UniProtKB - Q60829 (PPR1B_MOUSE)
Protein
Protein phosphatase 1 regulatory subunit 1B
Gene
Ppp1r1b
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibitor of protein-phosphatase 1.
GO - Molecular functioni
- D1 dopamine receptor binding Source: MGI
- D2 dopamine receptor binding Source: MGI
- D3 dopamine receptor binding Source: MGI
- D4 dopamine receptor binding Source: MGI
- D5 dopamine receptor binding Source: MGI
- protein phosphatase inhibitor activity Source: MGI
- protein serine/threonine phosphatase inhibitor activity Source: MGI
GO - Biological processi
- behavioral response to cocaine Source: MGI
- intracellular signal transduction Source: MGI
- locomotory behavior Source: MGI
- memory Source: MGI
- negative regulation of female receptivity Source: MGI
- negative regulation of phosphoprotein phosphatase activity Source: MGI
- response to amphetamine Source: MGI
- response to cocaine Source: MGI
- response to morphine Source: MGI
- response to nicotine Source: MGI
- transcription, DNA-templated Source: MGI
- visual learning Source: MGI
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Enzyme and pathway databases
Reactomei | R-MMU-180024, DARPP-32 events |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 1BAlternative name(s): DARPP-32 Dopamine- and cAMP-regulated neuronal phosphoprotein |
Gene namesi | Name:Ppp1r1b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:94860, Ppp1r1b |
Subcellular locationi
Other locations
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- dendritic spine head Source: MGI
- dendritic spine neck Source: MGI
- glutamatergic synapse Source: MGI
- neuronal cell body Source: MGI
- postsynapse Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071474 | 1 – 194 | Protein phosphatase 1 regulatory subunit 1BAdd BLAST | 194 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 34 | Phosphothreonine; by PKABy similarity | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphoserineCombined sources | 1 | |
Modified residuei | 75 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 130 | PhosphoserineBy similarity | 1 | |
Modified residuei | 192 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.By similarity
Phosphorylation of Thr-34 is required for activity.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q60829 |
PeptideAtlasi | Q60829 |
PRIDEi | Q60829 |
PTM databases
iPTMneti | Q60829 |
PhosphoSitePlusi | Q60829 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000061718, Expressed in caudate-putamen and 150 other tissues |
Genevisiblei | Q60829, MM |
Interactioni
GO - Molecular functioni
- D1 dopamine receptor binding Source: MGI
- D2 dopamine receptor binding Source: MGI
- D3 dopamine receptor binding Source: MGI
- D4 dopamine receptor binding Source: MGI
- D5 dopamine receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202338, 3 interactors |
IntActi | Q60829, 1 interactor |
MINTi | Q60829 |
STRINGi | 10090.ENSMUSP00000077760 |
Miscellaneous databases
RNActi | Q60829, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the protein phosphatase inhibitor 1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S19Z, Eukaryota |
GeneTreei | ENSGT00730000111283 |
HOGENOMi | CLU_092269_3_0_1 |
InParanoidi | Q60829 |
OMAi | SNPCAYT |
OrthoDBi | 1412891at2759 |
PhylomeDBi | Q60829 |
TreeFami | TF332576 |
Family and domain databases
InterProi | View protein in InterPro IPR015670, DARPP-32 IPR008466, PPP1R1A/B/C |
PANTHERi | PTHR15417, PTHR15417, 1 hit PTHR15417:SF2, PTHR15417:SF2, 1 hit |
Pfami | View protein in Pfam PF05395, DARPP-32, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q60829-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR VSEHSSPEEE
60 70 80 90 100
ASPHQRTSGE GHHPKSKRPN PCAYTPPSLK AVQHLQTISN LSENQASEEE
110 120 130 140 150
DELGELRELG YPQEDDEEDE DEEEDEEEDS QAEVLKGSRG TVGQKPTCGR
160 170 180 190
GLEGPWERPP PLDEPQRDGN SEDQVEGRAT LSEPGEEPQH PSPP
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025058 | 1 – 36 | Missing in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY640620 mRNA Translation: AAT66920.1 AY640621 mRNA Translation: AAT66921.1 AL591390 Genomic DNA No translation available. BC011122 mRNA Translation: AAH11122.1 BC026568 mRNA Translation: AAH26568.1 BC031129 mRNA Translation: AAH31129.1 U23160 Genomic DNA Translation: AAA93223.1 AK141563 mRNA Translation: BAE24736.1 |
CCDSi | CCDS25344.1 [Q60829-1] CCDS83889.1 [Q60829-2] |
RefSeqi | NP_001300899.1, NM_001313970.1 [Q60829-2] NP_659077.1, NM_144828.2 [Q60829-1] |
Genome annotation databases
Ensembli | ENSMUST00000078694; ENSMUSP00000077760; ENSMUSG00000061718 [Q60829-1] ENSMUST00000137634; ENSMUSP00000123528; ENSMUSG00000061718 [Q60829-2] ENSMUST00000150762; ENSMUSP00000121147; ENSMUSG00000061718 [Q60829-2] |
GeneIDi | 19049 |
KEGGi | mmu:19049 |
UCSCi | uc007lfz.1, mouse [Q60829-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY640620 mRNA Translation: AAT66920.1 AY640621 mRNA Translation: AAT66921.1 AL591390 Genomic DNA No translation available. BC011122 mRNA Translation: AAH11122.1 BC026568 mRNA Translation: AAH26568.1 BC031129 mRNA Translation: AAH31129.1 U23160 Genomic DNA Translation: AAA93223.1 AK141563 mRNA Translation: BAE24736.1 |
CCDSi | CCDS25344.1 [Q60829-1] CCDS83889.1 [Q60829-2] |
RefSeqi | NP_001300899.1, NM_001313970.1 [Q60829-2] NP_659077.1, NM_144828.2 [Q60829-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 202338, 3 interactors |
IntActi | Q60829, 1 interactor |
MINTi | Q60829 |
STRINGi | 10090.ENSMUSP00000077760 |
PTM databases
iPTMneti | Q60829 |
PhosphoSitePlusi | Q60829 |
Proteomic databases
PaxDbi | Q60829 |
PeptideAtlasi | Q60829 |
PRIDEi | Q60829 |
Protocols and materials databases
Antibodypediai | 28294, 725 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000078694; ENSMUSP00000077760; ENSMUSG00000061718 [Q60829-1] ENSMUST00000137634; ENSMUSP00000123528; ENSMUSG00000061718 [Q60829-2] ENSMUST00000150762; ENSMUSP00000121147; ENSMUSG00000061718 [Q60829-2] |
GeneIDi | 19049 |
KEGGi | mmu:19049 |
UCSCi | uc007lfz.1, mouse [Q60829-1] |
Organism-specific databases
CTDi | 84152 |
MGIi | MGI:94860, Ppp1r1b |
Phylogenomic databases
eggNOGi | ENOG502S19Z, Eukaryota |
GeneTreei | ENSGT00730000111283 |
HOGENOMi | CLU_092269_3_0_1 |
InParanoidi | Q60829 |
OMAi | SNPCAYT |
OrthoDBi | 1412891at2759 |
PhylomeDBi | Q60829 |
TreeFami | TF332576 |
Enzyme and pathway databases
Reactomei | R-MMU-180024, DARPP-32 events |
Miscellaneous databases
BioGRID-ORCSi | 19049, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ppp1r1b, mouse |
PROi | PR:Q60829 |
RNActi | Q60829, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000061718, Expressed in caudate-putamen and 150 other tissues |
Genevisiblei | Q60829, MM |
Family and domain databases
InterProi | View protein in InterPro IPR015670, DARPP-32 IPR008466, PPP1R1A/B/C |
PANTHERi | PTHR15417, PTHR15417, 1 hit PTHR15417:SF2, PTHR15417:SF2, 1 hit |
Pfami | View protein in Pfam PF05395, DARPP-32, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPR1B_MOUSE | |
Accessioni | Q60829Primary (citable) accession number: Q60829 Secondary accession number(s): A2A564 Q91XB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 10, 2002 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families