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Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

Cdkn2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
Gene namesi
Name:Cdkn2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:105387 Cdkn2d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441891 – 166Cyclin-dependent kinase 4 inhibitor DAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ60773
PaxDbiQ60773
PRIDEiQ60773

PTM databases

iPTMnetiQ60773
PhosphoSitePlusiQ60773

Expressioni

Gene expression databases

BgeeiENSMUSG00000096472 Expressed in 282 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ60773 baseline and differential
GenevisibleiQ60773 MM

Interactioni

Subunit structurei

Interacts with CDK6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ60773
IntActiQ60773, 1 interactor
STRINGi10090.ENSMUSP00000083561

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ60773
SMRiQ60773
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60773

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 69ANK 1Add BLAST29
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati138 – 165ANK 4Add BLAST28

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiQ60773
KOiK06623
OrthoDBiEOG091G0PMC
TreeFamiTF333311

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q60773-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG
160
AQNLMDILQG HMMIPM
Length:166
Mass (Da):17,809
Last modified:October 3, 2012 - v2
Checksum:i7B95D6C2294F9259
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRJ2A0A1L1SRJ2_MOUSE
Cyclin-dependent kinase 4 inhibitor...
Cdkn2d
163Annotation score:
A0A1N9MI08A0A1N9MI08_MOUSE
Cyclin-dependent kinase 4 inhibitor...
Cdkn2d
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16A → R in AAC52194 (PubMed:7739547).Curated1
Sequence conflicti17A → P in AAA85437 (PubMed:7739548).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19597 mRNA Translation: AAC52194.1
U20497 mRNA Translation: AAA85437.1
AK132906 mRNA Translation: BAE21414.1
AC122525 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25176.1
BC013898 mRNA Translation: AAH13898.1
CCDSiCCDS22901.1
PIRiA57379
B57378
RefSeqiNP_034008.2, NM_009878.3
XP_006510031.1, XM_006509968.1
UniGeneiMm.29020

Genome annotation databases

EnsembliENSMUST00000215619; ENSMUSP00000150701; ENSMUSG00000096472
GeneIDi12581
KEGGimmu:12581
UCSCiuc009okw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19597 mRNA Translation: AAC52194.1
U20497 mRNA Translation: AAA85437.1
AK132906 mRNA Translation: BAE21414.1
AC122525 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25176.1
BC013898 mRNA Translation: AAH13898.1
CCDSiCCDS22901.1
PIRiA57379
B57378
RefSeqiNP_034008.2, NM_009878.3
XP_006510031.1, XM_006509968.1
UniGeneiMm.29020

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AP7NMR-A1-166[»]
1BLXX-ray1.90B1-166[»]
ProteinModelPortaliQ60773
SMRiQ60773
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ60773
IntActiQ60773, 1 interactor
STRINGi10090.ENSMUSP00000083561

PTM databases

iPTMnetiQ60773
PhosphoSitePlusiQ60773

Proteomic databases

EPDiQ60773
PaxDbiQ60773
PRIDEiQ60773

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000215619; ENSMUSP00000150701; ENSMUSG00000096472
GeneIDi12581
KEGGimmu:12581
UCSCiuc009okw.1 mouse

Organism-specific databases

CTDi1032
MGIiMGI:105387 Cdkn2d

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiQ60773
KOiK06623
OrthoDBiEOG091G0PMC
TreeFamiTF333311

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Miscellaneous databases

EvolutionaryTraceiQ60773
PROiPR:Q60773
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000096472 Expressed in 282 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ60773 baseline and differential
GenevisibleiQ60773 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2D_MOUSE
AccessioniPrimary (citable) accession number: Q60773
Secondary accession number(s): Q60794, Q91YV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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