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Protein

Krueppel-like factor 2

Gene

Klf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri301 – 325C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri331 – 353C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 2
Alternative name(s):
Lung krueppel-like factor
Gene namesi
Name:Klf2
Synonyms:Lklf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1342772 Klf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi121K → R: Greatly impairs polyubiquitination. Abolishes polyubiquitination; when associated with R-146. 1 Publication1
Mutagenesisi146K → R: Abolishes polyubiquitination; when associated with R-121. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471631 – 354Krueppel-like factor 2Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphothreonineCombined sources1
Modified residuei243PhosphothreonineCombined sources1
Modified residuei246PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ60843
PaxDbiQ60843
PRIDEiQ60843

PTM databases

iPTMnetiQ60843
PhosphoSitePlusiQ60843

Expressioni

Tissue specificityi

Predominant expression in the lungs and spleen.

Gene expression databases

BgeeiENSMUSG00000055148 Expressed in 234 organ(s), highest expression level in spleen
CleanExiMM_KLF2
GenevisibleiQ60843 MM

Interactioni

Subunit structurei

Interacts with WWP1.2 Publications

Protein-protein interaction databases

BioGridi200964, 2 interactors
STRINGi10090.ENSMUSP00000064823

Structurei

3D structure databases

ProteinModelPortaliQ60843
SMRiQ60843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 267Interaction with WWP1Add BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 70Poly-ProAdd BLAST11
Compositional biasi165 – 169Poly-Pro5
Compositional biasi224 – 230Poly-Ala7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri301 – 325C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri331 – 353C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000060173
HOVERGENiHBG006220
InParanoidiQ60843
KOiK17845
OMAiMSFEQPR
OrthoDBiEOG091G1BN0
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q60843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSEPILPS FATFASPCER GLQERWPRNE PEAGGTDEDL NNVLDFILSM
60 70 80 90 100
GLDGLGAENP PEPPPQPPPP AFYYPEPGAP PPYSIPAASL GTELLRPDLD
110 120 130 140 150
PPQGPALHGR FLLAPPGRLV KAEPPEVDGG GYGCAPGLAH GPRGLKLEGA
160 170 180 190 200
PGATGACMRG PAGRPPPPPD TPPLSPDGPL RIPASGPRNP FPPPFGPGPS
210 220 230 240 250
FGGPGPALHY GPPAPGAFGL FEDAAAAAAA LGLAPPATRG LLTPPSSPLE
260 270 280 290 300
LLEAKPKRGR RSWPRKRAAT HTCSYTNCGK TYTKSSHLKA HLRTHTGEKP
310 320 330 340 350
YHCNWEGCGW KFARSDELTR HYRKHTGHRP FQCHLCDRAF SRSDHLALHM

KRHM
Length:354
Mass (Da):37,657
Last modified:July 27, 2011 - v2
Checksum:i31A99C00DFC5B810
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88A → D in AAA86728 (PubMed:7565748).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25096 mRNA Translation: AAA86728.1
BC138737 mRNA Translation: AAI38738.1
BC138738 mRNA Translation: AAI38739.1
CCDSiCCDS22412.1
RefSeqiNP_032478.2, NM_008452.2
UniGeneiMm.26938

Genome annotation databases

EnsembliENSMUST00000067912; ENSMUSP00000064823; ENSMUSG00000055148
GeneIDi16598
KEGGimmu:16598
UCSCiuc009mfq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25096 mRNA Translation: AAA86728.1
BC138737 mRNA Translation: AAI38738.1
BC138738 mRNA Translation: AAI38739.1
CCDSiCCDS22412.1
RefSeqiNP_032478.2, NM_008452.2
UniGeneiMm.26938

3D structure databases

ProteinModelPortaliQ60843
SMRiQ60843
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200964, 2 interactors
STRINGi10090.ENSMUSP00000064823

PTM databases

iPTMnetiQ60843
PhosphoSitePlusiQ60843

Proteomic databases

MaxQBiQ60843
PaxDbiQ60843
PRIDEiQ60843

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067912; ENSMUSP00000064823; ENSMUSG00000055148
GeneIDi16598
KEGGimmu:16598
UCSCiuc009mfq.2 mouse

Organism-specific databases

CTDi10365
MGIiMGI:1342772 Klf2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000060173
HOVERGENiHBG006220
InParanoidiQ60843
KOiK17845
OMAiMSFEQPR
OrthoDBiEOG091G1BN0
TreeFamiTF350556

Miscellaneous databases

PROiPR:Q60843
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055148 Expressed in 234 organ(s), highest expression level in spleen
CleanExiMM_KLF2
GenevisibleiQ60843 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF2_MOUSE
AccessioniPrimary (citable) accession number: Q60843
Secondary accession number(s): B2RS60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: October 10, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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