Krueppel-like factor 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells."
    Hoffmeyer K., Raggioli A., Rudloff S., Anton R., Hierholzer A., Del Valle I., Hein K., Vogt R., Kemler R.
    Science 336:1549-1554(2012) [PubMed] [Europe PMC] [Abstract]
• chromatin DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity."
    Szigety K.M., Liu F., Yuan C.Y., Moran D.J., Horrell J., Gochnauer H.R., Cohen R.N., Katz J.P., Kaestner K.H., Seykora J.T., Tobias J.W., Lazar M.A., Xu M., Millar S.E.
    Genes Dev 34:973-988(2020) [PubMed] [Europe PMC] [Abstract]
• cis-regulatory region sequence-specific DNA binding Source: MGI
• DNA binding Source: MGI <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Mammalian SP/KLF transcription factors: bring in the family."
    Suske G., Bruford E., Philipsen S.
    Genomics 85:551-556(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis."
    Rivero S., Diaz-Guerra M.J., Monsalve E.M., Laborda J., Garcia-Ramirez J.J.
    J Mol Biol 417:36-50(2012) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition."
    Patel S., Xi Z.F., Seo E.Y., McGaughey D., Segre J.A.
    Proc Natl Acad Sci U S A 103:18668-18673(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: CACAOInferred from direct assayⁱ
  • "A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation."
    Nishimura K., Aizawa S., Nugroho F.L., Shiomitsu E., Tran Y.T.H., Bui P.L., Borisova E., Sakuragi Y., Takada H., Kurisaki A., Hayashi Y., Fukuda A., Nakanishi M., Hisatake K.
    Stem Cell Reports 8:787-801(2017) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: MGI
• histone deacetylase binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• phosphatidylinositol 3-kinase regulator activity Source: MGI
• promoter-specific chromatin binding Source: UniProtKB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells."
    Hoffmeyer K., Raggioli A., Rudloff S., Anton R., Hierholzer A., Del Valle I., Hein K., Vogt R., Kemler R.
    Science 336:1549-1554(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity Source: BHF-UCLInferred from direct assayⁱ
  • "Transcriptional regulation of adipogenesis by KLF4."
    Birsoy K., Chen Z., Friedman J.
    Cell Metab 7:339-347(2008) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Transcriptional regulation of adipogenesis by KLF4."
    Birsoy K., Chen Z., Friedman J.
    Cell Metab 7:339-347(2008) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis."
    Rivero S., Diaz-Guerra M.J., Monsalve E.M., Laborda J., Garcia-Ramirez J.J.
    J Mol Biol 417:36-50(2012) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells."
    Garrett-Sinha L.A., Eberspaecher H., Seldin M.F., de Crombrugghe B.
    J. Biol. Chem. 271:31384-31390(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells."
    Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J., Matoba R., Ko M.S., Niwa H.
    Mol. Cell. Biol. 26:7772-7782(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• transcription coregulator binding Source: MGI

GO - Biological processⁱ

• canonical Wnt signaling pathway Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells."
    Hoffmeyer K., Raggioli A., Rudloff S., Anton R., Hierholzer A., Del Valle I., Hein K., Vogt R., Kemler R.
    Science 336:1549-1554(2012) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.13

    "Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells."
    Swamynathan S.K., Katz J.P., Kaestner K.H., Ashery-Padan R., Crawford M.A., Piatigorsky J.
    Mol. Cell. Biol. 27:182-194(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• cellular response to growth factor stimulus Source: MGI
• cellular response to laminar fluid shear stress Source: MGI
• cellular response to leukemia inhibitory factor Source: MGI <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells."
    Tarantino C., Paolella G., Cozzuto L., Minopoli G., Pastore L., Parisi S., Russo T.
    FASEB J 24:3255-3263(2010) [PubMed] [Europe PMC] [Abstract]
• defense response to tumor cell Source: MGI
• epidermal cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.9

    "Klf4 is a transcription factor required for establishing the barrier function of the skin."
    Segre J.A., Bauer C., Fuchs E.
    Nat. Genet. 22:356-360(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
• epidermis development Source: MGIInferred from mutant phenotypeⁱ
  • "HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity."
    Szigety K.M., Liu F., Yuan C.Y., Moran D.J., Horrell J., Gochnauer H.R., Cohen R.N., Katz J.P., Kaestner K.H., Seykora J.T., Tobias J.W., Lazar M.A., Xu M., Millar S.E.
    Genes Dev 34:973-988(2020) [PubMed] [Europe PMC] [Abstract]
• epidermis morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.9

    "Klf4 is a transcription factor required for establishing the barrier function of the skin."
    Segre J.A., Bauer C., Fuchs E.
    Nat. Genet. 22:356-360(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
• establishment of skin barrier Source: MGIInferred from mutant phenotypeⁱ
  • "HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity."
    Szigety K.M., Liu F., Yuan C.Y., Moran D.J., Horrell J., Gochnauer H.R., Cohen R.N., Katz J.P., Kaestner K.H., Seykora J.T., Tobias J.W., Lazar M.A., Xu M., Millar S.E.
    Genes Dev 34:973-988(2020) [PubMed] [Europe PMC] [Abstract]
• fat cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Transcriptional regulation of adipogenesis by KLF4."
    Birsoy K., Chen Z., Friedman J.
    Cell Metab 7:339-347(2008) [PubMed] [Europe PMC] [Abstract]
• gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation."
    Miyai M., Hamada M., Moriguchi T., Hiruma J., Kamitani-Kawamoto A., Watanabe H., Hara-Chikuma M., Takahashi K., Takahashi S., Kataoka K.
    J Invest Dermatol 136:1848-1857(2016) [PubMed] [Europe PMC] [Abstract]
  • "HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity."
    Szigety K.M., Liu F., Yuan C.Y., Moran D.J., Horrell J., Gochnauer H.R., Cohen R.N., Katz J.P., Kaestner K.H., Seykora J.T., Tobias J.W., Lazar M.A., Xu M., Millar S.E.
    Genes Dev 34:973-988(2020) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: MGI
• negative regulation of cell migration Source: CACAOInferred from mutant phenotypeⁱ
  • "Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis."
    Li J., Zheng H., Yu F., Yu T., Liu C., Huang S., Wang T.C., Ai W.
    Carcinogenesis 33:1239-1246(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration involved in sprouting angiogenesis Source: MGI
• negative regulation of cell population proliferation Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest."
    Shields J.M., Christy R.J., Yang V.W.
    J. Biol. Chem. 271:20009-20017(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• negative regulation of chemokine (C-X-C motif) ligand 2 production Source: MGI
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
• negative regulation of DNA-binding transcription factor activity Source: MGIInferred from mutant phenotypeⁱ
  • "Cross-talk between KLF4 and STAT3 regulates axon regeneration."
    Qin S., Zou Y., Zhang C.L.
    Nat Commun 4:2633-2633(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ERK1 and ERK2 cascade Source: MGI
• negative regulation of G1/S transition of mitotic cell cycle Source: MGI
• negative regulation of gene expression Source: MGI
• negative regulation of heterotypic cell-cell adhesion Source: MGI
• negative regulation of interleukin-8 production Source: MGI
• negative regulation of leukocyte adhesion to arterial endothelial cell Source: MGI
• negative regulation of muscle hyperplasia Source: MGI
• negative regulation of NF-kappaB transcription factor activity Source: MGI
• negative regulation of phosphatidylinositol 3-kinase signaling Source: MGI
• negative regulation of protein kinase B signaling Source: MGI
• negative regulation of response to cytokine stimulus Source: MGI
• negative regulation of smooth muscle cell proliferation Source: MGI
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains."
    Yet S.-F., McA'Nulty M.M., Folta S.C., Yen H.-W., Yoshizumi M., Hsieh C.-M., Layne M.D., Chin M.T., Wang H., Perrella M.A., Jain M.K., Lee M.-E.
    J. Biol. Chem. 273:1026-1031(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of cellular protein metabolic process Source: MGI
• positive regulation of core promoter binding Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells."
    Hoffmeyer K., Raggioli A., Rudloff S., Anton R., Hierholzer A., Del Valle I., Hein K., Vogt R., Kemler R.
    Science 336:1549-1554(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGI
• positive regulation of hemoglobin biosynthetic process Source: MGI
• positive regulation of miRNA transcription Source: MGI
• positive regulation of nitric oxide biosynthetic process Source: MGI
• positive regulation of protein metabolic process Source: MGI
• positive regulation of sprouting angiogenesis Source: MGI
• positive regulation of telomerase activity Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells."
    Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J., Matoba R., Ko M.S., Niwa H.
    Mol. Cell. Biol. 26:7772-7782(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.14

    "Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming."
    Wei Z., Yang Y., Zhang P., Andrianakos R., Hasegawa K., Lyu J., Chen X., Bai G., Liu C., Pera M., Lu W.
    Stem Cells 27:2969-2978(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POU5F1/OCT4 AND SOX2, BIOTECHNOLOGY.
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • Ref.13

    "Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells."
    Swamynathan S.K., Katz J.P., Kaestner K.H., Ashery-Padan R., Crawford M.A., Piatigorsky J.
    Mol. Cell. Biol. 27:182-194(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • "Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition."
    Patel S., Xi Z.F., Seo E.Y., McGaughey D., Segre J.A.
    Proc Natl Acad Sci U S A 103:18668-18673(2006) [PubMed] [Europe PMC] [Abstract]
  • Ref.17

    "Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator."
    Fujii Y., Kakegawa M., Koide H., Akagi T., Yokota T.
    Biochem. Biophys. Res. Commun. 441:411-417(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH ZNF296, SUBCELLULAR LOCATION.
• post-embryonic camera-type eye development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.13

    "Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells."
    Swamynathan S.K., Katz J.P., Kaestner K.H., Ashery-Padan R., Crawford M.A., Piatigorsky J.
    Mol. Cell. Biol. 27:182-194(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• post-embryonic hemopoiesis Source: MGI
• regulation of axon regeneration Source: MGIInferred from mutant phenotypeⁱ
  • "Cross-talk between KLF4 and STAT3 regulates axon regeneration."
    Qin S., Zou Y., Zhang C.L.
    Nat Commun 4:2633-2633(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of blastocyst development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.18

    "Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice."
    Ye B., Liu B., Hao L., Zhu X., Yang L., Wang S., Xia P., Du Y., Meng S., Huang G., Qin X., Wang Y., Yan X., Li C., Hao J., Zhu P., He L., Tian Y., Fan Z.
    Nat. Commun. 9:1261-1261(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH BTRC, GLUTAMYLATION AT GLU-381, UBIQUITINATION, MUTAGENESIS OF GLU-46; GLU-95; LYS-229; GLU-326 AND GLU-381.
• regulation of cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.14

    "Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming."
    Wei Z., Yang Y., Zhang P., Andrianakos R., Hasegawa K., Lyu J., Chen X., Bai G., Liu C., Pera M., Lu W.
    Stem Cells 27:2969-2978(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POU5F1/OCT4 AND SOX2, BIOTECHNOLOGY.
• regulation of cell population proliferation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis."
    Ghaleb A.M., McConnell B.B., Nandan M.O., Katz J.P., Kaestner K.H., Yang V.W.
    Cancer Res 67:7147-7154(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors."
    Nishiyama A., Xin L., Sharov A.A., Thomas M., Mowrer G., Meyers E., Piao Y., Mehta S., Yee S., Nakatake Y., Stagg C., Sharova L., Correa-Cerro L.S., Bassey U., Hoang H., Kim E., Tapnio R., Qian Y.

    , Dudekula D., Zalzman M., Li M., Falco G., Yang H.T., Lee S.L., Monti M., Stanghellini I., Islam M.N., Nagaraja R., Goldberg I., Wang W., Longo D.L., Schlessinger D., Ko M.S.
    Cell Stem Cell 5:420-433(2009) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: MGIInferred from direct assayⁱ
  • "Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency."
    Kunarso G., Wong K.Y., Stanton L.W., Lipovich L.
    BMC Genomics 9:155-155(2008) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: MGIInferred from direct assayⁱ
  • "Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency."
    Kunarso G., Wong K.Y., Stanton L.W., Lipovich L.
    BMC Genomics 9:155-155(2008) [PubMed] [Europe PMC] [Abstract]
• stem cell population maintenance Source: UniProtKBInferred from direct assayⁱ
  • Ref.14

    "Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming."
    Wei Z., Yang Y., Zhang P., Andrianakos R., Hasegawa K., Lyu J., Chen X., Bai G., Liu C., Pera M., Lu W.
    Stem Cells 27:2969-2978(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH POU5F1/OCT4 AND SOX2, BIOTECHNOLOGY.
• transcription, DNA-templated Source: CACAOInferred from mutant phenotypeⁱ
  • "Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation."
    Jean J.C., George E., Kaestner K.H., Brown L.A., Spira A., Joyce-Brady M.
    PLoS One 8:e54806-e54806(2013) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological useⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells."
    Hoffmeyer K., Raggioli A., Rudloff S., Anton R., Hierholzer A., Del Valle I., Hein K., Vogt R., Kemler R.
    Science 336:1549-1554(2012) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: MGI
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Transcriptional regulation of adipogenesis by KLF4."
    Birsoy K., Chen Z., Friedman J.
    Cell Metab 7:339-347(2008) [PubMed] [Europe PMC] [Abstract]
• transcription coregulator binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRPAGAP TNRWREELSH 
        60         70         80         90        100
MKRLPPLPGR PYDLAATVAT DLESGGAGAA CSSNNPALLA RRETEEFNDL 
       110        120        130        140        150
LDLDFILSNS LTHQESVAAT VTTSASASSS SSPASSGPAS APSTCSFSYP 
       160        170        180        190        200
IRAGGDPGVA ASNTGGGLLY SRESAPPPTA PFNLADINDV SPSGGFVAEL 
       210        220        230        240        250
LRPELDPVYI PPQQPQPPGG GLMGKFVLKA SLTTPGSEYS SPSVISVSKG 
       260        270        280        290        300
SPDGSHPVVV APYSGGPPRM CPKIKQEAVP SCTVSRSLEA HLSAGPQLSN 
       310        320        330        340        350
GHRPNTHDFP LGRQLPTRTT PTLSPEELLN SRDCHPGLPL PPGFHPHPGP 
       360        370        380        390        400
NYPPFLPDQM QSQVPSLHYQ ELMPPGSCLP EEPKPKRGRR SWPRKRTATH 
       410        420        430        440        450
TCDYAGCGKT YTKSSHLKAH LRTHTGEKPY HCDWDGCGWK FARSDELTRH 
       460        470        480 
YRKHTGHRPF QCQKCDRAFS RSDHLALHMK RHF                   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families