Segment polarity protein dishevelled homolog DVL-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• frizzled binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Direct interaction between NHERF1 and Frizzled regulates beta-catenin signaling."
    Wheeler D.S., Barrick S.R., Grubisha M.J., Brufsky A.M., Friedman P.A., Romero G.
    Oncogene 30:32-42(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization."
    Schwarz-Romond T., Fiedler M., Shibata N., Butler P.J., Kikuchi A., Higuchi Y., Bienz M.
    Nat. Struct. Mol. Biol. 14:484-492(2007) [PubMed] [Europe PMC] [Abstract]
  • Ref.10

    "Molecular basis of Wnt activation via the DIX-domain protein Ccd1."
    Liu Y.T., Dan Q.J., Wang J., Feng Y., Chen L., Liang J., Li Q., Lin S.C., Wang Z.X., Wu J.W.
    J. Biol. Chem. 286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DIXDC1, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-15; ILE-17; TYR-27; PHE-56; ASP-61; ASP-63; GLY-65; VAL-66 AND LYS-68, DOMAIN.
• protein binding, bridging Source: ParkinsonsUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol. Cell. Biol. 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: MGIInferred from physical interactionⁱ
  • "Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions."
    Luo W., Zou H., Jin L., Lin S., Li Q., Ye Z., Rui H., Lin S.C.
    J. Biol. Chem. 280:5054-5060(2005) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism."
    Bryja V., Schulte G., Rawal N., Grahn A., Arenas E.
    J. Cell. Sci. 120:586-595(2007) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Molecular basis of Wnt activation via the DIX-domain protein Ccd1."
    Liu Y.T., Dan Q.J., Wang J., Feng Y., Chen L., Liang J., Li Q., Lin S.C., Wang Z.X., Wu J.W.
    J. Biol. Chem. 286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DIXDC1, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-15; ILE-17; TYR-27; PHE-56; ASP-61; ASP-63; GLY-65; VAL-66 AND LYS-68, DOMAIN.
• Rac GTPase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol. Cell. Biol. 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• canonical Wnt signaling pathway Source: MGIInferred from direct assayⁱ
  • "Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex."
    Yamamoto S., Nishimura O., Misaki K., Nishita M., Minami Y., Yonemura S., Tarui H., Sasaki H.
    Dev. Cell 15:23-36(2008) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2."
    Klingensmith J., Yang Y., Axelrod J.D., Beier D.R., Perrimon N., Sussman D.J.
    Mech. Dev. 58:15-26(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• canonical Wnt signaling pathway involved in regulation of cell proliferation Source: MGI
• cellular protein localization Source: MGIInferred from direct assayⁱ
  • "Dynamic recruitment of axin by Dishevelled protein assemblies."
    Schwarz-Romond T., Metcalfe C., Bienz M.
    J. Cell. Sci. 120:2402-2412(2007) [PubMed] [Europe PMC] [Abstract]
• cochlea morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway."
    Wang J., Mark S., Zhang X., Qian D., Yoo S.J., Radde-Gallwitz K., Zhang Y., Lin X., Collazo A., Wynshaw-Boris A., Chen P.
    Nat. Genet. 37:980-985(2005) [PubMed] [Europe PMC] [Abstract]
  • "Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development."
    Etheridge S.L., Ray S., Li S., Hamblet N.S., Lijam N., Tsang M., Greer J., Kardos N., Wang J., Sussman D.J., Chen P., Wynshaw-Boris A.
    PLoS Genet. 4:e1000259-e1000259(2008) [PubMed] [Europe PMC] [Abstract]
• convergent extension involved in neural plate elongation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation."
    Wang J., Hamblet N.S., Mark S., Dickinson M.E., Brinkman B.C., Segil N., Fraser S.E., Chen P., Wallingford J.B., Wynshaw-Boris A.
    Development 133:1767-1778(2006) [PubMed] [Europe PMC] [Abstract]
• convergent extension involved in organogenesis Source: MGIInferred from genetic interactionⁱ
  • "Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway."
    Wang J., Mark S., Zhang X., Qian D., Yoo S.J., Radde-Gallwitz K., Zhang Y., Lin X., Collazo A., Wynshaw-Boris A., Chen P.
    Nat. Genet. 37:980-985(2005) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • "Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure."
    Hamblet N.S., Lijam N., Ruiz-Lozano P., Wang J., Yang Y., Luo Z., Mei L., Chien K.R., Sussman D.J., Wynshaw-Boris A.
    Development 129:5827-5838(2002) [PubMed] [Europe PMC] [Abstract]
  • "Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development."
    Kioussi C., Briata P., Baek S.H., Rose D.W., Hamblet N.S., Herman T., Ohgi K.A., Lin C., Gleiberman A., Wang J., Brault V., Ruiz-Lozano P., Nguyen H.D., Kemler R., Glass C.K., Wynshaw-Boris A., Rosenfeld M.G.
    Cell 111:673-685(2002) [PubMed] [Europe PMC] [Abstract]
• heart morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development."
    Etheridge S.L., Ray S., Li S., Hamblet N.S., Lijam N., Tsang M., Greer J., Kardos N., Wang J., Sussman D.J., Chen P., Wynshaw-Boris A.
    PLoS Genet. 4:e1000259-e1000259(2008) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: InterPro
• neural tube closure Source: MGIInferred from mutant phenotypeⁱ
  • "Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure."
    Hamblet N.S., Lijam N., Ruiz-Lozano P., Wang J., Yang Y., Luo Z., Mei L., Chien K.R., Sussman D.J., Wynshaw-Boris A.
    Development 129:5827-5838(2002) [PubMed] [Europe PMC] [Abstract]
• non-canonical Wnt signaling pathway Source: MGI
• outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development."
    Kioussi C., Briata P., Baek S.H., Rose D.W., Hamblet N.S., Herman T., Ohgi K.A., Lin C., Gleiberman A., Wang J., Brault V., Ruiz-Lozano P., Nguyen H.D., Kemler R., Glass C.K., Wynshaw-Boris A., Rosenfeld M.G.
    Cell 111:673-685(2002) [PubMed] [Europe PMC] [Abstract]
• planar cell polarity pathway involved in neural tube closure Source: MGIInferred from mutant phenotypeⁱ
  • "Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation."
    Wang J., Hamblet N.S., Mark S., Dickinson M.E., Brinkman B.C., Segil N., Fraser S.E., Chen P., Wallingford J.B., Wynshaw-Boris A.
    Development 133:1767-1778(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: MGI
• positive regulation of GTPase activity Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol. Cell. Biol. 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of JUN kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase."
    Zhang Y., Neo S.Y., Han J., Lin S.C.
    J. Biol. Chem. 275:25008-25014(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron projection arborization Source: Ensembl
• positive regulation of protein phosphorylation Source: MGI
• positive regulation of protein tyrosine kinase activity Source: MGIInferred from genetic interactionⁱ
  • "Dishevelled-2 docks and activates Src in a Wnt-dependent manner."
    Yokoyama N., Malbon C.C.
    J. Cell. Sci. 122:4439-4451(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: MGI
• protein complex oligomerization Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol. Cell. Biol. 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• segmentation Source: BHF-UCLInferred from genetic interactionⁱ
  • Ref.1

    "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2."
    Klingensmith J., Yang Y., Axelrod J.D., Beier D.R., Perrimon N., Sussman D.J.
    Mech. Dev. 58:15-26(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• segment specification Source: MGIInferred from mutant phenotypeⁱ
  • "Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure."
    Hamblet N.S., Lijam N., Ruiz-Lozano P., Wang J., Yang Y., Luo Z., Mei L., Chien K.R., Sussman D.J., Wynshaw-Boris A.
    Development 129:5827-5838(2002) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: MGI
• Wnt signaling pathway, planar cell polarity pathway Source: MGIInferred from genetic interactionⁱ
  • "Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway."
    Wang J., Mark S., Zhang X., Qian D., Yoo S.J., Radde-Gallwitz K., Zhang Y., Lin X., Collazo A., Wynshaw-Boris A., Chen P.
    Nat. Genet. 37:980-985(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• frizzled binding Source: UniProtKBInferred from physical interactionⁱ
  • "Direct interaction between NHERF1 and Frizzled regulates beta-catenin signaling."
    Wheeler D.S., Barrick S.R., Grubisha M.J., Brufsky A.M., Friedman P.A., Romero G.
    Oncogene 30:32-42(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization."
    Schwarz-Romond T., Fiedler M., Shibata N., Butler P.J., Kikuchi A., Higuchi Y., Bienz M.
    Nat. Struct. Mol. Biol. 14:484-492(2007) [PubMed] [Europe PMC] [Abstract]
  • Ref.10

    "Molecular basis of Wnt activation via the DIX-domain protein Ccd1."
    Liu Y.T., Dan Q.J., Wang J., Feng Y., Chen L., Liang J., Li Q., Lin S.C., Wang Z.X., Wu J.W.
    J. Biol. Chem. 286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DIXDC1, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-15; ILE-17; TYR-27; PHE-56; ASP-61; ASP-63; GLY-65; VAL-66 AND LYS-68, DOMAIN.
• protein binding, bridging Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol. Cell. Biol. 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: MGIInferred from physical interactionⁱ
  • "Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions."
    Luo W., Zou H., Jin L., Lin S., Li Q., Ye Z., Rui H., Lin S.C.
    J. Biol. Chem. 280:5054-5060(2005) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism."
    Bryja V., Schulte G., Rawal N., Grahn A., Arenas E.
    J. Cell. Sci. 120:586-595(2007) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Molecular basis of Wnt activation via the DIX-domain protein Ccd1."
    Liu Y.T., Dan Q.J., Wang J., Feng Y., Chen L., Liang J., Li Q., Lin S.C., Wang Z.X., Wu J.W.
    J. Biol. Chem. 286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH DIXDC1, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-15; ILE-17; TYR-27; PHE-56; ASP-61; ASP-63; GLY-65; VAL-66 AND LYS-68, DOMAIN.
• Rac GTPase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons."
    Cajanek L., Ganji R.S., Henriques-Oliveira C., Theofilopoulos S., Konik P., Bryja V., Arenas E.
    Mol. Cell. Biol. 33:59-70(2013) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAGSSAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP 
        60         70         80         90        100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDTPQPEVA 
       110        120        130        140        150
PPAHESRTEL VPPPPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE 
       160        170        180        190        200
TETESVVSLR RDRPRRRDSS EHGAGGHRPG GPSRLERHLA GYESSSTLMT 
       210        220        230        240        250
SELESTSLGD SDEDDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRMERT 
       260        270        280        290        300
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 
       310        320        330        340        350
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT 
       360        370        380        390        400
VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGAF PAYPGSSSMS 
       410        420        430        440        450
TITSGSSLPD GCEGRGLSVH MDMASVTKAM AAPESGLEVR DRMWLKITIP 
       460        470        480        490        500
NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ 
       510        520        530        540        550
CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT 
       560        570        580        590        600
FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 
       610        620        630        640        650
AGRTGRPEER APESKSGSGS ESELSSRGGS LRRGGEPGGT GDGGPPPSRG 
       660        670        680        690        700
STGAPPNLRA LPGLHPYGAP SGMALPYNPM MVVMMPPPPP PVSTAVQPPG 
       710        720        730 
APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM                

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot