Cdkn2c

Functionⁱ

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase inhibitor activity
Source: MGI
Inferred from direct assayⁱ
- 7739547
protein kinase binding
Source: MGI
Inferred from physical interactionⁱ
- 7739547

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest Source: MGI
G1/S transition of mitotic cell cycle Source: MGI
negative regulation of cell growth Source: MGI
negative regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 17409423
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Source: MGI
Inferred from direct assayⁱ
- 7739547
negative regulation of phosphorylation Source: MGI
oligodendrocyte differentiation Source: Ensembl
regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559585 Oncogene Induced Senescence R-MMU-69231 Cyclin D associated events in G1

Reactomeⁱ

R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 4 inhibitor C Alternative name(s): Cyclin-dependent kinase 6 inhibitor p18-INK4c p18-INK6
Gene namesⁱ	Name:Cdkn2c
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:105388 Cdkn2c

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144187	1 – 168	Cyclin-dependent kinase 4 inhibitor CAdd BLAST		168

Proteomic databases

EPDⁱ	Q60772
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q60772
PaxDbⁱ	Q60772
PeptideAtlas More...PeptideAtlasⁱ	Q60772
PRIDEⁱ	Q60772

PTM databases

iPTMnetⁱ	Q60772
PhosphoSitePlusⁱ	Q60772

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028551 Expressed in 223 organ(s), highest expression level in white adipose tissue
Genevisibleⁱ	Q60772 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer of p18 with CDK6.By similarity

GO - Molecular functionⁱ

protein kinase binding
Source: MGI
Inferred from physical interactionⁱ
- 7739547

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	Q60772
Database of interacting proteins More...DIPⁱ	DIP-60250N
IntActⁱ	Q60772, 1 interactor
STRINGⁱ	10090.ENSMUSP00000070313

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q60772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 33	ANK 1Add BLAST	30
Repeatⁱ	37 – 65	ANK 2Add BLAST	29
Repeatⁱ	69 – 98	ANK 3Add BLAST	30
Repeatⁱ	102 – 132	ANK 4Add BLAST	31
Repeatⁱ	136 – 165	ANK 5Add BLAST	30

Sequence similaritiesⁱ

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004527
HOGENOMⁱ	HOG000290191
HOVERGENⁱ	HBG050870
InParanoidⁱ	Q60772
KEGG Orthology (KO) More...KOⁱ	K06622
OMAⁱ	KHTASKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMC
PhylomeDBⁱ	Q60772
TreeFamⁱ	TF333311

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q60772-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP 
        60         70         80         90        100
EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED 
       110        120        130        140        150
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN 
       160 
EVISLMEANG VGGATSLQ

Length:168

Mass (Da):18,066

Last modified:November 1, 1996 - v1

Checksum:ⁱBC88D5489307E128

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U19596 mRNA Translation: AAC52193.1 BC027026 mRNA Translation: AAH27026.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18467.1
PIRⁱ	B57379
NCBI Reference Sequences More...RefSeqⁱ	NP_001288297.1, NM_001301368.1 NP_031697.1, NM_007671.3
UniGeneⁱ	Mm.1912

Genome annotation databases

Ensemblⁱ	ENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551 ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551
GeneIDⁱ	12580
KEGGⁱ	mmu:12580
UCSC genome browser More...UCSCⁱ	uc008ucr.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q60772	Cyclin-dependent kinase 4 inhibitor C	)	HUMAN		168	UniRef90_P42773
Cyclin dependent kinase inhibitor 2C		MACMU		168
CDKN2C isoform 1		PANTR		168
Cyclin dependent kinase inhibitor 2C		MACNE		168
Cyclin dependent kinase inhibitor 2C		CERAT		168
+98

Protein	Similar proteins		Species	Score	Length	Source
Q60772	Cyclin-dependent kinase 4 inhibitor C	)	HUMAN		168	UniRef50_P42773
Cyclin dependent kinase inhibitor 2C		MACMU		168
CDKN2C isoform 1		PANTR		168
Cyclin dependent kinase inhibitor 2C		MACNE		168
Cyclin dependent kinase inhibitor 2C		CERAT		168
+188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U19596 mRNA Translation: AAC52193.1 BC027026 mRNA Translation: AAH27026.1
CCDSⁱ	CCDS18467.1
PIRⁱ	B57379
RefSeqⁱ	NP_001288297.1, NM_001301368.1 NP_031697.1, NM_007671.3
UniGeneⁱ	Mm.1912

3D structure databases

ProteinModelPortalⁱ	Q60772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	Q60772
DIPⁱ	DIP-60250N
IntActⁱ	Q60772, 1 interactor
STRINGⁱ	10090.ENSMUSP00000070313

PTM databases

iPTMnetⁱ	Q60772
PhosphoSitePlusⁱ	Q60772

Proteomic databases

EPDⁱ	Q60772
MaxQBⁱ	Q60772
PaxDbⁱ	Q60772
PeptideAtlasⁱ	Q60772
PRIDEⁱ	Q60772

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551 ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551
GeneIDⁱ	12580
KEGGⁱ	mmu:12580
UCSCⁱ	uc008ucr.1 mouse

Organism-specific databases

CTDⁱ	1031
MGIⁱ	MGI:105388 Cdkn2c

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
GeneTreeⁱ	ENSGT00390000004527
HOGENOMⁱ	HOG000290191
HOVERGENⁱ	HBG050870
InParanoidⁱ	Q60772
KOⁱ	K06622
OMAⁱ	KHTASKV
OrthoDBⁱ	EOG091G0PMC
PhylomeDBⁱ	Q60772
TreeFamⁱ	TF333311

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559585 Oncogene Induced Senescence R-MMU-69231 Cyclin D associated events in G1

Reactomeⁱ

R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559585 Oncogene Induced Senescence
R-MMU-69231 Cyclin D associated events in G1

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q60772
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028551 Expressed in 223 organ(s), highest expression level in white adipose tissue
Genevisibleⁱ	Q60772 MM

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDN2C_MOUSE
Accessionⁱ	Q60772Primary (citable) accession number: Q60772
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q60772 (CDN2C_MOUSE)

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Cyclin-dependent kinase 4 inhibitor C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ