UniProtKB - Q60772 (CDN2C_MOUSE)
Protein
Cyclin-dependent kinase 4 inhibitor C
Gene
Cdkn2c
Organism
Mus musculus (Mouse)
Status
Functioni
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
- protein kinase binding Source: MGI
GO - Biological processi
- cell cycle arrest Source: MGI
- G1/S transition of mitotic cell cycle Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- negative regulation of phosphorylation Source: MGI
- oligodendrocyte differentiation Source: Ensembl
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
Keywordsi
Biological process | Cell cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 4 inhibitor CAlternative name(s): Cyclin-dependent kinase 6 inhibitor p18-INK4c p18-INK6 |
Gene namesi | Name:Cdkn2c |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105388, Cdkn2c |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144187 | 1 – 168 | Cyclin-dependent kinase 4 inhibitor CAdd BLAST | 168 |
Proteomic databases
EPDi | Q60772 |
MaxQBi | Q60772 |
PaxDbi | Q60772 |
PeptideAtlasi | Q60772 |
PRIDEi | Q60772 |
PTM databases
iPTMneti | Q60772 |
PhosphoSitePlusi | Q60772 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028551, Expressed in white adipose tissue and 246 other tissues |
Genevisiblei | Q60772, MM |
Interactioni
Subunit structurei
Heterodimer of p18 with CDK6.
By similarityGO - Molecular functioni
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198656, 2 interactors |
CORUMi | Q60772 |
DIPi | DIP-60250N |
IntActi | Q60772, 1 interactor |
STRINGi | 10090.ENSMUSP00000095534 |
Miscellaneous databases
RNActi | Q60772, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 33 | ANK 1Add BLAST | 30 | |
Repeati | 37 – 65 | ANK 2Add BLAST | 29 | |
Repeati | 69 – 98 | ANK 3Add BLAST | 30 | |
Repeati | 102 – 132 | ANK 4Add BLAST | 31 | |
Repeati | 136 – 165 | ANK 5Add BLAST | 30 |
Sequence similaritiesi
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000160194 |
HOGENOMi | CLU_000134_37_0_1 |
InParanoidi | Q60772 |
OMAi | MAEPLGN |
OrthoDBi | 1453965at2759 |
PhylomeDBi | Q60772 |
TreeFami | TF333311 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
i Sequence
Sequence statusi: Complete.
Q60772-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN
160
EVISLMEANG VGGATSLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19596 mRNA Translation: AAC52193.1 BC027026 mRNA Translation: AAH27026.1 |
CCDSi | CCDS18467.1 |
PIRi | B57379 |
RefSeqi | NP_001288297.1, NM_001301368.1 NP_031697.1, NM_007671.3 |
Genome annotation databases
Ensembli | ENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551 ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551 |
GeneIDi | 12580 |
KEGGi | mmu:12580 |
UCSCi | uc008ucr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19596 mRNA Translation: AAC52193.1 BC027026 mRNA Translation: AAH27026.1 |
CCDSi | CCDS18467.1 |
PIRi | B57379 |
RefSeqi | NP_001288297.1, NM_001301368.1 NP_031697.1, NM_007671.3 |
3D structure databases
SMRi | Q60772 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198656, 2 interactors |
CORUMi | Q60772 |
DIPi | DIP-60250N |
IntActi | Q60772, 1 interactor |
STRINGi | 10090.ENSMUSP00000095534 |
PTM databases
iPTMneti | Q60772 |
PhosphoSitePlusi | Q60772 |
Proteomic databases
EPDi | Q60772 |
MaxQBi | Q60772 |
PaxDbi | Q60772 |
PeptideAtlasi | Q60772 |
PRIDEi | Q60772 |
Protocols and materials databases
Antibodypediai | 3941, 527 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551 ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551 |
GeneIDi | 12580 |
KEGGi | mmu:12580 |
UCSCi | uc008ucr.1, mouse |
Organism-specific databases
CTDi | 1031 |
MGIi | MGI:105388, Cdkn2c |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000160194 |
HOGENOMi | CLU_000134_37_0_1 |
InParanoidi | Q60772 |
OMAi | MAEPLGN |
OrthoDBi | 1453965at2759 |
PhylomeDBi | Q60772 |
TreeFami | TF333311 |
Miscellaneous databases
BioGRID-ORCSi | 12580, 2 hits in 18 CRISPR screens |
PROi | PR:Q60772 |
RNActi | Q60772, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028551, Expressed in white adipose tissue and 246 other tissues |
Genevisiblei | Q60772, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDN2C_MOUSE | |
Accessioni | Q60772Primary (citable) accession number: Q60772 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families