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UniProtKB - Q60773 (CDN2D_MOUSE)
Protein
Cyclin-dependent kinase 4 inhibitor D
Gene
Cdkn2d
Organism
Mus musculus (Mouse)
Status
Functioni
Interacts strongly with CDK4 and CDK6 and inhibits them.
2 PublicationsGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
- protein kinase binding Source: MGI
GO - Biological processi
- autophagic cell death Source: MGI
- DNA synthesis involved in DNA repair Source: MGI
- G1/S transition of mitotic cell cycle Source: MGI
- negative regulation of cell cycle G1/S phase transition Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- negative regulation of phosphorylation Source: MGI
- regulation of cell cycle Source: MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- response to retinoic acid Source: MGI
- response to UV Source: MGI
- response to vitamin D Source: MGI
- sensory perception of sound Source: MGI
Keywordsi
Biological process | Cell cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 4 inhibitor DAlternative name(s): p19-INK4d |
Gene namesi | Name:Cdkn2d |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105387, Cdkn2d |
VEuPathDBi | HostDB:ENSMUSG00000096472 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cyclin D2-CDK4 complex Source: MGI
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144189 | 1 – 166 | Cyclin-dependent kinase 4 inhibitor DAdd BLAST | 166 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q60773 |
PaxDbi | Q60773 |
PRIDEi | Q60773 |
ProteomicsDBi | 283868 |
PTM databases
iPTMneti | Q60773 |
PhosphoSitePlusi | Q60773 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000096472, Expressed in bone marrow and 303 other tissues |
ExpressionAtlasi | Q60773, baseline and differential |
Genevisiblei | Q60773, MM |
Interactioni
Subunit structurei
Interacts with CDK6.
By similarityGO - Molecular functioni
- protein kinase binding Source: MGI
Protein-protein interaction databases
CORUMi | Q60773 |
IntActi | Q60773, 1 interactor |
STRINGi | 10090.ENSMUSP00000083561 |
Miscellaneous databases
RNActi | Q60773, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q60773 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q60773 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 41 – 69 | ANK 1Add BLAST | 29 | |
Repeati | 73 – 102 | ANK 2Add BLAST | 30 | |
Repeati | 106 – 135 | ANK 3Add BLAST | 30 | |
Repeati | 138 – 165 | ANK 4Add BLAST | 28 |
Sequence similaritiesi
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000159801 |
HOGENOMi | CLU_000134_37_0_1 |
InParanoidi | Q60773 |
OMAi | QGIGAQD |
OrthoDBi | 1453965at2759 |
PhylomeDBi | Q60773 |
TreeFami | TF333311 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF13857, Ank_5, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q60773-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG
160
AQNLMDILQG HMMIPM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SRJ2 | A0A1L1SRJ2_MOUSE | Cyclin-dependent kinase 4 inhibitor... | Cdkn2d | 163 | Annotation score: | ||
A0A1N9MI08 | A0A1N9MI08_MOUSE | Cyclin-dependent kinase 4 inhibitor... | Cdkn2d | 50 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | A → R in AAC52194 (PubMed:7739547).Curated | 1 | |
Sequence conflicti | 17 | A → P in AAA85437 (PubMed:7739548).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19597 mRNA Translation: AAC52194.1 U20497 mRNA Translation: AAA85437.1 AK132906 mRNA Translation: BAE21414.1 AC122525 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25176.1 BC013898 mRNA Translation: AAH13898.1 |
CCDSi | CCDS22901.1 |
PIRi | A57379 B57378 |
RefSeqi | NP_034008.2, NM_009878.3 XP_006510031.1, XM_006509968.1 |
Genome annotation databases
Ensembli | ENSMUST00000215619; ENSMUSP00000150701; ENSMUSG00000096472 |
GeneIDi | 12581 |
KEGGi | mmu:12581 |
UCSCi | uc009okw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19597 mRNA Translation: AAC52194.1 U20497 mRNA Translation: AAA85437.1 AK132906 mRNA Translation: BAE21414.1 AC122525 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25176.1 BC013898 mRNA Translation: AAH13898.1 |
CCDSi | CCDS22901.1 |
PIRi | A57379 B57378 |
RefSeqi | NP_034008.2, NM_009878.3 XP_006510031.1, XM_006509968.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AP7 | NMR | - | A | 1-166 | [»] | |
1BLX | X-ray | 1.90 | B | 1-166 | [»] | |
SMRi | Q60773 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | Q60773 |
IntActi | Q60773, 1 interactor |
STRINGi | 10090.ENSMUSP00000083561 |
PTM databases
iPTMneti | Q60773 |
PhosphoSitePlusi | Q60773 |
Proteomic databases
EPDi | Q60773 |
PaxDbi | Q60773 |
PRIDEi | Q60773 |
ProteomicsDBi | 283868 |
Protocols and materials databases
Antibodypediai | 4404, 296 antibodies from 34 providers |
DNASUi | 12581 |
Genome annotation databases
Ensembli | ENSMUST00000215619; ENSMUSP00000150701; ENSMUSG00000096472 |
GeneIDi | 12581 |
KEGGi | mmu:12581 |
UCSCi | uc009okw.1, mouse |
Organism-specific databases
CTDi | 1032 |
MGIi | MGI:105387, Cdkn2d |
VEuPathDBi | HostDB:ENSMUSG00000096472 |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000159801 |
HOGENOMi | CLU_000134_37_0_1 |
InParanoidi | Q60773 |
OMAi | QGIGAQD |
OrthoDBi | 1453965at2759 |
PhylomeDBi | Q60773 |
TreeFami | TF333311 |
Miscellaneous databases
BioGRID-ORCSi | 12581, 1 hit in 103 CRISPR screens |
EvolutionaryTracei | Q60773 |
PROi | PR:Q60773 |
RNActi | Q60773, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000096472, Expressed in bone marrow and 303 other tissues |
ExpressionAtlasi | Q60773, baseline and differential |
Genevisiblei | Q60773, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF13857, Ank_5, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDN2D_MOUSE | |
Accessioni | Q60773Primary (citable) accession number: Q60773 Secondary accession number(s): Q60794, Q91YV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families