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Entry version 141 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Interleukin-15 receptor subunit alpha

Gene

Il15ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity).By similarity1 Publication

Caution

It was shown that proteolytic cleavage of Il15ra involves ADAM17/TACE; this publication has later been retracted.1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8983432 Interleukin-15 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-15 receptor subunit alpha
Short name:
IL-15 receptor subunit alpha
Short name:
IL-15R-alpha
Short name:
IL-15RA
Alternative name(s):
CD_antigen: CD215
Cleaved into the following chain:
Soluble interleukin-15 receptor subunit alpha
Short name:
sIL-15 receptor subunit alpha
Short name:
sIL-15R-alpha
Short name:
sIL-15RA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il15ra
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104644 Il15ra

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 205ExtracellularSequence analysisAdd BLAST173
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 263CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane, Nucleus, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001104533 – 263Interleukin-15 receptor subunit alphaAdd BLAST231
ChainiPRO_000033385633 – ?Soluble interleukin-15 receptor subunit alpha

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 78PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi62 ↔ 96PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and O-glycosylated.By similarity
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (By similarity). It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60819

PRoteomics IDEntifications database

More...
PRIDEi
Q60819

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q60819

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023206 Expressed in 184 organ(s), highest expression level in brown adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60819 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q60819 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077878

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q60819

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q60819

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 98SushiPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWP4 Eukaryota
ENOG410Z8MM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000121

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q60819

KEGG Orthology (KO)

More...
KOi
K05074

Identification of Orthologs from Complete Genome Data

More...
OMAi
LLACYIK

Database of Orthologous Groups

More...
OrthoDBi
1326471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q60819

TreeFam database of animal gene trees

More...
TreeFami
TF338443

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPQLRGYG VQAIPVLLLL LLLLLLPLRV TPGTTCPPPV SIEHADIRVK
60 70 80 90 100
NYSVNSRERY VCNSGFKRKA GTSTLIECVI NKNTNVAHWT TPSLKCIRDP
110 120 130 140 150
SLAHYSPVPT VVTPKVTSQP ESPSPSAKEP EAFSPKSDTA MTTETAIMPG
160 170 180 190 200
SRLTPSQTTS AGTTGTGSHK SSRAPSLAAT MTLEPTASTS LRITEISPHS
210 220 230 240 250
SKMTKVAIST SVLLVGAGVV MAFLAWYIKS RQPSQPCRVE VETMETVPMT
260
VRASSKEDED TGA
Length:263
Mass (Da):28,061
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFCC2CE4BA58B504
GO
Isoform 2 (identifier: Q60819-2) [UniParc]FASTAAdd to basket
Also known as: 1A

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.
     141-161: Missing.

Show »
Length:230
Mass (Da):24,638
Checksum:i23CF1CE4DA3F70F1
GO
Isoform 3 (identifier: Q60819-3) [UniParc]FASTAAdd to basket
Also known as: 1B, IL-15R-alphadelta4

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.

Show »
Length:197
Mass (Da):21,366
Checksum:i1D16A75C518B986B
GO
Isoform 4 (identifier: Q60819-4) [UniParc]FASTAAdd to basket
Also known as: 1C, IL-15R-alphadelta34

The sequence of this isoform differs from the canonical sequence as follows:
     98-128: Missing.
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.
     195-195: E → K

Show »
Length:166
Mass (Da):18,122
Checksum:i94DC3A60B7CD883B
GO
Isoform 5 (identifier: Q60819-5) [UniParc]FASTAAdd to basket
Also known as: 2, 2A

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-128: Missing.
     129-140: Missing.

Show »
Length:123
Mass (Da):12,905
Checksum:iB43C11755D9823DC
GO
Isoform 6 (identifier: Q60819-6) [UniParc]FASTAAdd to basket
Also known as: IL-15R-alphadelta345

The sequence of this isoform differs from the canonical sequence as follows:
     98-128: Missing.
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.
     195-206: EISPHSSKMTKV → M

Show »
Length:155
Mass (Da):16,929
Checksum:iB74A423264627E66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AP38A2AP38_MOUSE
Interleukin-15 receptor subunit alp...
Il15ra
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA82E9QA82_MOUSE
Interleukin-15 receptor subunit alp...
Il15ra
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q810T6Q810T6_MOUSE
Interleukin 15 receptor alpha chain...
Il15ra
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0126271 – 97Missing in isoform 5. 2 PublicationsAdd BLAST97
Alternative sequenceiVSP_01262898 – 128Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_012629129 – 140Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_012630141 – 161Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012631162 – 194Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_012633195 – 206EISPH…KMTKV → M in isoform 6. CuratedAdd BLAST12
Alternative sequenceiVSP_012632195E → K in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U22339 Genomic DNA Translation: AAC52240.1
AY219715 mRNA Translation: AAO62310.1
AY219716 mRNA Translation: AAO62311.1
AY219717 mRNA Translation: AAO62312.1
AY221616 mRNA Translation: AAO74882.1
AL831794 Genomic DNA No translation available.
BC022705 mRNA Translation: AAH22705.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15686.1 [Q60819-1]
CCDS15687.1 [Q60819-5]
CCDS70977.1 [Q60819-2]
CCDS70978.1 [Q60819-3]
CCDS70979.1 [Q60819-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
S57346

NCBI Reference Sequences

More...
RefSeqi
NP_001258426.1, NM_001271497.1 [Q60819-5]
NP_001258428.1, NM_001271499.1 [Q60819-2]
NP_001258429.1, NM_001271500.1 [Q60819-3]
NP_001258430.1, NM_001271501.1 [Q60819-4]
NP_032384.1, NM_008358.2 [Q60819-1]
NP_598597.1, NM_133836.2 [Q60819-5]
XP_006497427.1, XM_006497364.1 [Q60819-5]
XP_017171184.1, XM_017315695.1 [Q60819-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000078834; ENSMUSP00000077878; ENSMUSG00000023206 [Q60819-1]
ENSMUST00000114831; ENSMUSP00000110480; ENSMUSG00000023206 [Q60819-2]
ENSMUST00000114832; ENSMUSP00000110481; ENSMUSG00000023206 [Q60819-6]
ENSMUST00000114833; ENSMUSP00000110482; ENSMUSG00000023206 [Q60819-4]
ENSMUST00000114834; ENSMUSP00000110483; ENSMUSG00000023206 [Q60819-3]
ENSMUST00000128156; ENSMUSP00000126364; ENSMUSG00000023206 [Q60819-5]
ENSMUST00000135341; ENSMUSP00000132731; ENSMUSG00000023206 [Q60819-5]
ENSMUST00000138349; ENSMUSP00000131473; ENSMUSG00000023206 [Q60819-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16169

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16169

UCSC genome browser

More...
UCSCi
uc008iiw.2 mouse [Q60819-6]
uc008iix.2 mouse [Q60819-1]
uc008iiy.2 mouse [Q60819-2]
uc008iiz.2 mouse [Q60819-3]
uc008ija.2 mouse [Q60819-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22339 Genomic DNA Translation: AAC52240.1
AY219715 mRNA Translation: AAO62310.1
AY219716 mRNA Translation: AAO62311.1
AY219717 mRNA Translation: AAO62312.1
AY221616 mRNA Translation: AAO74882.1
AL831794 Genomic DNA No translation available.
BC022705 mRNA Translation: AAH22705.1
CCDSiCCDS15686.1 [Q60819-1]
CCDS15687.1 [Q60819-5]
CCDS70977.1 [Q60819-2]
CCDS70978.1 [Q60819-3]
CCDS70979.1 [Q60819-4]
PIRiS57346
RefSeqiNP_001258426.1, NM_001271497.1 [Q60819-5]
NP_001258428.1, NM_001271499.1 [Q60819-2]
NP_001258429.1, NM_001271500.1 [Q60819-3]
NP_001258430.1, NM_001271501.1 [Q60819-4]
NP_032384.1, NM_008358.2 [Q60819-1]
NP_598597.1, NM_133836.2 [Q60819-5]
XP_006497427.1, XM_006497364.1 [Q60819-5]
XP_017171184.1, XM_017315695.1 [Q60819-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19C/F33-103[»]
SMRiQ60819
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077878

Proteomic databases

PaxDbiQ60819
PRIDEiQ60819

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078834; ENSMUSP00000077878; ENSMUSG00000023206 [Q60819-1]
ENSMUST00000114831; ENSMUSP00000110480; ENSMUSG00000023206 [Q60819-2]
ENSMUST00000114832; ENSMUSP00000110481; ENSMUSG00000023206 [Q60819-6]
ENSMUST00000114833; ENSMUSP00000110482; ENSMUSG00000023206 [Q60819-4]
ENSMUST00000114834; ENSMUSP00000110483; ENSMUSG00000023206 [Q60819-3]
ENSMUST00000128156; ENSMUSP00000126364; ENSMUSG00000023206 [Q60819-5]
ENSMUST00000135341; ENSMUSP00000132731; ENSMUSG00000023206 [Q60819-5]
ENSMUST00000138349; ENSMUSP00000131473; ENSMUSG00000023206 [Q60819-5]
GeneIDi16169
KEGGimmu:16169
UCSCiuc008iiw.2 mouse [Q60819-6]
uc008iix.2 mouse [Q60819-1]
uc008iiy.2 mouse [Q60819-2]
uc008iiz.2 mouse [Q60819-3]
uc008ija.2 mouse [Q60819-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3601
MGIiMGI:104644 Il15ra

Phylogenomic databases

eggNOGiENOG410IWP4 Eukaryota
ENOG410Z8MM LUCA
GeneTreeiENSGT00390000000121
InParanoidiQ60819
KOiK05074
OMAiLLACYIK
OrthoDBi1326471at2759
PhylomeDBiQ60819
TreeFamiTF338443

Enzyme and pathway databases

ReactomeiR-MMU-8983432 Interleukin-15 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Il15ra mouse
EvolutionaryTraceiQ60819
PMAP-CutDBiQ60819

Protein Ontology

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PROi
PR:Q60819

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023206 Expressed in 184 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ60819 baseline and differential
GenevisibleiQ60819 MM

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SUPFAMiSSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI15RA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60819
Secondary accession number(s): A2AP35
, A2AP36, A2AP37, Q80Z90, Q80Z91, Q80Z92, Q8R5E4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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