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Protein

Reelin

Gene

Reln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2061Zinc 11
Metal bindingi2074Zinc 11
Metal bindingi2179Zinc 11
Metal bindingi2264Zinc 11
Metal bindingi2397Zinc 21
Metal bindingi2399Zinc 21
Metal bindingi2460Zinc 21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Serine protease
Biological processCell adhesion
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8866376 Reelin signalling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reelin (EC:3.4.21.-)
Alternative name(s):
Reeler protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Reln
Synonyms:Rl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103022 Reln

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Reln are the cause of the autosomal recessive reeler (rl) phenotype which is characterized by impaired motor coordination, tremors and ataxia. Neurons in affected mice fail to reach their correct locations in the developing brain, disrupting the organization of the cerebellar and cerebral cortices and other laminated regions.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2101C → A: Fails to assemble into disulfide-bonded multimers, while still exhibiting non-covalently associated high molecular weight oligomeric states in solution; retains binding to LRP8 and VLDR receptors but fails to show signaling activity. 1 Publication1
Mutagenesisi2360K → A: Abolishes ApoER2-binding. 1 Publication1
Mutagenesisi2467K → A: Abolishes ApoER2-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003030527 – 3461ReelinAdd BLAST3435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 127PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 179PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi540 ↔ 581PROSITE-ProRule annotation
Disulfide bondi609 ↔ 614PROSITE-ProRule annotation
Glycosylationi629N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi675 ↔ 685PROSITE-ProRule annotation
Disulfide bondi692 ↔ 701PROSITE-ProRule annotation
Disulfide bondi895 ↔ 937PROSITE-ProRule annotation
Disulfide bondi968 ↔ 975PROSITE-ProRule annotation
Disulfide bondi1034 ↔ 1044PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1060PROSITE-ProRule annotation
Glycosylationi1267N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1271 ↔ 1310
Disulfide bondi1339 ↔ 1348
Glycosylationi1447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1600N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1633 ↔ 1673PROSITE-ProRule annotation
Disulfide bondi1702 ↔ 1709PROSITE-ProRule annotation
Glycosylationi1750N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1921N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1983 ↔ 2030
Disulfide bondi2059 ↔ 2070
Disulfide bondi2101Interchain
Disulfide bondi2133 ↔ 2143
Disulfide bondi2137 ↔ 2149
Glycosylationi2145N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2151 ↔ 2160
Disulfide bondi2195 ↔ 2235
Glycosylationi2269N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2317N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2348 ↔ 2387
Disulfide bondi2393 ↔ 2559
Disulfide bondi2482 ↔ 2492
Disulfide bondi2486 ↔ 2497
Disulfide bondi2499 ↔ 2508
Disulfide bondi2544 ↔ 2584
Glycosylationi2569N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2794 ↔ 2801PROSITE-ProRule annotation
Disulfide bondi2919 ↔ 2966PROSITE-ProRule annotation
Glycosylationi2962N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3016N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3073N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3160 ↔ 3170PROSITE-ProRule annotation
Glycosylationi3185N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3232 ↔ 3242PROSITE-ProRule annotation
Disulfide bondi3236 ↔ 3248PROSITE-ProRule annotation
Disulfide bondi3250 ↔ 3259PROSITE-ProRule annotation
Disulfide bondi3296 ↔ 3346PROSITE-ProRule annotation
Glycosylationi3412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3439N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and to a lesser extent also O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60841

PeptideAtlas

More...
PeptideAtlasi
Q60841

PRoteomics IDEntifications database

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PRIDEi
Q60841

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q60841

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q60841

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

The major isoform 1 is neuron-specific. It is abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. Expression is located in deeper layers in the developing hippocampus and olfactory bulb, low levels of expression are also detected in the immature striatum. At early developmental stages, expressed also in hypothalamic differentiation fields, tectum and spinal cord. A moderate to low level of expression occurs in the septal area, striatal fields, habenular nuclei, some thalamic nuclei, particularly the lateral geniculate, the retina and some nuclei of the reticular formation in the central field of the medulla. Very low levels found in liver and kidney. No expression in radial glial cells, cortical plate, Purkinje cells and inferior olivary neurons. The minor isoform 2 is only expressed in non neuronal cells. The minor isoform 3 is found in the same cells as isoform 1, but is almost undetectable in retina and brain stem.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at embryonic day 11.5. Expression increases up to birth and remains high from postnatal day 2 to 11 in both cerebellum and fore/midbrain. Expression declines thereafter and is largely brain specific in the adult.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042453 Expressed in 359 organ(s), highest expression level in olfactory bulb

CleanEx database of gene expression profiles

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CleanExi
MM_RELN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60841 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q60841 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-40924N

Protein interaction database and analysis system

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IntActi
Q60841, 6 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000124052

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q60841

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q60841

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q60841

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 191ReelinPROSITE-ProRule annotationAdd BLAST165
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati593 – 604BNR 1Add BLAST12
Domaini671 – 702EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Repeati799 – 810BNR 2Add BLAST12
Repeati952 – 963BNR 3Add BLAST12
Domaini1030 – 1061EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Repeati1157 – 1168BNR 4Add BLAST12
Repeati1323 – 1334BNR 5Add BLAST12
Domaini1409 – 1442EGF-like 3PROSITE-ProRule annotationAdd BLAST34
Repeati1535 – 1546BNR 6Add BLAST12
Repeati1686 – 1697BNR 7Add BLAST12
Domaini1765 – 1796EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Repeati1884 – 1895BNR 8Add BLAST12
Repeati2043 – 2054BNR 9Add BLAST12
Domaini2129 – 2161EGF-like 5PROSITE-ProRule annotationAdd BLAST33
Repeati2250 – 2261BNR 10Add BLAST12
Repeati2399 – 2410BNR 11Add BLAST12
Domaini2478 – 2509EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Repeati2598 – 2609BNR 12Add BLAST12
Repeati2778 – 2789BNR 13Add BLAST12
Domaini2853 – 2884EGF-like 7PROSITE-ProRule annotationAdd BLAST32
Repeati2979 – 2990BNR 14Add BLAST12
Repeati3143 – 3155BNR 15Add BLAST13
Domaini3228 – 3260EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Repeati3363 – 3374BNR 16Add BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3432 – 3461Arg-rich (basic)Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The basic C-terminal region is essential for secretion.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the reelin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEXI Eukaryota
ENOG410XQKB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00580000081623

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000252908

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG023117

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q60841

KEGG Orthology (KO)

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KOi
K06249

Identification of Orthologs from Complete Genome Data

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OMAi
NGGITWH

Database of Orthologous Groups

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OrthoDBi
EOG091G0016

TreeFam database of animal gene trees

More...
TreeFami
TF106479

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544 Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.260, 19 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002861 Reeler_dom
IPR034968 Reelin
IPR036278 Sialidase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11841 PTHR11841, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02014 Reeler, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50939 SSF50939, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 5 hits
PS51019 REELIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60841-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERGCWAPRA LVLAVLLLLA TLRARAATGY YPRFSPFFFL CTHHGELEGD
60 70 80 90 100
GEQGEVLISL HIAGNPTYYV PGQEYHVTIS TSTFFDGLLV TGLYTSTSIQ
110 120 130 140 150
SSQSIGGSSA FGFGIMSDHQ FGNQFMCSVV ASHVSHLPTT NLSFVWIAPP
160 170 180 190 200
AGTGCVNFMA TATHRGQVIF KDALAQQLCE QGAPTEATAY SHLAEIHSDS
210 220 230 240 250
VILRDDFDSY QQLELNPNIW VECSNCEMGE QCGTIMHGNA VTFCEPYGPR
260 270 280 290 300
ELTTTCLNTT TASVLQFSIG SGSCRFSYSD PSITVSYAKN NTADWIQLEK
310 320 330 340 350
IRAPSNVSTV IHILYLPEEA KGESVQFQWK QDSLRVGEVY EACWALDNIL
360 370 380 390 400
VINSAHREVV LEDNLDPVDT GNWLFFPGAT VKHSCQSDGN SIYFHGNEGS
410 420 430 440 450
EFNFATTRDV DLSTEDIQEQ WSEEFESQPT GWDILGAVVG ADCGTVESGL
460 470 480 490 500
SLVFLKDGER KLCTPYMDTT GYGNLRFYFV MGGICDPGVS HENDIILYAK
510 520 530 540 550
IEGRKEHIAL DTLTYSSYKV PSLVSVVINP ELQTPATKFC LRQKSHQGYN
560 570 580 590 600
RNVWAVDFFH VLPVLPSTMS HMIQFSINLG CGTHQPGNSV SLEFSTNHGR
610 620 630 640 650
SWSLLHTECL PEICAGPHLP HSTVYSSENY SGWNRITIPL PNAALTRDTR
660 670 680 690 700
IRWRQTGPIL GNMWAIDNVY IGPSCLKFCS GRGQCTRHGC KCDPGFSGPA
710 720 730 740 750
CEMASQTFPM FISESFGSAR LSSYHNFYSI RGAEVSFGCG VLASGKALVF
760 770 780 790 800
NKDGRRQLIT SFLDSSQSRF LQFTLRLGSK SVLSTCRAPD QPGEGVLLHY
810 820 830 840 850
SYDNGITWKL LEHYSYVNYH EPRIISVELP DDARQFGIQF RWWQPYHSSQ
860 870 880 890 900
GEDVWAIDEI VMTSVLFNSI SLDFTNLVEV TQSLGFYLGN VQPYCGHDWT
910 920 930 940 950
LCFTGDSKLA SSMRYVETQS MQIGASYMIQ FSLVMGCGQK YTPHMDNQVK
960 970 980 990 1000
LEYSANHGLT WHLVQEECLP SMPSCQEFTS ASIYHASEFT QWRRVTVVLP
1010 1020 1030 1040 1050
QKTWSGATRF RWSQSYYTAQ DEWALDNIYI GQQCPNMCSG HGSCDHGVCR
1060 1070 1080 1090 1100
CDQGYQGTEC HPEAALPSTI MSDFENPSSW ESDWQEVIGG EVVKPEQGCG
1110 1120 1130 1140 1150
VVSSGSSLYF SKAGKRQLVS WDLDTSWVDF VQFYIQIGGE SAACNKPDSR
1160 1170 1180 1190 1200
EEGILLQYSN NGGIQWHLLA EMYFSDFSKP RFVYLELPAA AKTPCTRFRW
1210 1220 1230 1240 1250
WQPVFSGEDY DQWAVDDIII LSEKQKQVIP VVNPTLPQNF YEKPAFDYPM
1260 1270 1280 1290 1300
NQMSVWLMLA NEGMAKNDSF CATTPSAMVF GKSDGDRFAV TRDLTLKPGY
1310 1320 1330 1340 1350
VLQFKLNIGC TSQFSSTAPV LLQYSHDAGM SWFLVKEGCF PASAGKGCEG
1360 1370 1380 1390 1400
NSRELSEPTV YYTGDFEEWT RITIAIPRSL ASSKTRFRWI QESSSQKNVP
1410 1420 1430 1440 1450
PFGLDGVYIS EPCPSYCSGH GDCISGVCFC DLGYTAAQGT CVSNTPNHSE
1460 1470 1480 1490 1500
MFDRFEGKLS PLWYKITGGQ VGTGCGTLND GRSLYFNGLG KREARTVPLD
1510 1520 1530 1540 1550
TRNIRLVQFY IQIGSKTSGI TCIKPRARNE GLVVQYSNDN GILWHLLREL
1560 1570 1580 1590 1600
DFMSFLEPQI ISIDLPREAK TPATAFRWWQ PQHGKHSAQW ALDDVLIGVN
1610 1620 1630 1640 1650
DSSQTGFQDK FDGSIDLQAN WYRIQGGQVD IDCLSMDTAL IFTENIGKPR
1660 1670 1680 1690 1700
YAETWDFHVS ASSFLQFEMN MGCSKPFSGA HGIQLQYSLN NGKDWQLVTE
1710 1720 1730 1740 1750
ECVPPTIGCV HYTESSTYTS ERFQNWRRVT VYLPLATNSP RTRFRWIQTN
1760 1770 1780 1790 1800
YTVGADSWAI DNVILASGCP WMCSGRGICD SGRCVCDRGF GGPFCVPVVP
1810 1820 1830 1840 1850
LPSILKDDFN GNLHPDLWPE VYGAERGNLN GETIKSGTCL IFKGEGLRML
1860 1870 1880 1890 1900
ISRDLDCTNT MYVQFSLRFI AKGTPERSHS ILLQFSVSGG VTWHLMDEFY
1910 1920 1930 1940 1950
FPQTTSILFI NVPLPYGAQT NATRFRLWQP YNNGKKEEIW IIDDFIIDGN
1960 1970 1980 1990 2000
NLNNPVLLLD TFDFGPREDN WFFYPGGNIG LYCPYSSKGA PEEDSAMVFV
2010 2020 2030 2040 2050
SNEVGEHSIT TRDLSVNENT IIQFEINVGC STDSSSADPV RLEFSRDFGA
2060 2070 2080 2090 2100
TWHLLLPLCY HSSSLVSSLC STEHHPSSTY YAGTTQGWRR EVVHFGKLHL
2110 2120 2130 2140 2150
CGSVRFRWYQ GFYPAGSQPV TWAIDNVYIG PQCEEMCYGH GSCINGTKCI
2160 2170 2180 2190 2200
CDPGYSGPTC KISTKNPDFL KDDFEGQLES DRFLLMSGGK PSRKCGILSS
2210 2220 2230 2240 2250
GNNLFFNEDG LRMLVTRDLD LSHARFVQFF MRLGCGKGVP DPRSQPVLLQ
2260 2270 2280 2290 2300
YSLNGGLSWS LLQEFLFSNS SNVGRYIALE MPLKARSGST RLRWWQPSEN
2310 2320 2330 2340 2350
GHFYSPWVID QILIGGNISG NTVLEDDFST LDSRKWLLHP GGTKMPVCGS
2360 2370 2380 2390 2400
TGDALVFIEK ASTRYVVTTD IAVNEDSFLQ IDFAASCSVT DSCYAIELEY
2410 2420 2430 2440 2450
SVDLGLSWHP LVRDCLPTNV ECSRYHLQRI LVSDTFNKWT RITLPLPSYT
2460 2470 2480 2490 2500
RSQATRFRWH QPAPFDKQQT WAIDNVYIGD GCLDMCSGHG RCVQGSCVCD
2510 2520 2530 2540 2550
EQWGGLYCDE PETSLPTQLK DNFNRAPSNQ NWLTVSGGKL STVCGAVASG
2560 2570 2580 2590 2600
LALHFSGGCS RLLVTVDLNL TNAEFIQFYF MYGCLITPSN RNQGVLLEYS
2610 2620 2630 2640 2650
VNGGITWNLL MEIFYDQYSK PGFVNILLPP DAKEIATRFR WWQPRHDGLD
2660 2670 2680 2690 2700
QNDWAIDNVL ISGSADQRTV MLDTFSSAPV PQHERSPADA GPVGRIAFEM
2710 2720 2730 2740 2750
FLEDKTSVNE NWLFHDDCTV ERFCDSPDGV MLCGSHDGRE VYAVTHDLTP
2760 2770 2780 2790 2800
TENWIMQFKI SVGCKVPEKI AQNQIHVQFS TDFGVSWSYL VPQCLPADPK
2810 2820 2830 2840 2850
CSGSVSQPSV FFPTEGWKRI TYPLPESLTG NPVRFRFYQK YSDVQWAIDN
2860 2870 2880 2890 2900
FYLGPGCLDN CGGHGDCLKE QCICDPGYSG PNCYLTHSLK TFLKERFDSE
2910 2920 2930 2940 2950
EIKPDLWMSL EGGSTCTECG VLAENTALYF GGSTVRQAIT QDLDLRGAKF
2960 2970 2980 2990 3000
LQYWGRIGSE NNMTSCHRPV CRKEGVLLDF STDGGITWTL LHEMDFQKYI
3010 3020 3030 3040 3050
SVRHDYILLP EGALTNTTRL RWWQPFVISN GLVVSGVERA QWALDNILIG
3060 3070 3080 3090 3100
GAEINPSQLV DTFDDEGSSH EENWSFYPNA VRTAGFCGNP SFHLYWPNKK
3110 3120 3130 3140 3150
KDKTHNALSS RELIIQPGYM MQFKIVVGCE ATSCGDLHSV MLEYTKDARS
3160 3170 3180 3190 3200
DSWQLVQTQC LPSSSNSIGC SPFQFHEATI YNAVNSSSWK RITIQLPDHV
3210 3220 3230 3240 3250
SSSATQFRWI QKGEETEKQS WAIDHVYIGE ACPKLCSGHG YCTTGAVCIC
3260 3270 3280 3290 3300
DESFQGDDCS VFSHELPSYI KDNFESARVT EANWETIQGG VIGSGCGQLA
3310 3320 3330 3340 3350
PYAHGDSLYF NGCQIRQAAT KPLDLTRASK IMFVLQIGSP AQTDSCNSDL
3360 3370 3380 3390 3400
SGPHTVDKAV LLQYSVNNGI TWHVIAQHQP KDFTQAQRVS YNVPLEARMK
3410 3420 3430 3440 3450
GVLLRWWQPR HNGTGHDQWA LDHVEVVLVS TRKQNYMMNF SRQHGLRHFY
3460
NRRRRSLRRY P
Length:3,461
Mass (Da):387,495
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CCE64C845160F2E
GO
Isoform 2 (identifier: Q60841-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3429-3430: Missing.

Show »
Length:3,459
Mass (Da):387,309
Checksum:iDC72A41DFC9B88C6
GO
Isoform 3 (identifier: Q60841-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3429-3461: Missing.

Show »
Length:3,428
Mass (Da):383,200
Checksum:iADA613A4F66D585A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6U2B2F6U2B2_MOUSE
Reelin
Reln
47Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA09788 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1191A → G in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1202Q → K in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1335V → L in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1345G → A in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1505R → S in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1522 – 1524CIK → YIT in AAB91599 (PubMed:7715726).Curated3
Sequence conflicti1529N → Y in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1593D → G in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1611F → L in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1648K → N in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1661A → E in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti1667F → W in AAB91599 (PubMed:7715726).Curated1
Sequence conflicti3066Missing in BAB30592 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0055783429 – 3461Missing in isoform 3. CuratedAdd BLAST33
Alternative sequenceiVSP_0055773429 – 3430Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U24703 mRNA Translation: AAB91599.1
AC113028 Genomic DNA No translation available.
AC116404 Genomic DNA No translation available.
AC119906 Genomic DNA No translation available.
AC121878 Genomic DNA No translation available.
D63520 mRNA Translation: BAA09788.1 Different initiation.
AK017094 mRNA Translation: BAB30592.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS39023.1 [Q60841-1]
CCDS80217.1 [Q60841-2]

Protein sequence database of the Protein Information Resource

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PIRi
S58870

NCBI Reference Sequences

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RefSeqi
NP_001297393.1, NM_001310464.1 [Q60841-2]
NP_035391.2, NM_011261.2 [Q60841-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.425236

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000062372; ENSMUSP00000058025; ENSMUSG00000042453 [Q60841-2]
ENSMUST00000161356; ENSMUSP00000124052; ENSMUSG00000042453 [Q60841-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
19699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19699

UCSC genome browser

More...
UCSCi
uc008wpi.1 mouse [Q60841-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24703 mRNA Translation: AAB91599.1
AC113028 Genomic DNA No translation available.
AC116404 Genomic DNA No translation available.
AC119906 Genomic DNA No translation available.
AC121878 Genomic DNA No translation available.
D63520 mRNA Translation: BAA09788.1 Different initiation.
AK017094 mRNA Translation: BAB30592.1
CCDSiCCDS39023.1 [Q60841-1]
CCDS80217.1 [Q60841-2]
PIRiS58870
RefSeqiNP_001297393.1, NM_001310464.1 [Q60841-2]
NP_035391.2, NM_011261.2 [Q60841-1]
UniGeneiMm.425236

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DDUX-ray2.05A1222-1597[»]
2E26X-ray2.00A1948-2661[»]
3A7QX-ray2.60A1948-2661[»]
5B4XX-ray3.20A/C1948-2662[»]
ProteinModelPortaliQ60841
SMRiQ60841
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-40924N
IntActiQ60841, 6 interactors
STRINGi10090.ENSMUSP00000124052

PTM databases

iPTMnetiQ60841
PhosphoSitePlusiQ60841

Proteomic databases

PaxDbiQ60841
PeptideAtlasiQ60841
PRIDEiQ60841

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062372; ENSMUSP00000058025; ENSMUSG00000042453 [Q60841-2]
ENSMUST00000161356; ENSMUSP00000124052; ENSMUSG00000042453 [Q60841-1]
GeneIDi19699
KEGGimmu:19699
UCSCiuc008wpi.1 mouse [Q60841-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5649
MGIiMGI:103022 Reln

Phylogenomic databases

eggNOGiENOG410IEXI Eukaryota
ENOG410XQKB LUCA
GeneTreeiENSGT00580000081623
HOGENOMiHOG000252908
HOVERGENiHBG023117
InParanoidiQ60841
KOiK06249
OMAiNGGITWH
OrthoDBiEOG091G0016
TreeFamiTF106479

Enzyme and pathway databases

ReactomeiR-MMU-8866376 Reelin signalling pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Reln mouse
EvolutionaryTraceiQ60841

Protein Ontology

More...
PROi
PR:Q60841

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042453 Expressed in 359 organ(s), highest expression level in olfactory bulb
CleanExiMM_RELN
ExpressionAtlasiQ60841 baseline and differential
GenevisibleiQ60841 MM

Family and domain databases

CDDicd08544 Reeler, 1 hit
Gene3Di2.60.120.260, 19 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002861 Reeler_dom
IPR034968 Reelin
IPR036278 Sialidase_sf
PANTHERiPTHR11841 PTHR11841, 5 hits
PfamiView protein in Pfam
PF02014 Reeler, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SUPFAMiSSF50939 SSF50939, 3 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 5 hits
PS51019 REELIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRELN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60841
Secondary accession number(s): E9PZ78, Q9CUA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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