Protein phosphatase 1 regulatory subunit 1B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• D1 dopamine receptor binding Source: MGI
• D2 dopamine receptor binding Source: MGI
• D3 dopamine receptor binding Source: MGI
• D4 dopamine receptor binding Source: MGI
• D5 dopamine receptor binding Source: MGI
• protein phosphatase inhibitor activity Source: MGI
• protein serine/threonine phosphatase inhibitor activity Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Regional distribution of DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA in mouse brain."
    Perez R.G., Lewis R.M.
    J. Comp. Neurol. 318:304-315(1992) [PubMed] [Europe PMC] [Abstract]
  • Ref.4

    "DARPP-32 promoter directs transgene expression to renal thick ascending limb of loop of Henle."
    Blau S., Daly L., Fienberg A., Teitelman G., Ehrlich M.E.
    Am. J. Physiol. 269:F564-F570(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.

GO - Biological processⁱ

• behavioral response to cocaine Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A phosphatase cascade by which rewarding stimuli control nucleosomal response."
    Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., Greengard P., Herve D., Girault J.A.
    Nature 453:879-884(2008) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: MGI
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • "A phosphatase cascade by which rewarding stimuli control nucleosomal response."
    Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., Greengard P., Herve D., Girault J.A.
    Nature 453:879-884(2008) [PubMed] [Europe PMC] [Abstract]
• memory Source: MGI
• negative regulation of female receptivity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice."
    Mani S.K., Fienberg A.A., O'Callaghan J.P., Snyder G.L., Allen P.B., Dash P.K., Moore A.N., Mitchell A.J., Bibb J., Greengard P., O'Malley B.W.
    Science 287:1053-1056(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of phosphoprotein phosphatase activity Source: MGI
• response to amphetamine Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice."
    Ehrman L.A., Williams M.T., Schaefer T.L., Gudelsky G.A., Reed T.M., Fienberg A.A., Greengard P., Vorhees C.V.
    Genes Brain Behav. 5:540-551(2006) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: MGI
• response to morphine Source: MGIInferred from mutant phenotypeⁱ
  • "A phosphatase cascade by which rewarding stimuli control nucleosomal response."
    Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., Greengard P., Herve D., Girault J.A.
    Nature 453:879-884(2008) [PubMed] [Europe PMC] [Abstract]
• response to nicotine Source: MGI
• transcription, DNA-templated Source: MGIInferred from mutant phenotypeⁱ
  • "Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32."
    Svenningsson P., Fienberg A.A., Allen P.B., Moine C.L., Lindskog M., Fisone G., Greengard P., Fredholm B.B.
    J. Neurochem. 75:248-257(2000) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: MGIInferred from genetic interactionⁱ
  • "Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice."
    Ehrman L.A., Williams M.T., Schaefer T.L., Gudelsky G.A., Reed T.M., Fienberg A.A., Greengard P., Vorhees C.V.
    Genes Brain Behav. 5:540-551(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• D1 dopamine receptor binding Source: MGI
• D2 dopamine receptor binding Source: MGI
• D3 dopamine receptor binding Source: MGI
• D4 dopamine receptor binding Source: MGI
• D5 dopamine receptor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR VSEHSSPEEE 
        60         70         80         90        100
ASPHQRTSGE GHHPKSKRPN PCAYTPPSLK AVQHLQTISN LSENQASEEE 
       110        120        130        140        150
DELGELRELG YPQEDDEEDE DEEEDEEEDS QAEVLKGSRG TVGQKPTCGR 
       160        170        180        190 
GLEGPWERPP PLDEPQRDGN SEDQVEGRAT LSEPGEEPQH PSPP       

        10         20         30         40         50
MLFRVSEHSS PEEEASPHQR TSGEGHHPKS KRPNPCAYTP PSLKAVQHLQ 
        60         70         80         90        100
TISNLSENQA SEEEDELGEL RELGYPQEDD EEDEDEEEDE EEDSQAEVLK 
       110        120        130        140        150
GSRGTVGQKP TCGRGLEGPW ERPPPLDEPQ RDGNSEDQVE GRATLSEPGE 

EPQHPSPP                                               

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot