UniProtKB - Q60775 (ELF1_MOUSE)
Protein
ETS-related transcription factor Elf-1
Gene
Elf1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that activates the LYN and BLK promoters.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 208 – 290 | ETSPROSITE-ProRule annotationAdd BLAST | 83 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: GO_Central
- negative regulation of T cell receptor signaling pathway Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of cytokine production Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling |
Names & Taxonomyi
Protein namesi | Recommended name: ETS-related transcription factor Elf-1Alternative name(s): E74-like factor 1 |
Gene namesi | Name:Elf1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107180, Elf1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204086 | 1 – 612 | ETS-related transcription factor Elf-1Add BLAST | 612 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | PhosphoserineBy similarity | 1 | |
Modified residuei | 163 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Modified residuei | 168 | PhosphoserineBy similarity | 1 | |
Modified residuei | 187 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 431 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q60775 |
jPOSTi | Q60775 |
MaxQBi | Q60775 |
PaxDbi | Q60775 |
PRIDEi | Q60775 |
ProteomicsDBi | 275451 |
PTM databases
iPTMneti | Q60775 |
PhosphoSitePlusi | Q60775 |
Expressioni
Tissue specificityi
Predominantly found in hematopoietic cells. Detected in other cell types such as fibroblasts.
Gene expression databases
Bgeei | ENSMUSG00000036461, Expressed in thymus and 291 other tissues |
ExpressionAtlasi | Q60775, baseline and differential |
Genevisiblei | Q60775, MM |
Interactioni
Subunit structurei
Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes.
Interacts with RUNX1.
Interacts with SP1; the interaction is inhibited by glycosylation of SP1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 199426, 6 interactors |
IntActi | Q60775, 2 interactors |
MINTi | Q60775 |
STRINGi | 10090.ENSMUSP00000046515 |
Miscellaneous databases
RNActi | Q60775, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 75 – 80 | Poly-Asp | 6 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000157039 |
HOGENOMi | CLU_027279_1_0_1 |
InParanoidi | Q60775 |
OMAi | HNYSGLT |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q60775 |
TreeFami | TF318679 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q60775-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVVQQNDL VFEFASNGME DEQQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH NGDETIETIE
110 120 130 140 150
AAEALLNIDS PSPPVLDEKQ INNNIFSSSE DDIVAPITHV SVTLDGIPEV
160 170 180 190 200
METQQVQETN ADSPGASSPE QRKRKKGRKT KPPRPDSPTT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYID
310 320 330 340 350
DEDPSSSIES SDQSLSSTTA SSRNQANRSR VSSSPGIKGG AATILKPGNS
360 370 380 390 400
KAANPKDPVE VGQPSEVLRT VQPSQAPYPT QLFRTVHVVQ PVQAVPEEAT
410 420 430 440 450
IASTMQEEAA NSSVPSIRTI QASTQVPVVV SPGNQQLHTV TVPLTTVIAS
460 470 480 490 500
IDPSSGAGSQ KFILQTIPSS QPMTVLKENV MLQSQKPGSP SIVLSPTQVQ
510 520 530 540 550
QVLTSNVQSI CNGAGSVASA PSFSATTPVV TFSRSSQLVA HPPGTVITSV
560 570 580 590 600
IKAQETKTLK QEVEKKAEDD LNEDAEKSAQ QPQPYVMVLS SSNGFSSQVA
610
VKQNELLEPN SF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BPX9 | A0A2I3BPX9_MOUSE | ETS-related transcription factor El... | Elf1 | 575 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19617 mRNA Translation: AAB17097.1 BC057134 mRNA Translation: AAH57134.1 |
CCDSi | CCDS27301.1 |
RefSeqi | NP_001273340.1, NM_001286411.1 NP_031946.1, NM_007920.4 XP_011243248.1, XM_011244946.2 XP_011243249.1, XM_011244947.1 |
Genome annotation databases
Ensembli | ENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461 ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461 |
GeneIDi | 13709 |
KEGGi | mmu:13709 |
UCSCi | uc007utb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19617 mRNA Translation: AAB17097.1 BC057134 mRNA Translation: AAH57134.1 |
CCDSi | CCDS27301.1 |
RefSeqi | NP_001273340.1, NM_001286411.1 NP_031946.1, NM_007920.4 XP_011243248.1, XM_011244946.2 XP_011243249.1, XM_011244947.1 |
3D structure databases
SMRi | Q60775 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199426, 6 interactors |
IntActi | Q60775, 2 interactors |
MINTi | Q60775 |
STRINGi | 10090.ENSMUSP00000046515 |
PTM databases
iPTMneti | Q60775 |
PhosphoSitePlusi | Q60775 |
Proteomic databases
EPDi | Q60775 |
jPOSTi | Q60775 |
MaxQBi | Q60775 |
PaxDbi | Q60775 |
PRIDEi | Q60775 |
ProteomicsDBi | 275451 |
Protocols and materials databases
Antibodypediai | 906, 368 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461 ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461 |
GeneIDi | 13709 |
KEGGi | mmu:13709 |
UCSCi | uc007utb.2, mouse |
Organism-specific databases
CTDi | 1997 |
MGIi | MGI:107180, Elf1 |
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000157039 |
HOGENOMi | CLU_027279_1_0_1 |
InParanoidi | Q60775 |
OMAi | HNYSGLT |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q60775 |
TreeFami | TF318679 |
Enzyme and pathway databases
Reactomei | R-MMU-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling |
Miscellaneous databases
BioGRID-ORCSi | 13709, 1 hit in 52 CRISPR screens |
ChiTaRSi | Elf1, mouse |
PROi | PR:Q60775 |
RNActi | Q60775, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036461, Expressed in thymus and 291 other tissues |
ExpressionAtlasi | Q60775, baseline and differential |
Genevisiblei | Q60775, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELF1_MOUSE | |
Accessioni | Q60775Primary (citable) accession number: Q60775 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families