt3b	O88509	4	EBI-3043887,EBI-7987547
Pcgf2	P23798	2	EBI-3043887,EBI-926857

Protein-protein interaction databases

BioGridⁱ	200271, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-43735N
IntActⁱ	Q60848, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q60848
STRINGⁱ	10090.ENSMUSP00000025965

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q60848
SMRⁱ	Q60848
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	218 – 386	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		169
Domainⁱ	586 – 736	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		151

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	14 – 96	Sequence analysisAdd BLAST		83

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	337 – 340	DEAH boxSequence analysis		4

Sequence similaritiesⁱ

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0386 Eukaryota COG0553 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000115593
HOGENOMⁱ	HOG000172362
HOVERGENⁱ	HBG060049
InParanoidⁱ	Q60848
KEGG Orthology (KO) More...KOⁱ	K19001
OMAⁱ	KSFESWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03LZ
PhylomeDBⁱ	Q60848
TreeFamⁱ	TF329077

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.40.50.10810, 1 hit
InterProⁱ	View protein in InterPro IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 3 hits
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 12 Publications (identifier: Q60848-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQTEPAVI TPAMLEEEEQ LEAAGLEKER KMLEEAQKSW DRESTEIRYR 
        60         70         80         90        100
RLQHLLEKSN IYSKFLLTKM EQQQLEEQKK KEKLEKKKRS LKLTEGKSLV 
       110        120        130        140        150
DGNGEKPVMK KKRGREDESY NISEVMSKEE ILSVAKKHKD NEDESSSTTS 
       160        170        180        190        200
LCVEDIQKNK DSNSMIKDRL SQTVRQNSKF FFDPVRKCNG QPVPFQQPKH 
       210        220        230        240        250
FTGGVMRWYQ VEGMEWLRML WENGINGILA DEMGLGKTVQ CIATIALMIQ 
       260        270        280        290        300
RGVPGPFLVC GPLSTLPNWM AEFKRFTPEI PTLLYHGTRE DRRKLVKNIH 
       310        320        330        340        350
KRQGTLQIHP VVVTSFEIAM RDQNALQHCY WKYLIVDEGH RIKNMKCRLI 
       360        370        380        390        400
RELKRFNADN KLLLTGTPLQ NNLSELWSLL NFLLPDVFDD LKSFESWFDI 
       410        420        430        440        450
TSLSETAEDI IAKEREQNVL HMLHQILTPF LLRRLKSDVA LEVPPKREVV 
       460        470        480        490        500
VYAPLCNKQE IFYTAIVNRT IANMFGSCEK ETVELSPTGR PKRRSRKSIN 
       510        520        530        540        550
YSELDQFPSE LEKLISQIQP EVNRERTVVE GNIPIESEVN LKLRNIMMLL 
       560        570        580        590        600
RKCCNHPYMI EYPIDPVTQE FKIDEELVTN SGKFLILDRM LPELKKRGHK 
       610        620        630        640        650
VLVFSQMTSM LDILMDYCHL RNFIFSRLDG SMSYSEREKN IYSFNTDPDV 
       660        670        680        690        700
FLFLVSTRAG GLGINLTAAD TVIIYDSDWN PQSDLQAQDR CHRIGQTKPV 
       710        720        730        740        750
VVYRLVTANT IDQKIVERAA AKRKLEKLII HKNHFKGGQS GLSQSKNFLD 
       760        770        780        790        800
AKELMELLKS RDYEREVKGS REKVISDEDL ELLLDRSDLI DQMKASRPIK 
       810        820 
GKTGIFKILE NSEDSSAECL F

Length:821

Mass (Da):95,126

Last modified:March 1, 2001 - v2

Checksum:ⁱ8DEC2F2EEFBBD2F5

Isoform 21 Publication (identifier: Q60848-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-13: Missing.

« Hide

        10         20         30         40         50
MLEEEEQLEA AGLEKERKML EEAQKSWDRE STEIRYRRLQ HLLEKSNIYS 
        60         70         80         90        100
KFLLTKMEQQ QLEEQKKKEK LEKKKRSLKL TEGKSLVDGN GEKPVMKKKR 
       110        120        130        140        150
GREDESYNIS EVMSKEEILS VAKKHKDNED ESSSTTSLCV EDIQKNKDSN 
       160        170        180        190        200
SMIKDRLSQT VRQNSKFFFD PVRKCNGQPV PFQQPKHFTG GVMRWYQVEG 
       210        220        230        240        250
MEWLRMLWEN GINGILADEM GLGKTVQCIA TIALMIQRGV PGPFLVCGPL 
       260        270        280        290        300
STLPNWMAEF KRFTPEIPTL LYHGTREDRR KLVKNIHKRQ GTLQIHPVVV 
       310        320        330        340        350
TSFEIAMRDQ NALQHCYWKY LIVDEGHRIK NMKCRLIREL KRFNADNKLL 
       360        370        380        390        400
LTGTPLQNNL SELWSLLNFL LPDVFDDLKS FESWFDITSL SETAEDIIAK 
       410        420        430        440        450
EREQNVLHML HQILTPFLLR RLKSDVALEV PPKREVVVYA PLCNKQEIFY 
       460        470        480        490        500
TAIVNRTIAN MFGSCEKETV ELSPTGRPKR RSRKSINYSE LDQFPSELEK 
       510        520        530        540        550
LISQIQPEVN RERTVVEGNI PIESEVNLKL RNIMMLLRKC CNHPYMIEYP 
       560        570        580        590        600
IDPVTQEFKI DEELVTNSGK FLILDRMLPE LKKRGHKVLV FSQMTSMLDI 
       610        620        630        640        650
LMDYCHLRNF IFSRLDGSMS YSEREKNIYS FNTDPDVFLF LVSTRAGGLG 
       660        670        680        690        700
INLTAADTVI IYDSDWNPQS DLQAQDRCHR IGQTKPVVVY RLVTANTIDQ 
       710        720        730        740        750
KIVERAAAKR KLEKLIIHKN HFKGGQSGLS QSKNFLDAKE LMELLKSRDY 
       760        770        780        790        800
EREVKGSREK VISDEDLELL LDRSDLIDQM KASRPIKGKT GIFKILENSE 

DSSAECLF

Note: No experimental confirmation available.Curated

Show »

Length:808

Mass (Da):93,786

Checksum:ⁱDBF5E847C1209568

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3Z414	D3Z414_MOUSE		Lymphocyte-specific helicase Lymphocyte-specific helicase	Hells	209	Annotation score:

Sequence cautionⁱ

The sequence AAH20056 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	497	K → R in AAI00395 (PubMed:15489334).Curated		1
Sequence conflictⁱ	620	L → P in AAI00395 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_052235	1 – 13	Missing in isoform 2. 1 PublicationAdd BLAST		13

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25691 mRNA Translation: AAB08015.2 AF155210 mRNA Translation: AAG43373.1 AK013266 mRNA Translation: BAB28757.2 AK147126 mRNA Translation: BAE27697.1 BC020056 mRNA Translation: AAH20056.1 Different initiation. BC100394 mRNA Translation: AAI00395.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29789.1 [Q60848-1]
PIRⁱ	JC4666
NCBI Reference Sequences More...RefSeqⁱ	NP_032260.2, NM_008234.3 [Q60848-1] XP_006526762.1, XM_006526699.3 [Q60848-1]
UniGeneⁱ	Mm.392920 Mm.486446 Mm.57223

Genome annotation databases

Ensemblⁱ	ENSMUST00000025965; ENSMUSP00000025965; ENSMUSG00000025001 [Q60848-1]
GeneIDⁱ	15201
KEGGⁱ	mmu:15201
UCSC genome browser More...UCSCⁱ	uc008hjt.1 mouse [Q60848-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q60848	Isoform 2 of Lymphocyte-specific helicase		MOUSE		808	UniRef100_Q60848
Lymphocyte-specific helicase (Fragment)		MOUSE		209
UPI0003D6F5C2		MOUSE		477

Protein	Similar proteins		Species	Score	Length	Source
Q60848	Isoform 2 of Lymphocyte-specific helicase		MOUSE		808	UniRef90_Q60848
Lymphocyte-specific helicase-like		RAT		837
lymphoid-specific helicase		MESAU		784
UPI0004ED28C5		NANGA		838
UPI000B4F0A3E		MERUN		837
+4

Protein	Similar proteins		Species	Score	Length	Source
Q60848	Lymphoid-specific helicase		HUMAN		838	UniRef50_Q60848
Isoform 2 of Lymphocyte-specific helicase		MOUSE		808
Lymphocyte-specific helicase-like		RAT		837
lymphoid-specific helicase		MESAU		784
Helicase, lymphoid specific		TETNG		867
+470

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25691 mRNA Translation: AAB08015.2 AF155210 mRNA Translation: AAG43373.1 AK013266 mRNA Translation: BAB28757.2 AK147126 mRNA Translation: BAE27697.1 BC020056 mRNA Translation: AAH20056.1 Different initiation. BC100394 mRNA Translation: AAI00395.1
CCDSⁱ	CCDS29789.1 [Q60848-1]
PIRⁱ	JC4666
RefSeqⁱ	NP_032260.2, NM_008234.3 [Q60848-1] XP_006526762.1, XM_006526699.3 [Q60848-1]
UniGeneⁱ	Mm.392920 Mm.486446 Mm.57223

3D structure databases

ProteinModelPortalⁱ	Q60848
SMRⁱ	Q60848
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200271, 6 interactors
DIPⁱ	DIP-43735N
IntActⁱ	Q60848, 7 interactors
MINTⁱ	Q60848
STRINGⁱ	10090.ENSMUSP00000025965

PTM databases

iPTMnetⁱ	Q60848
PhosphoSitePlusⁱ	Q60848

Proteomic databases

PaxDbⁱ	Q60848
PeptideAtlasⁱ	Q60848
PRIDEⁱ	Q60848

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	15201
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025965; ENSMUSP00000025965; ENSMUSG00000025001 [Q60848-1]
GeneIDⁱ	15201
KEGGⁱ	mmu:15201
UCSCⁱ	uc008hjt.1 mouse [Q60848-1]

Organism-specific databases

CTDⁱ	3070
MGIⁱ	MGI:106209 Hells

Phylogenomic databases

eggNOGⁱ	KOG0386 Eukaryota COG0553 LUCA
GeneTreeⁱ	ENSGT00740000115593
HOGENOMⁱ	HOG000172362
HOVERGENⁱ	HBG060049
InParanoidⁱ	Q60848
KOⁱ	K19001
OMAⁱ	KSFESWF
OrthoDBⁱ	EOG091G03LZ
PhylomeDBⁱ	Q60848
TreeFamⁱ	TF329077

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q60848
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025001 Expressed in 232 organ(s), highest expression level in embryonic stem cell
CleanExⁱ	MM_HELLS
ExpressionAtlasⁱ	Q60848 baseline and differential
Genevisibleⁱ	Q60848 MM

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.40.50.10810, 1 hit
InterProⁱ	View protein in InterPro IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N
Pfamⁱ	View protein in Pfam PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 3 hits
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HELLS_MOUSE
Accessionⁱ	Q60848Primary (citable) accession number: Q60848 Secondary accession number(s): Q497T3, Q8VDZ1, Q9CYV7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	March 1, 2001
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - Q60848 (HELLS_MOUSE)

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Lymphocyte-specific helicase

Hells

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ