Cldn11

Functionⁱ

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon ensheathment
Source: MGI
Inferred from mutant phenotypeⁱ
- 10612400
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
cell adhesion
Source: MGI
Inferred from mutant phenotypeⁱ
- 10612400
spermatogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10612400

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-11 Alternative name(s): Oligodendrocyte transmembrane protein Oligodendrocyte-specific protein
Gene namesⁱ	Name:Cldn11 Synonyms:Osp, Otm
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:106925 Cldn11

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1	CytoplasmicSequence analysis	1
Transmembraneⁱ	2 – 22	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	23 – 82	ExtracellularSequence analysisAdd BLAST	60
Transmembraneⁱ	83 – 103	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	104 – 122	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	123 – 143	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	144 – 157	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	158 – 178	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	179 – 207	CytoplasmicSequence analysisAdd BLAST	29

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144762	1 – 207	Claudin-11Add BLAST		207

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	193	PhosphoserineBy similarity	1
Modified residueⁱ	194	PhosphoserineCombined sources	1
Modified residueⁱ	197	PhosphoserineCombined sources	1
Modified residueⁱ	198	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q60771
PaxDbⁱ	Q60771
PeptideAtlas More...PeptideAtlasⁱ	Q60771
PRIDEⁱ	Q60771

PTM databases

iPTMnetⁱ	Q60771
PhosphoSitePlusⁱ	Q60771
SwissPalmⁱ	Q60771

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037625 Expressed in 185 organ(s), highest expression level in ventral horn of spinal cord
CleanExⁱ	MM_CLDN11
Genevisibleⁱ	Q60771 MM

Interactionⁱ

Subunit structureⁱ

Interacts with tetraspanin-3/TSPAN3 (PubMed:11309411). Interacts with OCLN (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Csf1	P07141	2	EBI-309095,EBI-777188

With

Entry

#Exp.

IntAct

Notes

Csf1

P07141

2

EBI-309095,EBI-777188

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	Q60771
IntActⁱ	Q60771, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q60771
STRINGⁱ	10090.ENSMUSP00000042181

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q60771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEXU Eukaryota ENOG41101XN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139496
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG102313
InParanoidⁱ	Q60771
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	YSLYTGW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MX2
PhylomeDBⁱ	Q60771
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003555 Claudin11 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF6 PTHR12002:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01384 CLAUDIN11
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q60771-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVATCLQVVG FVTSFVGWIG IIVTTSTNDW VVTCSYTIPT CRKMDELGSK 
        60         70         80         90        100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL 
       110        120        130        140        150
TVLPCIRMGH EPGVAKYRRA QLAGVLLILL ALCAIVATIW FPVCAHREIT 
       160        170        180        190        200
IVSFGYSLYA GWIGAVMCLV GGCVIVCCSG DAQSFGENRF YYSSGSSSPT 

HAKSAHV

Length:207

Mass (Da):22,114

Last modified:November 1, 1996 - v1

Checksum:ⁱA3F936F15958F27B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	196	S → C in BAB23860 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U19582 mRNA Translation: AAB50270.1 AF124426 mRNA Translation: AAD17321.1 AK005088 mRNA Translation: BAB23810.1 AK005171 mRNA Translation: BAB23860.1 AK161698 mRNA Translation: BAE36538.1 BC021659 mRNA Translation: AAH21659.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17290.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032796.1, NM_008770.3
UniGeneⁱ	Mm.4425

Genome annotation databases

Ensemblⁱ	ENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625
GeneIDⁱ	18417
KEGGⁱ	mmu:18417
UCSC genome browser More...UCSCⁱ	uc008ovw.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q60771	Claudin		RAT		207	UniRef100_Q60771
Claudin (Fragment)		RAT		111

Protein	Similar proteins		Species	Score	Length	Source
Q60771	Claudin-11		BOVIN		207	UniRef90_Q60771
Claudin-11		HUMAN		207
Claudin-11		MACFA		207
Claudin-11		RAT		207
Claudin-11		PONAB		200
+94

Protein	Similar proteins		Species	Score	Length	Source
Q60771	Claudin-11		BOVIN		207	UniRef50_Q60771
Claudin-11		HUMAN		207
Claudin-11		RAT		207
Claudin-11		MACFA		207
Claudin-11		PONAB		200
+167

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U19582 mRNA Translation: AAB50270.1 AF124426 mRNA Translation: AAD17321.1 AK005088 mRNA Translation: BAB23810.1 AK005171 mRNA Translation: BAB23860.1 AK161698 mRNA Translation: BAE36538.1 BC021659 mRNA Translation: AAH21659.1
CCDSⁱ	CCDS17290.1
RefSeqⁱ	NP_032796.1, NM_008770.3
UniGeneⁱ	Mm.4425

3D structure databases

ProteinModelPortalⁱ	Q60771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	Q60771
IntActⁱ	Q60771, 2 interactors
MINTⁱ	Q60771
STRINGⁱ	10090.ENSMUSP00000042181

PTM databases

iPTMnetⁱ	Q60771
PhosphoSitePlusⁱ	Q60771
SwissPalmⁱ	Q60771

Proteomic databases

MaxQBⁱ	Q60771
PaxDbⁱ	Q60771
PeptideAtlasⁱ	Q60771
PRIDEⁱ	Q60771

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625
GeneIDⁱ	18417
KEGGⁱ	mmu:18417
UCSCⁱ	uc008ovw.2 mouse

Organism-specific databases

CTDⁱ	5010
MGIⁱ	MGI:106925 Cldn11

Phylogenomic databases

eggNOGⁱ	ENOG410IEXU Eukaryota ENOG41101XN LUCA
GeneTreeⁱ	ENSGT00890000139496
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG102313
InParanoidⁱ	Q60771
KOⁱ	K06087
OMAⁱ	YSLYTGW
OrthoDBⁱ	EOG091G0MX2
PhylomeDBⁱ	Q60771
TreeFamⁱ	TF331936

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q60771
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037625 Expressed in 185 organ(s), highest expression level in ventral horn of spinal cord
CleanExⁱ	MM_CLDN11
Genevisibleⁱ	Q60771 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003555 Claudin11 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit PTHR12002:SF6 PTHR12002:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01384 CLAUDIN11
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD11_MOUSE
Accessionⁱ	Q60771Primary (citable) accession number: Q60771 Secondary accession number(s): Q545N5, Q9DB65
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q60771 (CLD11_MOUSE)

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Claudin-11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ