Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-11

Gene

Cldn11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-11
Alternative name(s):
Oligodendrocyte transmembrane protein
Oligodendrocyte-specific protein
Gene namesi
Name:Cldn11
Synonyms:Osp, Otm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106925 Cldn11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 82ExtracellularSequence analysisAdd BLAST60
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 122CytoplasmicSequence analysisAdd BLAST19
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 157ExtracellularSequence analysisAdd BLAST14
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 207CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447621 – 207Claudin-11Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60771
PaxDbiQ60771
PeptideAtlasiQ60771
PRIDEiQ60771

PTM databases

iPTMnetiQ60771
PhosphoSitePlusiQ60771
SwissPalmiQ60771

Expressioni

Gene expression databases

BgeeiENSMUSG00000037625 Expressed in 185 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_CLDN11
GenevisibleiQ60771 MM

Interactioni

Subunit structurei

Interacts with tetraspanin-3/TSPAN3 (PubMed:11309411). Interacts with OCLN (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Csf1P071412EBI-309095,EBI-777188

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ60771
IntActiQ60771, 2 interactors
MINTiQ60771
STRINGi10090.ENSMUSP00000042181

Structurei

3D structure databases

ProteinModelPortaliQ60771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXU Eukaryota
ENOG41101XN LUCA
GeneTreeiENSGT00890000139496
HOGENOMiHOG000220937
HOVERGENiHBG102313
InParanoidiQ60771
KOiK06087
OMAiYSLYTGW
OrthoDBiEOG091G0MX2
PhylomeDBiQ60771
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003555 Claudin11
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF6 PTHR12002:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01384 CLAUDIN11
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q60771-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVATCLQVVG FVTSFVGWIG IIVTTSTNDW VVTCSYTIPT CRKMDELGSK
60 70 80 90 100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL
110 120 130 140 150
TVLPCIRMGH EPGVAKYRRA QLAGVLLILL ALCAIVATIW FPVCAHREIT
160 170 180 190 200
IVSFGYSLYA GWIGAVMCLV GGCVIVCCSG DAQSFGENRF YYSSGSSSPT

HAKSAHV
Length:207
Mass (Da):22,114
Last modified:November 1, 1996 - v1
Checksum:iA3F936F15958F27B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196S → C in BAB23860 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19582 mRNA Translation: AAB50270.1
AF124426 mRNA Translation: AAD17321.1
AK005088 mRNA Translation: BAB23810.1
AK005171 mRNA Translation: BAB23860.1
AK161698 mRNA Translation: BAE36538.1
BC021659 mRNA Translation: AAH21659.1
CCDSiCCDS17290.1
RefSeqiNP_032796.1, NM_008770.3
UniGeneiMm.4425

Genome annotation databases

EnsembliENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625
GeneIDi18417
KEGGimmu:18417
UCSCiuc008ovw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19582 mRNA Translation: AAB50270.1
AF124426 mRNA Translation: AAD17321.1
AK005088 mRNA Translation: BAB23810.1
AK005171 mRNA Translation: BAB23860.1
AK161698 mRNA Translation: BAE36538.1
BC021659 mRNA Translation: AAH21659.1
CCDSiCCDS17290.1
RefSeqiNP_032796.1, NM_008770.3
UniGeneiMm.4425

3D structure databases

ProteinModelPortaliQ60771
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ60771
IntActiQ60771, 2 interactors
MINTiQ60771
STRINGi10090.ENSMUSP00000042181

PTM databases

iPTMnetiQ60771
PhosphoSitePlusiQ60771
SwissPalmiQ60771

Proteomic databases

MaxQBiQ60771
PaxDbiQ60771
PeptideAtlasiQ60771
PRIDEiQ60771

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625
GeneIDi18417
KEGGimmu:18417
UCSCiuc008ovw.2 mouse

Organism-specific databases

CTDi5010
MGIiMGI:106925 Cldn11

Phylogenomic databases

eggNOGiENOG410IEXU Eukaryota
ENOG41101XN LUCA
GeneTreeiENSGT00890000139496
HOGENOMiHOG000220937
HOVERGENiHBG102313
InParanoidiQ60771
KOiK06087
OMAiYSLYTGW
OrthoDBiEOG091G0MX2
PhylomeDBiQ60771
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q60771
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037625 Expressed in 185 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_CLDN11
GenevisibleiQ60771 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003555 Claudin11
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF6 PTHR12002:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01384 CLAUDIN11
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD11_MOUSE
AccessioniPrimary (citable) accession number: Q60771
Secondary accession number(s): Q545N5, Q9DB65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again