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Protein

Cyclin-dependent kinase 4 inhibitor C

Gene

Cdkn2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene namesi
Name:Cdkn2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105388 Cdkn2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441871 – 168Cyclin-dependent kinase 4 inhibitor CAdd BLAST168

Proteomic databases

EPDiQ60772
MaxQBiQ60772
PaxDbiQ60772
PeptideAtlasiQ60772
PRIDEiQ60772

PTM databases

iPTMnetiQ60772
PhosphoSitePlusiQ60772

Expressioni

Gene expression databases

BgeeiENSMUSG00000028551 Expressed in 223 organ(s), highest expression level in white adipose tissue
GenevisibleiQ60772 MM

Interactioni

Subunit structurei

Heterodimer of p18 with CDK6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ60772
DIPiDIP-60250N
IntActiQ60772, 1 interactor
STRINGi10090.ENSMUSP00000070313

Structurei

3D structure databases

ProteinModelPortaliQ60772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 33ANK 1Add BLAST30
Repeati37 – 65ANK 2Add BLAST29
Repeati69 – 98ANK 3Add BLAST30
Repeati102 – 132ANK 4Add BLAST31
Repeati136 – 165ANK 5Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiQ60772
KOiK06622
OMAiKHTASKV
OrthoDBiEOG091G0PMC
PhylomeDBiQ60772
TreeFamiTF333311

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q60772-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN
160
EVISLMEANG VGGATSLQ
Length:168
Mass (Da):18,066
Last modified:November 1, 1996 - v1
Checksum:iBC88D5489307E128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19596 mRNA Translation: AAC52193.1
BC027026 mRNA Translation: AAH27026.1
CCDSiCCDS18467.1
PIRiB57379
RefSeqiNP_001288297.1, NM_001301368.1
NP_031697.1, NM_007671.3
UniGeneiMm.1912

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551
GeneIDi12580
KEGGimmu:12580
UCSCiuc008ucr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19596 mRNA Translation: AAC52193.1
BC027026 mRNA Translation: AAH27026.1
CCDSiCCDS18467.1
PIRiB57379
RefSeqiNP_001288297.1, NM_001301368.1
NP_031697.1, NM_007671.3
UniGeneiMm.1912

3D structure databases

ProteinModelPortaliQ60772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ60772
DIPiDIP-60250N
IntActiQ60772, 1 interactor
STRINGi10090.ENSMUSP00000070313

PTM databases

iPTMnetiQ60772
PhosphoSitePlusiQ60772

Proteomic databases

EPDiQ60772
MaxQBiQ60772
PaxDbiQ60772
PeptideAtlasiQ60772
PRIDEiQ60772

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551
GeneIDi12580
KEGGimmu:12580
UCSCiuc008ucr.1 mouse

Organism-specific databases

CTDi1031
MGIiMGI:105388 Cdkn2c

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiQ60772
KOiK06622
OMAiKHTASKV
OrthoDBiEOG091G0PMC
PhylomeDBiQ60772
TreeFamiTF333311

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Miscellaneous databases

PROiPR:Q60772
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028551 Expressed in 223 organ(s), highest expression level in white adipose tissue
GenevisibleiQ60772 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2C_MOUSE
AccessioniPrimary (citable) accession number: Q60772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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