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Protein

ETS-related transcription factor Elf-1

Gene

Elf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that activates the LYN and BLK promoters.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-1
Alternative name(s):
E74-like factor 1
Gene namesi
Name:Elf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107180 Elf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040861 – 612ETS-related transcription factor Elf-1Add BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei190PhosphothreonineBy similarity1
Modified residuei431PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ60775
MaxQBiQ60775
PaxDbiQ60775
PRIDEiQ60775

PTM databases

iPTMnetiQ60775
PhosphoSitePlusiQ60775

Expressioni

Tissue specificityi

Predominantly found in hematopoietic cells. Detected in other cell types such as fibroblasts.

Gene expression databases

BgeeiENSMUSG00000036461 Expressed in 272 organ(s), highest expression level in thymus
CleanExiMM_ELF1
ExpressionAtlasiQ60775 baseline and differential
GenevisibleiQ60775 MM

Interactioni

Subunit structurei

Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1. Interacts with SP1; the interaction is inhibited by glycosylation of SP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199426, 3 interactors
IntActiQ60775, 2 interactors
MINTiQ60775
STRINGi10090.ENSMUSP00000046515

Structurei

3D structure databases

ProteinModelPortaliQ60775
SMRiQ60775
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Asp6

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiQ60775
KOiK09428
OMAiHLHTVTL
OrthoDBiEOG091G04RR
PhylomeDBiQ60775
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q60775-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVVQQNDL VFEFASNGME DEQQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH NGDETIETIE
110 120 130 140 150
AAEALLNIDS PSPPVLDEKQ INNNIFSSSE DDIVAPITHV SVTLDGIPEV
160 170 180 190 200
METQQVQETN ADSPGASSPE QRKRKKGRKT KPPRPDSPTT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYID
310 320 330 340 350
DEDPSSSIES SDQSLSSTTA SSRNQANRSR VSSSPGIKGG AATILKPGNS
360 370 380 390 400
KAANPKDPVE VGQPSEVLRT VQPSQAPYPT QLFRTVHVVQ PVQAVPEEAT
410 420 430 440 450
IASTMQEEAA NSSVPSIRTI QASTQVPVVV SPGNQQLHTV TVPLTTVIAS
460 470 480 490 500
IDPSSGAGSQ KFILQTIPSS QPMTVLKENV MLQSQKPGSP SIVLSPTQVQ
510 520 530 540 550
QVLTSNVQSI CNGAGSVASA PSFSATTPVV TFSRSSQLVA HPPGTVITSV
560 570 580 590 600
IKAQETKTLK QEVEKKAEDD LNEDAEKSAQ QPQPYVMVLS SSNGFSSQVA
610
VKQNELLEPN SF
Length:612
Mass (Da):66,221
Last modified:November 1, 1996 - v1
Checksum:i442F4C85142B31F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPX9A0A2I3BPX9_MOUSE
ETS-related transcription factor El...
Elf1
575Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19617 mRNA Translation: AAB17097.1
BC057134 mRNA Translation: AAH57134.1
CCDSiCCDS27301.1
RefSeqiNP_001273340.1, NM_001286411.1
NP_031946.1, NM_007920.4
XP_011243248.1, XM_011244946.2
XP_011243249.1, XM_011244947.1
UniGeneiMm.20938

Genome annotation databases

EnsembliENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461
ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461
GeneIDi13709
KEGGimmu:13709
UCSCiuc007utb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19617 mRNA Translation: AAB17097.1
BC057134 mRNA Translation: AAH57134.1
CCDSiCCDS27301.1
RefSeqiNP_001273340.1, NM_001286411.1
NP_031946.1, NM_007920.4
XP_011243248.1, XM_011244946.2
XP_011243249.1, XM_011244947.1
UniGeneiMm.20938

3D structure databases

ProteinModelPortaliQ60775
SMRiQ60775
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199426, 3 interactors
IntActiQ60775, 2 interactors
MINTiQ60775
STRINGi10090.ENSMUSP00000046515

PTM databases

iPTMnetiQ60775
PhosphoSitePlusiQ60775

Proteomic databases

EPDiQ60775
MaxQBiQ60775
PaxDbiQ60775
PRIDEiQ60775

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461
ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461
GeneIDi13709
KEGGimmu:13709
UCSCiuc007utb.2 mouse

Organism-specific databases

CTDi1997
MGIiMGI:107180 Elf1

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiQ60775
KOiK09428
OMAiHLHTVTL
OrthoDBiEOG091G04RR
PhylomeDBiQ60775
TreeFamiTF318679

Enzyme and pathway databases

ReactomeiR-MMU-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling

Miscellaneous databases

ChiTaRSiElf1 mouse
PROiPR:Q60775
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036461 Expressed in 272 organ(s), highest expression level in thymus
CleanExiMM_ELF1
ExpressionAtlasiQ60775 baseline and differential
GenevisibleiQ60775 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELF1_MOUSE
AccessioniPrimary (citable) accession number: Q60775
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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