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Protein

Segment polarity protein dishevelled homolog DVL-2

Gene

Dvl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.3 Publications

GO - Molecular functioni

  • frizzled binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein binding, bridging Source: ParkinsonsUK-UCL
  • protein domain specific binding Source: MGI
  • protein kinase binding Source: ParkinsonsUK-UCL
  • protein self-association Source: UniProtKB
  • Rac GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • canonical Wnt signaling pathway involved in regulation of cell proliferation Source: MGI
  • cellular protein localization Source: MGI
  • cochlea morphogenesis Source: MGI
  • convergent extension involved in neural plate elongation Source: MGI
  • convergent extension involved in organogenesis Source: MGI
  • heart development Source: MGI
  • heart morphogenesis Source: MGI
  • intracellular signal transduction Source: InterPro
  • neural tube closure Source: MGI
  • non-canonical Wnt signaling pathway Source: MGI
  • outflow tract morphogenesis Source: BHF-UCL
  • planar cell polarity pathway involved in neural tube closure Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of GTPase activity Source: ParkinsonsUK-UCL
  • positive regulation of JUN kinase activity Source: BHF-UCL
  • positive regulation of neuron projection arborization Source: Ensembl
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of protein tyrosine kinase activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • protein complex oligomerization Source: ParkinsonsUK-UCL
  • segmentation Source: BHF-UCL
  • segment specification Source: MGI
  • transcription by RNA polymerase II Source: MGI
  • Wnt signaling pathway Source: MGI
  • Wnt signaling pathway, planar cell polarity pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-201688 WNT mediated activation of DVL
R-MMU-2028269 Signaling by Hippo
R-MMU-4086400 PCP/CE pathway
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641258 Degradation of DVL
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5099900 WNT5A-dependent internalization of FZD4
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-2
Short name:
Dishevelled-2
Alternative name(s):
DSH homolog 2
Gene namesi
Name:Dvl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106613 Dvl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15K → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication1
Mutagenesisi17I → A: Reduces oligomerization. Abolishes interaction with DIXDC1. Reduces activation of Wnt signaling. 1 Publication1
Mutagenesisi27Y → D: Loss of oligomerization. Abolishes interaction with DIXDC1. Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi56F → H: Reduces oligomerization. Strongly reduced activation of Wnt signaling. 1 Publication1
Mutagenesisi61D → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication1
Mutagenesisi63D → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication1
Mutagenesisi64F → A: Reduces oligomerization. Reduces activation of Wnt signaling. 1
Mutagenesisi65G → D: Loss of oligomerization. Abolishes activation of Wnt signaling. 1 Publication1
Mutagenesisi66V → D: Reduces oligomerization. Reduces activation of Wnt signaling. 1 Publication1
Mutagenesisi68K → A: Loss of oligomerization. Strongly reduced activation of Wnt signaling. 1 Publication1
Mutagenesisi84R → A: Strongly reduced interaction with DIXDC1. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457471 – 736Segment polarity protein dishevelled homolog DVL-2Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei211PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CSNK1D (By similarity). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ60838
MaxQBiQ60838
PaxDbiQ60838
PRIDEiQ60838

PTM databases

iPTMnetiQ60838
PhosphoSitePlusiQ60838

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000020888
CleanExiMM_DVL2
GenevisibleiQ60838 MM

Interactioni

Subunit structurei

Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex. Interacts with FAM105B/otulin. Interacts with DCDC2. Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (By similarity). Interacts with MAPK15 (PubMed:25823377).By similarity7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • frizzled binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein binding, bridging Source: ParkinsonsUK-UCL
  • protein domain specific binding Source: MGI
  • protein kinase binding Source: ParkinsonsUK-UCL
  • protein self-association Source: UniProtKB
  • Rac GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi199343, 20 interactors
CORUMiQ60838
DIPiDIP-29399N
IntActiQ60838, 31 interactors
MINTiQ60838
STRINGi10090.ENSMUSP00000019362

Structurei

Secondary structure

1736
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi423 – 431Combined sources9
Beta strandi435 – 437Combined sources3
Beta strandi440 – 442Combined sources3
Beta strandi449 – 454Combined sources6
Helixi455 – 464Combined sources10
Helixi472 – 485Combined sources14
Beta strandi486 – 493Combined sources8
Beta strandi499 – 505Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ML6X-ray3.50A/B/C/D/E/F417-510[»]
ProteinModelPortaliQ60838
SMRiQ60838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 93DIXPROSITE-ProRule annotationAdd BLAST83
Domaini267 – 339PDZPROSITE-ProRule annotationAdd BLAST73
Domaini433 – 507DEPPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 12Poly-Gly6
Compositional biasi112 – 122Poly-ProAdd BLAST11
Compositional biasi235 – 240Poly-Arg6
Compositional biasi686 – 691Poly-Pro6

Domaini

The DIX domain mediates homooligomerization.1 Publication

Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00390000013552
HOGENOMiHOG000017084
HOVERGENiHBG005542
InParanoidiQ60838
KOiK02353
OMAiSFHLAMG
OrthoDBiEOG091G041O
TreeFamiTF318198

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008341 DVL2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF8 PTHR10878:SF8, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01762 DISHEVELLED2
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q60838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSSAGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP
60 70 80 90 100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDTPQPEVA
110 120 130 140 150
PPAHESRTEL VPPPPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE
160 170 180 190 200
TETESVVSLR RDRPRRRDSS EHGAGGHRPG GPSRLERHLA GYESSSTLMT
210 220 230 240 250
SELESTSLGD SDEDDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRMERT
260 270 280 290 300
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM
310 320 330 340 350
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT
360 370 380 390 400
VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGAF PAYPGSSSMS
410 420 430 440 450
TITSGSSLPD GCEGRGLSVH MDMASVTKAM AAPESGLEVR DRMWLKITIP
460 470 480 490 500
NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ
510 520 530 540 550
CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT
560 570 580 590 600
FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG
610 620 630 640 650
AGRTGRPEER APESKSGSGS ESELSSRGGS LRRGGEPGGT GDGGPPPSRG
660 670 680 690 700
STGAPPNLRA LPGLHPYGAP SGMALPYNPM MVVMMPPPPP PVSTAVQPPG
710 720 730
APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM
Length:736
Mass (Da):78,861
Last modified:July 27, 2011 - v2
Checksum:i928A527143BBBBB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356D → G in AAC52827 (PubMed:8887313).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24160 mRNA Translation: AAC52827.1
AK146822 mRNA Translation: BAE27460.1
AK159895 mRNA Translation: BAE35461.1
AK168376 mRNA Translation: BAE40307.1
AL596185 Genomic DNA Translation: CAI35165.1
CH466596 Genomic DNA Translation: EDL12520.1
BC053050 mRNA Translation: AAH53050.1
CCDSiCCDS24930.1
RefSeqiNP_031914.3, NM_007888.3
UniGeneiMm.5114

Genome annotation databases

EnsembliENSMUST00000019362; ENSMUSP00000019362; ENSMUSG00000020888
ENSMUST00000102575; ENSMUSP00000099635; ENSMUSG00000020888
ENSMUST00000190940; ENSMUSP00000140073; ENSMUSG00000020888
GeneIDi13543
KEGGimmu:13543
UCSCiuc007jtm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDVL2_MOUSE
AccessioniPrimary (citable) accession number: Q60838
Secondary accession number(s): Q7TN14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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