UniProtKB - Q60771 (CLD11_MOUSE)
Protein
Claudin-11
Gene
Cldn11
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- structural molecule activity Source: InterPro
GO - Biological processi
- axon ensheathment Source: MGI
- bicellular tight junction assembly Source: GO_Central
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
- cell adhesion Source: MGI
- spermatogenesis Source: MGI
- tight junction assembly Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Claudin-11Alternative name(s): Oligodendrocyte transmembrane protein Oligodendrocyte-specific protein |
Gene namesi | Name:Cldn11 Synonyms:Osp, Otm |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106925, Cldn11 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
Cytoskeleton
- neurofilament Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- axon Source: MGI
- basal part of cell Source: MGI
- bicellular tight junction Source: MGI
- cell junction Source: MGI
- lipid droplet Source: MGI
- myelin sheath Source: UniProtKB
- tight junction Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 2 – 22 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 23 – 82 | ExtracellularSequence analysisAdd BLAST | 60 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 122 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 157 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 207 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144762 | 1 – 207 | Claudin-11Add BLAST | 207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 193 | PhosphoserineBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Modified residuei | 198 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q60771 |
PaxDbi | Q60771 |
PeptideAtlasi | Q60771 |
PRIDEi | Q60771 |
PTM databases
iPTMneti | Q60771 |
PhosphoSitePlusi | Q60771 |
SwissPalmi | Q60771 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037625, Expressed in ventral horn of spinal cord and 213 other tissues |
Genevisiblei | Q60771, MM |
Interactioni
Subunit structurei
Interacts with tetraspanin-3/TSPAN3 (PubMed:11309411).
Interacts with OCLN (By similarity).
By similarity1 PublicationBinary interactionsi
Q60771
With | #Exp. | IntAct |
---|---|---|
Csf1 [P07141] | 2 | EBI-309095,EBI-777188 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 201987, 2 interactors |
CORUMi | Q60771 |
IntActi | Q60771, 2 interactors |
MINTi | Q60771 |
STRINGi | 10090.ENSMUSP00000042181 |
Miscellaneous databases
RNActi | Q60771, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the claudin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSDJ, Eukaryota |
GeneTreei | ENSGT00890000139496 |
HOGENOMi | CLU_094997_0_0_1 |
InParanoidi | Q60771 |
OMAi | MSMPCIS |
OrthoDBi | 1223820at2759 |
PhylomeDBi | Q60771 |
TreeFami | TF331936 |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR003555, Claudin11 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit PTHR12002:SF6, PTHR12002:SF6, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01384, CLAUDIN11 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q60771-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVATCLQVVG FVTSFVGWIG IIVTTSTNDW VVTCSYTIPT CRKMDELGSK
60 70 80 90 100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL
110 120 130 140 150
TVLPCIRMGH EPGVAKYRRA QLAGVLLILL ALCAIVATIW FPVCAHREIT
160 170 180 190 200
IVSFGYSLYA GWIGAVMCLV GGCVIVCCSG DAQSFGENRF YYSSGSSSPT
HAKSAHV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | S → C in BAB23860 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19582 mRNA Translation: AAB50270.1 AF124426 mRNA Translation: AAD17321.1 AK005088 mRNA Translation: BAB23810.1 AK005171 mRNA Translation: BAB23860.1 AK161698 mRNA Translation: BAE36538.1 BC021659 mRNA Translation: AAH21659.1 |
CCDSi | CCDS17290.1 |
RefSeqi | NP_032796.1, NM_008770.3 |
Genome annotation databases
Ensembli | ENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625 |
GeneIDi | 18417 |
KEGGi | mmu:18417 |
UCSCi | uc008ovw.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19582 mRNA Translation: AAB50270.1 AF124426 mRNA Translation: AAD17321.1 AK005088 mRNA Translation: BAB23810.1 AK005171 mRNA Translation: BAB23860.1 AK161698 mRNA Translation: BAE36538.1 BC021659 mRNA Translation: AAH21659.1 |
CCDSi | CCDS17290.1 |
RefSeqi | NP_032796.1, NM_008770.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 201987, 2 interactors |
CORUMi | Q60771 |
IntActi | Q60771, 2 interactors |
MINTi | Q60771 |
STRINGi | 10090.ENSMUSP00000042181 |
PTM databases
iPTMneti | Q60771 |
PhosphoSitePlusi | Q60771 |
SwissPalmi | Q60771 |
Proteomic databases
MaxQBi | Q60771 |
PaxDbi | Q60771 |
PeptideAtlasi | Q60771 |
PRIDEi | Q60771 |
Protocols and materials databases
Antibodypediai | 2785, 320 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625 |
GeneIDi | 18417 |
KEGGi | mmu:18417 |
UCSCi | uc008ovw.2, mouse |
Organism-specific databases
CTDi | 5010 |
MGIi | MGI:106925, Cldn11 |
Phylogenomic databases
eggNOGi | ENOG502QSDJ, Eukaryota |
GeneTreei | ENSGT00890000139496 |
HOGENOMi | CLU_094997_0_0_1 |
InParanoidi | Q60771 |
OMAi | MSMPCIS |
OrthoDBi | 1223820at2759 |
PhylomeDBi | Q60771 |
TreeFami | TF331936 |
Miscellaneous databases
BioGRID-ORCSi | 18417, 0 hits in 17 CRISPR screens |
PROi | PR:Q60771 |
RNActi | Q60771, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037625, Expressed in ventral horn of spinal cord and 213 other tissues |
Genevisiblei | Q60771, MM |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR003555, Claudin11 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit PTHR12002:SF6, PTHR12002:SF6, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01384, CLAUDIN11 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLD11_MOUSE | |
Accessioni | Q60771Primary (citable) accession number: Q60771 Secondary accession number(s): Q545N5, Q9DB65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families