UniProtKB - Q60838 (DVL2_MOUSE)
Segment polarity protein dishevelled homolog DVL-2
Dvl2
Functioni
GO - Molecular functioni
- frizzled binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein domain specific binding Source: MGI
- protein kinase binding Source: ParkinsonsUK-UCL
- protein-macromolecule adaptor activity Source: ParkinsonsUK-UCL
- protein self-association Source: UniProtKB
- Rac GTPase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- canonical Wnt signaling pathway Source: MGI
- canonical Wnt signaling pathway involved in regulation of cell proliferation Source: MGI
- cellular protein localization Source: MGI
- cochlea morphogenesis Source: MGI
- convergent extension involved in neural plate elongation Source: MGI
- convergent extension involved in organogenesis Source: MGI
- heart development Source: MGI
- heart morphogenesis Source: MGI
- intracellular signal transduction Source: InterPro
- neural tube closure Source: MGI
- non-canonical Wnt signaling pathway Source: MGI
- outflow tract morphogenesis Source: BHF-UCL
- planar cell polarity pathway involved in neural tube closure Source: MGI
- positive regulation of DNA-binding transcription factor activity Source: MGI
- positive regulation of GTPase activity Source: ParkinsonsUK-UCL
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of neuron projection arborization Source: Ensembl
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of protein tyrosine kinase activity Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- segmentation Source: BHF-UCL
- segment specification Source: MGI
- Wnt signaling pathway, planar cell polarity pathway Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-201688, WNT mediated activation of DVL R-MMU-2028269, Signaling by Hippo R-MMU-4086400, PCP/CE pathway R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641258, Degradation of DVL R-MMU-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-MMU-5099900, WNT5A-dependent internalization of FZD4 R-MMU-5663220, RHO GTPases Activate Formins R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Segment polarity protein dishevelled homolog DVL-2Short name: Dishevelled-2 Alternative name(s): DSH homolog 2 |
Gene namesi | Name:Dvl2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106613, Dvl2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol 1 Publication
Plasma membrane
- Cell membrane 2 Publications; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Other locations
- Cytoplasmic vesicle 2 Publications
Note: Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization (PubMed:21189423). Localizes to cytoplasmic puncta. Interaction with FOXK1 and FOXK2 induces nuclear translocation (By similarity).By similarity1 Publication
Cytoskeleton
- cytoskeleton Source: BHF-UCL
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- lateral plasma membrane Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- aggresome Source: MGI
- apical part of cell Source: MGI
- cell cortex Source: MGI
- clathrin-coated vesicle Source: MGI
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 15 | K → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 17 | I → A: Reduces oligomerization. Abolishes interaction with DIXDC1. Reduces activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 27 | Y → D: Loss of oligomerization. Abolishes interaction with DIXDC1. Abolishes activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 56 | F → H: Reduces oligomerization. Strongly reduced activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 61 | D → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 63 | D → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 64 | F → A: Reduces oligomerization. Reduces activation of Wnt signaling. | 1 | |
Mutagenesisi | 65 | G → D: Loss of oligomerization. Abolishes activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 66 | V → D: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 68 | K → A: Loss of oligomerization. Strongly reduced activation of Wnt signaling. 1 Publication | 1 | |
Mutagenesisi | 84 | R → A: Strongly reduced interaction with DIXDC1. | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145747 | 1 – 736 | Segment polarity protein dishevelled homolog DVL-2Add BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 211 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q60838 |
MaxQBi | Q60838 |
PaxDbi | Q60838 |
PRIDEi | Q60838 |
PTM databases
iPTMneti | Q60838 |
PhosphoSitePlusi | Q60838 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000020888, Expressed in retina and 217 other tissues |
Genevisiblei | Q60838, MM |
Interactioni
Subunit structurei
Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2.
Interacts with Rac.
Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain).
Interacts (via DIX domain) with DIXDC1 (via DIX domain).
Interacts (via DEP domain) with AP2M1 and the AP-2 complex.
Interacts with FAM105B/otulin.
Interacts with DCDC2.
Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (By similarity).
Interacts with MAPK15 (PubMed:25823377).
Interacts with PKD1 (via extracellular domain) (PubMed:27214281).
Interacts with LMBR1L (PubMed:31073040).
By similarity9 PublicationsBinary interactionsi
Hide detailsQ60838
GO - Molecular functioni
- frizzled binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein domain specific binding Source: MGI
- protein kinase binding Source: ParkinsonsUK-UCL
- protein self-association Source: UniProtKB
- Rac GTPase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 199343, 20 interactors |
CORUMi | Q60838 |
DIPi | DIP-29399N |
IntActi | Q60838, 32 interactors |
MINTi | Q60838 |
STRINGi | 10090.ENSMUSP00000019362 |
Miscellaneous databases
RNActi | Q60838, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q60838 |
SMRi | Q60838 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 93 | DIXPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 267 – 339 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 433 – 507 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 12 | Poly-Gly | 6 | |
Compositional biasi | 112 – 122 | Poly-ProAdd BLAST | 11 | |
Compositional biasi | 235 – 240 | Poly-Arg | 6 | |
Compositional biasi | 686 – 691 | Poly-Pro | 6 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_1_0_1 |
InParanoidi | Q60838 |
OMAi | TPWPLLH |
OrthoDBi | 474724at2759 |
TreeFami | TF318198 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
IDEALi | IID50127 |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008341, DVL2 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF8, PTHR10878:SF8, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED PR01762, DISHEVELLED2 |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAGSSAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP
60 70 80 90 100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDTPQPEVA
110 120 130 140 150
PPAHESRTEL VPPPPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE
160 170 180 190 200
TETESVVSLR RDRPRRRDSS EHGAGGHRPG GPSRLERHLA GYESSSTLMT
210 220 230 240 250
SELESTSLGD SDEDDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRMERT
260 270 280 290 300
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM
310 320 330 340 350
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT
360 370 380 390 400
VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGAF PAYPGSSSMS
410 420 430 440 450
TITSGSSLPD GCEGRGLSVH MDMASVTKAM AAPESGLEVR DRMWLKITIP
460 470 480 490 500
NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ
510 520 530 540 550
CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT
560 570 580 590 600
FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG
610 620 630 640 650
AGRTGRPEER APESKSGSGS ESELSSRGGS LRRGGEPGGT GDGGPPPSRG
660 670 680 690 700
STGAPPNLRA LPGLHPYGAP SGMALPYNPM MVVMMPPPPP PVSTAVQPPG
710 720 730
APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 356 | D → G in AAC52827 (PubMed:8887313).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24160 mRNA Translation: AAC52827.1 AK146822 mRNA Translation: BAE27460.1 AK159895 mRNA Translation: BAE35461.1 AK168376 mRNA Translation: BAE40307.1 AL596185 Genomic DNA No translation available. CH466596 Genomic DNA Translation: EDL12520.1 BC053050 mRNA Translation: AAH53050.1 |
CCDSi | CCDS24930.1 |
RefSeqi | NP_031914.3, NM_007888.3 |
Genome annotation databases
Ensembli | ENSMUST00000019362; ENSMUSP00000019362; ENSMUSG00000020888 ENSMUST00000102575; ENSMUSP00000099635; ENSMUSG00000020888 ENSMUST00000190940; ENSMUSP00000140073; ENSMUSG00000020888 |
GeneIDi | 13543 |
KEGGi | mmu:13543 |
UCSCi | uc007jtm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24160 mRNA Translation: AAC52827.1 AK146822 mRNA Translation: BAE27460.1 AK159895 mRNA Translation: BAE35461.1 AK168376 mRNA Translation: BAE40307.1 AL596185 Genomic DNA No translation available. CH466596 Genomic DNA Translation: EDL12520.1 BC053050 mRNA Translation: AAH53050.1 |
CCDSi | CCDS24930.1 |
RefSeqi | NP_031914.3, NM_007888.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ML6 | X-ray | 3.50 | A/B/C/D/E/F | 417-510 | [»] | |
6VCC | electron microscopy | 3.60 | A/B/C/D/E/F/G/H/I/J/K/L | 12-92 | [»] | |
BMRBi | Q60838 | |||||
SMRi | Q60838 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 199343, 20 interactors |
CORUMi | Q60838 |
DIPi | DIP-29399N |
IntActi | Q60838, 32 interactors |
MINTi | Q60838 |
STRINGi | 10090.ENSMUSP00000019362 |
PTM databases
iPTMneti | Q60838 |
PhosphoSitePlusi | Q60838 |
Proteomic databases
EPDi | Q60838 |
MaxQBi | Q60838 |
PaxDbi | Q60838 |
PRIDEi | Q60838 |
Protocols and materials databases
Antibodypediai | 3985, 459 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019362; ENSMUSP00000019362; ENSMUSG00000020888 ENSMUST00000102575; ENSMUSP00000099635; ENSMUSG00000020888 ENSMUST00000190940; ENSMUSP00000140073; ENSMUSG00000020888 |
GeneIDi | 13543 |
KEGGi | mmu:13543 |
UCSCi | uc007jtm.1, mouse |
Organism-specific databases
CTDi | 1856 |
MGIi | MGI:106613, Dvl2 |
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_1_0_1 |
InParanoidi | Q60838 |
OMAi | TPWPLLH |
OrthoDBi | 474724at2759 |
TreeFami | TF318198 |
Enzyme and pathway databases
Reactomei | R-MMU-201688, WNT mediated activation of DVL R-MMU-2028269, Signaling by Hippo R-MMU-4086400, PCP/CE pathway R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641258, Degradation of DVL R-MMU-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-MMU-5099900, WNT5A-dependent internalization of FZD4 R-MMU-5663220, RHO GTPases Activate Formins R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 13543, 0 hits in 12 CRISPR screens |
ChiTaRSi | Dvl2, mouse |
PROi | PR:Q60838 |
RNActi | Q60838, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020888, Expressed in retina and 217 other tissues |
Genevisiblei | Q60838, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
IDEALi | IID50127 |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008341, DVL2 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF8, PTHR10878:SF8, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED PR01762, DISHEVELLED2 |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DVL2_MOUSE | |
Accessioni | Q60838Primary (citable) accession number: Q60838 Secondary accession number(s): Q7TN14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families