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Protein

Growth arrest-specific protein 7

Gene

Gas7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

GO - Molecular functioni

  • actin filament binding Source: MGI
  • cytoskeletal protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 7
Short name:
GAS-7
Gene namesi
Name:Gas7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1202388 Gas7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760581 – 421Growth arrest-specific protein 7Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei108PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ60780
PeptideAtlasiQ60780
PRIDEiQ60780

PTM databases

iPTMnetiQ60780
PhosphoSitePlusiQ60780

Expressioni

Tissue specificityi

Expressed abundantly in brain with lower levels in heart and testis. In the brain, expressed prominently in the Purkinje layer of the cerebellum, moderately in hippocampus, and less extensively in cerebral cortex and caudate putamen.1 Publication

Gene expression databases

CleanExiMM_GAS7

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ60780, 2 interactors
MINTiQ60780
STRINGi10090.ENSMUSP00000104322

Structurei

3D structure databases

ProteinModelPortaliQ60780
SMRiQ60780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 55WWPROSITE-ProRule annotationAdd BLAST34
Domaini141 – 401F-BARPROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili254 – 328Sequence analysisAdd BLAST75

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
KOG2398 Eukaryota
ENOG410Z5NV LUCA
HOGENOMiHOG000294146
HOVERGENiHBG001320
InParanoidiQ60780
PhylomeDBiQ60780

Family and domain databases

CDDicd07649 F-BAR_GAS7, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR037957 GAS7_F-BAR
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60780-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATALQKPGM VPPPPGEESQ TVILPPGWHS YLSPQGRRYY VNTTTNETTW
60 70 80 90 100
ERPSSSPGIS ASPAPHRSSL PTTVNGYHAS GTPAHPPETA HMSLRKSTGD
110 120 130 140 150
SQNLGSSSPG RKQSKENTIT INCVTFPHPD TMPEQQLLKP TEWSYCDYFW
160 170 180 190 200
ADKKDPQGNG TVAGFELLLQ KQLKGKQMQK EMSEFIRERI KIEEEYAKNL
210 220 230 240 250
AKLSQNSLAA QEEGSLGEAW AQVKKSLADE AEVHLKFSAK LHSEVEKPLM
260 270 280 290 300
NFRENFKKDM KKCDHHIADL RKQLASRYAS VEKARKALTE RQKDLEMKTQ
310 320 330 340 350
QLEIKLSNKT EEDIKKARRK STQAGDDLMR CVDLYNQAQS KWFEEMVTTT
360 370 380 390 400
LELERLEVER VEMIRQHLCQ YTQLRHETDM FNQSTVEPVD QLLRKVDPAK
410 420
DRELWVREHK TGNIRPVDME I
Length:421
Mass (Da):48,174
Last modified:November 1, 1996 - v1
Checksum:i8659C5AE3BF36766
GO
Isoform 2 (identifier: Q60780-2) [UniParc]FASTAAdd to basket
Also known as: GAS7-CB

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-101: TPAHPPETAHMSLRKSTGDS → MGKKMSNMENSFDDGSHLSP

Show »
Length:340
Mass (Da):39,610
Checksum:iE2A4839235B900A0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U432Q3U432_MOUSE
Growth arrest-specific protein 7
Gas7
416Annotation score:
B1ATI9B1ATI9_MOUSE
Growth arrest-specific protein 7
Gas7
412Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068041 – 81Missing in isoform 2. CuratedAdd BLAST81
Alternative sequenceiVSP_00680582 – 101TPAHP…STGDS → MGKKMSNMENSFDDGSHLSP in isoform 2. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19860 mRNA Translation: AAA85259.1
AF133184 mRNA Translation: AAF15397.1
AF135442 Genomic DNA Translation: AAF15398.1
AF135442 Genomic DNA Translation: AAF15399.1
UniGeneiMm.152121
Mm.40338

Genome annotation databases

UCSCiuc007jmx.2 mouse [Q60780-2]
uc033fwm.1 mouse [Q60780-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19860 mRNA Translation: AAA85259.1
AF133184 mRNA Translation: AAF15397.1
AF135442 Genomic DNA Translation: AAF15398.1
AF135442 Genomic DNA Translation: AAF15399.1
UniGeneiMm.152121
Mm.40338

3D structure databases

ProteinModelPortaliQ60780
SMRiQ60780
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60780, 2 interactors
MINTiQ60780
STRINGi10090.ENSMUSP00000104322

PTM databases

iPTMnetiQ60780
PhosphoSitePlusiQ60780

Proteomic databases

PaxDbiQ60780
PeptideAtlasiQ60780
PRIDEiQ60780

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007jmx.2 mouse [Q60780-2]
uc033fwm.1 mouse [Q60780-1]

Organism-specific databases

MGIiMGI:1202388 Gas7

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
KOG2398 Eukaryota
ENOG410Z5NV LUCA
HOGENOMiHOG000294146
HOVERGENiHBG001320
InParanoidiQ60780
PhylomeDBiQ60780

Miscellaneous databases

ChiTaRSiGas7 mouse
PROiPR:Q60780
SOURCEiSearch...

Gene expression databases

CleanExiMM_GAS7

Family and domain databases

CDDicd07649 F-BAR_GAS7, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR037957 GAS7_F-BAR
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAS7_MOUSE
AccessioniPrimary (citable) accession number: Q60780
Secondary accession number(s): Q9QY25, Q9QY26, Q9QY34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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